Activities
827 items
You are exploring a subset of activities:
Activities related to compound CHEMBL1593867 (HARMINE HYDROCHLORIDE) and its parent (CHEMBL269538).
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Showing 1-20
out of 827 records
| # | Molecule ChEMBL ID | Compound Key | Standard Type | Standard Relation | Standard Value | Standard Text Value | Standard Units | pChEMBL Value | Comment | Assay ChEMBL ID | Assay Description | BAO Label | Assay Organism | Target ChEMBL ID | Target Name | Target Organism | Target Type | Document ChEMBL ID | Source Description | Cell ChEMBL ID | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |
SID56463102
|
Potency
|
---
|
18356.4
|
---
|
nM
|
---
|
Active
|
PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]
|
assay format
|
Homo sapiens
|
Nuclear factor erythroid 2-related factor 2
|
Homo sapiens
|
SINGLE PROTEIN
|
PubChem BioAssays
| ||||||
| 2. |
SID56463102
|
Potency
|
---
|
50118.7
|
---
|
nM
|
---
|
inconclusive
|
PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813]
|
assay format
|
---
|
Flap endonuclease 1
|
Homo sapiens
|
SINGLE PROTEIN
|
PubChem BioAssays
| ||||||
| 3. |
SID56463102
|
AC50
|
---
|
14390.0
|
---
|
nM
|
---
|
active
|
PubChem BioAssay. Identification of Inhibitors of RAD54 Measured in Biochemical System Using Plate Reader - 2159-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory)
|
biochemical format
|
Homo sapiens
|
DNA repair and recombination protein RAD54-like
|
Homo sapiens
|
SINGLE PROTEIN
|
PubChem BioAssays
| ||||||
| 4. |
Harmine HCl
|
Inhibition
|
=
|
50.86
|
---
|
%
|
---
|
---
|
Inhibition of electric eel AChE at 2 mg/ml by Ellman's method
|
single protein format
|
Electrophorus electricus
|
Acetylcholinesterase
|
Electrophorus electricus
|
SINGLE PROTEIN
|
Scientific Literature
| ||||||
| 5. |
SID56463102
|
Potency
|
---
|
35338.3
|
---
|
nM
|
---
|
inconclusive
|
PubChem BioAssay. qHTS screen for small molecules that inhibit ELG1-dependent DNA repair: Hit Confirmation with MMS Viability. (Class of assay: confirmatory)
|
assay format
|
Homo sapiens
|
ATPase family AAA domain-containing protein 5
|
Homo sapiens
|
SINGLE PROTEIN
|
PubChem BioAssays
| ||||||
| 6. |
SID56463102
|
Potency
|
---
|
11174.9
|
---
|
nM
|
---
|
active
|
PubChem BioAssay. qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1: Hit Confirmation using MMS Stimulated ELG1. (Class of assay: confirmatory)
|
assay format
|
Homo sapiens
|
ATPase family AAA domain-containing protein 5
|
Homo sapiens
|
SINGLE PROTEIN
|
PubChem BioAssays
| ||||||
| 7. |
Harmine HCl
|
Inhibition
|
=
|
12.05
|
---
|
%
|
---
|
---
|
Inhibition of horse BChE at 2 mg/ml by Ellman's method
|
single protein format
|
Equus caballus
|
Cholinesterase
|
Equus caballus
|
SINGLE PROTEIN
|
Scientific Literature
| ||||||
| 8. |
SID56463102
|
Potency
|
---
|
580.2
|
---
|
nM
|
---
|
inactive
|
PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143]
|
assay format
|
Homo sapiens
|
ATPase family AAA domain-containing protein 5
|
Homo sapiens
|
SINGLE PROTEIN
|
PubChem BioAssays
| ||||||
| 9. |
SID56463102
|
Potency
|
---
|
9200.0
|
---
|
nM
|
---
|
inconclusive
|
PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485345, AID485355]
|
assay format
|
---
|
Unchecked
|
---
|
UNCHECKED
|
PubChem BioAssays
| ||||||
| 10. |
SID56463102
|
EC50
|
=
|
45344.0
|
---
|
nM
|
4.34
|
inactive
|
PubChem BioAssay. Counterscreen for activators of kallikrein-7 (K7) zymogen: Fluorescence intensity-based biochemical high throughput dose reponse assay for activators that optically interfere with measurement of EDANS-DABCYL fluorescence. (Class of assay: confirmatory)
|
assay format
|
---
|
Unchecked
|
---
|
UNCHECKED
|
PubChem BioAssays
| ||||||
| 11. |
SID56463102
|
Potency
|
=
|
73.1
|
---
|
nM
|
7.14
|
Inconclusive
|
PUBCHEM_BIOASSAY: qHTS Assay for Lipid Storage Modulators in Drosophila S3 Cells. (Class of assay: confirmatory)
|
assay format
|
Drosophila
|
Unchecked
|
---
|
UNCHECKED
|
PubChem BioAssays
| ||||||
| 12. |
SID56463102
|
EC50
|
=
|
24845.0
|
---
|
nM
|
4.61
|
inactive
|
PubChem BioAssay. Fluorescence Intensity-based biochemical primary high throughput dose response assay to identify activators of kallikrein-7 (K7) zymogen. (Class of assay: confirmatory)
|
single protein format
|
---
|
Kallikrein 7
|
Homo sapiens
|
SINGLE PROTEIN
|
PubChem BioAssays
| ||||||
| 13. |
SID56463102
|
Potency
|
---
|
2059.6
|
---
|
nM
|
---
|
inactive
|
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262]
|
assay format
|
---
|
GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1
|
Homo sapiens
|
PROTEIN COMPLEX
|
PubChem BioAssays
| ||||||
| 14. |
SID56463102
|
Potency
|
---
|
3264.3
|
---
|
nM
|
---
|
active
|
PubChem BioAssay. qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT. (Class of assay: confirmatory)
|
assay format
|
---
|
Tyrosyl-DNA phosphodiesterase 1
|
Homo sapiens
|
SINGLE PROTEIN
|
PubChem BioAssays
| ||||||
| 15. |
SID56463102
|
Potency
|
---
|
31622.8
|
---
|
nM
|
---
|
inconclusive
|
PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory)
|
assay format
|
Bacillus subtilis
|
ATP-dependent Clp protease proteolytic subunit
|
Bacillus subtilis (strain 168)
|
SINGLE PROTEIN
|
PubChem BioAssays
| ||||||
| 16. |
SID56463102
|
Potency
|
---
|
79432.8
|
---
|
nM
|
---
|
inactive
|
PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771]
|
assay format
|
---
|
Thioredoxin reductase 1, cytoplasmic
|
Rattus norvegicus
|
SINGLE PROTEIN
|
PubChem BioAssays
| ||||||
| 17. |
SID56463102
|
Potency
|
---
|
3981.1
|
---
|
nM
|
---
|
inconclusive
|
PUBCHEM_BIOASSAY: qHTS for Inhibitors of Cell Surface uPA Generation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493178]
|
assay format
|
---
|
Unchecked
|
---
|
UNCHECKED
|
PubChem BioAssays
| ||||||
| 18. |
SID56463102
|
Potency
|
---
|
3162.3
|
---
|
nM
|
---
|
inconclusive
|
PubChem BioAssay. qHTS Assay for Inhibitors of Hepatitis C Virus (HCV). (Class of assay: confirmatory)
|
assay format
|
---
|
Unchecked
|
---
|
UNCHECKED
|
PubChem BioAssays
| ||||||
| 19. |
SID56463102
|
IC50
|
---
|
79000.0
|
---
|
nM
|
---
|
inactive
|
PubChem BioAssay. Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a TNFa-induced IL8 counterscreen. (Class of assay: confirmatory)
|
assay format
|
Homo sapiens
|
Interleukin-8
|
Homo sapiens
|
SINGLE PROTEIN
|
PubChem BioAssays
| ||||||
| 20. |
SID56463102
|
Potency
|
---
|
4610.9
|
---
|
nM
|
---
|
inconclusive
|
PubChem BioAssay. qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT. (Class of assay: confirmatory)
|
assay format
|
---
|
Tyrosyl-DNA phosphodiesterase 1
|
Homo sapiens
|
SINGLE PROTEIN
|
PubChem BioAssays
|
Showing 1-20
out of 827 records
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