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Showing 1-20 out of 44 records

#	Molecule ChEMBL ID	Compound Key	Standard Type	Standard Relation	Standard Value	Standard Text Value	Standard Units	pChEMBL Value	Comment	Assay ChEMBL ID	Assay Description	BAO Label	Assay Organism	Target ChEMBL ID	Target Name	Target Organism	Target Type	Document ChEMBL ID	Source Description	Cell ChEMBL ID
1.	Error: . CHEMBL1427	Hx	Activity	=	11.0	---	%	---	---	CHEMBL916833	Protection against 40 nM methotrexate-induced growth inhibition of human CCRF-CEM cells at 10 uM relative to control	cell-based format	Homo sapiens	CHEMBL382	CCRF-CEM	Homo sapiens	CELL-LINE	CHEMBL1149301	Scientific Literature	CHEMBL3307641
2.	Error: . CHEMBL1427	HYPOXANTHINE	Inhibition	=	92.05	---	%	---	---	CHEMBL3039488	Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM	cell-based format	Cricetulus griseus	CHEMBL1697668	Solute carrier organic anion transporter family member 1B1	Homo sapiens	SINGLE PROTEIN	CHEMBL3039007	Scientific Literature	CHEMBL3308072
3.	Error: . CHEMBL1427	SID170466739	Ac50	---	1.0	---	uM	---	inactive	CHEMBL3562152	PubChem BioAssay. qHTS Assay for Identifying Compounds that block Entry of Ebola Virus: Screen2, ratio channel. (Class of assay: confirmatory)	assay format	---	CHEMBL612545	Unchecked	---	UNCHECKED	CHEMBL1201862	PubChem BioAssays	---
4.	Error: . CHEMBL1427	Hx	Activity	=	101.0	---	%	---	---	CHEMBL916846	Growth inhibition of human CCRF-CEM cells at 10 uM relative to leucovorin	cell-based format	Homo sapiens	CHEMBL382	CCRF-CEM	Homo sapiens	CELL-LINE	CHEMBL1149301	Scientific Literature	CHEMBL3307641
5.	Error: . CHEMBL1427	Hx	Kieq	=	2500.0	---	nM	---	---	CHEMBL2162052	Inhibition of bovine PNP using 7-methylguanosine as substrate by spectrophotometric based coupled assay	single protein format	Bos taurus	CHEMBL2935	Purine nucleoside phosphorylase	Bos taurus	SINGLE PROTEIN	CHEMBL2157872	Scientific Literature	---
6.	Error: . CHEMBL1427	hypoxanthine	Activity	---	---	---	---	---	Not Active	CHEMBL912812	Antimalarial activity against Plasmodium falciparum 3D7 at 176 uM	organism-based format	Plasmodium falciparum	CHEMBL364	Plasmodium falciparum	Plasmodium falciparum	ORGANISM	CHEMBL1138206	Scientific Literature	---
7.	Error: . CHEMBL1427	hypoxanthine	Ki	=	17000.0	---	nM	4.77	---	CHEMBL766675	Tested for its ability to inhibit calf spleen purine nucleoside phosphorylase (PNP)	tissue-based format	Bos taurus	CHEMBL2395	Purine-nucleoside phosphorylase	Rattus norvegicus	SINGLE PROTEIN	CHEMBL1127601	Scientific Literature	---
8.	Error: . CHEMBL1427	hypoxanthine	Ratio	=	3.4	---	---	---	---	CHEMBL848598	Ratio of Ki values for guanine and related hypoxanthines in PNP inhibition assay	single protein format	Rattus norvegicus	CHEMBL2395	Purine-nucleoside phosphorylase	Rattus norvegicus	SINGLE PROTEIN	CHEMBL1127601	Scientific Literature	---
9.	Error: . CHEMBL1427	14	Inhibition	=	78.0	---	%	---	---	CHEMBL3253153	Inhibition of human erythrocyte purine nucleoside phosphorylase assessed as inhibition of guanosine phosphorylysis at 4 umol after 30 mins by orcinol reaction	single protein format	Homo sapiens	CHEMBL4338	Purine nucleoside phosphorylase	Homo sapiens	SINGLE PROTEIN	CHEMBL3244253	Scientific Literature	---
10.	Error: . CHEMBL1427	Hypoxanthine	Concentration	=	0.00005	---	M	---	---	CHEMBL708716	The concentration required (hypoxanthine+uridine) to inhibit the growth of L-1210 leukemic cells was evaluated	cell-based format	Mus musculus	CHEMBL386	L1210	Mus musculus	CELL-LINE	CHEMBL1123079	Scientific Literature	CHEMBL3308391
11.	Error: . CHEMBL1427	hypoxanthine	Km	=	3100.0	---	nM	---	---	CHEMBL853907	Inhibition of human HGPRT at pH 8.5	single protein format	Homo sapiens	CHEMBL2360	Hypoxanthine-guanine phosphoribosyltransferase	Homo sapiens	SINGLE PROTEIN	CHEMBL1138206	Scientific Literature	---
12.	Error: . CHEMBL1427	Hypoxanthine	Inhibition	=	5.96	---	%	---	---	CHEMBL4808150	Enzymatic assay of human HDAC6 with custom peptide substrate	single protein format	Homo sapiens	CHEMBL1865	Histone deacetylase 6	Homo sapiens	SINGLE PROTEIN	CHEMBL4808148	Fraunhofer Institute HDAC6 screening	---
13.	Error: . CHEMBL1427	SID26749634	Potency	=	39810.7	---	nM	4.40	Inconclusive	CHEMBL1614458	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	assay format	Homo sapiens	CHEMBL3577	Aldehyde dehydrogenase 1A1	Homo sapiens	SINGLE PROTEIN	CHEMBL1201862	PubChem BioAssays	---
14.	Error: . CHEMBL1427	Hypoxanthine	Ki	=	11000.0	---	nM	4.96	---	CHEMBL4156482	Inhibition of fungal FcyB expressed in Aspergillus nidulans assessed as reduction in FcyB-mediated [2,8-3H]-adenine accumulation	assay format	Fungi	CHEMBL612545	Unchecked	---	UNCHECKED	CHEMBL4152333	Scientific Literature	---
15.	Error: . CHEMBL1427	hypoxanthine	Km	=	3400.0	---	nM	---	---	CHEMBL909307	Inhibition of human HGPRT at pH 7.4	single protein format	Homo sapiens	CHEMBL2360	Hypoxanthine-guanine phosphoribosyltransferase	Homo sapiens	SINGLE PROTEIN	CHEMBL1138206	Scientific Literature	---
16.	Error: . CHEMBL1427	Hypoxanthine	Inhibition	=	-0.1	---	%	---	---	CHEMBL4513082	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	organism-based format	Chlorocebus sabaeus	CHEMBL4303835	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	ORGANISM	CHEMBL4495565	SARS-CoV-2 Screening Data	CHEMBL4295411
17.	Error: . CHEMBL1427	Hx	Kd	=	680.0	---	nM	6.17	---	CHEMBL2162055	Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetry	assay format	Bos taurus	CHEMBL2935	Purine nucleoside phosphorylase	Bos taurus	SINGLE PROTEIN	CHEMBL2157872	Scientific Literature	---
18.	Error: . CHEMBL1427	Hypoxanthine	Inhibition	=	57.82	---	%	---	---	CHEMBL4808149	Enzymatic assay of human HDAC6 with commercial peptide substrate	single protein format	Homo sapiens	CHEMBL1865	Histone deacetylase 6	Homo sapiens	SINGLE PROTEIN	CHEMBL4808148	Fraunhofer Institute HDAC6 screening	---
19.	Error: . CHEMBL1427	SID26749634	Potency	=	19905.4	---	nM	4.70	Inconclusive	CHEMBL1614275	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ]	assay format	Giardia intestinalis	CHEMBL1293234	Putative fructose-1,6-bisphosphate aldolase	Giardia intestinalis	SINGLE PROTEIN	CHEMBL1201862	PubChem BioAssays	---
20.	Error: . CHEMBL1427	Hypoxanthine	Inhibition	=	-0.1	---	%	---	---	CHEMBL4513082	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	organism-based format	Chlorocebus sabaeus	CHEMBL4303835	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	ORGANISM	CHEMBL4495565	SARS-CoV-2 Screening Data	CHEMBL4295411

Showing 1-20 out of 44 records

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