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Showing 1-20 out of 202 records

#	Molecule ChEMBL ID	Compound Key	Standard Type	Standard Relation	Standard Value	Standard Text Value	Standard Units	pChEMBL Value	Comment	Assay ChEMBL ID	Assay Description	BAO Label	Assay Organism	Target ChEMBL ID	Target Name	Target Organism	Target Type	Document ChEMBL ID	Source Description	Cell ChEMBL ID
1.	Error: . CHEMBL27266	1	Ki	=	135.6	---	nM	6.87	---	CHEMBL768244	Inhibition of [3H]phorbol-12,13-dibutyrate (PDBu) binding to Protein kinase C beta C1b domain	single protein format	---	CHEMBL2996	Protein kinase C delta	Homo sapiens	SINGLE PROTEIN	CHEMBL1134226	Scientific Literature	---
2.	Error: . CHEMBL27266	1	Activity	=	28.9	---	%	---	---	CHEMBL688592	Tested for epstein barr virus early antigen (EBV-EA) inducing activity in differentiated HL-60 cells at 10e-5 M	cell-based format	Homo sapiens	CHEMBL383	HL-60	Homo sapiens	CELL-LINE	CHEMBL1134226	Scientific Literature	CHEMBL3307654
3.	Error: . CHEMBL27266	SID174007218	Potency	---	6.0	---	nM	---	inactive	CHEMBL3215086	PubChem BioAssay. qHTS profiling for inhibitors of Plasmodium falciparum (HB3) proliferation. (Class of assay: confirmatory)	assay format	---	CHEMBL3879801	NON-PROTEIN TARGET	---	NON-MOLECULAR	CHEMBL1201862	PubChem BioAssays	---
4.	Error: . CHEMBL27266	Indolactam-V	Ki	=	2.01	---	nM	8.70	---	CHEMBL769094	Binding of Indolactam-V(ILV) to wild-type Protein kinase C delta C1b domain	single protein format	Mus musculus	CHEMBL2560	Protein kinase C delta	Mus musculus	SINGLE PROTEIN	CHEMBL1132277	Scientific Literature	---
5.	Error: . CHEMBL27266	3, ILV	Activity	---	---	---	---	---	Active	CHEMBL1227732	Induction of human HUES8 cell differentiation into pancreatic progenitor cell assessed as increase in SOX9 mRNA expression at 300 nM after 4 days by RT-PCR analysis cells pregrown in medium containing Wnt, activin, FGF10, KAAD-cyclopamine and retinoic acid	cell-based format	Homo sapiens	CHEMBL612545	Unchecked	---	UNCHECKED	CHEMBL1221225	Scientific Literature	---
6.	Error: . CHEMBL27266	3, ILV	Activity	---	---	---	---	---	Not Active	CHEMBL1227943	Induction of SOX1 expression in CD1 nude mouse ectoderm at 300 nM after 4 days by fluorescent confocal microscopy	tissue-based format	Mus musculus	CHEMBL612545	Unchecked	---	UNCHECKED	CHEMBL1221225	Scientific Literature	---
7.	Error: . CHEMBL27266	3, ILV	Activity	=	50.0	---	%	---	---	CHEMBL1227751	Induction of mouse AV3 cell differentiation into pancreatic lineage assessed as increase in Pdx-1 expression at 300 nM after 6 days by immunohistochemistry pretreated with 1000 ng/ml recombinant mouse Nodal for 5 days (Rvb = 4.0+/-1.5%)	cell-based format	Mus musculus	CHEMBL612545	Unchecked	---	UNCHECKED	CHEMBL1221225	Scientific Literature	---
8.	Error: . CHEMBL27266	3, ILV	Activity	---	---	---	---	---	Active	CHEMBL1227752	Induction of mouse AV3 Pdx1-expressing cell differentiation assessed as increase in SOX9 expression at 300 nM after 6 days by immunohistochemistry pretreated with 1000 ng/ml recombinant mouse Nodal for 5 days	assay format	Mus musculus	CHEMBL612545	Unchecked	---	UNCHECKED	CHEMBL1221225	Scientific Literature	---
9.	Error: . CHEMBL27266	3, ILV	Inhibition	=	1.2	---	%	---	---	CHEMBL1227925	Inhibition of PKC signaling in human HUES8 cells assessed as decrease in Pdx1-expressing cells at 4 uM after 4 days by immunocytochemistry in presence of ILV pregrown in medium with Wnt3a, activin A, FGF10, KAAD-cyclopamine and retinoic acid (Rvb = 26.9+/-2.8%)	cell-based format	Homo sapiens	CHEMBL612546	Molecular identity unknown	---	UNKNOWN	CHEMBL1221225	Scientific Literature	---
10.	Error: . CHEMBL27266	(-)-Indolactam-V (1)	Ki	=	126.9	---	nM	6.90	---	CHEMBL762310	Displacement of [3H]- PDBu from Protein kinase C alpha C1a domain	single protein format	---	CHEMBL299	Protein kinase C alpha	Homo sapiens	SINGLE PROTEIN	CHEMBL1133311	Scientific Literature	---
11.	Error: . CHEMBL27266	ILV	Ki	=	6.1	---	nM	8.21	---	CHEMBL761753	Displacement of [3H]- PDBu from recombinant PKC beta expressed in baculovirus	assay format	---	CHEMBL3045	Protein kinase C beta	Homo sapiens	SINGLE PROTEIN	CHEMBL1129999	Scientific Literature	---
12.	Error: . CHEMBL27266	3 (ILV)	Ki	=	66.2	---	nM	7.18	---	CHEMBL759075	Displacement of [3H]PDBu from protein kinase C delta C1b domain mutant (L20G)	single protein format	Mus musculus	CHEMBL2560	Protein kinase C delta	Mus musculus	SINGLE PROTEIN	CHEMBL1134767	Scientific Literature	---
13.	Error: . CHEMBL27266	Indolactam-V	Ratio	=	552.0	---	---	---	---	CHEMBL769095	Ratio of binding to PKC delta C1b domain wild type and mutant (Gln27 to Val)	single protein format	Mus musculus	CHEMBL2560	Protein kinase C delta	Mus musculus	SINGLE PROTEIN	CHEMBL1132277	Scientific Literature	---
14.	Error: . CHEMBL27266	3, ILV	Activity	=	91.3	---	%	---	---	CHEMBL1227561	Induction of human HUES8 cell differentiation into pancreatic progenitor cell assessed as HNF6 expression in cells pregrown in medium containing Wnt, activin, FGF10, KAAD-cyclopamine and retinoic acid at 300 nM after 4 days by immunocytochemistry relative to control	cell-based format	Homo sapiens	CHEMBL612545	Unchecked	---	UNCHECKED	CHEMBL1221225	Scientific Literature	---
15.	Error: . CHEMBL27266	3, ILV	Activity	---	---	---	---	---	Active	CHEMBL1227918	Induction of mouse AV3 cell differentiation into pancreatic lineage assessed as increase in Nkx2.2 mRNA expression at 300 nM after 6 days by RT-PCR analysis pretreated with 1000 ng/ml recombinant mouse Nodal for 5 days	cell-based format	Mus musculus	CHEMBL612545	Unchecked	---	UNCHECKED	CHEMBL1221225	Scientific Literature	---
16.	Error: . CHEMBL27266	(-)-Indolactam-V (ILV)	Ki	=	11.0	---	nM	7.96	---	CHEMBL769615	Displacement of phorbol 12,13-dibutyrate (PDBU) from recombinant Protein kinase C alpha	single protein format	---	CHEMBL299	Protein kinase C alpha	Homo sapiens	SINGLE PROTEIN	CHEMBL1131708	Scientific Literature	---
17.	Error: . CHEMBL27266	Indolactum V (ILV)	Ki	=	10.96	---	nM	7.96	---	CHEMBL769613	Displacement of [3H]PDBu from PKC alpha expressed in Sf9 cells	cell-based format	---	CHEMBL299	Protein kinase C alpha	Homo sapiens	SINGLE PROTEIN	CHEMBL1127255	Scientific Literature	CHEMBL3308860
18.	Error: . CHEMBL27266	1	Ratio	=	2.64	---	---	---	---	CHEMBL926299	Induction of GFP-tagged PKCeta translocation in HeLa cells assessed as ratio of protein level in plasma membrane to cytosol at 1 uM	cell-based format	---	CHEMBL3616	Protein kinase C eta	Homo sapiens	SINGLE PROTEIN	CHEMBL1140701	Scientific Literature	CHEMBL3308376
19.	Error: . CHEMBL27266	1	Activity	---	---	---	---	---	Active	CHEMBL5125797	Inhibition of GLI in mouse NIH/3T3 cells assessed as reduction in CMV-driven firefly luciferase activity in starvation medium at 100 nM incubated for 30 hrs by Bright-Glo luciferase assay	cell-based format	Mus musculus	CHEMBL612545	Unchecked	---	UNCHECKED	CHEMBL5120940	Scientific Literature	---
20.	Error: . CHEMBL27266	1	Ki	=	89.0	---	nM	7.05	---	CHEMBL927261	Displacement of [3H]PDBu from PKCgamma C1A domain	single protein format	---	CHEMBL2938	Protein kinase C gamma	Homo sapiens	SINGLE PROTEIN	CHEMBL1140701	Scientific Literature	---

Showing 1-20 out of 202 records

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