Docetaxel (DTX or DXL), sold under the brand name Taxotere among others, is a chemotherapy medication used to treat a number of types of cancer. This includes breast cancer, head and neck cancer, stomach cancer, prostate cancer and non-small-cell lung cancer. It may be used by itself or along with other chemotherapy medication. It is given by slow injection into a vein.
Common side effects include hair loss, cytopenia (low blood cell counts), numbness, shortness of breath, nausea, vomiting, and muscle pains. Other severe side effects include allergic reactions and future cancers. Docetaxel induced pneumotoxicity is also a well recognized adverse effect which has to be identified timely and treated after withholding the drug. Side effects are more common in people with liver problems. Use during pregnancy may harm the baby. Docetaxel is in the taxane family of medications. It works by disrupting the normal function of microtubules and thereby stopping cell division.
Docetaxel was patented in 1986 and approved for medical use in 1995. It is on the World Health Organization's List of Essential Medicines. Docetaxel is available as a generic medication.
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antimalarial
A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human.
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antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
photosensitizing agent
A chemical compound that can be excited by light of a specific wavelength and subsequently transfer energy to a chosen reactant. This is commonly molecular oxygen within a cancer tissue, which is converted to (highly rective) singlet state oxygen. This rapidly reacts with any nearby biomolecules, ultimately killing the cancer cells.
antimalarial
A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human.
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View more via ChEBI Ontology
4- (acetyloxy)- 13α- ({(2R,3S)- 3- [(tert- butoxycarbonyl)amino]- 2- hydroxy- 3- phenylpropanoyl}oxy)- 1,7β,10β- trihydroxy- 9- oxo- 5β,20- epoxytax- 11- en- 2α- yl benzoate
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Docetaxel
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KEGG COMPOUND
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Docetaxel anhydrous
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KEGG COMPOUND
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N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetylpaclitaxel
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ChEBI
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N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol
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ChEBI
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TXL
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DrugBank
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C11231
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KEGG COMPOUND
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D07866
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KEGG DRUG
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DB01248
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DrugBank
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Docetaxel
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Wikipedia
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EP253738
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Patent
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TXL
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PDBeChem
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US4814470
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Patent
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View more database links |
114977-28-5
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CAS Registry Number
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KEGG COMPOUND
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114977-28-5
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CAS Registry Number
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ChemIDplus
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4290183
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Beilstein Registry Number
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Beilstein
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2011-03-18
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Docetaxel is prepared from a natural precursor, 10-deacetylbaccatin III, extracted fron the needles of the European yew tree, Taxus baccata. It is used (often as the trihydrate) for the treatment of breast, ovarian, and non-small cell lung cancer, and with prednisone or prednisolone in hormone-refractory metastatic prostate cancer.
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