Activities

15 items

Tools
Filters
Custom
Per Property
4
AUC
2
Fu
1
CL
1
F
1
IC50
1
K(p,uu,CSF)
1
K(p,uu,brain)
1
Papp
1
Ratio
1
T1/2
1
Other
5
ORGANISM
5
TISSUE
4
ADMET
1
SINGLE PROTEIN
11
Eukaryotes
4
N/A
11
Mammalia
4
N/A
10
Rodentia
4
N/A
1
Primates
10
Rattus norvegicus
4
N/A
1
Homo sapiens
10
organism-based format
3
cell-based format
2
tissue-based format
14
N/A
1
[8,8.16]
15
Preclinical
0
N/A
15
0
0
N/A
15
[4,4.31]
0
N/A
15
[459,459.91]
15
Scientific Literature
Showing 1-15 out of 15 records
#Molecule ChEMBL IDCompound KeyStandard TypeStandard RelationStandard ValueStandard Text ValueStandard UnitspChEMBL ValueCommentAssay ChEMBL IDAssay DescriptionBAO LabelAssay OrganismTarget ChEMBL IDTarget NameTarget OrganismTarget TypeDocument ChEMBL IDSource DescriptionCell ChEMBL ID
1.
1n
Vdss
=
2.7
---
L.kg-1
---
---
Volume of distribution at steady state in Han Wistar rat at 1 mg/kg, iv
organism-based format
Rattus norvegicus
Rattus norvegicus
Rattus norvegicus
ORGANISM
Scientific Literature
2.
1n
AUC
=
1355.81
---
ng.hr.mL-1
---
standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW
AUC(0 to 24 hrs) in Han Wistar rat at 2 mg/kg, po
organism-based format
Rattus norvegicus
Rattus norvegicus
Rattus norvegicus
ORGANISM
Scientific Literature
3.
1n
AUC
=
889.93
---
ng.hr.mL-1
---
standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW
AUC (0 to 7 hrs) in Han Wistar rat brain at 2 mg/kg, po by LC-MS/MS analysis
organism-based format
Rattus norvegicus
Brain
Rattus norvegicus
TISSUE
Scientific Literature
4.
1n
K(p,uu,brain)
=
1.6
---
---
---
---
Ratio of unbound AUC (0 to 7 hrs) in brain to blood of Han Wistar rat at 2 mg/kg, po by LC-MS/MS analysis
organism-based format
Rattus norvegicus
ADMET
---
ADMET
Scientific Literature
5.
1n
IC50
=
6.9
---
nM
8.16
---
Inhibition of EGFR L858R mutant phosphorylation in human H3255 cells
cell-based format
Homo sapiens
Epidermal growth factor receptor erbB1
Homo sapiens
SINGLE PROTEIN
Scientific Literature
6.
1n
F
=
83.0
---
%
---
---
Oral bioavailability in Han Wistar rat at 2 mg/kg
organism-based format
Rattus norvegicus
Rattus norvegicus
Rattus norvegicus
ORGANISM
Scientific Literature
7.
1n
Ratio
=
0.92
---
---
---
---
Efflux ratio of permeability from basolateral to apical side over apical to basolateral side in MDCK2-MDR1 cells
cell-based format
Canis lupus familiaris
ADMET
---
ADMET
Scientific Literature
8.
1n
AUC
=
370.23
---
ng.hr.mL-1
---
standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW
AUC (0 to 7 hrs) in Han Wistar rat blood at 2 mg/kg, po by LC-MS/MS analysis
organism-based format
Rattus norvegicus
Blood
Rattus norvegicus
TISSUE
Scientific Literature
9.
1n
Fu
=
0.023
---
---
---
---
Fraction unbound in Han Wistar rat blood at 5 uM by equilibrium dialysis method
tissue-based format
Rattus norvegicus
Blood
Rattus norvegicus
TISSUE
Scientific Literature
10.
1n
Fu
=
0.015
---
---
---
---
Fraction unbound in Han Wistar rat brain at 5 uM by equilibrium dialysis method
tissue-based format
Rattus norvegicus
Brain
Rattus norvegicus
TISSUE
Scientific Literature
11.
1n
T1/2
=
2.4
---
hr
---
---
Elimination half life in Han Wistar rat at 1 mg/kg, iv
organism-based format
Rattus norvegicus
Rattus norvegicus
Rattus norvegicus
ORGANISM
Scientific Literature
12.
1n
CL
=
29.0
---
mL.min-1.kg-1
---
---
Clearance in Han Wistar rat at 1 mg/kg, iv
organism-based format
Rattus norvegicus
Rattus norvegicus
Rattus norvegicus
ORGANISM
Scientific Literature
13.
1n
Papp
=
51.0
---
10'-6 cm/s
---
---
Permeability from apical to basolateral side in MDCK2-MDR1 cells
cell-based format
Canis lupus familiaris
ADMET
---
ADMET
Scientific Literature
14.
1n
AUC
=
22.08
---
ng.hr.mL-1
---
standard_value was converted from uM.hr to ng.hr.mL-1 using the parent compound MW
AUC (0 to 7 hrs) in Han Wistar rat CSF at 2 mg/kg, po by LC-MS/MS analysis
organism-based format
Rattus norvegicus
Cerebrospinal fluid
Rattus norvegicus
TISSUE
Scientific Literature
15.
1n
K(p,uu,CSF)
=
2.6
---
---
---
---
Ratio of unbound AUC (0 to 7 hrs) in CSF to blood of Han Wistar rat at 2 mg/kg, po by LC-MS/MS analysis
organism-based format
Rattus norvegicus
ADMET
---
ADMET
Scientific Literature
Showing 1-15 out of 15 records
Global Bio Data logo
ChEMBL is part of the ELIXIR infrastructure
ChEMBL is and Elixir Core Data Resource Learn More
Global Bio Data logo
ChEMBL is a Global Core Biodata Resource