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Showing 1-20 out of 274 records

#	Molecule ChEMBL ID	Compound Key	Standard Type	Standard Relation	Standard Value	Standard Text Value	Standard Units	pChEMBL Value	Comment	Assay ChEMBL ID	Assay Description	BAO Label	Assay Organism	Target ChEMBL ID	Target Name	Target Organism	Target Type	Document ChEMBL ID	Source Description	Cell ChEMBL ID
1.	Error: . CHEMBL66	SID26719897	Potency	=	19952.6	---	nM	4.70	Active	CHEMBL1613914	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	assay format	Homo sapiens	CHEMBL1293226	Lysine-specific demethylase 4D-like	Homo sapiens	SINGLE PROTEIN	CHEMBL1201862	PubChem BioAssays	---
2.	Error: . CHEMBL66	Taxifolin (Dihydroquercetin)	Inhibition	=	-0.13	---	%	---	---	CHEMBL4513082	Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging	organism-based format	Chlorocebus sabaeus	CHEMBL4303835	SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2	ORGANISM	CHEMBL4495565	SARS-CoV-2 Screening Data	CHEMBL4295411
3.	Error: . CHEMBL66	13	IC50	---	---	---	---	---	Not Determined	CHEMBL2051212	Inhibition of human recombinant MMP1 catalytic domain incubated for 20 mins by fluorimetric assay	single protein format	Homo sapiens	CHEMBL332	Matrix metalloproteinase-1	Homo sapiens	SINGLE PROTEIN	CHEMBL2046344	Scientific Literature	---
4.	Error: . CHEMBL66	SID56463005	Potency	---	631.0	---	nM	---	inconclusive	CHEMBL2114780	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	cell-based format	Homo sapiens	CHEMBL1293278	Geminin	Homo sapiens	SINGLE PROTEIN	CHEMBL1201862	PubChem BioAssays	CHEMBL3307758
5.	Error: . CHEMBL66	SID56463005	Potency	---	79432.8	---	nM	---	active	CHEMBL1794483	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	assay format	---	CHEMBL5391	DNA polymerase iota	Homo sapiens	SINGLE PROTEIN	CHEMBL1201862	PubChem BioAssays	---
6.	Error: . CHEMBL66	20	Activity	=	92.0	---	%	---	---	CHEMBL3742745	Cytotoxicity against human MSC assessed as cell viability at 10 uM treated for 3 days measured on day 4 by alamar blue assay (Rvb = 97 to 100%)	assay format	Homo sapiens	CHEMBL612558	ADMET	---	ADMET	CHEMBL3739259	Scientific Literature	---
7.	Error: . CHEMBL66	56	Activity	---	---	---	---	---	Not Active	CHEMBL1110735	Binding affinity to amyloid beta (1 to 42) oligomers by change in fluorescence at 100 uM after 10 mins	assay format	---	CHEMBL612545	Unchecked	---	UNCHECKED	CHEMBL1156243	Scientific Literature	---
8.	Error: . CHEMBL66	61	IC50	=	300.0	---	ug.mL-1	---	---	CHEMBL941406	Inhibition of p40 tyrosine kinase	assay format	---	CHEMBL612545	Unchecked	---	UNCHECKED	CHEMBL1150213	Scientific Literature	---
9.	Error: . CHEMBL66	10	Ki	=	8500.0	---	nM	5.07	---	CHEMBL4402616	Competitive type inhibition of monophenolase activity of mushroom tyrosinase assessed as reduction in dopachrome formation using L-Tyrosine substrate by UV-Vis spectrophotometry based Dixon plot analysis	single protein format	Agaricus bisporus	CHEMBL3318	Tyrosinase	Agaricus bisporus	SINGLE PROTEIN	CHEMBL4402507	Scientific Literature	---
10.	Error: . CHEMBL66	36	Therapeutic index	=	1.0	---	---	---	---	CHEMBL852431	Therapeutic index was determined	assay format	Human immunodeficiency virus 1	CHEMBL612558	ADMET	---	ADMET	CHEMBL1126373	Scientific Literature	---
11.	Error: . CHEMBL66	13	Inhibition	>	30.0	---	%	---	---	CHEMBL2051221	Inhibition of human recombinant MMP9 catalytic domain at 10 uM incubated for 20 mins by fluorimetric assay	single protein format	Homo sapiens	CHEMBL321	Matrix metalloproteinase 9	Homo sapiens	SINGLE PROTEIN	CHEMBL2046344	Scientific Literature	---
12.	Error: . CHEMBL66	12	Inhibition	=	3.1	---	%	---	---	CHEMBL1068148	Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells at 3 uM after 72 hrs	cell-based format	Mus musculus	CHEMBL612545	Unchecked	---	UNCHECKED	CHEMBL1157646	Scientific Literature	CHEMBL4651378
13.	Error: . CHEMBL66	13	EC50	>	10000.0	---	nM	---	---	CHEMBL1107366	Cytotoxicity against human RPMI8226 cells assessed as viable cells after 72 hrs by calcein AM assay	cell-based format	Homo sapiens	CHEMBL614882	RPMI-8226	Homo sapiens	CELL-LINE	CHEMBL1157078	Scientific Literature	CHEMBL3307732
14.	Error: . CHEMBL66	14	Ratio CC50/IC50	<	1.0	---	---	---	---	CHEMBL979653	Selectivity index, ratio of CC50 for human MT4 cells to IC50 for HIV infected in human MT4 cells	cell-based format	---	CHEMBL612545	Unchecked	---	UNCHECKED	CHEMBL1144064	Scientific Literature	CHEMBL3308375
15.	Error: . CHEMBL66	14	MBC	>	100.0	---	ug ml-1	---	---	CHEMBL979659	Antimicrobial activity against Candida albicans	organism-based format	Candida albicans	CHEMBL366	Candida albicans	Candida albicans	ORGANISM	CHEMBL1144064	Scientific Literature	---
16.	Error: . CHEMBL66	Taxifolin	IC50	=	4000000.0	---	nM	---	---	CHEMBL4703851	Inhibition of quorum sensing system in Pseudomonas aeruginosa PAO1 assessed as reduction in pyocyanin production incubated for 8 hrs	assay format	Pseudomonas aeruginosa PAO1	CHEMBL612545	Unchecked	---	UNCHECKED	CHEMBL4699578	Scientific Literature	---
17.	Error: . CHEMBL66	(2R,3S)-taxifolin	Activity	=	2.84	---	mmolequiv/mmol	---	---	CHEMBL3423600	Antioxidant activity assessed as trolox equivalent of ABTS radical scavenging activity after 10 mins by lipophilic-TEAC fluorescence assay	small-molecule physicochemical format	---	CHEMBL2362975	No relevant target	---	NO TARGET	CHEMBL3421535	Scientific Literature	---
18.	Error: . CHEMBL66	13	Activity	---	---	---	---	---	Not Active	CHEMBL4192092	Antimicrobial activity against Klebsiella pneumoniae ATCC 700603 at 32 ug/ml after 18 hrs	organism-based format	Klebsiella pneumoniae	CHEMBL350	Klebsiella pneumoniae	Klebsiella pneumoniae	ORGANISM	CHEMBL4190246	Scientific Literature	---
19.	Error: . CHEMBL66	Taxifolin	Inhibition	=	67.0	---	%	---	---	CHEMBL4775948	Inhibition of cytochrome c (unknown origin) assessed as reduction in cyt c-CL peroxidase activity at 10 uM up to 20 mins in presence of cardiolipin by Amplex red staining based fluorescence assay relative to control	single protein format	Homo sapiens	CHEMBL2189163	Cytochrome c	Homo sapiens	SINGLE PROTEIN	CHEMBL4765494	Scientific Literature	---
20.	Error: . CHEMBL66	16	ID50	=	270.0	---	ug ml-1	---	---	CHEMBL1015773	Inhibition of bovine thymocytes protein tyrosine kinase assessed as angiotensin 1 phosphorylation	assay format	Bos taurus	CHEMBL612545	Unchecked	---	UNCHECKED	CHEMBL1147305	Scientific Literature	---

Showing 1-20 out of 274 records

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