Activities

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Activities related to compound CHEMBL55830 (TRYPTOPHAN METHYL ESTER) and its 1 alternative forms.

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Showing 1-20 out of 34 records

#	Molecule ChEMBL ID	Compound Key	Standard Type	Standard Relation	Standard Value	Standard Text Value	Standard Units	pChEMBL Value	Comment	Assay ChEMBL ID	Assay Description	BAO Label	Assay Organism	Target ChEMBL ID	Target Name	Target Organism	Target Type	Document ChEMBL ID	Source Description	Cell ChEMBL ID
1.	Error: . CHEMBL1222005	H-Trp-OMe HCl	Inhibition	<	15.0	---	%	---	---	CHEMBL1228071	Inhibition of nitrogen-starved wild type sigma1278b yeast Gap1-mediated amino acid uptake at 5 mM after 60 secs relative to L-citrulline	single protein format	Saccharomyces cerevisiae	CHEMBL3308953	General amino-acid permease GAP1	Saccharomyces cerevisiae	SINGLE PROTEIN	CHEMBL1221220	Scientific Literature	---
2.	Error: . CHEMBL55830	10	Activity	---	---	---	---	---	Not Active	CHEMBL1285721	Antioxidant activity assessed as superoxide radical scavenging activity by NBT reduction assay	assay format	---	CHEMBL3879801	NON-PROTEIN TARGET	---	NON-MOLECULAR	CHEMBL1275270	Scientific Literature	---
3.	Error: . CHEMBL55830	10	IC50	=	13100.0	---	nM	4.88	---	CHEMBL1285728	Antioxidant activity assessed as inhibition of peroxynitrite anion-induced oxidation of non-fluorescent DHR by rhodamine 123 staining in presence of NaHCO3	assay format	---	CHEMBL3879801	NON-PROTEIN TARGET	---	NON-MOLECULAR	CHEMBL1275270	Scientific Literature	---
4.	Error: . CHEMBL55830	22	IC50	=	1421000.0	---	nM	---	---	CHEMBL1211499	Antileishmanial activity against Leishmania donovani amastigotes after 48 hrs by MTT assay	organism-based format	Leishmania donovani	CHEMBL367	Leishmania donovani	Leishmania donovani	ORGANISM	CHEMBL1208686	Scientific Literature	---
5.	Error: . CHEMBL55830	6	Ratio IC50	=	3.6	---	---	---	---	CHEMBL3619818	Ratio of IC50 for NMDA receptor in Wistar rat brain membranes in presence of 50 mM K+ to IC50 for NMDA receptor in Wistar rat brain membranes in absence of 50 mM K+	cell membrane format	Rattus norvegicus	CHEMBL1907608	Glutamate NMDA receptor	Rattus norvegicus	PROTEIN COMPLEX GROUP	CHEMBL3616463	Scientific Literature	---
6.	Error: . CHEMBL55830	6	log(RatioIC50)	=	1.18	---	---	---	---	CHEMBL3619814	Ratio of IC50 for NMDA receptor in Wistar rat brain membranes in presence of 30 uM spermine to IC50 for NMDA receptor in Wistar rat brain membranes in absence of 30 uM spermine	cell membrane format	Rattus norvegicus	CHEMBL1907608	Glutamate NMDA receptor	Rattus norvegicus	PROTEIN COMPLEX GROUP	CHEMBL3616463	Scientific Literature	---
7.	Error: . CHEMBL55830	77	LogP	=	1.06	---	---	---	---	CHEMBL636806	Partition coefficient (logP)	small-molecule physicochemical format	---	CHEMBL2362975	No relevant target	---	NO TARGET	CHEMBL1123622	Scientific Literature	---
8.	Error: . CHEMBL55830	6	log(RatioIC50)	=	0.2	---	---	---	---	CHEMBL3619815	Ratio of IC50 for NMDA receptor in Wistar rat brain membranes in presence of 10 to 50 mM Tris to IC50 for NMDA receptor in Wistar rat brain membranes in absence of 10 to 50 mM Tris	cell membrane format	Rattus norvegicus	CHEMBL1907608	Glutamate NMDA receptor	Rattus norvegicus	PROTEIN COMPLEX GROUP	CHEMBL3616463	Scientific Literature	---
9.	Error: . CHEMBL55830	10	IC50	---	---	---	---	---	Not Active	CHEMBL1285726	Antioxidant activity assessed as inhibition of nitric oxide-induced oxidation of non-fluorescent DAF-2 by fluorescence assay	assay format	---	CHEMBL2362975	No relevant target	---	NO TARGET	CHEMBL1275270	Scientific Literature	---
10.	Error: . CHEMBL55830	10	IC50	=	47800.0	---	nM	4.32	---	CHEMBL1285727	Antioxidant activity assessed as inhibition of peroxynitrite anion-induced oxidation of non-fluorescent DHR by rhodamine 123 staining in absence of NaHCO3	assay format	---	CHEMBL3879801	NON-PROTEIN TARGET	---	NON-MOLECULAR	CHEMBL1275270	Scientific Literature	---
11.	Error: . CHEMBL55830	6	log(RatioIC50)	=	0.15	---	---	---	---	CHEMBL3619819	Ratio of IC50 for NMDA receptor in Wistar rat brain membranes in presence of 20 mM NH4+ to IC50 for NMDA receptor in Wistar rat brain membranes in absence of 20 mM NH4+	cell membrane format	Rattus norvegicus	CHEMBL1907608	Glutamate NMDA receptor	Rattus norvegicus	PROTEIN COMPLEX GROUP	CHEMBL3616463	Scientific Literature	---
12.	Error: . CHEMBL55830	6	Ratio IC50	=	3.72	---	---	---	---	CHEMBL3619817	Ratio of IC50 for NMDA receptor in Wistar rat brain membranes in presence of 3 to 50 mM Na+ to IC50 for NMDA receptor in Wistar rat brain membranes in absence of 3 to 50 mM Na+	cell membrane format	Rattus norvegicus	CHEMBL1907608	Glutamate NMDA receptor	Rattus norvegicus	PROTEIN COMPLEX GROUP	CHEMBL3616463	Scientific Literature	---
13.	Error: . CHEMBL55830	6	Ratio IC50	=	10.1	---	---	---	---	CHEMBL3619814	Ratio of IC50 for NMDA receptor in Wistar rat brain membranes in presence of 30 uM spermine to IC50 for NMDA receptor in Wistar rat brain membranes in absence of 30 uM spermine	cell membrane format	Rattus norvegicus	CHEMBL1907608	Glutamate NMDA receptor	Rattus norvegicus	PROTEIN COMPLEX GROUP	CHEMBL3616463	Scientific Literature	---
14.	Error: . CHEMBL55830	77	Log 1/T	=	2.76	---	---	---	---	CHEMBL848034	Bitter threshold value	assay format	---	CHEMBL612545	Unchecked	---	UNCHECKED	CHEMBL1123622	Scientific Literature	---
15.	Error: . CHEMBL55830	19	Kd	=	570000.0	---	nM	3.24	---	CHEMBL3430212	Binding affinity to RAD51 (unknown origin) by isothermal calorimetry	single protein format	Homo sapiens	CHEMBL2034807	DNA repair protein RAD51 homolog 1	Homo sapiens	SINGLE PROTEIN	CHEMBL3425399	Scientific Literature	---
16.	Error: . CHEMBL55830	6	Ratio IC50	=	8.57	---	---	---	---	CHEMBL3619816	Ratio of IC50 for NMDA receptor in Wistar rat brain membranes in presence of H+ at pH 6.4 to 8.2 to IC50 for NMDA receptor in Wistar rat brain membranes in absence of H+ at pH 6.4 to 8.2	cell membrane format	Rattus norvegicus	CHEMBL1907608	Glutamate NMDA receptor	Rattus norvegicus	PROTEIN COMPLEX GROUP	CHEMBL3616463	Scientific Literature	---
17.	Error: . CHEMBL55830	Tryptophan-methylester	Activity	---	---	---	---	---	is not an inhibitor [-]	CHEMBL2076200	TP_TRANSPORTER: inhibition of L-tryptophan uptake in Xenopus laevis oocytes	cell-based format	Xenopus laevis	CHEMBL2073717	Monocarboxylate transporter 10	Rattus norvegicus	SINGLE PROTEIN	CHEMBL2074257	TP-search Transporter Database	CHEMBL3308859
18.	Error: . CHEMBL55830	6	log(RatioIC50)	=	0.93	---	---	---	---	CHEMBL3619816	Ratio of IC50 for NMDA receptor in Wistar rat brain membranes in presence of H+ at pH 6.4 to 8.2 to IC50 for NMDA receptor in Wistar rat brain membranes in absence of H+ at pH 6.4 to 8.2	cell membrane format	Rattus norvegicus	CHEMBL1907608	Glutamate NMDA receptor	Rattus norvegicus	PROTEIN COMPLEX GROUP	CHEMBL3616463	Scientific Literature	---
19.	Error: . CHEMBL55830	6	Ratio IC50	=	1.67	---	---	---	---	CHEMBL3619815	Ratio of IC50 for NMDA receptor in Wistar rat brain membranes in presence of 10 to 50 mM Tris to IC50 for NMDA receptor in Wistar rat brain membranes in absence of 10 to 50 mM Tris	cell membrane format	Rattus norvegicus	CHEMBL1907608	Glutamate NMDA receptor	Rattus norvegicus	PROTEIN COMPLEX GROUP	CHEMBL3616463	Scientific Literature	---
20.	Error: . CHEMBL55830	6	log(RatioIC50)	=	0.99	---	---	---	---	CHEMBL3619820	Ratio of IC50 for NMDA receptor in Wistar rat brain membranes in presence of 1.3 mM Mg2+ to IC50 for NMDA receptor in Wistar rat brain membranes in absence of 1.3 mM Mg2+	cell membrane format	Rattus norvegicus	CHEMBL1907608	Glutamate NMDA receptor	Rattus norvegicus	PROTEIN COMPLEX GROUP	CHEMBL3616463	Scientific Literature	---

Showing 1-20 out of 34 records

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