20/chembl/api/data/target?limit=20&offset=20&pref_name__iregex=cdk1%7Ccdk227Homo sapiensCyclin-dependent kinase 2 and 4 (CDK2 and CDK4)CHEMBL2111326P11802Cyclin-dependent kinase 417PROTEINCOMPARATIVE PROTEINCDK4GENE_SYMBOLCyclin-dependent kinase 4UNIPROTCell division protein kinase 4UNIPROTPSK-J3UNIPROT2.7.11.22EC_NUMBER6P8GAPDBe6P8FAPDBe6P8HAPDBe2W96APDBe2W9FAPDBe3G33APDBe2W99APDBe2W9ZAPDBe6P8EAPDBe7SJ3APDBeGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0030332cyclin bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0006468protein phosphorylationGoProcessGO:0007165signal transductionGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010389regulation of G2/M transition of mitotic cell cycleGoProcessGO:0010971positive regulation of G2/M transition of mitotic cell cycleGoProcessGO:0048146positive regulation of fibroblast proliferationGoProcessGO:0051301cell divisionGoProcessGO:0051726regulation of cell cycleGoProcessGO:0061469regulation of type B pancreatic cell proliferationGoProcessGO:0071222cellular response to lipopolysaccharideGoProcessGO:1904628cellular response to phorbol 13-acetate 12-myristateGoProcessGO:1904637cellular response to ionomycinGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0000785chromatinGoComponentGO:0005654nucleoplasmGoComponentGO:0005730nucleolusGoComponentGO:0005829cytosolGoComponentGO:0005923bicellular tight junctionGoComponentGO:0016020membraneGoComponentGO:0031965nuclear membraneGoComponentGO:0005667transcription regulator complexGoComponentB2R9A0Cyclin-dependent kinase 4UniProtB4DNF9Cyclin-dependent kinase 4UniProtO00576Cyclin-dependent kinase 4UniProtQ6FG61Cyclin-dependent kinase 4UniProtP11802Cyclin-dependent kinase 4UniProt2W96PDB2W99PDB2W9FPDB2W9ZPDB3G33PDB5FWKPDB5FWLPDB5FWMPDB5FWPPDB6P8EPDB6P8FPDB6P8GPDB6P8HPDB7SJ3PDBP11802AlphaFoldDBP11802IntActHGNC:1773CDK4HGNCR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559580Oxidative Stress Induced SenescenceReactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-HSA-2559585Oncogene Induced SenescenceReactomeR-HSA-3214858RMTs methylate histone argininesReactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiationReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-75815Ubiquitin-dependent degradation of Cyclin DReactomeR-HSA-8849470PTK6 Regulates Cell CycleReactomeR-HSA-8878166Transcriptional regulation by RUNX2ReactomeR-HSA-912446Meiotic recombinationReactomeR-HSA-9616222Transcriptional regulation of granulopoiesisReactomeR-HSA-9630791Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4ReactomeR-HSA-9630794Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6ReactomeR-HSA-9632697Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4ReactomeR-HSA-9632700Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6ReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9754119Drug-mediated inhibition of CDK4/CDK6 activityReactomeP11802PharosP11802ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF129CYCLIN-DEPENDENT KINASE 4PANTHERPF00069PkinasePfamPA102cyclin dependent kinase 4PharmGKBP24941Cyclin-dependent kinase 236PROTEINCOMPARATIVE PROTEINCDKN2GENE_SYMBOL_OTHERCDK2GENE_SYMBOLCyclin-dependent kinase 2UNIPROTCell division protein kinase 2UNIPROTp33 protein kinaseUNIPROT2.7.11.22EC_NUMBER2DS1APDBe3RKBAPDBe3QHRAPDBe3DOGAPDBe3RK5APDBe7SA0APDBe3TNWAPDBe3RK7APDBe2FVDAPDBe3QHWAPDBe3RK9APDBe2VV9APDBe1AQ1APDBe4EONAPDBe4EOOAPDBe4EOPAPDBe2UUEAPDBe4EOQAPDBe4EORAPDBe7ZPCAPDBe4EOSAPDBe1VYZAPDBe1OL2APDBe4EOIAPDBe1OL1APDBe1VYWAPDBe4EOJAPDBe4EOKAPDBe4EOLAPDBe4EOMAPDBe2WXVAPDBe1OKWAPDBe1OKVAPDBe1B39APDBe3RMFAPDBe1B38APDBe2G9XAPDBe8OY2APDBe5FP6APDBe5FP5APDBe3RM6APDBe3RM7APDBe7UG1APDBe7RA5APDBe1KE9APDBe1KE8APDBe2BPMAPDBe1KE7APDBe1KE6APDBe1KE5APDBe4RJ3APDBe3RNIAPDBe2DUVAPDBe3F5XAPDBe3QL8APDBe3PJ8APDBe6SG4APDBe1E9HAPDBe3S0OAPDBe4ERWAPDBe1BUHAPDBe3S00APDBe2EXMAPDBe3RPOAPDBe3S1HAPDBe3ROYAPDBe2C4GAPDBe2A0CAPDBe3SQQAPDBe2R3JAPDBe2UZOAPDBe2R3IAPDBe4D1ZAPDBe2C5YAPDBe2R3HAPDBe2C5XAPDBe2C69APDBe2R3GAPDBe2C68APDBe2R3FAPDBe2C5VAPDBe3S2PAPDBe1HCKAPDBe2R3RAPDBe2R3QAPDBe2R3PAPDBe2R3OAPDBe7ACKAPDBe2R3NAPDBe2R3MAPDBe2UZLAPDBe2R3LAPDBe2R3KAPDBe2UZNAPDBe4D1XAPDBe3RPYAPDBe3FZ1APDBe3LE6APDBe2UZBAPDBe2UZDAPDBe2UZEAPDBe2BTSAPDBe5UQ2APDBe1P2AAPDBe2BTRAPDBe3RPRAPDBe5UQ1APDBe5UQ3APDBe2C5OAPDBe2C5NAPDBe3RPVAPDBe6RIJAPDBe2B55APDBe3R1QAPDBe2C6LAPDBe2C6KAPDBe2C6IAPDBe1R78APDBe4FX3APDBe1HCLAPDBe2B54APDBe2C6TAPDBe2B53APDBe2B52APDBe2C6OAPDBe2C6MAPDBe3QQKAPDBe3QQLAPDBe6GUCAPDBe6GUBAPDBe2R64APDBe3QQFAPDBe3QQGAPDBe3QQHAPDBe3QQJAPDBe3LFNAPDBe3R1SAPDBe3LFQAPDBe3R28APDBe3LFSAPDBe3R1YAPDBe3SW4APDBe6GVAAPDBe1PW2APDBe2A4LAPDBe1WCCAPDBe5D1JAPDBe3EZRAPDBe5NEVAPDBe3EZVAPDBe1P5EAPDBe6GUEAPDBe6GUFAPDBe6GUHAPDBe6GUKAPDBe3QRTAPDBe3SW7APDBe3QRUAPDBe4NJ3APDBe2JGZAPDBe4KD1APDBe1PXPAPDBe1PXOAPDBe3QU0APDBe1PXNAPDBe1PXMAPDBe3QTQAPDBe1PXLAPDBe3QTRAPDBe7QHLAPDBe1PXKAPDBe3QTSAPDBe1PXJAPDBe1PXIAPDBe3QTUAPDBe8FP5APDBe8FOWAPDBe5ANKAPDBe5ANJAPDBe4EZ3APDBe5ANOAPDBe8FP0APDBe4EZ7APDBe5ANEAPDBe5ANDAPDBe5ANGAPDBe5ANIAPDBe3R71APDBe3R73APDBe3QTWAPDBe3QTXAPDBe1PYEAPDBe3QTZAPDBe3R83APDBe3R7UAPDBe3R7VAPDBe3R7IAPDBe3R7EAPDBe1YKRAPDBe3R6XAPDBe8VQ3APDBe8VQ4APDBe1GIJAPDBe3QX2APDBe1GIIAPDBe1GIHAPDBe3QX4APDBe3R8UAPDBe3R8VAPDBe3QWJAPDBe3QWKAPDBe3R8LAPDBe3R8MAPDBe2WEVAPDBe3IGGAPDBe3R8PAPDBe7E34APDBe3WBLAPDBe5A14APDBe5MHQAPDBe3R7YAPDBe3IG7APDBe2WFYAPDBe5OO0APDBe5OO1APDBe8ERDAPDBe5OO3APDBe3R9NAPDBe3QXOAPDBe3R9OAPDBe3QXPAPDBe8H6PAPDBe3R9DAPDBe8H6TAPDBe3R9HAPDBe3R8ZAPDBe3RZBAPDBe2WHBAPDBe1FINAPDBe8ERNAPDBe9FR2APDBe3NS9APDBe4BZDAPDBe4GCJAPDBe3PXYAPDBe3PXZAPDBe5CYIAPDBe3PY0APDBe3PY1APDBe3PXQAPDBe3PXRAPDBe3QZFAPDBe3PXFAPDBe3QZGAPDBe3QZHAPDBe3QZIAPDBe5IF1APDBe1JSVAPDBe1JSUAPDBe1JSTAPDBe2WIPAPDBe2WIHAPDBe1H00APDBe2CCIAPDBe2CCHAPDBe6ATHAPDBe1H08APDBe1H07APDBe7UXKAPDBe8UV0APDBe1H01APDBe5IEYAPDBe7UXIAPDBe4II5APDBe5IEVAPDBe5IEXAPDBe2XNBAPDBe6Q48APDBe7S4TAPDBe5OSJAPDBe1H0WAPDBe1H0VAPDBe2XMYAPDBe5LMKAPDBe5OSMAPDBe6Q3CAPDBe6Q3BAPDBe1DI8APDBe6Q3FAPDBe1H1QAPDBe1H1PAPDBe2WMAAPDBe2WMBAPDBe6JGMAPDBe1JVPAPDBe3DDPAPDBe3DDQAPDBe6OQIAPDBe6Q4JAPDBe6Q4IAPDBe1H28APDBe1H27APDBe6Q4KAPDBe1H26APDBe1H25APDBe1H1SAPDBe1H24APDBe1H1RAPDBe6Q4BAPDBe6Q4AAPDBe6Q4DAPDBe6Q4CAPDBe6Q4FAPDBe6Q4EAPDBe6Q4HAPDBe6Q4GAPDBe6Q49APDBe6P3WAPDBe1FQ1APDBe7S84APDBe7S85APDBe3MY5APDBe1DM2APDBe3RAKAPDBe3RALAPDBe8CURAPDBe1W0XAPDBe7MKXAPDBe7S7AAPDBe3RAHAPDBe3RAIAPDBe1CKPAPDBe3EJ1APDBe2I40APDBe8RU8APDBe2WPAAPDBe7RWFAPDBe7RWEAPDBe3EIDAPDBe7S9XAPDBe1PF8APDBe7KJSAPDBe1V1KAPDBe7RXOAPDBe2W05APDBe2W06APDBe8B54APDBe2X1NAPDBe7B7SAPDBe2IW6APDBe2CJMAPDBe2W1HAPDBe5L2WAPDBe2BHHAPDBe2IW9APDBe2IW8APDBe3TI1APDBe2W17APDBe2BHEAPDBe2V0DAPDBe4BCMAPDBe4FKQAPDBe5JQ5APDBe4BCNAPDBe4FKRAPDBe1URCAPDBe4BCOAPDBe4FKSAPDBe1G5SAPDBe4BCPAPDBe4FKTAPDBe4BCQAPDBe4FKUAPDBe4FKVAPDBe5JQ8APDBe4FKWAPDBe3ULIAPDBe4FKIAPDBe3TIYAPDBe4FKJAPDBe3TIZAPDBe4FKLAPDBe1E1XAPDBe1E1VAPDBe4BCKAPDBe4FKOAPDBe4FKPAPDBe4FKGAPDBe1Y91APDBe1Y8YAPDBe4EK3APDBe4EK4APDBe4EK5APDBe4EK6APDBe4CFUAPDBe4EK8APDBe4CFVAPDBe2CLXAPDBe4CFMAPDBe4CFNAPDBe6YL1APDBe6YL6APDBe2J9MAPDBe1URWAPDBe1FVVAPDBe3BHTAPDBe1FVTAPDBe3BHUAPDBe3BHVAPDBe1F5QAPDBe3UNJAPDBe1GY3APDBe3UNKAPDBe2BKZAPDBe4ACMAPDBe4LYNAPDBe4CFWAPDBe4CFXAPDBe1OGUAPDBe6YLKAPDBe2V22APDBe2VTHAPDBe2VTIAPDBe2VTJAPDBe1GZ8APDBe2VTLAPDBe4I3ZAPDBe2VTMAPDBe1W8CAPDBe2VTNAPDBe2VTOAPDBe6INLAPDBe2VTAAPDBe7VDUAPDBe1PKDAPDBe7M2FAPDBe5K4JAPDBe1OI9APDBe3EOCAPDBe3RJCAPDBe7NVQAPDBe1OIRAPDBe1OIQAPDBe1W98APDBe4BGHAPDBe2VTPAPDBe1OIYAPDBe2VTQAPDBe1QMZAPDBe2VTRAPDBe2VU3APDBe2VTSAPDBe2VTTAPDBe1OIUAPDBe1OITAPDBeGO:0000287magnesium ion bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0019904protein domain specific bindingGoFunctionGO:0030332cyclin bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0006281DNA repairGoProcessGO:0006468protein phosphorylationGoProcessGO:0006813potassium ion transportGoProcessGO:0007099centriole replicationGoProcessGO:0007165signal transductionGoProcessGO:0007265Ras protein signal transductionGoProcessGO:0007346regulation of mitotic cell cycleGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010389regulation of G2/M transition of mitotic cell cycleGoProcessGO:0018105peptidyl-serine phosphorylationGoProcessGO:0031453positive regulation of heterochromatin formationGoProcessGO:0031571mitotic G1 DNA damage checkpoint signalingGoProcessGO:0032298positive regulation of DNA-templated DNA replication initiationGoProcessGO:0043247telomere maintenance in response to DNA damageGoProcessGO:0045740positive regulation of DNA replicationGoProcessGO:0045893positive regulation of DNA-templated transcriptionGoProcessGO:0051298centrosome duplicationGoProcessGO:0051301cell divisionGoProcessGO:0051321meiotic cell cycleGoProcessGO:0071732cellular response to nitric oxideGoProcessGO:0090398cellular senescenceGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0000781chromosome, telomeric regionGoComponentGO:0000793condensed chromosomeGoComponentGO:0000805X chromosomeGoComponentGO:0000806Y chromosomeGoComponentGO:0001673male germ cell nucleusGoComponentGO:0005635nuclear envelopeGoComponentGO:0005654nucleoplasmGoComponentGO:0005768endosomeGoComponentGO:0005813centrosomeGoComponentGO:0005829cytosolGoComponentGO:0005856cytoskeletonGoComponentGO:0015030Cajal bodyGoComponentGO:0005667transcription regulator complexGoComponentA8K7C6Cyclin-dependent kinase 2UniProtO75100Cyclin-dependent kinase 2UniProtP24941Cyclin-dependent kinase 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:1771CDK2HGNCR-HSA-1538133G0 and Early G1ReactomeR-HSA-171319Telomere Extension By TelomeraseReactomeR-HSA-176187Activation of ATR in response to replication stressReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-5693607Processing of DNA double-strand break endsReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-6804756Regulation of TP53 Activity through PhosphorylationReactomeR-HSA-6804757Regulation of TP53 DegradationReactomeR-HSA-68911G2 PhaseReactomeR-HSA-68949Orc1 removal from chromatinReactomeR-HSA-68962Activation of the pre-replicative complexReactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-HSA-69200Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesReactomeR-HSA-69202Cyclin E associated events during G1/S transitionReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69563p53-Dependent G1 DNA Damage ResponseReactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entryReactomeR-HSA-8849470PTK6 Regulates Cell CycleReactomeR-HSA-912446Meiotic recombinationReactomeR-HSA-9616222Transcriptional regulation of granulopoiesisReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9825892Regulation of MITF-M-dependent genes involved in cell cycle and proliferationReactomeR-HSA-983231Factors involved in megakaryocyte development and platelet productionReactomeP24941PharosP24941ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF521CYCLIN-DEPENDENT KINASE 2PANTHERPF00069PkinasePfamPA101cyclin dependent kinase 2PharmGKBSELECTIVITY GROUP9606CPX-2004Cyclin A2-CDK1 complexComplexPortalHomo sapiensCDK1/Cyclin ACHEMBL3038467P06493Cyclin-dependent kinase 17PROTEINPROTEIN SUBUNITCDC2GENE_SYMBOL_OTHERCDC28AGENE_SYMBOL_OTHERCDKN1GENE_SYMBOL_OTHERP34CDC2GENE_SYMBOL_OTHERCDK1GENE_SYMBOLCyclin-dependent kinase 1UNIPROTCell division control protein 2 homologUNIPROTCell division protein kinase 1UNIPROTp34 protein kinaseUNIPROTCDK1UNIPROT2.7.11.22EC_NUMBER2.7.11.23EC_NUMBER4YC6APDBe5LQFAPDBe6GU3APDBe6GU2APDBe4Y72APDBe6GU4APDBe6GU7APDBe5HQ0APDBe6GU6APDBe6TWNAPDBe4YC3APDBeGO:0001618virus receptor activityGoFunctionGO:0003682chromatin bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0030332cyclin bindingGoFunctionGO:0030544Hsp70 protein bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0000226microtubule cytoskeleton organizationGoProcessGO:0006281DNA repairGoProcessGO:0006915apoptotic processGoProcessGO:0006974DNA damage responseGoProcessGO:0007077mitotic nuclear membrane disassemblyGoProcessGO:0007095mitotic G2 DNA damage checkpoint signalingGoProcessGO:0007098centrosome cycleGoProcessGO:0009636response to toxic substanceGoProcessGO:0010628positive regulation of gene expressionGoProcessGO:0010629negative regulation of gene expressionGoProcessGO:0010971positive regulation of G2/M transition of mitotic cell cycleGoProcessGO:0014038regulation of Schwann cell differentiationGoProcessGO:0016477cell migrationGoProcessGO:0018105peptidyl-serine phosphorylationGoProcessGO:0018107peptidyl-threonine phosphorylationGoProcessGO:0030261chromosome condensationGoProcessGO:0030855epithelial cell differentiationGoProcessGO:0031100animal organ regenerationGoProcessGO:0034501protein localization to kinetochoreGoProcessGO:0042307positive regulation of protein import into nucleusGoProcessGO:0042542response to hydrogen peroxideGoProcessGO:0042752regulation of circadian rhythmGoProcessGO:0043066negative regulation of apoptotic processGoProcessGO:0044772mitotic cell cycle phase transitionGoProcessGO:0045740positive regulation of DNA replicationGoProcessGO:0045931positive regulation of mitotic cell cycleGoProcessGO:0045995regulation of embryonic developmentGoProcessGO:0046718symbiont entry into host cellGoProcessGO:0048144fibroblast proliferationGoProcessGO:0048511rhythmic processGoProcessGO:0048678response to axon injuryGoProcessGO:0051301cell divisionGoProcessGO:0055015ventricular cardiac muscle cell developmentGoProcessGO:0060045positive regulation of cardiac muscle cell proliferationGoProcessGO:0062033positive regulation of mitotic sister chromatid segregationGoProcessGO:0065003protein-containing complex assemblyGoProcessGO:0070301cellular response to hydrogen peroxideGoProcessGO:0070371ERK1 and ERK2 cascadeGoProcessGO:0071407cellular response to organic cyclic compoundGoProcessGO:1900182positive regulation of protein localization to nucleusGoProcessGO:1902423regulation of attachment of mitotic spindle microtubules to kinetochoreGoProcessGO:1902850microtubule cytoskeleton organization involved in mitosisGoProcessGO:1905448positive regulation of mitochondrial ATP synthesis coupled electron transportGoProcessGO:0005634nucleusGoComponentGO:0000781chromosome, telomeric regionGoComponentGO:0005654nucleoplasmGoComponentGO:0005737cytoplasmGoComponentGO:0005739mitochondrionGoComponentGO:0005789endoplasmic reticulum membraneGoComponentGO:0005813centrosomeGoComponentGO:0005829cytosolGoComponentGO:0005856cytoskeletonGoComponentGO:0005876spindle microtubuleGoComponentGO:0016020membraneGoComponentGO:0030496midbodyGoComponentGO:0070062extracellular exosomeGoComponentA8K7C4Cyclin-dependent kinase 1UniProtC9J497Cyclin-dependent kinase 1UniProtO60764Cyclin-dependent kinase 1UniProtP06493Cyclin-dependent kinase 1UniProt4Y72PDB4YC3PDB4YC6PDB5HQ0PDB5LQFPDB6GU2PDB6GU3PDB6GU4PDB6GU6PDB6GU7PDB6TWNPDB7NJ0PDBP06493AlphaFoldDBP06493IntActHGNC:1722CDK1HGNCR-HSA-110056MAPK3 (ERK1) activationReactomeR-HSA-113507E2F-enabled inhibition of pre-replication complex formationReactomeR-HSA-1362300Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1ReactomeR-HSA-162658Golgi Cisternae Pericentriolar Stack ReorganizationReactomeR-HSA-170145Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexesReactomeR-HSA-174048APC/C:Cdc20 mediated degradation of Cyclin BReactomeR-HSA-174184Cdc20:Phospho-APC/C mediated degradation of Cyclin AReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-176412Phosphorylation of the APC/CReactomeR-HSA-176417Phosphorylation of Emi1ReactomeR-HSA-2299718Condensation of Prophase ChromosomesReactomeR-HSA-2465910MASTL Facilitates Mitotic ProgressionReactomeR-HSA-2500257Resolution of Sister Chromatid CohesionReactomeR-HSA-2514853Condensation of Prometaphase ChromosomesReactomeR-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionReactomeR-HSA-2980767Activation of NIMA Kinases NEK9, NEK6, NEK7ReactomeR-HSA-2995383Initiation of Nuclear Envelope (NE) ReformationReactomeR-HSA-3301854Nuclear Pore Complex (NPC) DisassemblyReactomeR-HSA-380259Loss of Nlp from mitotic centrosomesReactomeR-HSA-380270Recruitment of mitotic centrosome proteins and complexesReactomeR-HSA-380284Loss of proteins required for interphase microtubule organization from the centrosomeReactomeR-HSA-380320Recruitment of NuMA to mitotic centrosomesReactomeR-HSA-4419969Depolymerization of the Nuclear LaminaReactomeR-HSA-5620912Anchoring of the basal body to the plasma membraneReactomeR-HSA-5687128MAPK6/MAPK4 signalingReactomeR-HSA-5689896Ovarian tumor domain proteasesReactomeR-HSA-6804114TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle ArrestReactomeR-HSA-6804757Regulation of TP53 DegradationReactomeR-HSA-68875Mitotic ProphaseReactomeR-HSA-69205G1/S-Specific TranscriptionReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69478G2/M DNA replication checkpointReactomeR-HSA-75035Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexReactomeR-HSA-8852276The role of GTSE1 in G2/M progression after G2 checkpointReactomeR-HSA-8854518AURKA Activation by TPX2ReactomeR-HSA-8878166Transcriptional regulation by RUNX2ReactomeR-HSA-9833482PKR-mediated signalingReactomeP06493PharosP06493ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF334CYCLIN-DEPENDENT KINASE 1PANTHERPF00069PkinasePfamPA99cyclin dependent kinase 1PharmGKBP20248Cyclin-A2918PROTEINPROTEIN SUBUNITCCNAGENE_SYMBOL_OTHERSynonyms=CCN1GENE_SYMBOL_OTHERCCNA GN GENE_SYMBOL_OTHERCCNA2GENE_SYMBOLCyclin-A2UNIPROTCyclin AUNIPROTCyclin-AUNIPROT3EJ1APDBe2I40APDBe2WHBAPDBe1FINAPDBe2WPAAPDBe3EIDAPDBe6GVAAPDBe5CYIAPDBe4EONAPDBe4EOOAPDBe4EOPAPDBe2UUEAPDBe4EOQAPDBe4EORAPDBe4EOSAPDBe1OL2APDBe4EOIAPDBe5NEVAPDBe8B54APDBe1OL1APDBe1VYWAPDBe4EOJAPDBe4EOKAPDBe4EOLAPDBe4EOMAPDBe1P5EAPDBe2WXVAPDBe2X1NAPDBe1OKWAPDBe1OKVAPDBe7B7SAPDBe2IW6APDBe2CJMAPDBe5IF1APDBe1JSUAPDBe1JSTAPDBe2IW9APDBe2IW8APDBe2WIPAPDBe7LUOAPDBe2BPMAPDBe2WIHAPDBe2CCIAPDBe4BCMAPDBe2CCHAPDBe4BCNAPDBe1URCAPDBe4BCPAPDBe7QHLAPDBe6ATHAPDBe3F5XAPDBe4BCKAPDBe6SG4APDBe1E9HAPDBe4CFUAPDBe4CFVAPDBe5LMKAPDBe4CFMAPDBe4CFNAPDBe1H1QAPDBe1H1PAPDBe2WMAAPDBe1FVVAPDBe2WMBAPDBe1GY3APDBe2BKZAPDBe1H28APDBe1H27APDBe1H26APDBe1H25APDBe1H1SAPDBe1H24APDBe1H1RAPDBe2C4GAPDBe4CFWAPDBe4CFXAPDBe1OGUAPDBe2V22APDBe2C5XAPDBe2C5VAPDBe6P3WAPDBe7ACKAPDBe2UZLAPDBe2WEVAPDBe1PKDAPDBe2UZBAPDBe2UZDAPDBe2UZEAPDBe1OI9APDBe2C5OAPDBe2C5NAPDBe3EOCAPDBe2WFYAPDBe6RIJAPDBe4FX3APDBe2C6TAPDBe1OIYAPDBe7MKXAPDBe1QMZAPDBe1OIUAPDBeGO:0005515protein bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0019904protein domain specific bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0007265Ras protein signal transductionGoProcessGO:0031100animal organ regenerationGoProcessGO:0044320cellular response to leptin stimulusGoProcessGO:0044772mitotic cell cycle phase transitionGoProcessGO:0044843cell cycle G1/S phase transitionGoProcessGO:0045893positive regulation of DNA-templated transcriptionGoProcessGO:0048146positive regulation of fibroblast proliferationGoProcessGO:0051301cell divisionGoProcessGO:0071314cellular response to cocaineGoProcessGO:0071373cellular response to luteinizing hormone stimulusGoProcessGO:0071392cellular response to estradiol stimulusGoProcessGO:0071407cellular response to organic cyclic compoundGoProcessGO:0071456cellular response to hypoxiaGoProcessGO:0071732cellular response to nitric oxideGoProcessGO:0090102cochlea developmentGoProcessGO:1990314cellular response to insulin-like growth factor stimulusGoProcessGO:2000573positive regulation of DNA biosynthetic processGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0001939female pronucleusGoComponentGO:0001940male pronucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005829cytosolGoComponentA8K7B6Cyclin-A2UniProtQ2M3U6Cyclin-A2UniProtQ4W5P4Cyclin-A2UniProtQ6LER8Cyclin-A2UniProtP20248Cyclin-A2UniProt1E9HPDB1FINPDB1FVVPDB1GY3PDB1H1PPDB1H1QPDB1H1RPDB1H1SPDB1H24PDB1H25PDB1H26PDB1H27PDB1H28PDB1JSTPDB1JSUPDB1OGUPDB1OI9PDB1OIUPDB1OIYPDB1OKVPDB1OKWPDB1OL1PDB1OL2PDB1P5EPDB1PKDPDB1QMZPDB1URCPDB1VYWPDB2BKZPDB2BPMPDB2C4GPDB2C5NPDB2C5OPDB2C5VPDB2C5XPDB2C6TPDB2CCHPDB2CCIPDB2CJMPDB2I40PDB2IW6PDB2IW8PDB2IW9PDB2UUEPDB2UZBPDB2UZDPDB2UZEPDB2UZLPDB2V22PDB2WEVPDB2WFYPDB2WHBPDB2WIHPDB2WIPPDB2WMAPDB2WMBPDB2WPAPDB2WXVPDB2X1NPDB3EIDPDB3EJ1PDB3EOCPDB3F5XPDB4BCKPDB4BCMPDB4BCNPDB4BCPPDB4CFMPDB4CFNPDB4CFUPDB4CFVPDB4CFWPDB4CFXPDB4EOIPDB4EOJPDB4EOKPDB4EOLPDB4EOMPDB4EONPDB4EOOPDB4EOPPDB4EOQPDB4EORPDB4EOSPDB4FX3PDB5CYIPDB5IF1PDB5LMKPDB5NEVPDB6ATHPDB6GVAPDB6P3WPDB6Q6GPDB6Q6HPDB6RIJPDB6SG4PDB7ACKPDB7B5LPDB7B5RPDB7B7SPDB7LUOPDB7MKXPDB7QHLPDB8B54PDB8BYAPDB8BZOPDBP20248AlphaFoldDBP20248IntActHGNC:1578CCNA2HGNCR-HSA-1362300Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1ReactomeR-HSA-1538133G0 and Early G1ReactomeR-HSA-170145Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexesReactomeR-HSA-171319Telomere Extension By TelomeraseReactomeR-HSA-174184Cdc20:Phospho-APC/C mediated degradation of Cyclin AReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-5689880Ub-specific processing proteasesReactomeR-HSA-5693607Processing of DNA double-strand break endsReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-6804756Regulation of TP53 Activity through PhosphorylationReactomeR-HSA-6804757Regulation of TP53 DegradationReactomeR-HSA-68911G2 PhaseReactomeR-HSA-68949Orc1 removal from chromatinReactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69563p53-Dependent G1 DNA Damage ResponseReactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entryReactomeP20248PharosIPR039361CyclinInterProIPR032447Cyclin-A_NInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR046965Cyclin_A/B-likeInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamPF16500Cyclin_N2PfamPA94cyclin A2PharmGKBPROTEIN COMPLEX9606Homo sapiensCDK1/Cyclin ECHEMBL3038468P06493Cyclin-dependent kinase 17PROTEINPROTEIN SUBUNITCDC2GENE_SYMBOL_OTHERCDC28AGENE_SYMBOL_OTHERCDKN1GENE_SYMBOL_OTHERP34CDC2GENE_SYMBOL_OTHERCDK1GENE_SYMBOLCyclin-dependent kinase 1UNIPROTCell division control protein 2 homologUNIPROTCell division protein kinase 1UNIPROTp34 protein kinaseUNIPROTCDK1UNIPROT2.7.11.22EC_NUMBER2.7.11.23EC_NUMBER4YC6APDBe5LQFAPDBe6GU3APDBe6GU2APDBe4Y72APDBe6GU4APDBe6GU7APDBe5HQ0APDBe6GU6APDBe6TWNAPDBe4YC3APDBeGO:0001618virus receptor activityGoFunctionGO:0003682chromatin bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0030332cyclin bindingGoFunctionGO:0030544Hsp70 protein bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0000226microtubule cytoskeleton organizationGoProcessGO:0006281DNA repairGoProcessGO:0006915apoptotic processGoProcessGO:0006974DNA damage responseGoProcessGO:0007077mitotic nuclear membrane disassemblyGoProcessGO:0007095mitotic G2 DNA damage checkpoint signalingGoProcessGO:0007098centrosome cycleGoProcessGO:0009636response to toxic substanceGoProcessGO:0010628positive regulation of gene expressionGoProcessGO:0010629negative regulation of gene expressionGoProcessGO:0010971positive regulation of G2/M transition of mitotic cell cycleGoProcessGO:0014038regulation of Schwann cell differentiationGoProcessGO:0016477cell migrationGoProcessGO:0018105peptidyl-serine phosphorylationGoProcessGO:0018107peptidyl-threonine phosphorylationGoProcessGO:0030261chromosome condensationGoProcessGO:0030855epithelial cell differentiationGoProcessGO:0031100animal organ regenerationGoProcessGO:0034501protein localization to kinetochoreGoProcessGO:0042307positive regulation of protein import into nucleusGoProcessGO:0042542response to hydrogen peroxideGoProcessGO:0042752regulation of circadian rhythmGoProcessGO:0043066negative regulation of apoptotic processGoProcessGO:0044772mitotic cell cycle phase transitionGoProcessGO:0045740positive regulation of DNA replicationGoProcessGO:0045931positive regulation of mitotic cell cycleGoProcessGO:0045995regulation of embryonic developmentGoProcessGO:0046718symbiont entry into host cellGoProcessGO:0048144fibroblast proliferationGoProcessGO:0048511rhythmic processGoProcessGO:0048678response to axon injuryGoProcessGO:0051301cell divisionGoProcessGO:0055015ventricular cardiac muscle cell developmentGoProcessGO:0060045positive regulation of cardiac muscle cell proliferationGoProcessGO:0062033positive regulation of mitotic sister chromatid segregationGoProcessGO:0065003protein-containing complex assemblyGoProcessGO:0070301cellular response to hydrogen peroxideGoProcessGO:0070371ERK1 and ERK2 cascadeGoProcessGO:0071407cellular response to organic cyclic compoundGoProcessGO:1900182positive regulation of protein localization to nucleusGoProcessGO:1902423regulation of attachment of mitotic spindle microtubules to kinetochoreGoProcessGO:1902850microtubule cytoskeleton organization involved in mitosisGoProcessGO:1905448positive regulation of mitochondrial ATP synthesis coupled electron transportGoProcessGO:0005634nucleusGoComponentGO:0000781chromosome, telomeric regionGoComponentGO:0005654nucleoplasmGoComponentGO:0005737cytoplasmGoComponentGO:0005739mitochondrionGoComponentGO:0005789endoplasmic reticulum membraneGoComponentGO:0005813centrosomeGoComponentGO:0005829cytosolGoComponentGO:0005856cytoskeletonGoComponentGO:0005876spindle microtubuleGoComponentGO:0016020membraneGoComponentGO:0030496midbodyGoComponentGO:0070062extracellular exosomeGoComponentA8K7C4Cyclin-dependent kinase 1UniProtC9J497Cyclin-dependent kinase 1UniProtO60764Cyclin-dependent kinase 1UniProtP06493Cyclin-dependent kinase 1UniProt4Y72PDB4YC3PDB4YC6PDB5HQ0PDB5LQFPDB6GU2PDB6GU3PDB6GU4PDB6GU6PDB6GU7PDB6TWNPDB7NJ0PDBP06493AlphaFoldDBP06493IntActHGNC:1722CDK1HGNCR-HSA-110056MAPK3 (ERK1) activationReactomeR-HSA-113507E2F-enabled inhibition of pre-replication complex formationReactomeR-HSA-1362300Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1ReactomeR-HSA-162658Golgi Cisternae Pericentriolar Stack ReorganizationReactomeR-HSA-170145Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexesReactomeR-HSA-174048APC/C:Cdc20 mediated degradation of Cyclin BReactomeR-HSA-174184Cdc20:Phospho-APC/C mediated degradation of Cyclin AReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-176412Phosphorylation of the APC/CReactomeR-HSA-176417Phosphorylation of Emi1ReactomeR-HSA-2299718Condensation of Prophase ChromosomesReactomeR-HSA-2465910MASTL Facilitates Mitotic ProgressionReactomeR-HSA-2500257Resolution of Sister Chromatid CohesionReactomeR-HSA-2514853Condensation of Prometaphase ChromosomesReactomeR-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionReactomeR-HSA-2980767Activation of NIMA Kinases NEK9, NEK6, NEK7ReactomeR-HSA-2995383Initiation of Nuclear Envelope (NE) ReformationReactomeR-HSA-3301854Nuclear Pore Complex (NPC) DisassemblyReactomeR-HSA-380259Loss of Nlp from mitotic centrosomesReactomeR-HSA-380270Recruitment of mitotic centrosome proteins and complexesReactomeR-HSA-380284Loss of proteins required for interphase microtubule organization from the centrosomeReactomeR-HSA-380320Recruitment of NuMA to mitotic centrosomesReactomeR-HSA-4419969Depolymerization of the Nuclear LaminaReactomeR-HSA-5620912Anchoring of the basal body to the plasma membraneReactomeR-HSA-5687128MAPK6/MAPK4 signalingReactomeR-HSA-5689896Ovarian tumor domain proteasesReactomeR-HSA-6804114TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle ArrestReactomeR-HSA-6804757Regulation of TP53 DegradationReactomeR-HSA-68875Mitotic ProphaseReactomeR-HSA-69205G1/S-Specific TranscriptionReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69478G2/M DNA replication checkpointReactomeR-HSA-75035Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexReactomeR-HSA-8852276The role of GTSE1 in G2/M progression after G2 checkpointReactomeR-HSA-8854518AURKA Activation by TPX2ReactomeR-HSA-8878166Transcriptional regulation by RUNX2ReactomeR-HSA-9833482PKR-mediated signalingReactomeP06493PharosP06493ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF334CYCLIN-DEPENDENT KINASE 1PANTHERPF00069PkinasePfamPA99cyclin dependent kinase 1PharmGKBP24864G1/S-specific cyclin-E135PROTEINPROTEIN SUBUNITCCNEGENE_SYMBOL_OTHERCCNE1GENE_SYMBOLG1/S-specific cyclin-E1UNIPROT8H6PAPDBe7XQKAPDBe1W98APDBe8H4RAPDBe8H6TAPDBe5L2WAPDBe7KJSAPDBe8VQ3APDBe8VQ4APDBeGO:0006468protein phosphorylationGoProcessGO:0005515protein bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0000723telomere maintenanceGoProcessGO:0006270DNA replication initiationGoProcessGO:0007129homologous chromosome pairing at meiosisGoProcessGO:0016055Wnt signaling pathwayGoProcessGO:0032880regulation of protein localizationGoProcessGO:0051301cell divisionGoProcessGO:0051726regulation of cell cycleGoProcessGO:0070192chromosome organization involved in meiotic cell cycleGoProcessGO:1900087positive regulation of G1/S transition of mitotic cell cycleGoProcessGO:1902462positive regulation of mesenchymal stem cell proliferationGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0005654nucleoplasmGoComponentGO:0005829cytosolGoComponentA8K684G1/S-specific cyclin-E1UniProtQ14091G1/S-specific cyclin-E1UniProtQ8NFG1G1/S-specific cyclin-E1UniProtQ92501G1/S-specific cyclin-E1UniProtQ9UD21G1/S-specific cyclin-E1UniProtP24864G1/S-specific cyclin-E1UniProt1W98PDB5L2WPDB7KJSPDB7XQKPDB8H4RPDB8H6PPDB8H6TPDB8VQ3PDB8VQ4PDBP24864AlphaFoldDBP24864IntActHGNC:1589CCNE1HGNCR-HSA-1538133G0 and Early G1ReactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-390471Association of TriC/CCT with target proteins during biosynthesisReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-HSA-69200Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesReactomeR-HSA-69202Cyclin E associated events during G1/S transitionReactomeR-HSA-69205G1/S-Specific TranscriptionReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-69563p53-Dependent G1 DNA Damage ResponseReactomeR-HSA-8849470PTK6 Regulates Cell CycleReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9706019RHOBTB3 ATPase cycleReactomeP24864PharosP24864ExpressionAtlasIPR039361CyclinInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamPA96cyclin E1PharmGKBPROTEIN COMPLEX9606CPX-2006Cyclin A2-CDK2 complexComplexPortalHomo sapiensCDK2/Cyclin A2CHEMBL3038469P24941Cyclin-dependent kinase 236PROTEINPROTEIN SUBUNITCDKN2GENE_SYMBOL_OTHERCDK2GENE_SYMBOLCyclin-dependent kinase 2UNIPROTCell division protein kinase 2UNIPROTp33 protein kinaseUNIPROT2.7.11.22EC_NUMBER2DS1APDBe3RKBAPDBe3QHRAPDBe3DOGAPDBe3RK5APDBe7SA0APDBe3TNWAPDBe3RK7APDBe2FVDAPDBe3QHWAPDBe3RK9APDBe2VV9APDBe1AQ1APDBe4EONAPDBe4EOOAPDBe4EOPAPDBe2UUEAPDBe4EOQAPDBe4EORAPDBe7ZPCAPDBe4EOSAPDBe1VYZAPDBe1OL2APDBe4EOIAPDBe1OL1APDBe1VYWAPDBe4EOJAPDBe4EOKAPDBe4EOLAPDBe4EOMAPDBe2WXVAPDBe1OKWAPDBe1OKVAPDBe1B39APDBe3RMFAPDBe1B38APDBe2G9XAPDBe8OY2APDBe5FP6APDBe5FP5APDBe3RM6APDBe3RM7APDBe7UG1APDBe7RA5APDBe1KE9APDBe1KE8APDBe2BPMAPDBe1KE7APDBe1KE6APDBe1KE5APDBe4RJ3APDBe3RNIAPDBe2DUVAPDBe3F5XAPDBe3QL8APDBe3PJ8APDBe6SG4APDBe1E9HAPDBe3S0OAPDBe4ERWAPDBe1BUHAPDBe3S00APDBe2EXMAPDBe3RPOAPDBe3S1HAPDBe3ROYAPDBe2C4GAPDBe2A0CAPDBe3SQQAPDBe2R3JAPDBe2UZOAPDBe2R3IAPDBe4D1ZAPDBe2C5YAPDBe2R3HAPDBe2C5XAPDBe2C69APDBe2R3GAPDBe2C68APDBe2R3FAPDBe2C5VAPDBe3S2PAPDBe1HCKAPDBe2R3RAPDBe2R3QAPDBe2R3PAPDBe2R3OAPDBe7ACKAPDBe2R3NAPDBe2R3MAPDBe2UZLAPDBe2R3LAPDBe2R3KAPDBe2UZNAPDBe4D1XAPDBe3RPYAPDBe3FZ1APDBe3LE6APDBe2UZBAPDBe2UZDAPDBe2UZEAPDBe2BTSAPDBe5UQ2APDBe1P2AAPDBe2BTRAPDBe3RPRAPDBe5UQ1APDBe5UQ3APDBe2C5OAPDBe2C5NAPDBe3RPVAPDBe6RIJAPDBe2B55APDBe3R1QAPDBe2C6LAPDBe2C6KAPDBe2C6IAPDBe1R78APDBe4FX3APDBe1HCLAPDBe2B54APDBe2C6TAPDBe2B53APDBe2B52APDBe2C6OAPDBe2C6MAPDBe3QQKAPDBe3QQLAPDBe6GUCAPDBe6GUBAPDBe2R64APDBe3QQFAPDBe3QQGAPDBe3QQHAPDBe3QQJAPDBe3LFNAPDBe3R1SAPDBe3LFQAPDBe3R28APDBe3LFSAPDBe3R1YAPDBe3SW4APDBe6GVAAPDBe1PW2APDBe2A4LAPDBe1WCCAPDBe5D1JAPDBe3EZRAPDBe5NEVAPDBe3EZVAPDBe1P5EAPDBe6GUEAPDBe6GUFAPDBe6GUHAPDBe6GUKAPDBe3QRTAPDBe3SW7APDBe3QRUAPDBe4NJ3APDBe2JGZAPDBe4KD1APDBe1PXPAPDBe1PXOAPDBe3QU0APDBe1PXNAPDBe1PXMAPDBe3QTQAPDBe1PXLAPDBe3QTRAPDBe7QHLAPDBe1PXKAPDBe3QTSAPDBe1PXJAPDBe1PXIAPDBe3QTUAPDBe8FP5APDBe8FOWAPDBe5ANKAPDBe5ANJAPDBe4EZ3APDBe5ANOAPDBe8FP0APDBe4EZ7APDBe5ANEAPDBe5ANDAPDBe5ANGAPDBe5ANIAPDBe3R71APDBe3R73APDBe3QTWAPDBe3QTXAPDBe1PYEAPDBe3QTZAPDBe3R83APDBe3R7UAPDBe3R7VAPDBe3R7IAPDBe3R7EAPDBe1YKRAPDBe3R6XAPDBe8VQ3APDBe8VQ4APDBe1GIJAPDBe3QX2APDBe1GIIAPDBe1GIHAPDBe3QX4APDBe3R8UAPDBe3R8VAPDBe3QWJAPDBe3QWKAPDBe3R8LAPDBe3R8MAPDBe2WEVAPDBe3IGGAPDBe3R8PAPDBe7E34APDBe3WBLAPDBe5A14APDBe5MHQAPDBe3R7YAPDBe3IG7APDBe2WFYAPDBe5OO0APDBe5OO1APDBe8ERDAPDBe5OO3APDBe3R9NAPDBe3QXOAPDBe3R9OAPDBe3QXPAPDBe8H6PAPDBe3R9DAPDBe8H6TAPDBe3R9HAPDBe3R8ZAPDBe3RZBAPDBe2WHBAPDBe1FINAPDBe8ERNAPDBe9FR2APDBe3NS9APDBe4BZDAPDBe4GCJAPDBe3PXYAPDBe3PXZAPDBe5CYIAPDBe3PY0APDBe3PY1APDBe3PXQAPDBe3PXRAPDBe3QZFAPDBe3PXFAPDBe3QZGAPDBe3QZHAPDBe3QZIAPDBe5IF1APDBe1JSVAPDBe1JSUAPDBe1JSTAPDBe2WIPAPDBe2WIHAPDBe1H00APDBe2CCIAPDBe2CCHAPDBe6ATHAPDBe1H08APDBe1H07APDBe7UXKAPDBe8UV0APDBe1H01APDBe5IEYAPDBe7UXIAPDBe4II5APDBe5IEVAPDBe5IEXAPDBe2XNBAPDBe6Q48APDBe7S4TAPDBe5OSJAPDBe1H0WAPDBe1H0VAPDBe2XMYAPDBe5LMKAPDBe5OSMAPDBe6Q3CAPDBe6Q3BAPDBe1DI8APDBe6Q3FAPDBe1H1QAPDBe1H1PAPDBe2WMAAPDBe2WMBAPDBe6JGMAPDBe1JVPAPDBe3DDPAPDBe3DDQAPDBe6OQIAPDBe6Q4JAPDBe6Q4IAPDBe1H28APDBe1H27APDBe6Q4KAPDBe1H26APDBe1H25APDBe1H1SAPDBe1H24APDBe1H1RAPDBe6Q4BAPDBe6Q4AAPDBe6Q4DAPDBe6Q4CAPDBe6Q4FAPDBe6Q4EAPDBe6Q4HAPDBe6Q4GAPDBe6Q49APDBe6P3WAPDBe1FQ1APDBe7S84APDBe7S85APDBe3MY5APDBe1DM2APDBe3RAKAPDBe3RALAPDBe8CURAPDBe1W0XAPDBe7MKXAPDBe7S7AAPDBe3RAHAPDBe3RAIAPDBe1CKPAPDBe3EJ1APDBe2I40APDBe8RU8APDBe2WPAAPDBe7RWFAPDBe7RWEAPDBe3EIDAPDBe7S9XAPDBe1PF8APDBe7KJSAPDBe1V1KAPDBe7RXOAPDBe2W05APDBe2W06APDBe8B54APDBe2X1NAPDBe7B7SAPDBe2IW6APDBe2CJMAPDBe2W1HAPDBe5L2WAPDBe2BHHAPDBe2IW9APDBe2IW8APDBe3TI1APDBe2W17APDBe2BHEAPDBe2V0DAPDBe4BCMAPDBe4FKQAPDBe5JQ5APDBe4BCNAPDBe4FKRAPDBe1URCAPDBe4BCOAPDBe4FKSAPDBe1G5SAPDBe4BCPAPDBe4FKTAPDBe4BCQAPDBe4FKUAPDBe4FKVAPDBe5JQ8APDBe4FKWAPDBe3ULIAPDBe4FKIAPDBe3TIYAPDBe4FKJAPDBe3TIZAPDBe4FKLAPDBe1E1XAPDBe1E1VAPDBe4BCKAPDBe4FKOAPDBe4FKPAPDBe4FKGAPDBe1Y91APDBe1Y8YAPDBe4EK3APDBe4EK4APDBe4EK5APDBe4EK6APDBe4CFUAPDBe4EK8APDBe4CFVAPDBe2CLXAPDBe4CFMAPDBe4CFNAPDBe6YL1APDBe6YL6APDBe2J9MAPDBe1URWAPDBe1FVVAPDBe3BHTAPDBe1FVTAPDBe3BHUAPDBe3BHVAPDBe1F5QAPDBe3UNJAPDBe1GY3APDBe3UNKAPDBe2BKZAPDBe4ACMAPDBe4LYNAPDBe4CFWAPDBe4CFXAPDBe1OGUAPDBe6YLKAPDBe2V22APDBe2VTHAPDBe2VTIAPDBe2VTJAPDBe1GZ8APDBe2VTLAPDBe4I3ZAPDBe2VTMAPDBe1W8CAPDBe2VTNAPDBe2VTOAPDBe6INLAPDBe2VTAAPDBe7VDUAPDBe1PKDAPDBe7M2FAPDBe5K4JAPDBe1OI9APDBe3EOCAPDBe3RJCAPDBe7NVQAPDBe1OIRAPDBe1OIQAPDBe1W98APDBe4BGHAPDBe2VTPAPDBe1OIYAPDBe2VTQAPDBe1QMZAPDBe2VTRAPDBe2VU3APDBe2VTSAPDBe2VTTAPDBe1OIUAPDBe1OITAPDBeGO:0000287magnesium ion bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0019904protein domain specific bindingGoFunctionGO:0030332cyclin bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0006281DNA repairGoProcessGO:0006468protein phosphorylationGoProcessGO:0006813potassium ion transportGoProcessGO:0007099centriole replicationGoProcessGO:0007165signal transductionGoProcessGO:0007265Ras protein signal transductionGoProcessGO:0007346regulation of mitotic cell cycleGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010389regulation of G2/M transition of mitotic cell cycleGoProcessGO:0018105peptidyl-serine phosphorylationGoProcessGO:0031453positive regulation of heterochromatin formationGoProcessGO:0031571mitotic G1 DNA damage checkpoint signalingGoProcessGO:0032298positive regulation of DNA-templated DNA replication initiationGoProcessGO:0043247telomere maintenance in response to DNA damageGoProcessGO:0045740positive regulation of DNA replicationGoProcessGO:0045893positive regulation of DNA-templated transcriptionGoProcessGO:0051298centrosome duplicationGoProcessGO:0051301cell divisionGoProcessGO:0051321meiotic cell cycleGoProcessGO:0071732cellular response to nitric oxideGoProcessGO:0090398cellular senescenceGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0000781chromosome, telomeric regionGoComponentGO:0000793condensed chromosomeGoComponentGO:0000805X chromosomeGoComponentGO:0000806Y chromosomeGoComponentGO:0001673male germ cell nucleusGoComponentGO:0005635nuclear envelopeGoComponentGO:0005654nucleoplasmGoComponentGO:0005768endosomeGoComponentGO:0005813centrosomeGoComponentGO:0005829cytosolGoComponentGO:0005856cytoskeletonGoComponentGO:0015030Cajal bodyGoComponentGO:0005667transcription regulator complexGoComponentA8K7C6Cyclin-dependent kinase 2UniProtO75100Cyclin-dependent kinase 2UniProtP24941Cyclin-dependent kinase 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:1771CDK2HGNCR-HSA-1538133G0 and Early G1ReactomeR-HSA-171319Telomere Extension By TelomeraseReactomeR-HSA-176187Activation of ATR in response to replication stressReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-5693607Processing of DNA double-strand break endsReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-6804756Regulation of TP53 Activity through PhosphorylationReactomeR-HSA-6804757Regulation of TP53 DegradationReactomeR-HSA-68911G2 PhaseReactomeR-HSA-68949Orc1 removal from chromatinReactomeR-HSA-68962Activation of the pre-replicative complexReactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-HSA-69200Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesReactomeR-HSA-69202Cyclin E associated events during G1/S transitionReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69563p53-Dependent G1 DNA Damage ResponseReactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entryReactomeR-HSA-8849470PTK6 Regulates Cell CycleReactomeR-HSA-912446Meiotic recombinationReactomeR-HSA-9616222Transcriptional regulation of granulopoiesisReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9825892Regulation of MITF-M-dependent genes involved in cell cycle and proliferationReactomeR-HSA-983231Factors involved in megakaryocyte development and platelet productionReactomeP24941PharosP24941ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF521CYCLIN-DEPENDENT KINASE 2PANTHERPF00069PkinasePfamPA101cyclin dependent kinase 2PharmGKBP20248Cyclin-A2918PROTEINPROTEIN SUBUNITCCNAGENE_SYMBOL_OTHERSynonyms=CCN1GENE_SYMBOL_OTHERCCNA GN GENE_SYMBOL_OTHERCCNA2GENE_SYMBOLCyclin-A2UNIPROTCyclin AUNIPROTCyclin-AUNIPROT3EJ1APDBe2I40APDBe2WHBAPDBe1FINAPDBe2WPAAPDBe3EIDAPDBe6GVAAPDBe5CYIAPDBe4EONAPDBe4EOOAPDBe4EOPAPDBe2UUEAPDBe4EOQAPDBe4EORAPDBe4EOSAPDBe1OL2APDBe4EOIAPDBe5NEVAPDBe8B54APDBe1OL1APDBe1VYWAPDBe4EOJAPDBe4EOKAPDBe4EOLAPDBe4EOMAPDBe1P5EAPDBe2WXVAPDBe2X1NAPDBe1OKWAPDBe1OKVAPDBe7B7SAPDBe2IW6APDBe2CJMAPDBe5IF1APDBe1JSUAPDBe1JSTAPDBe2IW9APDBe2IW8APDBe2WIPAPDBe7LUOAPDBe2BPMAPDBe2WIHAPDBe2CCIAPDBe4BCMAPDBe2CCHAPDBe4BCNAPDBe1URCAPDBe4BCPAPDBe7QHLAPDBe6ATHAPDBe3F5XAPDBe4BCKAPDBe6SG4APDBe1E9HAPDBe4CFUAPDBe4CFVAPDBe5LMKAPDBe4CFMAPDBe4CFNAPDBe1H1QAPDBe1H1PAPDBe2WMAAPDBe1FVVAPDBe2WMBAPDBe1GY3APDBe2BKZAPDBe1H28APDBe1H27APDBe1H26APDBe1H25APDBe1H1SAPDBe1H24APDBe1H1RAPDBe2C4GAPDBe4CFWAPDBe4CFXAPDBe1OGUAPDBe2V22APDBe2C5XAPDBe2C5VAPDBe6P3WAPDBe7ACKAPDBe2UZLAPDBe2WEVAPDBe1PKDAPDBe2UZBAPDBe2UZDAPDBe2UZEAPDBe1OI9APDBe2C5OAPDBe2C5NAPDBe3EOCAPDBe2WFYAPDBe6RIJAPDBe4FX3APDBe2C6TAPDBe1OIYAPDBe7MKXAPDBe1QMZAPDBe1OIUAPDBeGO:0005515protein bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0019904protein domain specific bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0007265Ras protein signal transductionGoProcessGO:0031100animal organ regenerationGoProcessGO:0044320cellular response to leptin stimulusGoProcessGO:0044772mitotic cell cycle phase transitionGoProcessGO:0044843cell cycle G1/S phase transitionGoProcessGO:0045893positive regulation of DNA-templated transcriptionGoProcessGO:0048146positive regulation of fibroblast proliferationGoProcessGO:0051301cell divisionGoProcessGO:0071314cellular response to cocaineGoProcessGO:0071373cellular response to luteinizing hormone stimulusGoProcessGO:0071392cellular response to estradiol stimulusGoProcessGO:0071407cellular response to organic cyclic compoundGoProcessGO:0071456cellular response to hypoxiaGoProcessGO:0071732cellular response to nitric oxideGoProcessGO:0090102cochlea developmentGoProcessGO:1990314cellular response to insulin-like growth factor stimulusGoProcessGO:2000573positive regulation of DNA biosynthetic processGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0001939female pronucleusGoComponentGO:0001940male pronucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005829cytosolGoComponentA8K7B6Cyclin-A2UniProtQ2M3U6Cyclin-A2UniProtQ4W5P4Cyclin-A2UniProtQ6LER8Cyclin-A2UniProtP20248Cyclin-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:1578CCNA2HGNCR-HSA-1362300Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1ReactomeR-HSA-1538133G0 and Early G1ReactomeR-HSA-170145Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexesReactomeR-HSA-171319Telomere Extension By TelomeraseReactomeR-HSA-174184Cdc20:Phospho-APC/C mediated degradation of Cyclin AReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-5689880Ub-specific processing proteasesReactomeR-HSA-5693607Processing of DNA double-strand break endsReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-6804756Regulation of TP53 Activity through PhosphorylationReactomeR-HSA-6804757Regulation of TP53 DegradationReactomeR-HSA-68911G2 PhaseReactomeR-HSA-68949Orc1 removal from chromatinReactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69563p53-Dependent G1 DNA Damage ResponseReactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entryReactomeP20248PharosIPR039361CyclinInterProIPR032447Cyclin-A_NInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR046965Cyclin_A/B-likeInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamPF16500Cyclin_N2PfamPA94cyclin A2PharmGKBPROTEIN COMPLEX9606CPX-2005Cyclin A1-CDK2 complexComplexPortalHomo sapiensCDK2/Cyclin A1CHEMBL3038470P24941Cyclin-dependent kinase 236PROTEINPROTEIN SUBUNITCDKN2GENE_SYMBOL_OTHERCDK2GENE_SYMBOLCyclin-dependent kinase 2UNIPROTCell division protein kinase 2UNIPROTp33 protein kinaseUNIPROT2.7.11.22EC_NUMBER2DS1APDBe3RKBAPDBe3QHRAPDBe3DOGAPDBe3RK5APDBe7SA0APDBe3TNWAPDBe3RK7APDBe2FVDAPDBe3QHWAPDBe3RK9APDBe2VV9APDBe1AQ1APDBe4EONAPDBe4EOOAPDBe4EOPAPDBe2UUEAPDBe4EOQAPDBe4EORAPDBe7ZPCAPDBe4EOSAPDBe1VYZAPDBe1OL2APDBe4EOIAPDBe1OL1APDBe1VYWAPDBe4EOJAPDBe4EOKAPDBe4EOLAPDBe4EOMAPDBe2WXVAPDBe1OKWAPDBe1OKVAPDBe1B39APDBe3RMFAPDBe1B38APDBe2G9XAPDBe8OY2APDBe5FP6APDBe5FP5APDBe3RM6APDBe3RM7APDBe7UG1APDBe7RA5APDBe1KE9APDBe1KE8APDBe2BPMAPDBe1KE7APDBe1KE6APDBe1KE5APDBe4RJ3APDBe3RNIAPDBe2DUVAPDBe3F5XAPDBe3QL8APDBe3PJ8APDBe6SG4APDBe1E9HAPDBe3S0OAPDBe4ERWAPDBe1BUHAPDBe3S00APDBe2EXMAPDBe3RPOAPDBe3S1HAPDBe3ROYAPDBe2C4GAPDBe2A0CAPDBe3SQQAPDBe2R3JAPDBe2UZOAPDBe2R3IAPDBe4D1ZAPDBe2C5YAPDBe2R3HAPDBe2C5XAPDBe2C69APDBe2R3GAPDBe2C68APDBe2R3FAPDBe2C5VAPDBe3S2PAPDBe1HCKAPDBe2R3RAPDBe2R3QAPDBe2R3PAPDBe2R3OAPDBe7ACKAPDBe2R3NAPDBe2R3MAPDBe2UZLAPDBe2R3LAPDBe2R3KAPDBe2UZNAPDBe4D1XAPDBe3RPYAPDBe3FZ1APDBe3LE6APDBe2UZBAPDBe2UZDAPDBe2UZEAPDBe2BTSAPDBe5UQ2APDBe1P2AAPDBe2BTRAPDBe3RPRAPDBe5UQ1APDBe5UQ3APDBe2C5OAPDBe2C5NAPDBe3RPVAPDBe6RIJAPDBe2B55APDBe3R1QAPDBe2C6LAPDBe2C6KAPDBe2C6IAPDBe1R78APDBe4FX3APDBe1HCLAPDBe2B54APDBe2C6TAPDBe2B53APDBe2B52APDBe2C6OAPDBe2C6MAPDBe3QQKAPDBe3QQLAPDBe6GUCAPDBe6GUBAPDBe2R64APDBe3QQFAPDBe3QQGAPDBe3QQHAPDBe3QQJAPDBe3LFNAPDBe3R1SAPDBe3LFQAPDBe3R28APDBe3LFSAPDBe3R1YAPDBe3SW4APDBe6GVAAPDBe1PW2APDBe2A4LAPDBe1WCCAPDBe5D1JAPDBe3EZRAPDBe5NEVAPDBe3EZVAPDBe1P5EAPDBe6GUEAPDBe6GUFAPDBe6GUHAPDBe6GUKAPDBe3QRTAPDBe3SW7APDBe3QRUAPDBe4NJ3APDBe2JGZAPDBe4KD1APDBe1PXPAPDBe1PXOAPDBe3QU0APDBe1PXNAPDBe1PXMAPDBe3QTQAPDBe1PXLAPDBe3QTRAPDBe7QHLAPDBe1PXKAPDBe3QTSAPDBe1PXJAPDBe1PXIAPDBe3QTUAPDBe8FP5APDBe8FOWAPDBe5ANKAPDBe5ANJAPDBe4EZ3APDBe5ANOAPDBe8FP0APDBe4EZ7APDBe5ANEAPDBe5ANDAPDBe5ANGAPDBe5ANIAPDBe3R71APDBe3R73APDBe3QTWAPDBe3QTXAPDBe1PYEAPDBe3QTZAPDBe3R83APDBe3R7UAPDBe3R7VAPDBe3R7IAPDBe3R7EAPDBe1YKRAPDBe3R6XAPDBe8VQ3APDBe8VQ4APDBe1GIJAPDBe3QX2APDBe1GIIAPDBe1GIHAPDBe3QX4APDBe3R8UAPDBe3R8VAPDBe3QWJAPDBe3QWKAPDBe3R8LAPDBe3R8MAPDBe2WEVAPDBe3IGGAPDBe3R8PAPDBe7E34APDBe3WBLAPDBe5A14APDBe5MHQAPDBe3R7YAPDBe3IG7APDBe2WFYAPDBe5OO0APDBe5OO1APDBe8ERDAPDBe5OO3APDBe3R9NAPDBe3QXOAPDBe3R9OAPDBe3QXPAPDBe8H6PAPDBe3R9DAPDBe8H6TAPDBe3R9HAPDBe3R8ZAPDBe3RZBAPDBe2WHBAPDBe1FINAPDBe8ERNAPDBe9FR2APDBe3NS9APDBe4BZDAPDBe4GCJAPDBe3PXYAPDBe3PXZAPDBe5CYIAPDBe3PY0APDBe3PY1APDBe3PXQAPDBe3PXRAPDBe3QZFAPDBe3PXFAPDBe3QZGAPDBe3QZHAPDBe3QZIAPDBe5IF1APDBe1JSVAPDBe1JSUAPDBe1JSTAPDBe2WIPAPDBe2WIHAPDBe1H00APDBe2CCIAPDBe2CCHAPDBe6ATHAPDBe1H08APDBe1H07APDBe7UXKAPDBe8UV0APDBe1H01APDBe5IEYAPDBe7UXIAPDBe4II5APDBe5IEVAPDBe5IEXAPDBe2XNBAPDBe6Q48APDBe7S4TAPDBe5OSJAPDBe1H0WAPDBe1H0VAPDBe2XMYAPDBe5LMKAPDBe5OSMAPDBe6Q3CAPDBe6Q3BAPDBe1DI8APDBe6Q3FAPDBe1H1QAPDBe1H1PAPDBe2WMAAPDBe2WMBAPDBe6JGMAPDBe1JVPAPDBe3DDPAPDBe3DDQAPDBe6OQIAPDBe6Q4JAPDBe6Q4IAPDBe1H28APDBe1H27APDBe6Q4KAPDBe1H26APDBe1H25APDBe1H1SAPDBe1H24APDBe1H1RAPDBe6Q4BAPDBe6Q4AAPDBe6Q4DAPDBe6Q4CAPDBe6Q4FAPDBe6Q4EAPDBe6Q4HAPDBe6Q4GAPDBe6Q49APDBe6P3WAPDBe1FQ1APDBe7S84APDBe7S85APDBe3MY5APDBe1DM2APDBe3RAKAPDBe3RALAPDBe8CURAPDBe1W0XAPDBe7MKXAPDBe7S7AAPDBe3RAHAPDBe3RAIAPDBe1CKPAPDBe3EJ1APDBe2I40APDBe8RU8APDBe2WPAAPDBe7RWFAPDBe7RWEAPDBe3EIDAPDBe7S9XAPDBe1PF8APDBe7KJSAPDBe1V1KAPDBe7RXOAPDBe2W05APDBe2W06APDBe8B54APDBe2X1NAPDBe7B7SAPDBe2IW6APDBe2CJMAPDBe2W1HAPDBe5L2WAPDBe2BHHAPDBe2IW9APDBe2IW8APDBe3TI1APDBe2W17APDBe2BHEAPDBe2V0DAPDBe4BCMAPDBe4FKQAPDBe5JQ5APDBe4BCNAPDBe4FKRAPDBe1URCAPDBe4BCOAPDBe4FKSAPDBe1G5SAPDBe4BCPAPDBe4FKTAPDBe4BCQAPDBe4FKUAPDBe4FKVAPDBe5JQ8APDBe4FKWAPDBe3ULIAPDBe4FKIAPDBe3TIYAPDBe4FKJAPDBe3TIZAPDBe4FKLAPDBe1E1XAPDBe1E1VAPDBe4BCKAPDBe4FKOAPDBe4FKPAPDBe4FKGAPDBe1Y91APDBe1Y8YAPDBe4EK3APDBe4EK4APDBe4EK5APDBe4EK6APDBe4CFUAPDBe4EK8APDBe4CFVAPDBe2CLXAPDBe4CFMAPDBe4CFNAPDBe6YL1APDBe6YL6APDBe2J9MAPDBe1URWAPDBe1FVVAPDBe3BHTAPDBe1FVTAPDBe3BHUAPDBe3BHVAPDBe1F5QAPDBe3UNJAPDBe1GY3APDBe3UNKAPDBe2BKZAPDBe4ACMAPDBe4LYNAPDBe4CFWAPDBe4CFXAPDBe1OGUAPDBe6YLKAPDBe2V22APDBe2VTHAPDBe2VTIAPDBe2VTJAPDBe1GZ8APDBe2VTLAPDBe4I3ZAPDBe2VTMAPDBe1W8CAPDBe2VTNAPDBe2VTOAPDBe6INLAPDBe2VTAAPDBe7VDUAPDBe1PKDAPDBe7M2FAPDBe5K4JAPDBe1OI9APDBe3EOCAPDBe3RJCAPDBe7NVQAPDBe1OIRAPDBe1OIQAPDBe1W98APDBe4BGHAPDBe2VTPAPDBe1OIYAPDBe2VTQAPDBe1QMZAPDBe2VTRAPDBe2VU3APDBe2VTSAPDBe2VTTAPDBe1OIUAPDBe1OITAPDBeGO:0000287magnesium ion bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0019904protein domain specific bindingGoFunctionGO:0030332cyclin bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0006281DNA repairGoProcessGO:0006468protein phosphorylationGoProcessGO:0006813potassium ion transportGoProcessGO:0007099centriole replicationGoProcessGO:0007165signal transductionGoProcessGO:0007265Ras protein signal transductionGoProcessGO:0007346regulation of mitotic cell cycleGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010389regulation of G2/M transition of mitotic cell cycleGoProcessGO:0018105peptidyl-serine phosphorylationGoProcessGO:0031453positive regulation of heterochromatin formationGoProcessGO:0031571mitotic G1 DNA damage checkpoint signalingGoProcessGO:0032298positive regulation of DNA-templated DNA replication initiationGoProcessGO:0043247telomere maintenance in response to DNA damageGoProcessGO:0045740positive regulation of DNA replicationGoProcessGO:0045893positive regulation of DNA-templated transcriptionGoProcessGO:0051298centrosome duplicationGoProcessGO:0051301cell divisionGoProcessGO:0051321meiotic cell cycleGoProcessGO:0071732cellular response to nitric oxideGoProcessGO:0090398cellular senescenceGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0000781chromosome, telomeric regionGoComponentGO:0000793condensed chromosomeGoComponentGO:0000805X chromosomeGoComponentGO:0000806Y chromosomeGoComponentGO:0001673male germ cell nucleusGoComponentGO:0005635nuclear envelopeGoComponentGO:0005654nucleoplasmGoComponentGO:0005768endosomeGoComponentGO:0005813centrosomeGoComponentGO:0005829cytosolGoComponentGO:0005856cytoskeletonGoComponentGO:0015030Cajal bodyGoComponentGO:0005667transcription regulator complexGoComponentA8K7C6Cyclin-dependent kinase 2UniProtO75100Cyclin-dependent kinase 2UniProtP24941Cyclin-dependent kinase 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:1771CDK2HGNCR-HSA-1538133G0 and Early G1ReactomeR-HSA-171319Telomere Extension By TelomeraseReactomeR-HSA-176187Activation of ATR in response to replication stressReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-5693607Processing of DNA double-strand break endsReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-6804756Regulation of TP53 Activity through PhosphorylationReactomeR-HSA-6804757Regulation of TP53 DegradationReactomeR-HSA-68911G2 PhaseReactomeR-HSA-68949Orc1 removal from chromatinReactomeR-HSA-68962Activation of the pre-replicative complexReactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-HSA-69200Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesReactomeR-HSA-69202Cyclin E associated events during G1/S transitionReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69563p53-Dependent G1 DNA Damage ResponseReactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entryReactomeR-HSA-8849470PTK6 Regulates Cell CycleReactomeR-HSA-912446Meiotic recombinationReactomeR-HSA-9616222Transcriptional regulation of granulopoiesisReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9825892Regulation of MITF-M-dependent genes involved in cell cycle and proliferationReactomeR-HSA-983231Factors involved in megakaryocyte development and platelet productionReactomeP24941PharosP24941ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF521CYCLIN-DEPENDENT KINASE 2PANTHERPF00069PkinasePfamPA101cyclin dependent kinase 2PharmGKBP78396Cyclin-A11927PROTEINPROTEIN SUBUNITCCNA1GENE_SYMBOLCyclin-A1UNIPROTGO:0005515protein bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0007141male meiosis IGoProcessGO:0007283spermatogenesisGoProcessGO:0051301cell divisionGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0005654nucleoplasmGoComponentGO:0005829cytosolGoComponentGO:0015630microtubule cytoskeletonGoComponentB7Z7E3Cyclin-A1UniProtQ5T3V0Cyclin-A1UniProtQ5U0G2Cyclin-A1UniProtQ8IY91Cyclin-A1UniProtP78396Cyclin-A1UniProtP78396AlphaFoldDBP78396IntActHGNC:1577CCNA1HGNCR-HSA-1538133G0 and Early G1ReactomeR-HSA-170145Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexesReactomeR-HSA-171319Telomere Extension By TelomeraseReactomeR-HSA-174184Cdc20:Phospho-APC/C mediated degradation of Cyclin AReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-5689880Ub-specific processing proteasesReactomeR-HSA-5693607Processing of DNA double-strand break endsReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-6804756Regulation of TP53 Activity through PhosphorylationReactomeR-HSA-6804757Regulation of TP53 DegradationReactomeR-HSA-68911G2 PhaseReactomeR-HSA-68949Orc1 removal from chromatinReactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-HSA-69205G1/S-Specific TranscriptionReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69563p53-Dependent G1 DNA Damage ResponseReactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entryReactomeP78396PharosP78396ExpressionAtlasIPR039361CyclinInterProIPR032447Cyclin-A_NInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamPF16500Cyclin_N2PfamPA26147cyclin A1PharmGKBPROTEIN COMPLEX9606Homo sapiensCDK2/CDK4CHEMBL3038517P11802Cyclin-dependent kinase 417PROTEINGROUP MEMBERCDK4GENE_SYMBOLCyclin-dependent kinase 4UNIPROTCell division protein kinase 4UNIPROTPSK-J3UNIPROT2.7.11.22EC_NUMBER6P8GAPDBe6P8FAPDBe6P8HAPDBe2W96APDBe2W9FAPDBe3G33APDBe2W99APDBe2W9ZAPDBe6P8EAPDBe7SJ3APDBeGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0030332cyclin bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0006468protein phosphorylationGoProcessGO:0007165signal transductionGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010389regulation of G2/M transition of mitotic cell cycleGoProcessGO:0010971positive regulation of G2/M transition of mitotic cell cycleGoProcessGO:0048146positive regulation of fibroblast proliferationGoProcessGO:0051301cell divisionGoProcessGO:0051726regulation of cell cycleGoProcessGO:0061469regulation of type B pancreatic cell proliferationGoProcessGO:0071222cellular response to lipopolysaccharideGoProcessGO:1904628cellular response to phorbol 13-acetate 12-myristateGoProcessGO:1904637cellular response to ionomycinGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0000785chromatinGoComponentGO:0005654nucleoplasmGoComponentGO:0005730nucleolusGoComponentGO:0005829cytosolGoComponentGO:0005923bicellular tight junctionGoComponentGO:0016020membraneGoComponentGO:0031965nuclear membraneGoComponentGO:0005667transcription regulator complexGoComponentB2R9A0Cyclin-dependent kinase 4UniProtB4DNF9Cyclin-dependent kinase 4UniProtO00576Cyclin-dependent kinase 4UniProtQ6FG61Cyclin-dependent kinase 4UniProtP11802Cyclin-dependent kinase 4UniProt2W96PDB2W99PDB2W9FPDB2W9ZPDB3G33PDB5FWKPDB5FWLPDB5FWMPDB5FWPPDB6P8EPDB6P8FPDB6P8GPDB6P8HPDB7SJ3PDBP11802AlphaFoldDBP11802IntActHGNC:1773CDK4HGNCR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559580Oxidative Stress Induced SenescenceReactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-HSA-2559585Oncogene Induced SenescenceReactomeR-HSA-3214858RMTs methylate histone argininesReactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiationReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-75815Ubiquitin-dependent degradation of Cyclin DReactomeR-HSA-8849470PTK6 Regulates Cell CycleReactomeR-HSA-8878166Transcriptional regulation by RUNX2ReactomeR-HSA-912446Meiotic recombinationReactomeR-HSA-9616222Transcriptional regulation of granulopoiesisReactomeR-HSA-9630791Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4ReactomeR-HSA-9630794Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6ReactomeR-HSA-9632697Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4ReactomeR-HSA-9632700Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6ReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9754119Drug-mediated inhibition of CDK4/CDK6 activityReactomeP11802PharosP11802ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF129CYCLIN-DEPENDENT KINASE 4PANTHERPF00069PkinasePfamPA102cyclin dependent kinase 4PharmGKBP24941Cyclin-dependent kinase 236PROTEINGROUP MEMBERCDKN2GENE_SYMBOL_OTHERCDK2GENE_SYMBOLCyclin-dependent kinase 2UNIPROTCell division protein kinase 2UNIPROTp33 protein kinaseUNIPROT2.7.11.22EC_NUMBER2DS1APDBe3RKBAPDBe3QHRAPDBe3DOGAPDBe3RK5APDBe7SA0APDBe3TNWAPDBe3RK7APDBe2FVDAPDBe3QHWAPDBe3RK9APDBe2VV9APDBe1AQ1APDBe4EONAPDBe4EOOAPDBe4EOPAPDBe2UUEAPDBe4EOQAPDBe4EORAPDBe7ZPCAPDBe4EOSAPDBe1VYZAPDBe1OL2APDBe4EOIAPDBe1OL1APDBe1VYWAPDBe4EOJAPDBe4EOKAPDBe4EOLAPDBe4EOMAPDBe2WXVAPDBe1OKWAPDBe1OKVAPDBe1B39APDBe3RMFAPDBe1B38APDBe2G9XAPDBe8OY2APDBe5FP6APDBe5FP5APDBe3RM6APDBe3RM7APDBe7UG1APDBe7RA5APDBe1KE9APDBe1KE8APDBe2BPMAPDBe1KE7APDBe1KE6APDBe1KE5APDBe4RJ3APDBe3RNIAPDBe2DUVAPDBe3F5XAPDBe3QL8APDBe3PJ8APDBe6SG4APDBe1E9HAPDBe3S0OAPDBe4ERWAPDBe1BUHAPDBe3S00APDBe2EXMAPDBe3RPOAPDBe3S1HAPDBe3ROYAPDBe2C4GAPDBe2A0CAPDBe3SQQAPDBe2R3JAPDBe2UZOAPDBe2R3IAPDBe4D1ZAPDBe2C5YAPDBe2R3HAPDBe2C5XAPDBe2C69APDBe2R3GAPDBe2C68APDBe2R3FAPDBe2C5VAPDBe3S2PAPDBe1HCKAPDBe2R3RAPDBe2R3QAPDBe2R3PAPDBe2R3OAPDBe7ACKAPDBe2R3NAPDBe2R3MAPDBe2UZLAPDBe2R3LAPDBe2R3KAPDBe2UZNAPDBe4D1XAPDBe3RPYAPDBe3FZ1APDBe3LE6APDBe2UZBAPDBe2UZDAPDBe2UZEAPDBe2BTSAPDBe5UQ2APDBe1P2AAPDBe2BTRAPDBe3RPRAPDBe5UQ1APDBe5UQ3APDBe2C5OAPDBe2C5NAPDBe3RPVAPDBe6RIJAPDBe2B55APDBe3R1QAPDBe2C6LAPDBe2C6KAPDBe2C6IAPDBe1R78APDBe4FX3APDBe1HCLAPDBe2B54APDBe2C6TAPDBe2B53APDBe2B52APDBe2C6OAPDBe2C6MAPDBe3QQKAPDBe3QQLAPDBe6GUCAPDBe6GUBAPDBe2R64APDBe3QQFAPDBe3QQGAPDBe3QQHAPDBe3QQJAPDBe3LFNAPDBe3R1SAPDBe3LFQAPDBe3R28APDBe3LFSAPDBe3R1YAPDBe3SW4APDBe6GVAAPDBe1PW2APDBe2A4LAPDBe1WCCAPDBe5D1JAPDBe3EZRAPDBe5NEVAPDBe3EZVAPDBe1P5EAPDBe6GUEAPDBe6GUFAPDBe6GUHAPDBe6GUKAPDBe3QRTAPDBe3SW7APDBe3QRUAPDBe4NJ3APDBe2JGZAPDBe4KD1APDBe1PXPAPDBe1PXOAPDBe3QU0APDBe1PXNAPDBe1PXMAPDBe3QTQAPDBe1PXLAPDBe3QTRAPDBe7QHLAPDBe1PXKAPDBe3QTSAPDBe1PXJAPDBe1PXIAPDBe3QTUAPDBe8FP5APDBe8FOWAPDBe5ANKAPDBe5ANJAPDBe4EZ3APDBe5ANOAPDBe8FP0APDBe4EZ7APDBe5ANEAPDBe5ANDAPDBe5ANGAPDBe5ANIAPDBe3R71APDBe3R73APDBe3QTWAPDBe3QTXAPDBe1PYEAPDBe3QTZAPDBe3R83APDBe3R7UAPDBe3R7VAPDBe3R7IAPDBe3R7EAPDBe1YKRAPDBe3R6XAPDBe8VQ3APDBe8VQ4APDBe1GIJAPDBe3QX2APDBe1GIIAPDBe1GIHAPDBe3QX4APDBe3R8UAPDBe3R8VAPDBe3QWJAPDBe3QWKAPDBe3R8LAPDBe3R8MAPDBe2WEVAPDBe3IGGAPDBe3R8PAPDBe7E34APDBe3WBLAPDBe5A14APDBe5MHQAPDBe3R7YAPDBe3IG7APDBe2WFYAPDBe5OO0APDBe5OO1APDBe8ERDAPDBe5OO3APDBe3R9NAPDBe3QXOAPDBe3R9OAPDBe3QXPAPDBe8H6PAPDBe3R9DAPDBe8H6TAPDBe3R9HAPDBe3R8ZAPDBe3RZBAPDBe2WHBAPDBe1FINAPDBe8ERNAPDBe9FR2APDBe3NS9APDBe4BZDAPDBe4GCJAPDBe3PXYAPDBe3PXZAPDBe5CYIAPDBe3PY0APDBe3PY1APDBe3PXQAPDBe3PXRAPDBe3QZFAPDBe3PXFAPDBe3QZGAPDBe3QZHAPDBe3QZIAPDBe5IF1APDBe1JSVAPDBe1JSUAPDBe1JSTAPDBe2WIPAPDBe2WIHAPDBe1H00APDBe2CCIAPDBe2CCHAPDBe6ATHAPDBe1H08APDBe1H07APDBe7UXKAPDBe8UV0APDBe1H01APDBe5IEYAPDBe7UXIAPDBe4II5APDBe5IEVAPDBe5IEXAPDBe2XNBAPDBe6Q48APDBe7S4TAPDBe5OSJAPDBe1H0WAPDBe1H0VAPDBe2XMYAPDBe5LMKAPDBe5OSMAPDBe6Q3CAPDBe6Q3BAPDBe1DI8APDBe6Q3FAPDBe1H1QAPDBe1H1PAPDBe2WMAAPDBe2WMBAPDBe6JGMAPDBe1JVPAPDBe3DDPAPDBe3DDQAPDBe6OQIAPDBe6Q4JAPDBe6Q4IAPDBe1H28APDBe1H27APDBe6Q4KAPDBe1H26APDBe1H25APDBe1H1SAPDBe1H24APDBe1H1RAPDBe6Q4BAPDBe6Q4AAPDBe6Q4DAPDBe6Q4CAPDBe6Q4FAPDBe6Q4EAPDBe6Q4HAPDBe6Q4GAPDBe6Q49APDBe6P3WAPDBe1FQ1APDBe7S84APDBe7S85APDBe3MY5APDBe1DM2APDBe3RAKAPDBe3RALAPDBe8CURAPDBe1W0XAPDBe7MKXAPDBe7S7AAPDBe3RAHAPDBe3RAIAPDBe1CKPAPDBe3EJ1APDBe2I40APDBe8RU8APDBe2WPAAPDBe7RWFAPDBe7RWEAPDBe3EIDAPDBe7S9XAPDBe1PF8APDBe7KJSAPDBe1V1KAPDBe7RXOAPDBe2W05APDBe2W06APDBe8B54APDBe2X1NAPDBe7B7SAPDBe2IW6APDBe2CJMAPDBe2W1HAPDBe5L2WAPDBe2BHHAPDBe2IW9APDBe2IW8APDBe3TI1APDBe2W17APDBe2BHEAPDBe2V0DAPDBe4BCMAPDBe4FKQAPDBe5JQ5APDBe4BCNAPDBe4FKRAPDBe1URCAPDBe4BCOAPDBe4FKSAPDBe1G5SAPDBe4BCPAPDBe4FKTAPDBe4BCQAPDBe4FKUAPDBe4FKVAPDBe5JQ8APDBe4FKWAPDBe3ULIAPDBe4FKIAPDBe3TIYAPDBe4FKJAPDBe3TIZAPDBe4FKLAPDBe1E1XAPDBe1E1VAPDBe4BCKAPDBe4FKOAPDBe4FKPAPDBe4FKGAPDBe1Y91APDBe1Y8YAPDBe4EK3APDBe4EK4APDBe4EK5APDBe4EK6APDBe4CFUAPDBe4EK8APDBe4CFVAPDBe2CLXAPDBe4CFMAPDBe4CFNAPDBe6YL1APDBe6YL6APDBe2J9MAPDBe1URWAPDBe1FVVAPDBe3BHTAPDBe1FVTAPDBe3BHUAPDBe3BHVAPDBe1F5QAPDBe3UNJAPDBe1GY3APDBe3UNKAPDBe2BKZAPDBe4ACMAPDBe4LYNAPDBe4CFWAPDBe4CFXAPDBe1OGUAPDBe6YLKAPDBe2V22APDBe2VTHAPDBe2VTIAPDBe2VTJAPDBe1GZ8APDBe2VTLAPDBe4I3ZAPDBe2VTMAPDBe1W8CAPDBe2VTNAPDBe2VTOAPDBe6INLAPDBe2VTAAPDBe7VDUAPDBe1PKDAPDBe7M2FAPDBe5K4JAPDBe1OI9APDBe3EOCAPDBe3RJCAPDBe7NVQAPDBe1OIRAPDBe1OIQAPDBe1W98APDBe4BGHAPDBe2VTPAPDBe1OIYAPDBe2VTQAPDBe1QMZAPDBe2VTRAPDBe2VU3APDBe2VTSAPDBe2VTTAPDBe1OIUAPDBe1OITAPDBeGO:0000287magnesium ion bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0019904protein domain specific bindingGoFunctionGO:0030332cyclin bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0006281DNA repairGoProcessGO:0006468protein phosphorylationGoProcessGO:0006813potassium ion transportGoProcessGO:0007099centriole replicationGoProcessGO:0007165signal transductionGoProcessGO:0007265Ras protein signal transductionGoProcessGO:0007346regulation of mitotic cell cycleGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010389regulation of G2/M transition of mitotic cell cycleGoProcessGO:0018105peptidyl-serine phosphorylationGoProcessGO:0031453positive regulation of heterochromatin formationGoProcessGO:0031571mitotic G1 DNA damage checkpoint signalingGoProcessGO:0032298positive regulation of DNA-templated DNA replication initiationGoProcessGO:0043247telomere maintenance in response to DNA damageGoProcessGO:0045740positive regulation of DNA replicationGoProcessGO:0045893positive regulation of DNA-templated transcriptionGoProcessGO:0051298centrosome duplicationGoProcessGO:0051301cell divisionGoProcessGO:0051321meiotic cell cycleGoProcessGO:0071732cellular response to nitric oxideGoProcessGO:0090398cellular senescenceGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0000781chromosome, telomeric regionGoComponentGO:0000793condensed chromosomeGoComponentGO:0000805X chromosomeGoComponentGO:0000806Y chromosomeGoComponentGO:0001673male germ cell nucleusGoComponentGO:0005635nuclear envelopeGoComponentGO:0005654nucleoplasmGoComponentGO:0005768endosomeGoComponentGO:0005813centrosomeGoComponentGO:0005829cytosolGoComponentGO:0005856cytoskeletonGoComponentGO:0015030Cajal bodyGoComponentGO:0005667transcription regulator complexGoComponentA8K7C6Cyclin-dependent kinase 2UniProtO75100Cyclin-dependent kinase 2UniProtP24941Cyclin-dependent kinase 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:1771CDK2HGNCR-HSA-1538133G0 and Early G1ReactomeR-HSA-171319Telomere Extension By TelomeraseReactomeR-HSA-176187Activation of ATR in response to replication stressReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-5693607Processing of DNA double-strand break endsReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-6804756Regulation of TP53 Activity through PhosphorylationReactomeR-HSA-6804757Regulation of TP53 DegradationReactomeR-HSA-68911G2 PhaseReactomeR-HSA-68949Orc1 removal from chromatinReactomeR-HSA-68962Activation of the pre-replicative complexReactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-HSA-69200Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesReactomeR-HSA-69202Cyclin E associated events during G1/S transitionReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69563p53-Dependent G1 DNA Damage ResponseReactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entryReactomeR-HSA-8849470PTK6 Regulates Cell CycleReactomeR-HSA-912446Meiotic recombinationReactomeR-HSA-9616222Transcriptional regulation of granulopoiesisReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9825892Regulation of MITF-M-dependent genes involved in cell cycle and proliferationReactomeR-HSA-983231Factors involved in megakaryocyte development and platelet productionReactomeP24941PharosP24941ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF521CYCLIN-DEPENDENT KINASE 2PANTHERPF00069PkinasePfamPA101cyclin dependent kinase 2PharmGKBPROTEIN FAMILY9606Homo sapiensCDK2/Cyclin OCHEMBL4106152P24941Cyclin-dependent kinase 236PROTEINPROTEIN SUBUNITCDKN2GENE_SYMBOL_OTHERCDK2GENE_SYMBOLCyclin-dependent kinase 2UNIPROTCell division protein kinase 2UNIPROTp33 protein kinaseUNIPROT2.7.11.22EC_NUMBER2DS1APDBe3RKBAPDBe3QHRAPDBe3DOGAPDBe3RK5APDBe7SA0APDBe3TNWAPDBe3RK7APDBe2FVDAPDBe3QHWAPDBe3RK9APDBe2VV9APDBe1AQ1APDBe4EONAPDBe4EOOAPDBe4EOPAPDBe2UUEAPDBe4EOQAPDBe4EORAPDBe7ZPCAPDBe4EOSAPDBe1VYZAPDBe1OL2APDBe4EOIAPDBe1OL1APDBe1VYWAPDBe4EOJAPDBe4EOKAPDBe4EOLAPDBe4EOMAPDBe2WXVAPDBe1OKWAPDBe1OKVAPDBe1B39APDBe3RMFAPDBe1B38APDBe2G9XAPDBe8OY2APDBe5FP6APDBe5FP5APDBe3RM6APDBe3RM7APDBe7UG1APDBe7RA5APDBe1KE9APDBe1KE8APDBe2BPMAPDBe1KE7APDBe1KE6APDBe1KE5APDBe4RJ3APDBe3RNIAPDBe2DUVAPDBe3F5XAPDBe3QL8APDBe3PJ8APDBe6SG4APDBe1E9HAPDBe3S0OAPDBe4ERWAPDBe1BUHAPDBe3S00APDBe2EXMAPDBe3RPOAPDBe3S1HAPDBe3ROYAPDBe2C4GAPDBe2A0CAPDBe3SQQAPDBe2R3JAPDBe2UZOAPDBe2R3IAPDBe4D1ZAPDBe2C5YAPDBe2R3HAPDBe2C5XAPDBe2C69APDBe2R3GAPDBe2C68APDBe2R3FAPDBe2C5VAPDBe3S2PAPDBe1HCKAPDBe2R3RAPDBe2R3QAPDBe2R3PAPDBe2R3OAPDBe7ACKAPDBe2R3NAPDBe2R3MAPDBe2UZLAPDBe2R3LAPDBe2R3KAPDBe2UZNAPDBe4D1XAPDBe3RPYAPDBe3FZ1APDBe3LE6APDBe2UZBAPDBe2UZDAPDBe2UZEAPDBe2BTSAPDBe5UQ2APDBe1P2AAPDBe2BTRAPDBe3RPRAPDBe5UQ1APDBe5UQ3APDBe2C5OAPDBe2C5NAPDBe3RPVAPDBe6RIJAPDBe2B55APDBe3R1QAPDBe2C6LAPDBe2C6KAPDBe2C6IAPDBe1R78APDBe4FX3APDBe1HCLAPDBe2B54APDBe2C6TAPDBe2B53APDBe2B52APDBe2C6OAPDBe2C6MAPDBe3QQKAPDBe3QQLAPDBe6GUCAPDBe6GUBAPDBe2R64APDBe3QQFAPDBe3QQGAPDBe3QQHAPDBe3QQJAPDBe3LFNAPDBe3R1SAPDBe3LFQAPDBe3R28APDBe3LFSAPDBe3R1YAPDBe3SW4APDBe6GVAAPDBe1PW2APDBe2A4LAPDBe1WCCAPDBe5D1JAPDBe3EZRAPDBe5NEVAPDBe3EZVAPDBe1P5EAPDBe6GUEAPDBe6GUFAPDBe6GUHAPDBe6GUKAPDBe3QRTAPDBe3SW7APDBe3QRUAPDBe4NJ3APDBe2JGZAPDBe4KD1APDBe1PXPAPDBe1PXOAPDBe3QU0APDBe1PXNAPDBe1PXMAPDBe3QTQAPDBe1PXLAPDBe3QTRAPDBe7QHLAPDBe1PXKAPDBe3QTSAPDBe1PXJAPDBe1PXIAPDBe3QTUAPDBe8FP5APDBe8FOWAPDBe5ANKAPDBe5ANJAPDBe4EZ3APDBe5ANOAPDBe8FP0APDBe4EZ7APDBe5ANEAPDBe5ANDAPDBe5ANGAPDBe5ANIAPDBe3R71APDBe3R73APDBe3QTWAPDBe3QTXAPDBe1PYEAPDBe3QTZAPDBe3R83APDBe3R7UAPDBe3R7VAPDBe3R7IAPDBe3R7EAPDBe1YKRAPDBe3R6XAPDBe8VQ3APDBe8VQ4APDBe1GIJAPDBe3QX2APDBe1GIIAPDBe1GIHAPDBe3QX4APDBe3R8UAPDBe3R8VAPDBe3QWJAPDBe3QWKAPDBe3R8LAPDBe3R8MAPDBe2WEVAPDBe3IGGAPDBe3R8PAPDBe7E34APDBe3WBLAPDBe5A14APDBe5MHQAPDBe3R7YAPDBe3IG7APDBe2WFYAPDBe5OO0APDBe5OO1APDBe8ERDAPDBe5OO3APDBe3R9NAPDBe3QXOAPDBe3R9OAPDBe3QXPAPDBe8H6PAPDBe3R9DAPDBe8H6TAPDBe3R9HAPDBe3R8ZAPDBe3RZBAPDBe2WHBAPDBe1FINAPDBe8ERNAPDBe9FR2APDBe3NS9APDBe4BZDAPDBe4GCJAPDBe3PXYAPDBe3PXZAPDBe5CYIAPDBe3PY0APDBe3PY1APDBe3PXQAPDBe3PXRAPDBe3QZFAPDBe3PXFAPDBe3QZGAPDBe3QZHAPDBe3QZIAPDBe5IF1APDBe1JSVAPDBe1JSUAPDBe1JSTAPDBe2WIPAPDBe2WIHAPDBe1H00APDBe2CCIAPDBe2CCHAPDBe6ATHAPDBe1H08APDBe1H07APDBe7UXKAPDBe8UV0APDBe1H01APDBe5IEYAPDBe7UXIAPDBe4II5APDBe5IEVAPDBe5IEXAPDBe2XNBAPDBe6Q48APDBe7S4TAPDBe5OSJAPDBe1H0WAPDBe1H0VAPDBe2XMYAPDBe5LMKAPDBe5OSMAPDBe6Q3CAPDBe6Q3BAPDBe1DI8APDBe6Q3FAPDBe1H1QAPDBe1H1PAPDBe2WMAAPDBe2WMBAPDBe6JGMAPDBe1JVPAPDBe3DDPAPDBe3DDQAPDBe6OQIAPDBe6Q4JAPDBe6Q4IAPDBe1H28APDBe1H27APDBe6Q4KAPDBe1H26APDBe1H25APDBe1H1SAPDBe1H24APDBe1H1RAPDBe6Q4BAPDBe6Q4AAPDBe6Q4DAPDBe6Q4CAPDBe6Q4FAPDBe6Q4EAPDBe6Q4HAPDBe6Q4GAPDBe6Q49APDBe6P3WAPDBe1FQ1APDBe7S84APDBe7S85APDBe3MY5APDBe1DM2APDBe3RAKAPDBe3RALAPDBe8CURAPDBe1W0XAPDBe7MKXAPDBe7S7AAPDBe3RAHAPDBe3RAIAPDBe1CKPAPDBe3EJ1APDBe2I40APDBe8RU8APDBe2WPAAPDBe7RWFAPDBe7RWEAPDBe3EIDAPDBe7S9XAPDBe1PF8APDBe7KJSAPDBe1V1KAPDBe7RXOAPDBe2W05APDBe2W06APDBe8B54APDBe2X1NAPDBe7B7SAPDBe2IW6APDBe2CJMAPDBe2W1HAPDBe5L2WAPDBe2BHHAPDBe2IW9APDBe2IW8APDBe3TI1APDBe2W17APDBe2BHEAPDBe2V0DAPDBe4BCMAPDBe4FKQAPDBe5JQ5APDBe4BCNAPDBe4FKRAPDBe1URCAPDBe4BCOAPDBe4FKSAPDBe1G5SAPDBe4BCPAPDBe4FKTAPDBe4BCQAPDBe4FKUAPDBe4FKVAPDBe5JQ8APDBe4FKWAPDBe3ULIAPDBe4FKIAPDBe3TIYAPDBe4FKJAPDBe3TIZAPDBe4FKLAPDBe1E1XAPDBe1E1VAPDBe4BCKAPDBe4FKOAPDBe4FKPAPDBe4FKGAPDBe1Y91APDBe1Y8YAPDBe4EK3APDBe4EK4APDBe4EK5APDBe4EK6APDBe4CFUAPDBe4EK8APDBe4CFVAPDBe2CLXAPDBe4CFMAPDBe4CFNAPDBe6YL1APDBe6YL6APDBe2J9MAPDBe1URWAPDBe1FVVAPDBe3BHTAPDBe1FVTAPDBe3BHUAPDBe3BHVAPDBe1F5QAPDBe3UNJAPDBe1GY3APDBe3UNKAPDBe2BKZAPDBe4ACMAPDBe4LYNAPDBe4CFWAPDBe4CFXAPDBe1OGUAPDBe6YLKAPDBe2V22APDBe2VTHAPDBe2VTIAPDBe2VTJAPDBe1GZ8APDBe2VTLAPDBe4I3ZAPDBe2VTMAPDBe1W8CAPDBe2VTNAPDBe2VTOAPDBe6INLAPDBe2VTAAPDBe7VDUAPDBe1PKDAPDBe7M2FAPDBe5K4JAPDBe1OI9APDBe3EOCAPDBe3RJCAPDBe7NVQAPDBe1OIRAPDBe1OIQAPDBe1W98APDBe4BGHAPDBe2VTPAPDBe1OIYAPDBe2VTQAPDBe1QMZAPDBe2VTRAPDBe2VU3APDBe2VTSAPDBe2VTTAPDBe1OIUAPDBe1OITAPDBeGO:0000287magnesium ion bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0019904protein domain specific bindingGoFunctionGO:0030332cyclin bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0006281DNA repairGoProcessGO:0006468protein phosphorylationGoProcessGO:0006813potassium ion transportGoProcessGO:0007099centriole replicationGoProcessGO:0007165signal transductionGoProcessGO:0007265Ras protein signal transductionGoProcessGO:0007346regulation of mitotic cell cycleGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010389regulation of G2/M transition of mitotic cell cycleGoProcessGO:0018105peptidyl-serine phosphorylationGoProcessGO:0031453positive regulation of heterochromatin formationGoProcessGO:0031571mitotic G1 DNA damage checkpoint signalingGoProcessGO:0032298positive regulation of DNA-templated DNA replication initiationGoProcessGO:0043247telomere maintenance in response to DNA damageGoProcessGO:0045740positive regulation of DNA replicationGoProcessGO:0045893positive regulation of DNA-templated transcriptionGoProcessGO:0051298centrosome duplicationGoProcessGO:0051301cell divisionGoProcessGO:0051321meiotic cell cycleGoProcessGO:0071732cellular response to nitric oxideGoProcessGO:0090398cellular senescenceGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0000781chromosome, telomeric regionGoComponentGO:0000793condensed chromosomeGoComponentGO:0000805X chromosomeGoComponentGO:0000806Y chromosomeGoComponentGO:0001673male germ cell nucleusGoComponentGO:0005635nuclear envelopeGoComponentGO:0005654nucleoplasmGoComponentGO:0005768endosomeGoComponentGO:0005813centrosomeGoComponentGO:0005829cytosolGoComponentGO:0005856cytoskeletonGoComponentGO:0015030Cajal bodyGoComponentGO:0005667transcription regulator complexGoComponentA8K7C6Cyclin-dependent kinase 2UniProtO75100Cyclin-dependent kinase 2UniProtP24941Cyclin-dependent kinase 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:1771CDK2HGNCR-HSA-1538133G0 and Early G1ReactomeR-HSA-171319Telomere Extension By TelomeraseReactomeR-HSA-176187Activation of ATR in response to replication stressReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-5693607Processing of DNA double-strand break endsReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-6804756Regulation of TP53 Activity through PhosphorylationReactomeR-HSA-6804757Regulation of TP53 DegradationReactomeR-HSA-68911G2 PhaseReactomeR-HSA-68949Orc1 removal from chromatinReactomeR-HSA-68962Activation of the pre-replicative complexReactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-HSA-69200Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesReactomeR-HSA-69202Cyclin E associated events during G1/S transitionReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69563p53-Dependent G1 DNA Damage ResponseReactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entryReactomeR-HSA-8849470PTK6 Regulates Cell CycleReactomeR-HSA-912446Meiotic recombinationReactomeR-HSA-9616222Transcriptional regulation of granulopoiesisReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9825892Regulation of MITF-M-dependent genes involved in cell cycle and proliferationReactomeR-HSA-983231Factors involved in megakaryocyte development and platelet productionReactomeP24941PharosP24941ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF521CYCLIN-DEPENDENT KINASE 2PANTHERPF00069PkinasePfamPA101cyclin dependent kinase 2PharmGKBP22674Cyclin-O17747PROTEINPROTEIN SUBUNITCCNOGENE_SYMBOLCyclin-OUNIPROTGO:0005515protein bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000278mitotic cell cycleGoProcessGO:0051301cell divisionGoProcessGO:0060271cilium assemblyGoProcessGO:1903251multi-ciliated epithelial cell differentiationGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0005730nucleolusGoComponentGO:0034451centriolar satelliteGoComponentA8K1W5Cyclin-OUniProtQ0P6J2Cyclin-OUniProtQ9H6B0Cyclin-OUniProtQ9UMD5Cyclin-OUniProtP22674Cyclin-OUniProtP22674AlphaFoldDBP22674IntActHGNC:18576CCNOHGNCP22674PharosIPR039361CyclinInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamPA38350cyclin OPharmGKBPROTEIN COMPLEX9606Homo sapiensCDK2/Bovine cyclin ACHEMBL4106153P24941Cyclin-dependent kinase 236PROTEINPROTEIN SUBUNITCDKN2GENE_SYMBOL_OTHERCDK2GENE_SYMBOLCyclin-dependent kinase 2UNIPROTCell division protein kinase 2UNIPROTp33 protein kinaseUNIPROT2.7.11.22EC_NUMBER2DS1APDBe3RKBAPDBe3QHRAPDBe3DOGAPDBe3RK5APDBe7SA0APDBe3TNWAPDBe3RK7APDBe2FVDAPDBe3QHWAPDBe3RK9APDBe2VV9APDBe1AQ1APDBe4EONAPDBe4EOOAPDBe4EOPAPDBe2UUEAPDBe4EOQAPDBe4EORAPDBe7ZPCAPDBe4EOSAPDBe1VYZAPDBe1OL2APDBe4EOIAPDBe1OL1APDBe1VYWAPDBe4EOJAPDBe4EOKAPDBe4EOLAPDBe4EOMAPDBe2WXVAPDBe1OKWAPDBe1OKVAPDBe1B39APDBe3RMFAPDBe1B38APDBe2G9XAPDBe8OY2APDBe5FP6APDBe5FP5APDBe3RM6APDBe3RM7APDBe7UG1APDBe7RA5APDBe1KE9APDBe1KE8APDBe2BPMAPDBe1KE7APDBe1KE6APDBe1KE5APDBe4RJ3APDBe3RNIAPDBe2DUVAPDBe3F5XAPDBe3QL8APDBe3PJ8APDBe6SG4APDBe1E9HAPDBe3S0OAPDBe4ERWAPDBe1BUHAPDBe3S00APDBe2EXMAPDBe3RPOAPDBe3S1HAPDBe3ROYAPDBe2C4GAPDBe2A0CAPDBe3SQQAPDBe2R3JAPDBe2UZOAPDBe2R3IAPDBe4D1ZAPDBe2C5YAPDBe2R3HAPDBe2C5XAPDBe2C69APDBe2R3GAPDBe2C68APDBe2R3FAPDBe2C5VAPDBe3S2PAPDBe1HCKAPDBe2R3RAPDBe2R3QAPDBe2R3PAPDBe2R3OAPDBe7ACKAPDBe2R3NAPDBe2R3MAPDBe2UZLAPDBe2R3LAPDBe2R3KAPDBe2UZNAPDBe4D1XAPDBe3RPYAPDBe3FZ1APDBe3LE6APDBe2UZBAPDBe2UZDAPDBe2UZEAPDBe2BTSAPDBe5UQ2APDBe1P2AAPDBe2BTRAPDBe3RPRAPDBe5UQ1APDBe5UQ3APDBe2C5OAPDBe2C5NAPDBe3RPVAPDBe6RIJAPDBe2B55APDBe3R1QAPDBe2C6LAPDBe2C6KAPDBe2C6IAPDBe1R78APDBe4FX3APDBe1HCLAPDBe2B54APDBe2C6TAPDBe2B53APDBe2B52APDBe2C6OAPDBe2C6MAPDBe3QQKAPDBe3QQLAPDBe6GUCAPDBe6GUBAPDBe2R64APDBe3QQFAPDBe3QQGAPDBe3QQHAPDBe3QQJAPDBe3LFNAPDBe3R1SAPDBe3LFQAPDBe3R28APDBe3LFSAPDBe3R1YAPDBe3SW4APDBe6GVAAPDBe1PW2APDBe2A4LAPDBe1WCCAPDBe5D1JAPDBe3EZRAPDBe5NEVAPDBe3EZVAPDBe1P5EAPDBe6GUEAPDBe6GUFAPDBe6GUHAPDBe6GUKAPDBe3QRTAPDBe3SW7APDBe3QRUAPDBe4NJ3APDBe2JGZAPDBe4KD1APDBe1PXPAPDBe1PXOAPDBe3QU0APDBe1PXNAPDBe1PXMAPDBe3QTQAPDBe1PXLAPDBe3QTRAPDBe7QHLAPDBe1PXKAPDBe3QTSAPDBe1PXJAPDBe1PXIAPDBe3QTUAPDBe8FP5APDBe8FOWAPDBe5ANKAPDBe5ANJAPDBe4EZ3APDBe5ANOAPDBe8FP0APDBe4EZ7APDBe5ANEAPDBe5ANDAPDBe5ANGAPDBe5ANIAPDBe3R71APDBe3R73APDBe3QTWAPDBe3QTXAPDBe1PYEAPDBe3QTZAPDBe3R83APDBe3R7UAPDBe3R7VAPDBe3R7IAPDBe3R7EAPDBe1YKRAPDBe3R6XAPDBe8VQ3APDBe8VQ4APDBe1GIJAPDBe3QX2APDBe1GIIAPDBe1GIHAPDBe3QX4APDBe3R8UAPDBe3R8VAPDBe3QWJAPDBe3QWKAPDBe3R8LAPDBe3R8MAPDBe2WEVAPDBe3IGGAPDBe3R8PAPDBe7E34APDBe3WBLAPDBe5A14APDBe5MHQAPDBe3R7YAPDBe3IG7APDBe2WFYAPDBe5OO0APDBe5OO1APDBe8ERDAPDBe5OO3APDBe3R9NAPDBe3QXOAPDBe3R9OAPDBe3QXPAPDBe8H6PAPDBe3R9DAPDBe8H6TAPDBe3R9HAPDBe3R8ZAPDBe3RZBAPDBe2WHBAPDBe1FINAPDBe8ERNAPDBe9FR2APDBe3NS9APDBe4BZDAPDBe4GCJAPDBe3PXYAPDBe3PXZAPDBe5CYIAPDBe3PY0APDBe3PY1APDBe3PXQAPDBe3PXRAPDBe3QZFAPDBe3PXFAPDBe3QZGAPDBe3QZHAPDBe3QZIAPDBe5IF1APDBe1JSVAPDBe1JSUAPDBe1JSTAPDBe2WIPAPDBe2WIHAPDBe1H00APDBe2CCIAPDBe2CCHAPDBe6ATHAPDBe1H08APDBe1H07APDBe7UXKAPDBe8UV0APDBe1H01APDBe5IEYAPDBe7UXIAPDBe4II5APDBe5IEVAPDBe5IEXAPDBe2XNBAPDBe6Q48APDBe7S4TAPDBe5OSJAPDBe1H0WAPDBe1H0VAPDBe2XMYAPDBe5LMKAPDBe5OSMAPDBe6Q3CAPDBe6Q3BAPDBe1DI8APDBe6Q3FAPDBe1H1QAPDBe1H1PAPDBe2WMAAPDBe2WMBAPDBe6JGMAPDBe1JVPAPDBe3DDPAPDBe3DDQAPDBe6OQIAPDBe6Q4JAPDBe6Q4IAPDBe1H28APDBe1H27APDBe6Q4KAPDBe1H26APDBe1H25APDBe1H1SAPDBe1H24APDBe1H1RAPDBe6Q4BAPDBe6Q4AAPDBe6Q4DAPDBe6Q4CAPDBe6Q4FAPDBe6Q4EAPDBe6Q4HAPDBe6Q4GAPDBe6Q49APDBe6P3WAPDBe1FQ1APDBe7S84APDBe7S85APDBe3MY5APDBe1DM2APDBe3RAKAPDBe3RALAPDBe8CURAPDBe1W0XAPDBe7MKXAPDBe7S7AAPDBe3RAHAPDBe3RAIAPDBe1CKPAPDBe3EJ1APDBe2I40APDBe8RU8APDBe2WPAAPDBe7RWFAPDBe7RWEAPDBe3EIDAPDBe7S9XAPDBe1PF8APDBe7KJSAPDBe1V1KAPDBe7RXOAPDBe2W05APDBe2W06APDBe8B54APDBe2X1NAPDBe7B7SAPDBe2IW6APDBe2CJMAPDBe2W1HAPDBe5L2WAPDBe2BHHAPDBe2IW9APDBe2IW8APDBe3TI1APDBe2W17APDBe2BHEAPDBe2V0DAPDBe4BCMAPDBe4FKQAPDBe5JQ5APDBe4BCNAPDBe4FKRAPDBe1URCAPDBe4BCOAPDBe4FKSAPDBe1G5SAPDBe4BCPAPDBe4FKTAPDBe4BCQAPDBe4FKUAPDBe4FKVAPDBe5JQ8APDBe4FKWAPDBe3ULIAPDBe4FKIAPDBe3TIYAPDBe4FKJAPDBe3TIZAPDBe4FKLAPDBe1E1XAPDBe1E1VAPDBe4BCKAPDBe4FKOAPDBe4FKPAPDBe4FKGAPDBe1Y91APDBe1Y8YAPDBe4EK3APDBe4EK4APDBe4EK5APDBe4EK6APDBe4CFUAPDBe4EK8APDBe4CFVAPDBe2CLXAPDBe4CFMAPDBe4CFNAPDBe6YL1APDBe6YL6APDBe2J9MAPDBe1URWAPDBe1FVVAPDBe3BHTAPDBe1FVTAPDBe3BHUAPDBe3BHVAPDBe1F5QAPDBe3UNJAPDBe1GY3APDBe3UNKAPDBe2BKZAPDBe4ACMAPDBe4LYNAPDBe4CFWAPDBe4CFXAPDBe1OGUAPDBe6YLKAPDBe2V22APDBe2VTHAPDBe2VTIAPDBe2VTJAPDBe1GZ8APDBe2VTLAPDBe4I3ZAPDBe2VTMAPDBe1W8CAPDBe2VTNAPDBe2VTOAPDBe6INLAPDBe2VTAAPDBe7VDUAPDBe1PKDAPDBe7M2FAPDBe5K4JAPDBe1OI9APDBe3EOCAPDBe3RJCAPDBe7NVQAPDBe1OIRAPDBe1OIQAPDBe1W98APDBe4BGHAPDBe2VTPAPDBe1OIYAPDBe2VTQAPDBe1QMZAPDBe2VTRAPDBe2VU3APDBe2VTSAPDBe2VTTAPDBe1OIUAPDBe1OITAPDBeGO:0000287magnesium ion bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0019904protein domain specific bindingGoFunctionGO:0030332cyclin bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0006281DNA repairGoProcessGO:0006468protein phosphorylationGoProcessGO:0006813potassium ion transportGoProcessGO:0007099centriole replicationGoProcessGO:0007165signal transductionGoProcessGO:0007265Ras protein signal transductionGoProcessGO:0007346regulation of mitotic cell cycleGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010389regulation of G2/M transition of mitotic cell cycleGoProcessGO:0018105peptidyl-serine phosphorylationGoProcessGO:0031453positive regulation of heterochromatin formationGoProcessGO:0031571mitotic G1 DNA damage checkpoint signalingGoProcessGO:0032298positive regulation of DNA-templated DNA replication initiationGoProcessGO:0043247telomere maintenance in response to DNA damageGoProcessGO:0045740positive regulation of DNA replicationGoProcessGO:0045893positive regulation of DNA-templated transcriptionGoProcessGO:0051298centrosome duplicationGoProcessGO:0051301cell divisionGoProcessGO:0051321meiotic cell cycleGoProcessGO:0071732cellular response to nitric oxideGoProcessGO:0090398cellular senescenceGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0000781chromosome, telomeric regionGoComponentGO:0000793condensed chromosomeGoComponentGO:0000805X chromosomeGoComponentGO:0000806Y chromosomeGoComponentGO:0001673male germ cell nucleusGoComponentGO:0005635nuclear envelopeGoComponentGO:0005654nucleoplasmGoComponentGO:0005768endosomeGoComponentGO:0005813centrosomeGoComponentGO:0005829cytosolGoComponentGO:0005856cytoskeletonGoComponentGO:0015030Cajal bodyGoComponentGO:0005667transcription regulator complexGoComponentA8K7C6Cyclin-dependent kinase 2UniProtO75100Cyclin-dependent kinase 2UniProtP24941Cyclin-dependent kinase 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:1771CDK2HGNCR-HSA-1538133G0 and Early G1ReactomeR-HSA-171319Telomere Extension By TelomeraseReactomeR-HSA-176187Activation of ATR in response to replication stressReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-5693607Processing of DNA double-strand break endsReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-6804756Regulation of TP53 Activity through PhosphorylationReactomeR-HSA-6804757Regulation of TP53 DegradationReactomeR-HSA-68911G2 PhaseReactomeR-HSA-68949Orc1 removal from chromatinReactomeR-HSA-68962Activation of the pre-replicative complexReactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-HSA-69200Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesReactomeR-HSA-69202Cyclin E associated events during G1/S transitionReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69563p53-Dependent G1 DNA Damage ResponseReactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entryReactomeR-HSA-8849470PTK6 Regulates Cell CycleReactomeR-HSA-912446Meiotic recombinationReactomeR-HSA-9616222Transcriptional regulation of granulopoiesisReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9825892Regulation of MITF-M-dependent genes involved in cell cycle and proliferationReactomeR-HSA-983231Factors involved in megakaryocyte development and platelet productionReactomeP24941PharosP24941ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF521CYCLIN-DEPENDENT KINASE 2PANTHERPF00069PkinasePfamPA101cyclin dependent kinase 2PharmGKBP30274Cyclin-A217935PROTEINPROTEIN SUBUNITCCNA2GENE_SYMBOLCyclin-A2UNIPROTCyclin-AUNIPROT4BCNAPDBe4BCOAPDBe2G9XAPDBe3BHTAPDBe3BHUAPDBe4BCQAPDBe3BHVAPDBe3DDPAPDBe3DDQAPDBe6GUCAPDBe6GUBAPDBe3MY5APDBe3DOGAPDBe3TNWAPDBe6GUEAPDBe6GUFAPDBe1VINAPDBeGO:0005515protein bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0044772mitotic cell cycle phase transitionGoProcessGO:0044843cell cycle G1/S phase transitionGoProcessGO:0051301cell divisionGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentPF02984Cyclin_CPfamQ17QS7Cyclin-A2UniProtP30274Cyclin-A2UniProt1VINPDB2G9XPDB3BHTPDB3BHUPDB3BHVPDB3DDPPDB3DDQPDB3DOGPDB3MY5PDB3TNWPDB4BCNPDB4BCOPDB4BCQPDB6GUBPDB6GUCPDB6GUEPDB6GUFPDB8ROZPDBP30274AlphaFoldDBP30274IntActIPR039361CyclinInterProIPR032447Cyclin-A_NInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR046965Cyclin_A/B-likeInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF00134Cyclin_NPfamPF16500Cyclin_N2PfamPA94cyclin A2PharmGKBPROTEIN COMPLEX9606Homo sapiensCDK18/Cyclin YCHEMBL4106161Q07002Cyclin-dependent kinase 183613PROTEINPROTEIN SUBUNITPCTAIRE3GENE_SYMBOL_OTHERPCTK3GENE_SYMBOL_OTHERCDK18GENE_SYMBOLCyclin-dependent kinase 18UNIPROTCell division protein kinase 18UNIPROTPCTAIRE-motif protein kinase 3UNIPROTSerine/threonine-protein kinase PCTAIRE-3UNIPROT2.7.11.22EC_NUMBERGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0031643positive regulation of myelinationGoProcessGO:1901987regulation of cell cycle phase transitionGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005739mitochondrionGoComponentQ5VXQ2Cyclin-dependent kinase 18UniProtQ6V3A2Cyclin-dependent kinase 18UniProtQ6V3A3Cyclin-dependent kinase 18UniProtQ96F90Cyclin-dependent kinase 18UniProtQ07002Cyclin-dependent kinase 18UniProtQ07002AlphaFoldDBQ07002IntActHGNC:8751CDK18HGNCQ07002PharosQ07002ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF52CYCLIN-DEPENDENT KINASE 18PANTHERPF00069PkinasePfamPA33097cyclin dependent kinase 18PharmGKBQ8ND76Cyclin-Y10084PROTEINPROTEIN SUBUNITC10orf9GENE_SYMBOL_OTHERCBCP1GENE_SYMBOL_OTHERCFP1GENE_SYMBOL_OTHERCCNYGENE_SYMBOLCyclin-YUNIPROTCyclin box protein 1UNIPROTCyclin fold protein 1UNIPROTcyclin-XUNIPROTCyc-YUNIPROTGO:0005515protein bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0007283spermatogenesisGoProcessGO:0010508positive regulation of autophagyGoProcessGO:0016055Wnt signaling pathwayGoProcessGO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activityGoProcessGO:0051301cell divisionGoProcessGO:0060828regulation of canonical Wnt signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005730nucleolusGoComponentB7ZKX9Cyclin-YUniProtD3DRY9Cyclin-YUniProtQ2M3V4Cyclin-YUniProtQ2TU96Cyclin-YUniProtQ6NT86Cyclin-YUniProtQ7Z4U7Cyclin-YUniProtQ8TEX2Cyclin-YUniProtQ8TEX3Cyclin-YUniProtQ96M99Cyclin-YUniProtQ96P45Cyclin-YUniProtQ8ND76Cyclin-YUniProtQ8ND76AlphaFoldDBQ8ND76IntActHGNC:23354CCNYHGNCQ8ND76PharosQ8ND76ExpressionAtlasIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR006671Cyclin_NInterProIPR012399Cyclin_YInterProPTHR14248CYCLIN Y, ISOFORM APANTHERPF00134Cyclin_NPfamPA162381980cyclin YPharmGKBPROTEIN COMPLEX9606CPX-241Cyclin K-CDK12 complexComplexPortalHomo sapiensCDK12/Cyclin KCHEMBL4106169O75909Cyclin-K7311PROTEINPROTEIN SUBUNITCPR4GENE_SYMBOL_OTHERCCNKGENE_SYMBOLCyclin-KUNIPROT8BUEAPDBe8BUFAPDBe8BUCAPDBe8BUDAPDBe8BUIAPDBe8BUJAPDBe8BUGAPDBe8BUHAPDBe9FMRAPDBe8P81APDBe8BUAAPDBe8BUBAPDBe8BU5APDBe8BU6APDBe5ACBAPDBe8BU3APDBe8BU4APDBe6TD3APDBe8BU9APDBe8BU7APDBe4UN0APDBe8BU1APDBe8BU2APDBe4CXAAPDBe2I53APDBe5EFQAPDBe4NSTAPDBe6CKXAPDBe6B3EAPDBe7NXKAPDBe8BUSAPDBe7NXJAPDBe8BUTAPDBe8BUMAPDBe8BUNAPDBe8BUKAPDBe8BULAPDBe8BUQAPDBe8BURAPDBe8BUOAPDBe8BUPAPDBeGO:0006974DNA damage responseGoProcessGO:0005515protein bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0000079regulation of cyclin-dependent protein serine/threonine kinase activityGoProcessGO:0009966regulation of signal transductionGoProcessGO:0032786positive regulation of DNA-templated transcription, elongationGoProcessGO:0032968positive regulation of transcription elongation by RNA polymerase IIGoProcessGO:0044828negative regulation by host of viral genome replicationGoProcessGO:0045944positive regulation of transcription by RNA polymerase IIGoProcessGO:0051301cell divisionGoProcessGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0008024cyclin/CDK positive transcription elongation factor complexGoComponentQ59FT6Cyclin-KUniProtQ86U16Cyclin-KUniProtQ96B63Cyclin-KUniProtQ9NNY9Cyclin-KUniProtO75909Cyclin-KUniProt2I53PDB4CXAPDB4NSTPDB4UN0PDB5ACBPDB5EFQPDB6B3EPDB6CKXPDB6TD3PDB7NXJPDB7NXKPDB8BU1PDB8BU2PDB8BU3PDB8BU4PDB8BU5PDB8BU6PDB8BU7PDB8BU9PDB8BUAPDB8BUBPDB8BUCPDB8BUDPDB8BUEPDB8BUFPDB8BUGPDB8BUHPDB8BUIPDB8BUJPDB8BUKPDB8BULPDB8BUMPDB8BUNPDB8BUOPDB8BUPPDB8BUQPDB8BURPDB8BUSPDB8BUTPDB8P81PDB9FMRPDBO75909AlphaFoldDBO75909IntActHGNC:1596CCNKHGNCR-HSA-112382Formation of RNA Pol II elongation complexReactomeR-HSA-167152Formation of HIV elongation complex in the absence of HIV TatReactomeR-HSA-167287HIV elongation arrest and recoveryReactomeR-HSA-167290Pausing and recovery of HIV elongationReactomeR-HSA-2173796SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionReactomeR-HSA-674695RNA Polymerase II Pre-transcription EventsReactomeR-HSA-6796648TP53 Regulates Transcription of DNA Repair GenesReactomeR-HSA-6807505RNA polymerase II transcribes snRNA genesReactomeR-HSA-75955RNA Polymerase II Transcription ElongationReactomeO75909PharosO75909ExpressionAtlasIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR043198Cyclin/Ssn8InterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProPTHR10026CYCLINPANTHERPF00134Cyclin_NPfamPF21797CycT2-like_CPfamPA26161cyclin KPharmGKBQ9NYV4Cyclin-dependent kinase 129926PROTEINPROTEIN SUBUNITCRK7GENE_SYMBOL_OTHERCRKRSGENE_SYMBOL_OTHERKIAA0904GENE_SYMBOL_OTHER2.7.11.22EC_NUMBER2.7.11.23EC_NUMBERCDK12GENE_SYMBOLCyclin-dependent kinase 12UNIPROTCdc2-related kinase, arginine/serine-richUNIPROTCell division cycle 2-related protein kinase 7UNIPROTCell division protein kinase 12UNIPROTCrkRSUNIPROTCDC2-related protein kinase 7UNIPROThCDK12UNIPROT8BUEAPDBe8BUFAPDBe8BUCAPDBe8BUDAPDBe8BUIAPDBe8BUJAPDBe8BUGAPDBe8BUHAPDBe9FMRAPDBe8P81APDBe8BUAAPDBe8BUBAPDBe8BU5APDBe8BU6APDBe5ACBAPDBe8BU3APDBe8BU4APDBe6TD3APDBe8BU9APDBe8BU7APDBe4UN0APDBe8BU1APDBe8BU2APDBe4CXAAPDBe4NSTAPDBe6CKXAPDBe6B3EAPDBe7NXKAPDBe8BUSAPDBe8BUTAPDBe8BUMAPDBe8BUNAPDBe8BUKAPDBe8BULAPDBe8BUQAPDBe8BURAPDBe8BUOAPDBe8BUPAPDBeGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0030332cyclin bindingGoFunctionGO:0006397mRNA processingGoProcessGO:0008380RNA splicingGoProcessGO:0032968positive regulation of transcription elongation by RNA polymerase IIGoProcessGO:0043405regulation of MAP kinase activityGoProcessGO:0045944positive regulation of transcription by RNA polymerase IIGoProcessGO:0046777protein autophosphorylationGoProcessGO:0051726regulation of cell cycleGoProcessGO:2000737negative regulation of stem cell differentiationGoProcessGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0016607nuclear speckGoComponentGO:0008024cyclin/CDK positive transcription elongation factor complexGoComponentA7E2B2Cyclin-dependent kinase 12UniProtB4DYX4Cyclin-dependent kinase 12UniProtB9EIQ6Cyclin-dependent kinase 12UniProtO94978Cyclin-dependent kinase 12UniProtQ9NYV4Cyclin-dependent kinase 12UniProt4CXAPDB4NSTPDB4UN0PDB5ACBPDB6B3EPDB6CKXPDB6TD3PDB7NXKPDB8BU1PDB8BU2PDB8BU3PDB8BU4PDB8BU5PDB8BU6PDB8BU7PDB8BU9PDB8BUAPDB8BUBPDB8BUCPDB8BUDPDB8BUEPDB8BUFPDB8BUGPDB8BUHPDB8BUIPDB8BUJPDB8BUKPDB8BULPDB8BUMPDB8BUNPDB8BUOPDB8BUPPDB8BUQPDB8BURPDB8BUSPDB8BUTPDB8P81PDB9FMRPDBQ9NYV4AlphaFoldDBQ9NYV4IntActHGNC:24224CDK12HGNCR-HSA-6796648TP53 Regulates Transcription of DNA Repair GenesReactomeQ9NYV4PharosQ9NYV4ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF126CYCLIN-DEPENDENT KINASE 12PANTHERPF00069PkinasePfamPA165431656cyclin dependent kinase 12PharmGKBPROTEIN COMPLEX9606Mus musculusCDK2/CDK4CHEMBL4106185P30285Cyclin-dependent kinase 4476PROTEINGROUP MEMBERCrk3GENE_SYMBOL_OTHERCdk4GENE_SYMBOLCyclin-dependent kinase 4UNIPROTCRK3UNIPROTCell division protein kinase 4UNIPROTPSK-J3UNIPROT2.7.11.22EC_NUMBERGO:0007165signal transductionGoProcessGO:0051726regulation of cell cycleGoProcessGO:0061469regulation of type B pancreatic cell proliferationGoProcessGO:0071222cellular response to lipopolysaccharideGoProcessGO:1904628cellular response to phorbol 13-acetate 12-myristateGoProcessGO:1904637cellular response to ionomycinGoProcessGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0030332cyclin bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010971positive regulation of G2/M transition of mitotic cell cycleGoProcessGO:0048146positive regulation of fibroblast proliferationGoProcessGO:0051301cell divisionGoProcessGO:0000785chromatinGoComponentGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005730nucleolusGoComponentGO:0005737cytoplasmGoComponentGO:0005829cytosolGoComponentGO:0005923bicellular tight junctionGoComponentGO:0016020membraneGoComponentGO:0031965nuclear membraneGoComponentGO:0005667transcription regulator complexGoComponentP30285Cyclin-dependent kinase 4UniProtP30285AlphaFoldDBP30285IntActR-MMU-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-MMU-2559580Oxidative Stress Induced SenescenceReactomeR-MMU-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-MMU-2559585Oncogene Induced SenescenceReactomeR-MMU-3214858RMTs methylate histone argininesReactomeR-MMU-69231Cyclin D associated events in G1ReactomeR-MMU-75815Ubiquitin-dependent degradation of Cyclin DReactomeR-MMU-8849470PTK6 Regulates Cell CycleReactomeR-MMU-8878166Transcriptional regulation by RUNX2ReactomeR-MMU-9616222Transcriptional regulation of granulopoiesisReactomeR-MMU-9754119Drug-mediated inhibition of CDK4/CDK6 activityReactomeP30285ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF129CYCLIN-DEPENDENT KINASE 4PANTHERPF00069PkinasePfamP97377Cyclin-dependent kinase 217858PROTEINGROUP MEMBERCdkn2GENE_SYMBOL_OTHERCdk2GENE_SYMBOLCyclin-dependent kinase 2UNIPROTCell division protein kinase 2UNIPROT2.7.11.22EC_NUMBERGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0006813potassium ion transportGoProcessGO:0032298positive regulation of DNA-templated DNA replication initiationGoProcessGO:0045893positive regulation of DNA-templated transcriptionGoProcessGO:0000287magnesium ion bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0019904protein domain specific bindingGoFunctionGO:0030332cyclin bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0006281DNA repairGoProcessGO:0007099centriole replicationGoProcessGO:0007265Ras protein signal transductionGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0018105peptidyl-serine phosphorylationGoProcessGO:0031453positive regulation of heterochromatin formationGoProcessGO:0043247telomere maintenance in response to DNA damageGoProcessGO:0051301cell divisionGoProcessGO:0051321meiotic cell cycleGoProcessGO:0051726regulation of cell cycleGoProcessGO:0000781chromosome, telomeric regionGoComponentGO:0000793condensed chromosomeGoComponentGO:0000805X chromosomeGoComponentGO:0000806Y chromosomeGoComponentGO:0001673male germ cell nucleusGoComponentGO:0005634nucleusGoComponentGO:0005635nuclear envelopeGoComponentGO:0005654nucleoplasmGoComponentGO:0005737cytoplasmGoComponentGO:0005768endosomeGoComponentGO:0005813centrosomeGoComponentGO:0005856cytoskeletonGoComponentGO:0015030Cajal bodyGoComponentGO:0005667transcription regulator complexGoComponentO55105Cyclin-dependent kinase 2UniProtP97377Cyclin-dependent kinase 2UniProtP97377AlphaFoldDBP97377IntActR-MMU-1538133G0 and Early G1ReactomeR-MMU-171319Telomere Extension By TelomeraseReactomeR-MMU-176187Activation of ATR in response to replication stressReactomeR-MMU-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-MMU-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-MMU-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-MMU-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-MMU-5693607Processing of DNA double-strand break endsReactomeR-MMU-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-MMU-6804756Regulation of TP53 Activity through PhosphorylationReactomeR-MMU-6804757Regulation of TP53 DegradationReactomeR-MMU-68911G2 PhaseReactomeR-MMU-68949Orc1 removal from chromatinReactomeR-MMU-68962Activation of the pre-replicative complexReactomeR-MMU-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-MMU-69200Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesReactomeR-MMU-69202Cyclin E associated events during G1/S transitionReactomeR-MMU-69231Cyclin D associated events in G1ReactomeR-MMU-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-MMU-69563p53-Dependent G1 DNA Damage ResponseReactomeR-MMU-69656Cyclin A:Cdk2-associated events at S phase entryReactomeR-MMU-8849470PTK6 Regulates Cell CycleReactomeR-MMU-9616222Transcriptional regulation of granulopoiesisReactomeP97377ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF521CYCLIN-DEPENDENT KINASE 2PANTHERPF00069PkinasePfamPROTEIN FAMILY10090Mus musculusCDK2/CDK9CHEMBL4106186Q99J95Cyclin-dependent kinase 917727PROTEINGROUP MEMBERCdk9GENE_SYMBOLCyclin-dependent kinase 9UNIPROTCell division protein kinase 9UNIPROT2.7.11.22EC_NUMBER2.7.11.23EC_NUMBERGO:0000976transcription cis-regulatory region bindingGoFunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingGoFunctionGO:0001223transcription coactivator bindingGoFunctionGO:0003677DNA bindingGoFunctionGO:0003682chromatin bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0017069snRNA bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:00973227SK snRNA bindingGoFunctionGO:0006281DNA repairGoProcessGO:0006282regulation of DNA repairGoProcessGO:0031297replication fork processingGoProcessGO:0032968positive regulation of transcription elongation by RNA polymerase IIGoProcessGO:0043923positive regulation by host of viral transcriptionGoProcessGO:0045944positive regulation of transcription by RNA polymerase IIGoProcessGO:0051147regulation of muscle cell differentiationGoProcessGO:0051726regulation of cell cycleGoProcessGO:0120186negative regulation of protein localization to chromatinGoProcessGO:0120187positive regulation of protein localization to chromatinGoProcessGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005737cytoplasmGoComponentGO:0016605PML bodyGoComponentGO:0036464cytoplasmic ribonucleoprotein granuleGoComponentGO:0008023transcription elongation factor complexGoComponentGO:0008024cyclin/CDK positive transcription elongation factor complexGoComponentGO:0070691P-TEFb complexGoComponentB0R020Cyclin-dependent kinase 9UniProtQ3U002Cyclin-dependent kinase 9UniProtQ3UMY2Cyclin-dependent kinase 9UniProtQ3UPT3Cyclin-dependent kinase 9UniProtQ3UQI6Cyclin-dependent kinase 9UniProtQ8BTN0Cyclin-dependent kinase 9UniProtQ99J95Cyclin-dependent kinase 9UniProtQ99J95AlphaFoldDBQ99J95IntActR-MMU-112382Formation of RNA Pol II elongation complexReactomeR-MMU-2173796SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionReactomeR-MMU-674695RNA Polymerase II Pre-transcription EventsReactomeR-MMU-6796648TP53 Regulates Transcription of DNA Repair GenesReactomeR-MMU-6807505RNA polymerase II transcribes snRNA genesReactomeR-MMU-75955RNA Polymerase II Transcription ElongationReactomeR-MMU-9018519Estrogen-dependent gene expressionReactomeQ99J95ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF233CYCLIN-DEPENDENT KINASE 9PANTHERPF00069PkinasePfamP97377Cyclin-dependent kinase 217858PROTEINGROUP MEMBERCdkn2GENE_SYMBOL_OTHERCdk2GENE_SYMBOLCyclin-dependent kinase 2UNIPROTCell division protein kinase 2UNIPROT2.7.11.22EC_NUMBERGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0006813potassium ion transportGoProcessGO:0032298positive regulation of DNA-templated DNA replication initiationGoProcessGO:0045893positive regulation of DNA-templated transcriptionGoProcessGO:0000287magnesium ion bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0019904protein domain specific bindingGoFunctionGO:0030332cyclin bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0006281DNA repairGoProcessGO:0007099centriole replicationGoProcessGO:0007265Ras protein signal transductionGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0018105peptidyl-serine phosphorylationGoProcessGO:0031453positive regulation of heterochromatin formationGoProcessGO:0043247telomere maintenance in response to DNA damageGoProcessGO:0051301cell divisionGoProcessGO:0051321meiotic cell cycleGoProcessGO:0051726regulation of cell cycleGoProcessGO:0000781chromosome, telomeric regionGoComponentGO:0000793condensed chromosomeGoComponentGO:0000805X chromosomeGoComponentGO:0000806Y chromosomeGoComponentGO:0001673male germ cell nucleusGoComponentGO:0005634nucleusGoComponentGO:0005635nuclear envelopeGoComponentGO:0005654nucleoplasmGoComponentGO:0005737cytoplasmGoComponentGO:0005768endosomeGoComponentGO:0005813centrosomeGoComponentGO:0005856cytoskeletonGoComponentGO:0015030Cajal bodyGoComponentGO:0005667transcription regulator complexGoComponentO55105Cyclin-dependent kinase 2UniProtP97377Cyclin-dependent kinase 2UniProtP97377AlphaFoldDBP97377IntActR-MMU-1538133G0 and Early G1ReactomeR-MMU-171319Telomere Extension By TelomeraseReactomeR-MMU-176187Activation of ATR in response to replication stressReactomeR-MMU-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-MMU-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-MMU-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-MMU-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-MMU-5693607Processing of DNA double-strand break endsReactomeR-MMU-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-MMU-6804756Regulation of TP53 Activity through PhosphorylationReactomeR-MMU-6804757Regulation of TP53 DegradationReactomeR-MMU-68911G2 PhaseReactomeR-MMU-68949Orc1 removal from chromatinReactomeR-MMU-68962Activation of the pre-replicative complexReactomeR-MMU-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-MMU-69200Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesReactomeR-MMU-69202Cyclin E associated events during G1/S transitionReactomeR-MMU-69231Cyclin D associated events in G1ReactomeR-MMU-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-MMU-69563p53-Dependent G1 DNA Damage ResponseReactomeR-MMU-69656Cyclin A:Cdk2-associated events at S phase entryReactomeR-MMU-8849470PTK6 Regulates Cell CycleReactomeR-MMU-9616222Transcriptional regulation of granulopoiesisReactomeP97377ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF521CYCLIN-DEPENDENT KINASE 2PANTHERPF00069PkinasePfamPROTEIN FAMILY10090CPX-2016Cyclin E2-CDK2 complexComplexPortalHomo sapiensCDK2/Cyclin-E2CHEMBL4523633P24941Cyclin-dependent kinase 236PROTEINPROTEIN SUBUNITCDKN2GENE_SYMBOL_OTHERCDK2GENE_SYMBOLCyclin-dependent kinase 2UNIPROTCell division protein kinase 2UNIPROTp33 protein kinaseUNIPROT2.7.11.22EC_NUMBER2DS1APDBe3RKBAPDBe3QHRAPDBe3DOGAPDBe3RK5APDBe7SA0APDBe3TNWAPDBe3RK7APDBe2FVDAPDBe3QHWAPDBe3RK9APDBe2VV9APDBe1AQ1APDBe4EONAPDBe4EOOAPDBe4EOPAPDBe2UUEAPDBe4EOQAPDBe4EORAPDBe7ZPCAPDBe4EOSAPDBe1VYZAPDBe1OL2APDBe4EOIAPDBe1OL1APDBe1VYWAPDBe4EOJAPDBe4EOKAPDBe4EOLAPDBe4EOMAPDBe2WXVAPDBe1OKWAPDBe1OKVAPDBe1B39APDBe3RMFAPDBe1B38APDBe2G9XAPDBe8OY2APDBe5FP6APDBe5FP5APDBe3RM6APDBe3RM7APDBe7UG1APDBe7RA5APDBe1KE9APDBe1KE8APDBe2BPMAPDBe1KE7APDBe1KE6APDBe1KE5APDBe4RJ3APDBe3RNIAPDBe2DUVAPDBe3F5XAPDBe3QL8APDBe3PJ8APDBe6SG4APDBe1E9HAPDBe3S0OAPDBe4ERWAPDBe1BUHAPDBe3S00APDBe2EXMAPDBe3RPOAPDBe3S1HAPDBe3ROYAPDBe2C4GAPDBe2A0CAPDBe3SQQAPDBe2R3JAPDBe2UZOAPDBe2R3IAPDBe4D1ZAPDBe2C5YAPDBe2R3HAPDBe2C5XAPDBe2C69APDBe2R3GAPDBe2C68APDBe2R3FAPDBe2C5VAPDBe3S2PAPDBe1HCKAPDBe2R3RAPDBe2R3QAPDBe2R3PAPDBe2R3OAPDBe7ACKAPDBe2R3NAPDBe2R3MAPDBe2UZLAPDBe2R3LAPDBe2R3KAPDBe2UZNAPDBe4D1XAPDBe3RPYAPDBe3FZ1APDBe3LE6APDBe2UZBAPDBe2UZDAPDBe2UZEAPDBe2BTSAPDBe5UQ2APDBe1P2AAPDBe2BTRAPDBe3RPRAPDBe5UQ1APDBe5UQ3APDBe2C5OAPDBe2C5NAPDBe3RPVAPDBe6RIJAPDBe2B55APDBe3R1QAPDBe2C6LAPDBe2C6KAPDBe2C6IAPDBe1R78APDBe4FX3APDBe1HCLAPDBe2B54APDBe2C6TAPDBe2B53APDBe2B52APDBe2C6OAPDBe2C6MAPDBe3QQKAPDBe3QQLAPDBe6GUCAPDBe6GUBAPDBe2R64APDBe3QQFAPDBe3QQGAPDBe3QQHAPDBe3QQJAPDBe3LFNAPDBe3R1SAPDBe3LFQAPDBe3R28APDBe3LFSAPDBe3R1YAPDBe3SW4APDBe6GVAAPDBe1PW2APDBe2A4LAPDBe1WCCAPDBe5D1JAPDBe3EZRAPDBe5NEVAPDBe3EZVAPDBe1P5EAPDBe6GUEAPDBe6GUFAPDBe6GUHAPDBe6GUKAPDBe3QRTAPDBe3SW7APDBe3QRUAPDBe4NJ3APDBe2JGZAPDBe4KD1APDBe1PXPAPDBe1PXOAPDBe3QU0APDBe1PXNAPDBe1PXMAPDBe3QTQAPDBe1PXLAPDBe3QTRAPDBe7QHLAPDBe1PXKAPDBe3QTSAPDBe1PXJAPDBe1PXIAPDBe3QTUAPDBe8FP5APDBe8FOWAPDBe5ANKAPDBe5ANJAPDBe4EZ3APDBe5ANOAPDBe8FP0APDBe4EZ7APDBe5ANEAPDBe5ANDAPDBe5ANGAPDBe5ANIAPDBe3R71APDBe3R73APDBe3QTWAPDBe3QTXAPDBe1PYEAPDBe3QTZAPDBe3R83APDBe3R7UAPDBe3R7VAPDBe3R7IAPDBe3R7EAPDBe1YKRAPDBe3R6XAPDBe8VQ3APDBe8VQ4APDBe1GIJAPDBe3QX2APDBe1GIIAPDBe1GIHAPDBe3QX4APDBe3R8UAPDBe3R8VAPDBe3QWJAPDBe3QWKAPDBe3R8LAPDBe3R8MAPDBe2WEVAPDBe3IGGAPDBe3R8PAPDBe7E34APDBe3WBLAPDBe5A14APDBe5MHQAPDBe3R7YAPDBe3IG7APDBe2WFYAPDBe5OO0APDBe5OO1APDBe8ERDAPDBe5OO3APDBe3R9NAPDBe3QXOAPDBe3R9OAPDBe3QXPAPDBe8H6PAPDBe3R9DAPDBe8H6TAPDBe3R9HAPDBe3R8ZAPDBe3RZBAPDBe2WHBAPDBe1FINAPDBe8ERNAPDBe9FR2APDBe3NS9APDBe4BZDAPDBe4GCJAPDBe3PXYAPDBe3PXZAPDBe5CYIAPDBe3PY0APDBe3PY1APDBe3PXQAPDBe3PXRAPDBe3QZFAPDBe3PXFAPDBe3QZGAPDBe3QZHAPDBe3QZIAPDBe5IF1APDBe1JSVAPDBe1JSUAPDBe1JSTAPDBe2WIPAPDBe2WIHAPDBe1H00APDBe2CCIAPDBe2CCHAPDBe6ATHAPDBe1H08APDBe1H07APDBe7UXKAPDBe8UV0APDBe1H01APDBe5IEYAPDBe7UXIAPDBe4II5APDBe5IEVAPDBe5IEXAPDBe2XNBAPDBe6Q48APDBe7S4TAPDBe5OSJAPDBe1H0WAPDBe1H0VAPDBe2XMYAPDBe5LMKAPDBe5OSMAPDBe6Q3CAPDBe6Q3BAPDBe1DI8APDBe6Q3FAPDBe1H1QAPDBe1H1PAPDBe2WMAAPDBe2WMBAPDBe6JGMAPDBe1JVPAPDBe3DDPAPDBe3DDQAPDBe6OQIAPDBe6Q4JAPDBe6Q4IAPDBe1H28APDBe1H27APDBe6Q4KAPDBe1H26APDBe1H25APDBe1H1SAPDBe1H24APDBe1H1RAPDBe6Q4BAPDBe6Q4AAPDBe6Q4DAPDBe6Q4CAPDBe6Q4FAPDBe6Q4EAPDBe6Q4HAPDBe6Q4GAPDBe6Q49APDBe6P3WAPDBe1FQ1APDBe7S84APDBe7S85APDBe3MY5APDBe1DM2APDBe3RAKAPDBe3RALAPDBe8CURAPDBe1W0XAPDBe7MKXAPDBe7S7AAPDBe3RAHAPDBe3RAIAPDBe1CKPAPDBe3EJ1APDBe2I40APDBe8RU8APDBe2WPAAPDBe7RWFAPDBe7RWEAPDBe3EIDAPDBe7S9XAPDBe1PF8APDBe7KJSAPDBe1V1KAPDBe7RXOAPDBe2W05APDBe2W06APDBe8B54APDBe2X1NAPDBe7B7SAPDBe2IW6APDBe2CJMAPDBe2W1HAPDBe5L2WAPDBe2BHHAPDBe2IW9APDBe2IW8APDBe3TI1APDBe2W17APDBe2BHEAPDBe2V0DAPDBe4BCMAPDBe4FKQAPDBe5JQ5APDBe4BCNAPDBe4FKRAPDBe1URCAPDBe4BCOAPDBe4FKSAPDBe1G5SAPDBe4BCPAPDBe4FKTAPDBe4BCQAPDBe4FKUAPDBe4FKVAPDBe5JQ8APDBe4FKWAPDBe3ULIAPDBe4FKIAPDBe3TIYAPDBe4FKJAPDBe3TIZAPDBe4FKLAPDBe1E1XAPDBe1E1VAPDBe4BCKAPDBe4FKOAPDBe4FKPAPDBe4FKGAPDBe1Y91APDBe1Y8YAPDBe4EK3APDBe4EK4APDBe4EK5APDBe4EK6APDBe4CFUAPDBe4EK8APDBe4CFVAPDBe2CLXAPDBe4CFMAPDBe4CFNAPDBe6YL1APDBe6YL6APDBe2J9MAPDBe1URWAPDBe1FVVAPDBe3BHTAPDBe1FVTAPDBe3BHUAPDBe3BHVAPDBe1F5QAPDBe3UNJAPDBe1GY3APDBe3UNKAPDBe2BKZAPDBe4ACMAPDBe4LYNAPDBe4CFWAPDBe4CFXAPDBe1OGUAPDBe6YLKAPDBe2V22APDBe2VTHAPDBe2VTIAPDBe2VTJAPDBe1GZ8APDBe2VTLAPDBe4I3ZAPDBe2VTMAPDBe1W8CAPDBe2VTNAPDBe2VTOAPDBe6INLAPDBe2VTAAPDBe7VDUAPDBe1PKDAPDBe7M2FAPDBe5K4JAPDBe1OI9APDBe3EOCAPDBe3RJCAPDBe7NVQAPDBe1OIRAPDBe1OIQAPDBe1W98APDBe4BGHAPDBe2VTPAPDBe1OIYAPDBe2VTQAPDBe1QMZAPDBe2VTRAPDBe2VU3APDBe2VTSAPDBe2VTTAPDBe1OIUAPDBe1OITAPDBeGO:0000287magnesium ion bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0019904protein domain specific bindingGoFunctionGO:0030332cyclin bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0006281DNA repairGoProcessGO:0006468protein phosphorylationGoProcessGO:0006813potassium ion transportGoProcessGO:0007099centriole replicationGoProcessGO:0007165signal transductionGoProcessGO:0007265Ras protein signal transductionGoProcessGO:0007346regulation of mitotic cell cycleGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010389regulation of G2/M transition of mitotic cell cycleGoProcessGO:0018105peptidyl-serine phosphorylationGoProcessGO:0031453positive regulation of heterochromatin formationGoProcessGO:0031571mitotic G1 DNA damage checkpoint signalingGoProcessGO:0032298positive regulation of DNA-templated DNA replication initiationGoProcessGO:0043247telomere maintenance in response to DNA damageGoProcessGO:0045740positive regulation of DNA replicationGoProcessGO:0045893positive regulation of DNA-templated transcriptionGoProcessGO:0051298centrosome duplicationGoProcessGO:0051301cell divisionGoProcessGO:0051321meiotic cell cycleGoProcessGO:0071732cellular response to nitric oxideGoProcessGO:0090398cellular senescenceGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0000781chromosome, telomeric regionGoComponentGO:0000793condensed chromosomeGoComponentGO:0000805X chromosomeGoComponentGO:0000806Y chromosomeGoComponentGO:0001673male germ cell nucleusGoComponentGO:0005635nuclear envelopeGoComponentGO:0005654nucleoplasmGoComponentGO:0005768endosomeGoComponentGO:0005813centrosomeGoComponentGO:0005829cytosolGoComponentGO:0005856cytoskeletonGoComponentGO:0015030Cajal bodyGoComponentGO:0005667transcription regulator complexGoComponentA8K7C6Cyclin-dependent kinase 2UniProtO75100Cyclin-dependent kinase 2UniProtP24941Cyclin-dependent kinase 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:1771CDK2HGNCR-HSA-1538133G0 and Early G1ReactomeR-HSA-171319Telomere Extension By TelomeraseReactomeR-HSA-176187Activation of ATR in response to replication stressReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-5693607Processing of DNA double-strand break endsReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-6804756Regulation of TP53 Activity through PhosphorylationReactomeR-HSA-6804757Regulation of TP53 DegradationReactomeR-HSA-68911G2 PhaseReactomeR-HSA-68949Orc1 removal from chromatinReactomeR-HSA-68962Activation of the pre-replicative complexReactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-HSA-69200Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesReactomeR-HSA-69202Cyclin E associated events during G1/S transitionReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69563p53-Dependent G1 DNA Damage ResponseReactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entryReactomeR-HSA-8849470PTK6 Regulates Cell CycleReactomeR-HSA-912446Meiotic recombinationReactomeR-HSA-9616222Transcriptional regulation of granulopoiesisReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9825892Regulation of MITF-M-dependent genes involved in cell cycle and proliferationReactomeR-HSA-983231Factors involved in megakaryocyte development and platelet productionReactomeP24941PharosP24941ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF521CYCLIN-DEPENDENT KINASE 2PANTHERPF00069PkinasePfamPA101cyclin dependent kinase 2PharmGKBO96020G1/S-specific cyclin-E21213PROTEINPROTEIN SUBUNITCCNE2GENE_SYMBOLG1/S-specific cyclin-E2UNIPROT8HN9APDBeGO:0005515protein bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0000079regulation of cyclin-dependent protein serine/threonine kinase activityGoProcessGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000723telomere maintenanceGoProcessGO:0006270DNA replication initiationGoProcessGO:0007129homologous chromosome pairing at meiosisGoProcessGO:0032880regulation of protein localizationGoProcessGO:0051301cell divisionGoProcessGO:0051726regulation of cell cycleGoProcessGO:0070192chromosome organization involved in meiotic cell cycleGoProcessGO:1900087positive regulation of G1/S transition of mitotic cell cycleGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0005654nucleoplasmGoComponentGO:0005829cytosolGoComponentO95439G1/S-specific cyclin-E2UniProtO96020G1/S-specific cyclin-E2UniProt8HN9PDBO96020AlphaFoldDBO96020IntActHGNC:1590CCNE2HGNCR-HSA-1538133G0 and Early G1ReactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-390471Association of TriC/CCT with target proteins during biosynthesisReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-HSA-69200Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesReactomeR-HSA-69202Cyclin E associated events during G1/S transitionReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-69563p53-Dependent G1 DNA Damage ResponseReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeO96020PharosO96020ExpressionAtlasIPR039361CyclinInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamPA26155cyclin E2PharmGKBPROTEIN COMPLEX9606Homo sapiensCDK2/Cyclin-YCHEMBL4523634P24941Cyclin-dependent kinase 236PROTEINPROTEIN SUBUNITCDKN2GENE_SYMBOL_OTHERCDK2GENE_SYMBOLCyclin-dependent kinase 2UNIPROTCell division protein kinase 2UNIPROTp33 protein kinaseUNIPROT2.7.11.22EC_NUMBER2DS1APDBe3RKBAPDBe3QHRAPDBe3DOGAPDBe3RK5APDBe7SA0APDBe3TNWAPDBe3RK7APDBe2FVDAPDBe3QHWAPDBe3RK9APDBe2VV9APDBe1AQ1APDBe4EONAPDBe4EOOAPDBe4EOPAPDBe2UUEAPDBe4EOQAPDBe4EORAPDBe7ZPCAPDBe4EOSAPDBe1VYZAPDBe1OL2APDBe4EOIAPDBe1OL1APDBe1VYWAPDBe4EOJAPDBe4EOKAPDBe4EOLAPDBe4EOMAPDBe2WXVAPDBe1OKWAPDBe1OKVAPDBe1B39APDBe3RMFAPDBe1B38APDBe2G9XAPDBe8OY2APDBe5FP6APDBe5FP5APDBe3RM6APDBe3RM7APDBe7UG1APDBe7RA5APDBe1KE9APDBe1KE8APDBe2BPMAPDBe1KE7APDBe1KE6APDBe1KE5APDBe4RJ3APDBe3RNIAPDBe2DUVAPDBe3F5XAPDBe3QL8APDBe3PJ8APDBe6SG4APDBe1E9HAPDBe3S0OAPDBe4ERWAPDBe1BUHAPDBe3S00APDBe2EXMAPDBe3RPOAPDBe3S1HAPDBe3ROYAPDBe2C4GAPDBe2A0CAPDBe3SQQAPDBe2R3JAPDBe2UZOAPDBe2R3IAPDBe4D1ZAPDBe2C5YAPDBe2R3HAPDBe2C5XAPDBe2C69APDBe2R3GAPDBe2C68APDBe2R3FAPDBe2C5VAPDBe3S2PAPDBe1HCKAPDBe2R3RAPDBe2R3QAPDBe2R3PAPDBe2R3OAPDBe7ACKAPDBe2R3NAPDBe2R3MAPDBe2UZLAPDBe2R3LAPDBe2R3KAPDBe2UZNAPDBe4D1XAPDBe3RPYAPDBe3FZ1APDBe3LE6APDBe2UZBAPDBe2UZDAPDBe2UZEAPDBe2BTSAPDBe5UQ2APDBe1P2AAPDBe2BTRAPDBe3RPRAPDBe5UQ1APDBe5UQ3APDBe2C5OAPDBe2C5NAPDBe3RPVAPDBe6RIJAPDBe2B55APDBe3R1QAPDBe2C6LAPDBe2C6KAPDBe2C6IAPDBe1R78APDBe4FX3APDBe1HCLAPDBe2B54APDBe2C6TAPDBe2B53APDBe2B52APDBe2C6OAPDBe2C6MAPDBe3QQKAPDBe3QQLAPDBe6GUCAPDBe6GUBAPDBe2R64APDBe3QQFAPDBe3QQGAPDBe3QQHAPDBe3QQJAPDBe3LFNAPDBe3R1SAPDBe3LFQAPDBe3R28APDBe3LFSAPDBe3R1YAPDBe3SW4APDBe6GVAAPDBe1PW2APDBe2A4LAPDBe1WCCAPDBe5D1JAPDBe3EZRAPDBe5NEVAPDBe3EZVAPDBe1P5EAPDBe6GUEAPDBe6GUFAPDBe6GUHAPDBe6GUKAPDBe3QRTAPDBe3SW7APDBe3QRUAPDBe4NJ3APDBe2JGZAPDBe4KD1APDBe1PXPAPDBe1PXOAPDBe3QU0APDBe1PXNAPDBe1PXMAPDBe3QTQAPDBe1PXLAPDBe3QTRAPDBe7QHLAPDBe1PXKAPDBe3QTSAPDBe1PXJAPDBe1PXIAPDBe3QTUAPDBe8FP5APDBe8FOWAPDBe5ANKAPDBe5ANJAPDBe4EZ3APDBe5ANOAPDBe8FP0APDBe4EZ7APDBe5ANEAPDBe5ANDAPDBe5ANGAPDBe5ANIAPDBe3R71APDBe3R73APDBe3QTWAPDBe3QTXAPDBe1PYEAPDBe3QTZAPDBe3R83APDBe3R7UAPDBe3R7VAPDBe3R7IAPDBe3R7EAPDBe1YKRAPDBe3R6XAPDBe8VQ3APDBe8VQ4APDBe1GIJAPDBe3QX2APDBe1GIIAPDBe1GIHAPDBe3QX4APDBe3R8UAPDBe3R8VAPDBe3QWJAPDBe3QWKAPDBe3R8LAPDBe3R8MAPDBe2WEVAPDBe3IGGAPDBe3R8PAPDBe7E34APDBe3WBLAPDBe5A14APDBe5MHQAPDBe3R7YAPDBe3IG7APDBe2WFYAPDBe5OO0APDBe5OO1APDBe8ERDAPDBe5OO3APDBe3R9NAPDBe3QXOAPDBe3R9OAPDBe3QXPAPDBe8H6PAPDBe3R9DAPDBe8H6TAPDBe3R9HAPDBe3R8ZAPDBe3RZBAPDBe2WHBAPDBe1FINAPDBe8ERNAPDBe9FR2APDBe3NS9APDBe4BZDAPDBe4GCJAPDBe3PXYAPDBe3PXZAPDBe5CYIAPDBe3PY0APDBe3PY1APDBe3PXQAPDBe3PXRAPDBe3QZFAPDBe3PXFAPDBe3QZGAPDBe3QZHAPDBe3QZIAPDBe5IF1APDBe1JSVAPDBe1JSUAPDBe1JSTAPDBe2WIPAPDBe2WIHAPDBe1H00APDBe2CCIAPDBe2CCHAPDBe6ATHAPDBe1H08APDBe1H07APDBe7UXKAPDBe8UV0APDBe1H01APDBe5IEYAPDBe7UXIAPDBe4II5APDBe5IEVAPDBe5IEXAPDBe2XNBAPDBe6Q48APDBe7S4TAPDBe5OSJAPDBe1H0WAPDBe1H0VAPDBe2XMYAPDBe5LMKAPDBe5OSMAPDBe6Q3CAPDBe6Q3BAPDBe1DI8APDBe6Q3FAPDBe1H1QAPDBe1H1PAPDBe2WMAAPDBe2WMBAPDBe6JGMAPDBe1JVPAPDBe3DDPAPDBe3DDQAPDBe6OQIAPDBe6Q4JAPDBe6Q4IAPDBe1H28APDBe1H27APDBe6Q4KAPDBe1H26APDBe1H25APDBe1H1SAPDBe1H24APDBe1H1RAPDBe6Q4BAPDBe6Q4AAPDBe6Q4DAPDBe6Q4CAPDBe6Q4FAPDBe6Q4EAPDBe6Q4HAPDBe6Q4GAPDBe6Q49APDBe6P3WAPDBe1FQ1APDBe7S84APDBe7S85APDBe3MY5APDBe1DM2APDBe3RAKAPDBe3RALAPDBe8CURAPDBe1W0XAPDBe7MKXAPDBe7S7AAPDBe3RAHAPDBe3RAIAPDBe1CKPAPDBe3EJ1APDBe2I40APDBe8RU8APDBe2WPAAPDBe7RWFAPDBe7RWEAPDBe3EIDAPDBe7S9XAPDBe1PF8APDBe7KJSAPDBe1V1KAPDBe7RXOAPDBe2W05APDBe2W06APDBe8B54APDBe2X1NAPDBe7B7SAPDBe2IW6APDBe2CJMAPDBe2W1HAPDBe5L2WAPDBe2BHHAPDBe2IW9APDBe2IW8APDBe3TI1APDBe2W17APDBe2BHEAPDBe2V0DAPDBe4BCMAPDBe4FKQAPDBe5JQ5APDBe4BCNAPDBe4FKRAPDBe1URCAPDBe4BCOAPDBe4FKSAPDBe1G5SAPDBe4BCPAPDBe4FKTAPDBe4BCQAPDBe4FKUAPDBe4FKVAPDBe5JQ8APDBe4FKWAPDBe3ULIAPDBe4FKIAPDBe3TIYAPDBe4FKJAPDBe3TIZAPDBe4FKLAPDBe1E1XAPDBe1E1VAPDBe4BCKAPDBe4FKOAPDBe4FKPAPDBe4FKGAPDBe1Y91APDBe1Y8YAPDBe4EK3APDBe4EK4APDBe4EK5APDBe4EK6APDBe4CFUAPDBe4EK8APDBe4CFVAPDBe2CLXAPDBe4CFMAPDBe4CFNAPDBe6YL1APDBe6YL6APDBe2J9MAPDBe1URWAPDBe1FVVAPDBe3BHTAPDBe1FVTAPDBe3BHUAPDBe3BHVAPDBe1F5QAPDBe3UNJAPDBe1GY3APDBe3UNKAPDBe2BKZAPDBe4ACMAPDBe4LYNAPDBe4CFWAPDBe4CFXAPDBe1OGUAPDBe6YLKAPDBe2V22APDBe2VTHAPDBe2VTIAPDBe2VTJAPDBe1GZ8APDBe2VTLAPDBe4I3ZAPDBe2VTMAPDBe1W8CAPDBe2VTNAPDBe2VTOAPDBe6INLAPDBe2VTAAPDBe7VDUAPDBe1PKDAPDBe7M2FAPDBe5K4JAPDBe1OI9APDBe3EOCAPDBe3RJCAPDBe7NVQAPDBe1OIRAPDBe1OIQAPDBe1W98APDBe4BGHAPDBe2VTPAPDBe1OIYAPDBe2VTQAPDBe1QMZAPDBe2VTRAPDBe2VU3APDBe2VTSAPDBe2VTTAPDBe1OIUAPDBe1OITAPDBeGO:0000287magnesium ion bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0019904protein domain specific bindingGoFunctionGO:0030332cyclin bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0006281DNA repairGoProcessGO:0006468protein phosphorylationGoProcessGO:0006813potassium ion transportGoProcessGO:0007099centriole replicationGoProcessGO:0007165signal transductionGoProcessGO:0007265Ras protein signal transductionGoProcessGO:0007346regulation of mitotic cell cycleGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010389regulation of G2/M transition of mitotic cell cycleGoProcessGO:0018105peptidyl-serine phosphorylationGoProcessGO:0031453positive regulation of heterochromatin formationGoProcessGO:0031571mitotic G1 DNA damage checkpoint signalingGoProcessGO:0032298positive regulation of DNA-templated DNA replication initiationGoProcessGO:0043247telomere maintenance in response to DNA damageGoProcessGO:0045740positive regulation of DNA replicationGoProcessGO:0045893positive regulation of DNA-templated transcriptionGoProcessGO:0051298centrosome duplicationGoProcessGO:0051301cell divisionGoProcessGO:0051321meiotic cell cycleGoProcessGO:0071732cellular response to nitric oxideGoProcessGO:0090398cellular senescenceGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0000781chromosome, telomeric regionGoComponentGO:0000793condensed chromosomeGoComponentGO:0000805X chromosomeGoComponentGO:0000806Y chromosomeGoComponentGO:0001673male germ cell nucleusGoComponentGO:0005635nuclear envelopeGoComponentGO:0005654nucleoplasmGoComponentGO:0005768endosomeGoComponentGO:0005813centrosomeGoComponentGO:0005829cytosolGoComponentGO:0005856cytoskeletonGoComponentGO:0015030Cajal bodyGoComponentGO:0005667transcription regulator complexGoComponentA8K7C6Cyclin-dependent kinase 2UniProtO75100Cyclin-dependent kinase 2UniProtP24941Cyclin-dependent kinase 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:1771CDK2HGNCR-HSA-1538133G0 and Early G1ReactomeR-HSA-171319Telomere Extension By TelomeraseReactomeR-HSA-176187Activation of ATR in response to replication stressReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-5693607Processing of DNA double-strand break endsReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-6804756Regulation of TP53 Activity through PhosphorylationReactomeR-HSA-6804757Regulation of TP53 DegradationReactomeR-HSA-68911G2 PhaseReactomeR-HSA-68949Orc1 removal from chromatinReactomeR-HSA-68962Activation of the pre-replicative complexReactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-HSA-69200Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesReactomeR-HSA-69202Cyclin E associated events during G1/S transitionReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69563p53-Dependent G1 DNA Damage ResponseReactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entryReactomeR-HSA-8849470PTK6 Regulates Cell CycleReactomeR-HSA-912446Meiotic recombinationReactomeR-HSA-9616222Transcriptional regulation of granulopoiesisReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9825892Regulation of MITF-M-dependent genes involved in cell cycle and proliferationReactomeR-HSA-983231Factors involved in megakaryocyte development and platelet productionReactomeP24941PharosP24941ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF521CYCLIN-DEPENDENT KINASE 2PANTHERPF00069PkinasePfamPA101cyclin dependent kinase 2PharmGKBQ8ND76Cyclin-Y10084PROTEINPROTEIN SUBUNITC10orf9GENE_SYMBOL_OTHERCBCP1GENE_SYMBOL_OTHERCFP1GENE_SYMBOL_OTHERCCNYGENE_SYMBOLCyclin-YUNIPROTCyclin box protein 1UNIPROTCyclin fold protein 1UNIPROTcyclin-XUNIPROTCyc-YUNIPROTGO:0005515protein bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0007283spermatogenesisGoProcessGO:0010508positive regulation of autophagyGoProcessGO:0016055Wnt signaling pathwayGoProcessGO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activityGoProcessGO:0051301cell divisionGoProcessGO:0060828regulation of canonical Wnt signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005730nucleolusGoComponentB7ZKX9Cyclin-YUniProtD3DRY9Cyclin-YUniProtQ2M3V4Cyclin-YUniProtQ2TU96Cyclin-YUniProtQ6NT86Cyclin-YUniProtQ7Z4U7Cyclin-YUniProtQ8TEX2Cyclin-YUniProtQ8TEX3Cyclin-YUniProtQ96M99Cyclin-YUniProtQ96P45Cyclin-YUniProtQ8ND76Cyclin-YUniProtQ8ND76AlphaFoldDBQ8ND76IntActHGNC:23354CCNYHGNCQ8ND76PharosQ8ND76ExpressionAtlasIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR006671Cyclin_NInterProIPR012399Cyclin_YInterProPTHR14248CYCLIN Y, ISOFORM APANTHERPF00134Cyclin_NPfamPA162381980cyclin YPharmGKBPROTEIN COMPLEX9606Homo sapiensCDK17/Cyclin-A2CHEMBL4523636P20248Cyclin-A2918PROTEINPROTEIN SUBUNITCCNAGENE_SYMBOL_OTHERSynonyms=CCN1GENE_SYMBOL_OTHERCCNA GN GENE_SYMBOL_OTHERCCNA2GENE_SYMBOLCyclin-A2UNIPROTCyclin AUNIPROTCyclin-AUNIPROT3EJ1APDBe2I40APDBe2WHBAPDBe1FINAPDBe2WPAAPDBe3EIDAPDBe6GVAAPDBe5CYIAPDBe4EONAPDBe4EOOAPDBe4EOPAPDBe2UUEAPDBe4EOQAPDBe4EORAPDBe4EOSAPDBe1OL2APDBe4EOIAPDBe5NEVAPDBe8B54APDBe1OL1APDBe1VYWAPDBe4EOJAPDBe4EOKAPDBe4EOLAPDBe4EOMAPDBe1P5EAPDBe2WXVAPDBe2X1NAPDBe1OKWAPDBe1OKVAPDBe7B7SAPDBe2IW6APDBe2CJMAPDBe5IF1APDBe1JSUAPDBe1JSTAPDBe2IW9APDBe2IW8APDBe2WIPAPDBe7LUOAPDBe2BPMAPDBe2WIHAPDBe2CCIAPDBe4BCMAPDBe2CCHAPDBe4BCNAPDBe1URCAPDBe4BCPAPDBe7QHLAPDBe6ATHAPDBe3F5XAPDBe4BCKAPDBe6SG4APDBe1E9HAPDBe4CFUAPDBe4CFVAPDBe5LMKAPDBe4CFMAPDBe4CFNAPDBe1H1QAPDBe1H1PAPDBe2WMAAPDBe1FVVAPDBe2WMBAPDBe1GY3APDBe2BKZAPDBe1H28APDBe1H27APDBe1H26APDBe1H25APDBe1H1SAPDBe1H24APDBe1H1RAPDBe2C4GAPDBe4CFWAPDBe4CFXAPDBe1OGUAPDBe2V22APDBe2C5XAPDBe2C5VAPDBe6P3WAPDBe7ACKAPDBe2UZLAPDBe2WEVAPDBe1PKDAPDBe2UZBAPDBe2UZDAPDBe2UZEAPDBe1OI9APDBe2C5OAPDBe2C5NAPDBe3EOCAPDBe2WFYAPDBe6RIJAPDBe4FX3APDBe2C6TAPDBe1OIYAPDBe7MKXAPDBe1QMZAPDBe1OIUAPDBeGO:0005515protein bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0019904protein domain specific bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0007265Ras protein signal transductionGoProcessGO:0031100animal organ regenerationGoProcessGO:0044320cellular response to leptin stimulusGoProcessGO:0044772mitotic cell cycle phase transitionGoProcessGO:0044843cell cycle G1/S phase transitionGoProcessGO:0045893positive regulation of DNA-templated transcriptionGoProcessGO:0048146positive regulation of fibroblast proliferationGoProcessGO:0051301cell divisionGoProcessGO:0071314cellular response to cocaineGoProcessGO:0071373cellular response to luteinizing hormone stimulusGoProcessGO:0071392cellular response to estradiol stimulusGoProcessGO:0071407cellular response to organic cyclic compoundGoProcessGO:0071456cellular response to hypoxiaGoProcessGO:0071732cellular response to nitric oxideGoProcessGO:0090102cochlea developmentGoProcessGO:1990314cellular response to insulin-like growth factor stimulusGoProcessGO:2000573positive regulation of DNA biosynthetic processGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0001939female pronucleusGoComponentGO:0001940male pronucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005829cytosolGoComponentA8K7B6Cyclin-A2UniProtQ2M3U6Cyclin-A2UniProtQ4W5P4Cyclin-A2UniProtQ6LER8Cyclin-A2UniProtP20248Cyclin-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:1578CCNA2HGNCR-HSA-1362300Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1ReactomeR-HSA-1538133G0 and Early G1ReactomeR-HSA-170145Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexesReactomeR-HSA-171319Telomere Extension By TelomeraseReactomeR-HSA-174184Cdc20:Phospho-APC/C mediated degradation of Cyclin AReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-5689880Ub-specific processing proteasesReactomeR-HSA-5693607Processing of DNA double-strand break endsReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-6804756Regulation of TP53 Activity through PhosphorylationReactomeR-HSA-6804757Regulation of TP53 DegradationReactomeR-HSA-68911G2 PhaseReactomeR-HSA-68949Orc1 removal from chromatinReactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69563p53-Dependent G1 DNA Damage ResponseReactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entryReactomeP20248PharosIPR039361CyclinInterProIPR032447Cyclin-A_NInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR046965Cyclin_A/B-likeInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamPF16500Cyclin_N2PfamPA94cyclin A2PharmGKBQ00537Cyclin-dependent kinase 174203PROTEINPROTEIN SUBUNITPCTAIRE2GENE_SYMBOL_OTHERPCTK2GENE_SYMBOL_OTHERCDK17GENE_SYMBOLCyclin-dependent kinase 17UNIPROTCell division protein kinase 17UNIPROTPCTAIRE-motif protein kinase 2UNIPROTSerine/threonine-protein kinase PCTAIRE-2UNIPROT2.7.11.22EC_NUMBERGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0006468protein phosphorylationGoProcessGO:1901987regulation of cell cycle phase transitionGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentA8K1U6Cyclin-dependent kinase 17UniProtB2RCQ2Cyclin-dependent kinase 17UniProtQ8NEB8Cyclin-dependent kinase 17UniProtQ00537Cyclin-dependent kinase 17UniProtQ00537AlphaFoldDBQ00537IntActHGNC:8750CDK17HGNCQ00537PharosQ00537ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF128CYCLIN-DEPENDENT KINASE 17PANTHERPF00069PkinasePfamPA33096cyclin dependent kinase 17PharmGKBPROTEIN COMPLEX9606Homo sapiensCDK17/Cyclin-YCHEMBL4523637Q00537Cyclin-dependent kinase 174203PROTEINPROTEIN SUBUNITPCTAIRE2GENE_SYMBOL_OTHERPCTK2GENE_SYMBOL_OTHERCDK17GENE_SYMBOLCyclin-dependent kinase 17UNIPROTCell division protein kinase 17UNIPROTPCTAIRE-motif protein kinase 2UNIPROTSerine/threonine-protein kinase PCTAIRE-2UNIPROT2.7.11.22EC_NUMBERGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0006468protein phosphorylationGoProcessGO:1901987regulation of cell cycle phase transitionGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentA8K1U6Cyclin-dependent kinase 17UniProtB2RCQ2Cyclin-dependent kinase 17UniProtQ8NEB8Cyclin-dependent kinase 17UniProtQ00537Cyclin-dependent kinase 17UniProtQ00537AlphaFoldDBQ00537IntActHGNC:8750CDK17HGNCQ00537PharosQ00537ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF128CYCLIN-DEPENDENT KINASE 17PANTHERPF00069PkinasePfamPA33096cyclin dependent kinase 17PharmGKBQ8ND76Cyclin-Y10084PROTEINPROTEIN SUBUNITC10orf9GENE_SYMBOL_OTHERCBCP1GENE_SYMBOL_OTHERCFP1GENE_SYMBOL_OTHERCCNYGENE_SYMBOLCyclin-YUNIPROTCyclin box protein 1UNIPROTCyclin fold protein 1UNIPROTcyclin-XUNIPROTCyc-YUNIPROTGO:0005515protein bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0007283spermatogenesisGoProcessGO:0010508positive regulation of autophagyGoProcessGO:0016055Wnt signaling pathwayGoProcessGO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activityGoProcessGO:0051301cell divisionGoProcessGO:0060828regulation of canonical Wnt signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005730nucleolusGoComponentB7ZKX9Cyclin-YUniProtD3DRY9Cyclin-YUniProtQ2M3V4Cyclin-YUniProtQ2TU96Cyclin-YUniProtQ6NT86Cyclin-YUniProtQ7Z4U7Cyclin-YUniProtQ8TEX2Cyclin-YUniProtQ8TEX3Cyclin-YUniProtQ96M99Cyclin-YUniProtQ96P45Cyclin-YUniProtQ8ND76Cyclin-YUniProtQ8ND76AlphaFoldDBQ8ND76IntActHGNC:23354CCNYHGNCQ8ND76PharosQ8ND76ExpressionAtlasIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR006671Cyclin_NInterProIPR012399Cyclin_YInterProPTHR14248CYCLIN Y, ISOFORM APANTHERPF00134Cyclin_NPfamPA162381980cyclin YPharmGKBPROTEIN COMPLEX9606Homo sapiensCDK4/CDK1CHEMBL4523963P06493Cyclin-dependent kinase 17PROTEINCOMPARATIVE PROTEINCDC2GENE_SYMBOL_OTHERCDC28AGENE_SYMBOL_OTHERCDKN1GENE_SYMBOL_OTHERP34CDC2GENE_SYMBOL_OTHERCDK1GENE_SYMBOLCyclin-dependent kinase 1UNIPROTCell division control protein 2 homologUNIPROTCell division protein kinase 1UNIPROTp34 protein kinaseUNIPROTCDK1UNIPROT2.7.11.22EC_NUMBER2.7.11.23EC_NUMBER4YC6APDBe5LQFAPDBe6GU3APDBe6GU2APDBe4Y72APDBe6GU4APDBe6GU7APDBe5HQ0APDBe6GU6APDBe6TWNAPDBe4YC3APDBeGO:0001618virus receptor activityGoFunctionGO:0003682chromatin bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0030332cyclin bindingGoFunctionGO:0030544Hsp70 protein bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0000226microtubule cytoskeleton organizationGoProcessGO:0006281DNA repairGoProcessGO:0006915apoptotic processGoProcessGO:0006974DNA damage responseGoProcessGO:0007077mitotic nuclear membrane disassemblyGoProcessGO:0007095mitotic G2 DNA damage checkpoint signalingGoProcessGO:0007098centrosome cycleGoProcessGO:0009636response to toxic substanceGoProcessGO:0010628positive regulation of gene expressionGoProcessGO:0010629negative regulation of gene expressionGoProcessGO:0010971positive regulation of G2/M transition of mitotic cell cycleGoProcessGO:0014038regulation of Schwann cell differentiationGoProcessGO:0016477cell migrationGoProcessGO:0018105peptidyl-serine phosphorylationGoProcessGO:0018107peptidyl-threonine phosphorylationGoProcessGO:0030261chromosome condensationGoProcessGO:0030855epithelial cell differentiationGoProcessGO:0031100animal organ regenerationGoProcessGO:0034501protein localization to kinetochoreGoProcessGO:0042307positive regulation of protein import into nucleusGoProcessGO:0042542response to hydrogen peroxideGoProcessGO:0042752regulation of circadian rhythmGoProcessGO:0043066negative regulation of apoptotic processGoProcessGO:0044772mitotic cell cycle phase transitionGoProcessGO:0045740positive regulation of DNA replicationGoProcessGO:0045931positive regulation of mitotic cell cycleGoProcessGO:0045995regulation of embryonic developmentGoProcessGO:0046718symbiont entry into host cellGoProcessGO:0048144fibroblast proliferationGoProcessGO:0048511rhythmic processGoProcessGO:0048678response to axon injuryGoProcessGO:0051301cell divisionGoProcessGO:0055015ventricular cardiac muscle cell developmentGoProcessGO:0060045positive regulation of cardiac muscle cell proliferationGoProcessGO:0062033positive regulation of mitotic sister chromatid segregationGoProcessGO:0065003protein-containing complex assemblyGoProcessGO:0070301cellular response to hydrogen peroxideGoProcessGO:0070371ERK1 and ERK2 cascadeGoProcessGO:0071407cellular response to organic cyclic compoundGoProcessGO:1900182positive regulation of protein localization to nucleusGoProcessGO:1902423regulation of attachment of mitotic spindle microtubules to kinetochoreGoProcessGO:1902850microtubule cytoskeleton organization involved in mitosisGoProcessGO:1905448positive regulation of mitochondrial ATP synthesis coupled electron transportGoProcessGO:0005634nucleusGoComponentGO:0000781chromosome, telomeric regionGoComponentGO:0005654nucleoplasmGoComponentGO:0005737cytoplasmGoComponentGO:0005739mitochondrionGoComponentGO:0005789endoplasmic reticulum membraneGoComponentGO:0005813centrosomeGoComponentGO:0005829cytosolGoComponentGO:0005856cytoskeletonGoComponentGO:0005876spindle microtubuleGoComponentGO:0016020membraneGoComponentGO:0030496midbodyGoComponentGO:0070062extracellular exosomeGoComponentA8K7C4Cyclin-dependent kinase 1UniProtC9J497Cyclin-dependent kinase 1UniProtO60764Cyclin-dependent kinase 1UniProtP06493Cyclin-dependent kinase 1UniProt4Y72PDB4YC3PDB4YC6PDB5HQ0PDB5LQFPDB6GU2PDB6GU3PDB6GU4PDB6GU6PDB6GU7PDB6TWNPDB7NJ0PDBP06493AlphaFoldDBP06493IntActHGNC:1722CDK1HGNCR-HSA-110056MAPK3 (ERK1) activationReactomeR-HSA-113507E2F-enabled inhibition of pre-replication complex formationReactomeR-HSA-1362300Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1ReactomeR-HSA-162658Golgi Cisternae Pericentriolar Stack ReorganizationReactomeR-HSA-170145Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexesReactomeR-HSA-174048APC/C:Cdc20 mediated degradation of Cyclin BReactomeR-HSA-174184Cdc20:Phospho-APC/C mediated degradation of Cyclin AReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-176412Phosphorylation of the APC/CReactomeR-HSA-176417Phosphorylation of Emi1ReactomeR-HSA-2299718Condensation of Prophase ChromosomesReactomeR-HSA-2465910MASTL Facilitates Mitotic ProgressionReactomeR-HSA-2500257Resolution of Sister Chromatid CohesionReactomeR-HSA-2514853Condensation of Prometaphase ChromosomesReactomeR-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionReactomeR-HSA-2980767Activation of NIMA Kinases NEK9, NEK6, NEK7ReactomeR-HSA-2995383Initiation of Nuclear Envelope (NE) ReformationReactomeR-HSA-3301854Nuclear Pore Complex (NPC) DisassemblyReactomeR-HSA-380259Loss of Nlp from mitotic centrosomesReactomeR-HSA-380270Recruitment of mitotic centrosome proteins and complexesReactomeR-HSA-380284Loss of proteins required for interphase microtubule organization from the centrosomeReactomeR-HSA-380320Recruitment of NuMA to mitotic centrosomesReactomeR-HSA-4419969Depolymerization of the Nuclear LaminaReactomeR-HSA-5620912Anchoring of the basal body to the plasma membraneReactomeR-HSA-5687128MAPK6/MAPK4 signalingReactomeR-HSA-5689896Ovarian tumor domain proteasesReactomeR-HSA-6804114TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle ArrestReactomeR-HSA-6804757Regulation of TP53 DegradationReactomeR-HSA-68875Mitotic ProphaseReactomeR-HSA-69205G1/S-Specific TranscriptionReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69478G2/M DNA replication checkpointReactomeR-HSA-75035Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexReactomeR-HSA-8852276The role of GTSE1 in G2/M progression after G2 checkpointReactomeR-HSA-8854518AURKA Activation by TPX2ReactomeR-HSA-8878166Transcriptional regulation by RUNX2ReactomeR-HSA-9833482PKR-mediated signalingReactomeP06493PharosP06493ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF334CYCLIN-DEPENDENT KINASE 1PANTHERPF00069PkinasePfamPA99cyclin dependent kinase 1PharmGKBP11802Cyclin-dependent kinase 417PROTEINCOMPARATIVE PROTEINCDK4GENE_SYMBOLCyclin-dependent kinase 4UNIPROTCell division protein kinase 4UNIPROTPSK-J3UNIPROT2.7.11.22EC_NUMBER6P8GAPDBe6P8FAPDBe6P8HAPDBe2W96APDBe2W9FAPDBe3G33APDBe2W99APDBe2W9ZAPDBe6P8EAPDBe7SJ3APDBeGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0030332cyclin bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0006468protein phosphorylationGoProcessGO:0007165signal transductionGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010389regulation of G2/M transition of mitotic cell cycleGoProcessGO:0010971positive regulation of G2/M transition of mitotic cell cycleGoProcessGO:0048146positive regulation of fibroblast proliferationGoProcessGO:0051301cell divisionGoProcessGO:0051726regulation of cell cycleGoProcessGO:0061469regulation of type B pancreatic cell proliferationGoProcessGO:0071222cellular response to lipopolysaccharideGoProcessGO:1904628cellular response to phorbol 13-acetate 12-myristateGoProcessGO:1904637cellular response to ionomycinGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0000785chromatinGoComponentGO:0005654nucleoplasmGoComponentGO:0005730nucleolusGoComponentGO:0005829cytosolGoComponentGO:0005923bicellular tight junctionGoComponentGO:0016020membraneGoComponentGO:0031965nuclear membraneGoComponentGO:0005667transcription regulator complexGoComponentB2R9A0Cyclin-dependent kinase 4UniProtB4DNF9Cyclin-dependent kinase 4UniProtO00576Cyclin-dependent kinase 4UniProtQ6FG61Cyclin-dependent kinase 4UniProtP11802Cyclin-dependent kinase 4UniProt2W96PDB2W99PDB2W9FPDB2W9ZPDB3G33PDB5FWKPDB5FWLPDB5FWMPDB5FWPPDB6P8EPDB6P8FPDB6P8GPDB6P8HPDB7SJ3PDBP11802AlphaFoldDBP11802IntActHGNC:1773CDK4HGNCR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559580Oxidative Stress Induced SenescenceReactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-HSA-2559585Oncogene Induced SenescenceReactomeR-HSA-3214858RMTs methylate histone argininesReactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiationReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-75815Ubiquitin-dependent degradation of Cyclin DReactomeR-HSA-8849470PTK6 Regulates Cell CycleReactomeR-HSA-8878166Transcriptional regulation by RUNX2ReactomeR-HSA-912446Meiotic recombinationReactomeR-HSA-9616222Transcriptional regulation of granulopoiesisReactomeR-HSA-9630791Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4ReactomeR-HSA-9630794Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6ReactomeR-HSA-9632697Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4ReactomeR-HSA-9632700Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6ReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9754119Drug-mediated inhibition of CDK4/CDK6 activityReactomeP11802PharosP11802ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF129CYCLIN-DEPENDENT KINASE 4PANTHERPF00069PkinasePfamPA102cyclin dependent kinase 4PharmGKBSELECTIVITY GROUP9606Homo sapiensCDK2/Cyclin CCHEMBL4888454P24941Cyclin-dependent kinase 236PROTEINPROTEIN SUBUNITCDKN2GENE_SYMBOL_OTHERCDK2GENE_SYMBOLCyclin-dependent kinase 2UNIPROTCell division protein kinase 2UNIPROTp33 protein kinaseUNIPROT2.7.11.22EC_NUMBER2DS1APDBe3RKBAPDBe3QHRAPDBe3DOGAPDBe3RK5APDBe7SA0APDBe3TNWAPDBe3RK7APDBe2FVDAPDBe3QHWAPDBe3RK9APDBe2VV9APDBe1AQ1APDBe4EONAPDBe4EOOAPDBe4EOPAPDBe2UUEAPDBe4EOQAPDBe4EORAPDBe7ZPCAPDBe4EOSAPDBe1VYZAPDBe1OL2APDBe4EOIAPDBe1OL1APDBe1VYWAPDBe4EOJAPDBe4EOKAPDBe4EOLAPDBe4EOMAPDBe2WXVAPDBe1OKWAPDBe1OKVAPDBe1B39APDBe3RMFAPDBe1B38APDBe2G9XAPDBe8OY2APDBe5FP6APDBe5FP5APDBe3RM6APDBe3RM7APDBe7UG1APDBe7RA5APDBe1KE9APDBe1KE8APDBe2BPMAPDBe1KE7APDBe1KE6APDBe1KE5APDBe4RJ3APDBe3RNIAPDBe2DUVAPDBe3F5XAPDBe3QL8APDBe3PJ8APDBe6SG4APDBe1E9HAPDBe3S0OAPDBe4ERWAPDBe1BUHAPDBe3S00APDBe2EXMAPDBe3RPOAPDBe3S1HAPDBe3ROYAPDBe2C4GAPDBe2A0CAPDBe3SQQAPDBe2R3JAPDBe2UZOAPDBe2R3IAPDBe4D1ZAPDBe2C5YAPDBe2R3HAPDBe2C5XAPDBe2C69APDBe2R3GAPDBe2C68APDBe2R3FAPDBe2C5VAPDBe3S2PAPDBe1HCKAPDBe2R3RAPDBe2R3QAPDBe2R3PAPDBe2R3OAPDBe7ACKAPDBe2R3NAPDBe2R3MAPDBe2UZLAPDBe2R3LAPDBe2R3KAPDBe2UZNAPDBe4D1XAPDBe3RPYAPDBe3FZ1APDBe3LE6APDBe2UZBAPDBe2UZDAPDBe2UZEAPDBe2BTSAPDBe5UQ2APDBe1P2AAPDBe2BTRAPDBe3RPRAPDBe5UQ1APDBe5UQ3APDBe2C5OAPDBe2C5NAPDBe3RPVAPDBe6RIJAPDBe2B55APDBe3R1QAPDBe2C6LAPDBe2C6KAPDBe2C6IAPDBe1R78APDBe4FX3APDBe1HCLAPDBe2B54APDBe2C6TAPDBe2B53APDBe2B52APDBe2C6OAPDBe2C6MAPDBe3QQKAPDBe3QQLAPDBe6GUCAPDBe6GUBAPDBe2R64APDBe3QQFAPDBe3QQGAPDBe3QQHAPDBe3QQJAPDBe3LFNAPDBe3R1SAPDBe3LFQAPDBe3R28APDBe3LFSAPDBe3R1YAPDBe3SW4APDBe6GVAAPDBe1PW2APDBe2A4LAPDBe1WCCAPDBe5D1JAPDBe3EZRAPDBe5NEVAPDBe3EZVAPDBe1P5EAPDBe6GUEAPDBe6GUFAPDBe6GUHAPDBe6GUKAPDBe3QRTAPDBe3SW7APDBe3QRUAPDBe4NJ3APDBe2JGZAPDBe4KD1APDBe1PXPAPDBe1PXOAPDBe3QU0APDBe1PXNAPDBe1PXMAPDBe3QTQAPDBe1PXLAPDBe3QTRAPDBe7QHLAPDBe1PXKAPDBe3QTSAPDBe1PXJAPDBe1PXIAPDBe3QTUAPDBe8FP5APDBe8FOWAPDBe5ANKAPDBe5ANJAPDBe4EZ3APDBe5ANOAPDBe8FP0APDBe4EZ7APDBe5ANEAPDBe5ANDAPDBe5ANGAPDBe5ANIAPDBe3R71APDBe3R73APDBe3QTWAPDBe3QTXAPDBe1PYEAPDBe3QTZAPDBe3R83APDBe3R7UAPDBe3R7VAPDBe3R7IAPDBe3R7EAPDBe1YKRAPDBe3R6XAPDBe8VQ3APDBe8VQ4APDBe1GIJAPDBe3QX2APDBe1GIIAPDBe1GIHAPDBe3QX4APDBe3R8UAPDBe3R8VAPDBe3QWJAPDBe3QWKAPDBe3R8LAPDBe3R8MAPDBe2WEVAPDBe3IGGAPDBe3R8PAPDBe7E34APDBe3WBLAPDBe5A14APDBe5MHQAPDBe3R7YAPDBe3IG7APDBe2WFYAPDBe5OO0APDBe5OO1APDBe8ERDAPDBe5OO3APDBe3R9NAPDBe3QXOAPDBe3R9OAPDBe3QXPAPDBe8H6PAPDBe3R9DAPDBe8H6TAPDBe3R9HAPDBe3R8ZAPDBe3RZBAPDBe2WHBAPDBe1FINAPDBe8ERNAPDBe9FR2APDBe3NS9APDBe4BZDAPDBe4GCJAPDBe3PXYAPDBe3PXZAPDBe5CYIAPDBe3PY0APDBe3PY1APDBe3PXQAPDBe3PXRAPDBe3QZFAPDBe3PXFAPDBe3QZGAPDBe3QZHAPDBe3QZIAPDBe5IF1APDBe1JSVAPDBe1JSUAPDBe1JSTAPDBe2WIPAPDBe2WIHAPDBe1H00APDBe2CCIAPDBe2CCHAPDBe6ATHAPDBe1H08APDBe1H07APDBe7UXKAPDBe8UV0APDBe1H01APDBe5IEYAPDBe7UXIAPDBe4II5APDBe5IEVAPDBe5IEXAPDBe2XNBAPDBe6Q48APDBe7S4TAPDBe5OSJAPDBe1H0WAPDBe1H0VAPDBe2XMYAPDBe5LMKAPDBe5OSMAPDBe6Q3CAPDBe6Q3BAPDBe1DI8APDBe6Q3FAPDBe1H1QAPDBe1H1PAPDBe2WMAAPDBe2WMBAPDBe6JGMAPDBe1JVPAPDBe3DDPAPDBe3DDQAPDBe6OQIAPDBe6Q4JAPDBe6Q4IAPDBe1H28APDBe1H27APDBe6Q4KAPDBe1H26APDBe1H25APDBe1H1SAPDBe1H24APDBe1H1RAPDBe6Q4BAPDBe6Q4AAPDBe6Q4DAPDBe6Q4CAPDBe6Q4FAPDBe6Q4EAPDBe6Q4HAPDBe6Q4GAPDBe6Q49APDBe6P3WAPDBe1FQ1APDBe7S84APDBe7S85APDBe3MY5APDBe1DM2APDBe3RAKAPDBe3RALAPDBe8CURAPDBe1W0XAPDBe7MKXAPDBe7S7AAPDBe3RAHAPDBe3RAIAPDBe1CKPAPDBe3EJ1APDBe2I40APDBe8RU8APDBe2WPAAPDBe7RWFAPDBe7RWEAPDBe3EIDAPDBe7S9XAPDBe1PF8APDBe7KJSAPDBe1V1KAPDBe7RXOAPDBe2W05APDBe2W06APDBe8B54APDBe2X1NAPDBe7B7SAPDBe2IW6APDBe2CJMAPDBe2W1HAPDBe5L2WAPDBe2BHHAPDBe2IW9APDBe2IW8APDBe3TI1APDBe2W17APDBe2BHEAPDBe2V0DAPDBe4BCMAPDBe4FKQAPDBe5JQ5APDBe4BCNAPDBe4FKRAPDBe1URCAPDBe4BCOAPDBe4FKSAPDBe1G5SAPDBe4BCPAPDBe4FKTAPDBe4BCQAPDBe4FKUAPDBe4FKVAPDBe5JQ8APDBe4FKWAPDBe3ULIAPDBe4FKIAPDBe3TIYAPDBe4FKJAPDBe3TIZAPDBe4FKLAPDBe1E1XAPDBe1E1VAPDBe4BCKAPDBe4FKOAPDBe4FKPAPDBe4FKGAPDBe1Y91APDBe1Y8YAPDBe4EK3APDBe4EK4APDBe4EK5APDBe4EK6APDBe4CFUAPDBe4EK8APDBe4CFVAPDBe2CLXAPDBe4CFMAPDBe4CFNAPDBe6YL1APDBe6YL6APDBe2J9MAPDBe1URWAPDBe1FVVAPDBe3BHTAPDBe1FVTAPDBe3BHUAPDBe3BHVAPDBe1F5QAPDBe3UNJAPDBe1GY3APDBe3UNKAPDBe2BKZAPDBe4ACMAPDBe4LYNAPDBe4CFWAPDBe4CFXAPDBe1OGUAPDBe6YLKAPDBe2V22APDBe2VTHAPDBe2VTIAPDBe2VTJAPDBe1GZ8APDBe2VTLAPDBe4I3ZAPDBe2VTMAPDBe1W8CAPDBe2VTNAPDBe2VTOAPDBe6INLAPDBe2VTAAPDBe7VDUAPDBe1PKDAPDBe7M2FAPDBe5K4JAPDBe1OI9APDBe3EOCAPDBe3RJCAPDBe7NVQAPDBe1OIRAPDBe1OIQAPDBe1W98APDBe4BGHAPDBe2VTPAPDBe1OIYAPDBe2VTQAPDBe1QMZAPDBe2VTRAPDBe2VU3APDBe2VTSAPDBe2VTTAPDBe1OIUAPDBe1OITAPDBeGO:0000287magnesium ion bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0019904protein domain specific bindingGoFunctionGO:0030332cyclin bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0006281DNA repairGoProcessGO:0006468protein phosphorylationGoProcessGO:0006813potassium ion transportGoProcessGO:0007099centriole replicationGoProcessGO:0007165signal transductionGoProcessGO:0007265Ras protein signal transductionGoProcessGO:0007346regulation of mitotic cell cycleGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010389regulation of G2/M transition of mitotic cell cycleGoProcessGO:0018105peptidyl-serine phosphorylationGoProcessGO:0031453positive regulation of heterochromatin formationGoProcessGO:0031571mitotic G1 DNA damage checkpoint signalingGoProcessGO:0032298positive regulation of DNA-templated DNA replication initiationGoProcessGO:0043247telomere maintenance in response to DNA damageGoProcessGO:0045740positive regulation of DNA replicationGoProcessGO:0045893positive regulation of DNA-templated transcriptionGoProcessGO:0051298centrosome duplicationGoProcessGO:0051301cell divisionGoProcessGO:0051321meiotic cell cycleGoProcessGO:0071732cellular response to nitric oxideGoProcessGO:0090398cellular senescenceGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0000781chromosome, telomeric regionGoComponentGO:0000793condensed chromosomeGoComponentGO:0000805X chromosomeGoComponentGO:0000806Y chromosomeGoComponentGO:0001673male germ cell nucleusGoComponentGO:0005635nuclear envelopeGoComponentGO:0005654nucleoplasmGoComponentGO:0005768endosomeGoComponentGO:0005813centrosomeGoComponentGO:0005829cytosolGoComponentGO:0005856cytoskeletonGoComponentGO:0015030Cajal bodyGoComponentGO:0005667transcription regulator complexGoComponentA8K7C6Cyclin-dependent kinase 2UniProtO75100Cyclin-dependent kinase 2UniProtP24941Cyclin-dependent kinase 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:1771CDK2HGNCR-HSA-1538133G0 and Early G1ReactomeR-HSA-171319Telomere Extension By TelomeraseReactomeR-HSA-176187Activation of ATR in response to replication stressReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-5693607Processing of DNA double-strand break endsReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-6804756Regulation of TP53 Activity through PhosphorylationReactomeR-HSA-6804757Regulation of TP53 DegradationReactomeR-HSA-68911G2 PhaseReactomeR-HSA-68949Orc1 removal from chromatinReactomeR-HSA-68962Activation of the pre-replicative complexReactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-HSA-69200Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesReactomeR-HSA-69202Cyclin E associated events during G1/S transitionReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69563p53-Dependent G1 DNA Damage ResponseReactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entryReactomeR-HSA-8849470PTK6 Regulates Cell CycleReactomeR-HSA-912446Meiotic recombinationReactomeR-HSA-9616222Transcriptional regulation of granulopoiesisReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9825892Regulation of MITF-M-dependent genes involved in cell cycle and proliferationReactomeR-HSA-983231Factors involved in megakaryocyte development and platelet productionReactomeP24941PharosP24941ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF521CYCLIN-DEPENDENT KINASE 2PANTHERPF00069PkinasePfamPA101cyclin dependent kinase 2PharmGKBP24863Cyclin-C8180PROTEINPROTEIN SUBUNITCCNCGENE_SYMBOLCyclin-CUNIPROTSRB11 homologUNIPROThSRB11UNIPROT6T41APDBe6R3SAPDBe3RGFAPDBe6QTJAPDBe5CEIAPDBe5FGKAPDBe9H8SAPDBe4CRLAPDBe4F7NAPDBe4F7SAPDBe6TPAAPDBe6QTGAPDBe5IDPAPDBe5XS2APDBe4F7JAPDBe4F7LAPDBe5HBHAPDBe5I5ZAPDBe9H8CAPDBe5HBJAPDBe5IDNAPDBe4F6UAPDBe4F6WAPDBe6Y0AAPDBe5HBEAPDBe5HVYAPDBe5BNJAPDBe4G6LAPDBe4F70APDBe5XQXAPDBe4F6SAPDBe5ICPAPDBe5HNBAPDBeGO:0005515protein bindingGoFunctionGO:0042802identical protein bindingGoFunctionGO:0045023G0 to G1 transitionGoProcessGO:0045746negative regulation of Notch signaling pathwayGoProcessGO:0045944positive regulation of transcription by RNA polymerase IIGoProcessGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0016592mediator complexGoComponentB4DPZ1Cyclin-CUniProtQ9H543Cyclin-CUniProtP24863Cyclin-CUniProt3RGFPDB4CRLPDB4F6SPDB4F6UPDB4F6WPDB4F70PDB4F7JPDB4F7LPDB4F7NPDB4F7SPDB4G6LPDB5BNJPDB5CEIPDB5FGKPDB5HBEPDB5HBHPDB5HBJPDB5HNBPDB5HVYPDB5I5ZPDB5ICPPDB5IDNPDB5IDPPDB5XQXPDB5XS2PDB6QTGPDB6QTJPDB6R3SPDB6T41PDB6TPAPDB6Y0APDB8TQ2PDB8TQCPDB8TQWPDB9H8CPDB9H8SPDBP24863AlphaFoldDBP24863IntActHGNC:1581CCNCHGNCR-HSA-1989781PPARA activates gene expressionReactomeR-HSA-2122947NOTCH1 Intracellular Domain Regulates TranscriptionReactomeR-HSA-212436Generic Transcription PathwayReactomeR-HSA-2173796SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionReactomeR-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain MutantsReactomeR-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsReactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiationReactomeR-HSA-9833110RSV-host interactionsReactomeR-HSA-9841922MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosisReactomeP24863PharosP24863ExpressionAtlasIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR043198Cyclin/Ssn8InterProIPR031658Cyclin_C_2InterProIPR006671Cyclin_NInterProPTHR10026CYCLINPANTHERPF16899Cyclin_C_2PfamPF00134Cyclin_NPfamPA26149cyclin CPharmGKBPROTEIN COMPLEX9606Mus musculusCDK8/CDK19CHEMBL4888455Q8R3L8Cyclin-dependent kinase 818450PROTEINGROUP MEMBERCdk8GENE_SYMBOLCyclin-dependent kinase 8UNIPROTCell division protein kinase 8UNIPROTMediator complex subunit CDK8UNIPROTMediator of RNA polymerase II transcription subunit CDK8UNIPROT2.7.11.22EC_NUMBER2.7.11.23EC_NUMBERGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0061630ubiquitin protein ligase activityGoFunctionGO:0045944positive regulation of transcription by RNA polymerase IIGoProcessGO:0051726regulation of cell cycleGoProcessGO:0090209negative regulation of triglyceride metabolic processGoProcessGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005730nucleolusGoComponentGO:0000151ubiquitin ligase complexGoComponentGO:0016592mediator complexGoComponentGO:0032991protein-containing complexGoComponentQ8R3L8Cyclin-dependent kinase 8UniProtQ8R3L8AlphaFoldDBQ8R3L8IntActR-MMU-2173796SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionReactomeQ8R3L8ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF243CYCLIN-DEPENDENT KINASE 8PANTHERPF00069PkinasePfamQ8BWD8Cyclin-dependent kinase 1919944PROTEINGROUP MEMBERCdc2l6GENE_SYMBOL_OTHERKiaa1028GENE_SYMBOL_OTHERCdk19GENE_SYMBOLCyclin-dependent kinase 19UNIPROTCDC2-related protein kinase 6UNIPROTCell division cycle 2-like protein kinase 6UNIPROTCell division protein kinase 19UNIPROT2.7.11.22EC_NUMBERGO:0005524ATP bindingGoFunctionGO:0043065positive regulation of apoptotic processGoProcessGO:0051726regulation of cell cycleGoProcessGO:0071222cellular response to lipopolysaccharideGoProcessGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005737cytoplasmGoComponentGO:0005829cytosolGoComponentGO:0048471perinuclear region of cytoplasmGoComponentQ8BWD8ExpressionAtlasQ80TM1Cyclin-dependent kinase 19UniProtQ8BWD8Cyclin-dependent kinase 19UniProtQ8BWD8AlphaFoldDBQ8BWD8IntActIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF570CYCLIN-DEPENDENT KINASE 19PANTHERPF00069PkinasePfamPROTEIN FAMILY10090Homo sapiensProtein cereblon/CDK13CHEMBL5169085Q14004Cyclin-dependent kinase 135767PROTEININTERACTING PROTEINCDC2LGENE_SYMBOL_OTHERCDC2L5GENE_SYMBOL_OTHERCHEDGENE_SYMBOL_OTHERKIAA1791GENE_SYMBOL_OTHERCDK13GENE_SYMBOLCyclin-dependent kinase 13UNIPROTCDC2-related protein kinase 5UNIPROTCell division cycle 2-like protein kinase 5UNIPROTCell division protein kinase 13UNIPROTCholinesterase-related cell division controllerUNIPROThCDK13UNIPROT2.7.11.22EC_NUMBER2.7.11.23EC_NUMBER5EFQAPDBe7NXJAPDBeGO:0003723RNA bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0030332cyclin bindingGoFunctionGO:0000380alternative mRNA splicing, via spliceosomeGoProcessGO:0006397mRNA processingGoProcessGO:0008380RNA splicingGoProcessGO:0009966regulation of signal transductionGoProcessGO:0030097hemopoiesisGoProcessGO:0032968positive regulation of transcription elongation by RNA polymerase IIGoProcessGO:0045944positive regulation of transcription by RNA polymerase IIGoProcessGO:0051726regulation of cell cycleGoProcessGO:2000737negative regulation of stem cell differentiationGoProcessGO:0005634nucleusGoComponentGO:0005576extracellular regionGoComponentGO:0005615extracellular spaceGoComponentGO:0005654nucleoplasmGoComponentGO:0005794Golgi apparatusGoComponentGO:0005829cytosolGoComponentGO:0016607nuclear speckGoComponentGO:1904813ficolin-1-rich granule lumenGoComponentGO:0008024cyclin/CDK positive transcription elongation factor complexGoComponentQ53G78Cyclin-dependent kinase 13UniProtQ6DKQ9Cyclin-dependent kinase 13UniProtQ75MH4Cyclin-dependent kinase 13UniProtQ75MH5Cyclin-dependent kinase 13UniProtQ96JN4Cyclin-dependent kinase 13UniProtQ9H4A0Cyclin-dependent kinase 13UniProtQ9H4A1Cyclin-dependent kinase 13UniProtQ9UDR4Cyclin-dependent kinase 13UniProtQ14004Cyclin-dependent kinase 13UniProt5EFQPDB7NXJPDBQ14004AlphaFoldDBQ14004IntActHGNC:1733CDK13HGNCR-HSA-6796648TP53 Regulates Transcription of DNA Repair GenesReactomeR-HSA-6798695Neutrophil degranulationReactomeQ14004PharosQ14004ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF459CYCLIN-DEPENDENT KINASE 13PANTHERPF00069PkinasePfamPA26264cyclin dependent kinase 13PharmGKBQ96SW2Protein cereblon16927PROTEININTERACTING PROTEINCRBNGENE_SYMBOLProtein cereblonUNIPROT8RQ1APDBe8TZXAPDBe5HXBAPDBe9GAOAPDBe7BQVAPDBe8OJHAPDBe8OIZAPDBe7BQUAPDBe8G66APDBe7U8FAPDBe8U16APDBe6BNBAPDBe8U17APDBe8DEYAPDBe8U15APDBe5FQDAPDBe9CUOAPDBe9FJXAPDBe4TZ4APDBe7LPSAPDBe9DJXAPDBe5V3OAPDBe6UMLAPDBe4M91APDBe6XK9APDBe6BN7APDBe6BN9APDBe6BN8APDBe6BOYAPDBe9DJTAPDBe6H0GAPDBe8RQAAPDBe6H0FAPDBe8RQCAPDBe8RQ9APDBe8RQ8APDBeGO:0005515protein bindingGoFunctionGO:0044325transmembrane transporter bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0030177positive regulation of Wnt signaling pathwayGoProcessGO:0031333negative regulation of protein-containing complex assemblyGoProcessGO:0031334positive regulation of protein-containing complex assemblyGoProcessGO:0034766negative regulation of monoatomic ion transmembrane transportGoProcessGO:0035641locomotory exploration behaviorGoProcessGO:0043161proteasome-mediated ubiquitin-dependent protein catabolic processGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005829cytosolGoComponentGO:0016020membraneGoComponentGO:0048471perinuclear region of cytoplasmGoComponentGO:0031464Cul4A-RING E3 ubiquitin ligase complexGoComponentB2R6H4Protein cereblonUniProtC9IZA9Protein cereblonUniProtC9JAH6Protein cereblonUniProtQ6AI62Protein cereblonUniProtQ6NVZ0Protein cereblonUniProtQ9UHW4Protein cereblonUniProtQ96SW2Protein cereblonUniProt4M91PDB4TZ4PDB5FQDPDB5HXBPDB5V3OPDB6BN7PDB6BN8PDB6BN9PDB6BNBPDB6BOYPDB6H0FPDB6H0GPDB6UMLPDB6XK9PDB7BQUPDB7BQVPDB7LPSPDB7U8FPDB8CVPPDB8D7UPDB8D7VPDB8D7WPDB8D7XPDB8D7YPDB8D7ZPDB8D80PDB8D81PDB8DEYPDB8G66PDB8OIZPDB8OJHPDB8RQ1PDB8RQ8PDB8RQ9PDB8RQAPDB8RQCPDB8TNPPDB8TNQPDB8TNRPDB8TZXPDB8U15PDB8U16PDB8U17PDB8UH6PDB9CUOPDB9DJTPDB9DJXPDB9DQDPDB9FJXPDB9GAOPDBQ96SW2AlphaFoldDBQ96SW2IntActHGNC:30185CRBNHGNCR-HSA-9679191Potential therapeutics for SARSReactomeQ96SW2PharosQ96SW2ExpressionAtlasIPR034750CULTInterProIPR003111Lon_prtase_NInterProIPR046336Lon_prtase_N_sfInterProIPR015947PUA-like_sfInterProIPR004910Yippee/Mis18/CereblonInterProPTHR14255CEREBLONPANTHERPTHR14255:SF4PROTEIN CEREBLONPANTHERPF02190LON_substr_bdgPfamPF03226Yippee-Mis18PfamPA134926851cereblonPharmGKBPROTEIN-PROTEIN INTERACTION9606