parbendazole (CHEBI:94267)

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ChEBI Name	parbendazole

ChEBI ID	CHEBI:94267

Definition	A member of the class of benzimidazoles that is 1H-benzimidazole substituted by (methoxycarbonyl)amino and butyl groups at positions 2 and 5, respectively. It is a potent inhibitor of microtubule assembly and also exhibits anthelminthic activity.

Stars	This entity has been manually annotated by the ChEBI Team.

Supplier Information

Download	Molfile XML SDF

Formula

C13H17N3O2

Net Charge

Average Mass

247.298

Monoisotopic Mass

247.13208

InChI

InChI=1S/C13H17N3O2/c1-3-4-5-9-6-7-10-11(8-9)15-12(14-10)16-13(17)18-2/h6-8H,3-5H2,1-2H3,(H2,14,15,16,17)

InChIKey

YRWLZFXJFBZBEY-UHFFFAOYSA-N

SMILES

CCCCC1=CC2=C(NC(NC(=O)OC)=N2)C=C1

Roles Classification
Biological Role(s):	microtubule-destabilising agent Any substance that interacts with tubulin to inhibit polymerisation of microtubules.

Application(s):	anthelminthic drug Substance intended to kill parasitic worms (helminths). antinematodal drug A substance used in the treatment or control of nematode infestations. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms.

ChEBI Ontology
Outgoing	parbendazole (CHEBI:94267) has role anthelminthic drug (CHEBI:35443) parbendazole (CHEBI:94267) has role antinematodal drug (CHEBI:35444) parbendazole (CHEBI:94267) has role antineoplastic agent (CHEBI:35610) parbendazole (CHEBI:94267) has role microtubule-destabilising agent (CHEBI:61951) parbendazole (CHEBI:94267) is a benzimidazoles (CHEBI:22715) parbendazole (CHEBI:94267) is a carbamate ester (CHEBI:23003)

IUPAC Name

methyl (5-butyl-1H-benzimidazol-2-yl)carbamate

Synonyms	Sources
5-butyl-2-(carbomethoxyamino)benzimidazole	ChEBI
methyl 5-butylbenzimidazole-2-carbamate	ChEBI
N-(5-butyl-1H-benzimidazol-2-yl)carbamic acid methyl ester	ChEBI
PBZ	ChEBI
SK&F 29044	ChEBI
SKF 29044	ChEBI
SK&F-29044	ChEBI
SKF-29044	ChEBI
SKF29044	ChEBI

Registry Number	Type	Source
14255-87-9	CAS Registry Number	KEGG DRUG

Last Modified

19 July 2024