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HYDROCORTISONE

Compound

Name and Classification

ID: CHEMBL389621

Name: HYDROCORTISONE

Max Phase:

Approved Learn more

First Approval: 1952

Molecular Formula: C21H30O5

Molecular Weight: 362.47

Molecule Type: Small molecule

Synonyms and Trade Names:

Cor-Oticin Cortifoam CORTISOL FLEXICORT HIDROCORTISONA

Representations

Molfile:

Canonical SMILES:

Standard InChI:

Standard InChI Key:

Sources

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Scientific Literature TP-search Transporter Database PubChem BioAssays FDA Orange Book Drugs DrugMatrix SARS-CoV-2 Screening Data United States Adopted Names (USAN) Clinical Candidate Compounds British National Formulary (BNF) IMI-CARE SARS-CoV-2 Data CO-ADD Antimicrobial Screening WHO Anatomical Therapeutic Chemical (ATC) Classification of Drugs Fraunhofer Institute HDAC6 screening Active Ingredient of a Prodrug European Medicines Agency (EMA) Karolinska Institute dNTPase SAMHD1 screening

Alternative Forms

Alternative forms of compound CHEMBL389621

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Parent:

CHEMBL389621

HYDROCORTISONE

Similar Compounds

Compounds similar to CHEMBL389621

Compounds with at least 85% similarity.

Browse All REST Service Call

CHEMBL1730629

Similarity: 100.00

CHEMBL1474522

Similarity: 100.00

CHEMBL1472865

Similarity: 100.00

CHEMBL1092578

Similarity: 100.00

1 - 4 out of 6

Activity Charts

Bioactivity Summary

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Total

1499

Tissue Severity Score

IC50

Activity

AC50

Inhibition

permeability

GI50

Potency

Peff

ED50

ID50

LogD

RBA

Relative amount

ALB

ALP

ALT

AST

BASO

Other

Assay Summary

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Total

918

F - Functional

B - Binding

A - ADME

P - Physicochemical

T - Toxicity

Target Summary

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Total

276

N/A

Membrane receptor

Enzyme

Transcription factor

Transporter

Ion channel

Unclassified protein

Epigenetic regulator

Secreted protein

Other cytosolic protein

Literature

Histogram Settings

Interval Size (1)

Total

240

Journal:

J Med Chem

Eur J Med Chem

Bioorg Med Chem Lett

J Nat Prod

Bioorg Med Chem

N/A

Drug Metab Dispos

Medchemcomm

ACS Med Chem Lett

Pharm Res

Mol Pharmacol

Nat Chem Biol

J Biol Chem

Am J Physiol

Biochem J

J Pharmacol Exp Ther

Annu Rev Pharmacol Toxicol

Endocrinology

J Neuroendocrinol

Gastroenterol Clin Biol

Antimicrob Agents Chemother

Chem Res Toxicol

J Agric Food Chem

PLoS Comput Biol

Drug Discov Today

RSC Med Chem

Nat Commun

iScience

Items with no Year (4)

The table below displays ChEMBL targets which are predicted to interact with HYDROCORTISONE (CHEMBL389621). The target prediction returns four classes: ‘active’ or ‘inactive’ depending on whether or not HYDROCORTISONE (CHEMBL389621) is predicted to interact or not with the target. The value returned can also be 'empty' if the model was not able to predict the compound or 'both' if it could not conclude. The predictions are given at three different confidence levels. More information on the methodology is available at: https://jcheminf.biomedcentral.com/articles/10.1186/s13321-018-0325-4

Target	Target Pref. Name	Confidence 70%	Confidence 80%	Confidence 90%	Activity Threshold
CHEMBL2902	Dihydrofolate reductase	inactive	inactive	inactive	6
CHEMBL2725	Beta-lactamase	inactive	inactive	both	6
CHEMBL5062	Coagulation factor X	empty	empty	active	6.5
CHEMBL1947	Thyroid hormone receptor beta-1	empty	empty	inactive	7
CHEMBL2157850	Ubiquitin carboxyl-terminal hydrolase 7	empty	empty	inactive	6