Activities
835 items
You are exploring a subset of activities:
Activities related to compound CHEMBL269538 (HARMINE) and its 2 alternative forms.
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Showing 1-20
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| # | Molecule ChEMBL ID | Compound Key | Standard Type | Standard Relation | Standard Value | Standard Text Value | Standard Units | pChEMBL Value | Comment | Assay ChEMBL ID | Assay Description | BAO Label | Assay Organism | Target ChEMBL ID | Target Name | Target Organism | Target Type | Document ChEMBL ID | Source Description | Cell ChEMBL ID | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. |
harmine hydrochloride hydrate
|
Activity
|
---
|
---
|
---
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---
|
---
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Toxic
|
Genotoxicity in CHO cells assessed as mitotic inhibition at 5 ppm after 60 mins in dark followed by 5 W/m'2 UV irradiation for 30 mins
|
cell-based format
|
Cricetulus griseus
|
CHO
|
Cricetulus griseus
|
CELL-LINE
|
Scientific Literature
| ||||||
| 2. |
harmine hydrochloride hydrate
|
Activity
|
=
|
0.0
|
---
|
%
|
---
|
---
|
Genotoxicity in CHO cells assessed as chromosomal aberrations at 10 ppm after 90 mins in dark
|
cell-based format
|
Cricetulus griseus
|
CHO
|
Cricetulus griseus
|
CELL-LINE
|
Scientific Literature
| ||||||
| 3. |
harmine hydrochloride hydrate
|
Activity
|
=
|
21.7
|
---
|
%
|
---
|
---
|
Genotoxicity in CHO cells assessed as chromosomal aberrations at 0.62 ppm after 60 mins in dark followed by 5 W/m'2 UV irradiation for 30 mins
|
cell-based format
|
Cricetulus griseus
|
CHO
|
Cricetulus griseus
|
CELL-LINE
|
Scientific Literature
| ||||||
| 4. |
harmine hydrochloride hydrate
|
Activity
|
=
|
2.4
|
---
|
%
|
---
|
---
|
Genotoxicity in CHO cells assessed as chromosomal aberrations at 0.15 ppm after 60 mins in dark followed by 5 W/m'2 UV irradiation for 30 mins
|
cell-based format
|
Cricetulus griseus
|
CHO
|
Cricetulus griseus
|
CELL-LINE
|
Scientific Literature
| ||||||
| 5. |
SID56463102
|
Potency
|
---
|
18356.4
|
---
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nM
|
---
|
Active
|
PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]
|
assay format
|
Homo sapiens
|
Nuclear factor erythroid 2-related factor 2
|
Homo sapiens
|
SINGLE PROTEIN
|
PubChem BioAssays
| ||||||
| 6. |
harmine hydrochloride hydrate
|
Activity
|
---
|
---
|
---
|
---
|
---
|
Toxic
|
Genotoxicity in CHO cells assessed as chromosomal aberrations at 10 ppm after 60 mins in dark followed by 5 W/m'2 UV irradiation for 30 mins
|
cell-based format
|
Cricetulus griseus
|
CHO
|
Cricetulus griseus
|
CELL-LINE
|
Scientific Literature
| ||||||
| 7. |
harmine hydrochloride hydrate
|
Activity
|
=
|
7.5
|
---
|
%
|
---
|
---
|
Genotoxicity in CHO cells assessed as chromosomal aberrations at 0.31 ppm after 60 mins in dark followed by 5 W/m'2 UV irradiation for 30 mins
|
cell-based format
|
Cricetulus griseus
|
CHO
|
Cricetulus griseus
|
CELL-LINE
|
Scientific Literature
| ||||||
| 8. |
harmine hydrochloride hydrate
|
Activity
|
---
|
---
|
---
|
---
|
---
|
Toxic
|
Genotoxicity in CHO cells assessed as chromosomal aberrations at 1.25 ppm after 60 mins in dark followed by 5 W/m'2 UV irradiation for 30 mins
|
cell-based format
|
Cricetulus griseus
|
CHO
|
Cricetulus griseus
|
CELL-LINE
|
Scientific Literature
| ||||||
| 9. |
harmine hydrochloride hydrate
|
Activity
|
---
|
---
|
---
|
---
|
---
|
Toxic
|
Genotoxicity in CHO cells assessed as chromosomal aberrations at 2.5 ppm after 60 mins in dark followed by 5 W/m'2 UV irradiation for 30 mins
|
cell-based format
|
Cricetulus griseus
|
CHO
|
Cricetulus griseus
|
CELL-LINE
|
Scientific Literature
| ||||||
| 10. |
SID56463102
|
Potency
|
---
|
50118.7
|
---
|
nM
|
---
|
inconclusive
|
PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813]
|
assay format
|
---
|
Flap endonuclease 1
|
Homo sapiens
|
SINGLE PROTEIN
|
PubChem BioAssays
| ||||||
| 11. |
SID56463102
|
AC50
|
---
|
14390.0
|
---
|
nM
|
---
|
active
|
PubChem BioAssay. Identification of Inhibitors of RAD54 Measured in Biochemical System Using Plate Reader - 2159-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory)
|
biochemical format
|
Homo sapiens
|
DNA repair and recombination protein RAD54-like
|
Homo sapiens
|
SINGLE PROTEIN
|
PubChem BioAssays
| ||||||
| 12. |
Harmine HCl
|
Inhibition
|
=
|
50.86
|
---
|
%
|
---
|
---
|
Inhibition of electric eel AChE at 2 mg/ml by Ellman's method
|
single protein format
|
Electrophorus electricus
|
Acetylcholinesterase
|
Electrophorus electricus
|
SINGLE PROTEIN
|
Scientific Literature
| ||||||
| 13. |
SID56463102
|
Potency
|
---
|
35338.3
|
---
|
nM
|
---
|
inconclusive
|
PubChem BioAssay. qHTS screen for small molecules that inhibit ELG1-dependent DNA repair: Hit Confirmation with MMS Viability. (Class of assay: confirmatory)
|
assay format
|
Homo sapiens
|
ATPase family AAA domain-containing protein 5
|
Homo sapiens
|
SINGLE PROTEIN
|
PubChem BioAssays
| ||||||
| 14. |
SID56463102
|
Potency
|
---
|
11174.9
|
---
|
nM
|
---
|
active
|
PubChem BioAssay. qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1: Hit Confirmation using MMS Stimulated ELG1. (Class of assay: confirmatory)
|
assay format
|
Homo sapiens
|
ATPase family AAA domain-containing protein 5
|
Homo sapiens
|
SINGLE PROTEIN
|
PubChem BioAssays
| ||||||
| 15. |
Harmine HCl
|
Inhibition
|
=
|
12.05
|
---
|
%
|
---
|
---
|
Inhibition of horse BChE at 2 mg/ml by Ellman's method
|
single protein format
|
Equus caballus
|
Cholinesterase
|
Equus caballus
|
SINGLE PROTEIN
|
Scientific Literature
| ||||||
| 16. |
SID56463102
|
Potency
|
---
|
580.2
|
---
|
nM
|
---
|
inactive
|
PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143]
|
assay format
|
Homo sapiens
|
ATPase family AAA domain-containing protein 5
|
Homo sapiens
|
SINGLE PROTEIN
|
PubChem BioAssays
| ||||||
| 17. |
SID56463102
|
Potency
|
---
|
9200.0
|
---
|
nM
|
---
|
inconclusive
|
PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485345, AID485355]
|
assay format
|
---
|
Unchecked
|
---
|
UNCHECKED
|
PubChem BioAssays
| ||||||
| 18. |
SID56463102
|
EC50
|
=
|
45344.0
|
---
|
nM
|
4.34
|
inactive
|
PubChem BioAssay. Counterscreen for activators of kallikrein-7 (K7) zymogen: Fluorescence intensity-based biochemical high throughput dose reponse assay for activators that optically interfere with measurement of EDANS-DABCYL fluorescence. (Class of assay: confirmatory)
|
assay format
|
---
|
Unchecked
|
---
|
UNCHECKED
|
PubChem BioAssays
| ||||||
| 19. |
SID56463102
|
Potency
|
=
|
73.1
|
---
|
nM
|
7.14
|
Inconclusive
|
PUBCHEM_BIOASSAY: qHTS Assay for Lipid Storage Modulators in Drosophila S3 Cells. (Class of assay: confirmatory)
|
assay format
|
Drosophila
|
Unchecked
|
---
|
UNCHECKED
|
PubChem BioAssays
| ||||||
| 20. |
SID56463102
|
EC50
|
=
|
24845.0
|
---
|
nM
|
4.61
|
inactive
|
PubChem BioAssay. Fluorescence Intensity-based biochemical primary high throughput dose response assay to identify activators of kallikrein-7 (K7) zymogen. (Class of assay: confirmatory)
|
single protein format
|
---
|
Kallikrein 7
|
Homo sapiens
|
SINGLE PROTEIN
|
PubChem BioAssays
|
Showing 1-20
out of 835 records
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