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Bioactivity data for target CHEMBL2095230 (Serotonin 1 receptors; 5-HT1B & 5-HT1D)
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# | Molecule ChEMBL ID | Compound Key | Standard Type | Standard Relation | Standard Value | Standard Text Value | Standard Units | pChEMBL Value | Comment | Assay ChEMBL ID | Assay Description | BAO Label | Assay Organism | Target ChEMBL ID | Target Name | Target Organism | Target Type | Document ChEMBL ID | Source Description | Cell ChEMBL ID | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1. |
Sumatriptan (1)
|
Selectivity
|
=
|
2.0
|
---
|
---
|
---
|
---
|
Selectivity of compound towards human 5-HT1D receptor over human 5-HT1B receptor
|
protein format
|
---
|
Serotonin 1 receptors; 5-HT1B & 5-HT1D
|
Homo sapiens
|
SELECTIVITY GROUP
|
Scientific Literature
| ||||||
2. |
L-747201 (4)
|
Selectivity
|
=
|
9.0
|
---
|
---
|
---
|
---
|
Selectivity of compound towards human 5-HT1D receptor over human 5-HT1B receptor
|
protein format
|
---
|
Serotonin 1 receptors; 5-HT1B & 5-HT1D
|
Homo sapiens
|
SELECTIVITY GROUP
|
Scientific Literature
| ||||||
3. |
Sumatriptan
|
Ratio
|
=
|
3.2
|
---
|
---
|
---
|
---
|
Relative binding affinity for 5-HT1B and 5-HT1D receptor
|
protein format
|
---
|
Serotonin 1 receptors; 5-HT1B & 5-HT1D
|
Homo sapiens
|
SELECTIVITY GROUP
|
Scientific Literature
| ||||||
4. |
Sumatriptan (1)
|
Selectivity
|
=
|
2.0
|
---
|
---
|
---
|
---
|
Selectivity of compound for human 5-HT1D receptor over human 5-HT1B receptor
|
protein format
|
---
|
Serotonin 1 receptors; 5-HT1B & 5-HT1D
|
Homo sapiens
|
SELECTIVITY GROUP
|
Scientific Literature
| ||||||
5. |
2
|
Selectivity
|
=
|
62.0
|
---
|
---
|
---
|
---
|
Selectivity ratio for h-5-HT 1B receptor to that of h5-HT 1D receptors.
|
protein format
|
---
|
Serotonin 1 receptors; 5-HT1B & 5-HT1D
|
Homo sapiens
|
SELECTIVITY GROUP
|
Scientific Literature
| ||||||
6. |
11d
|
Relative efficacy
|
=
|
68.0
|
---
|
%
|
---
|
---
|
Relative efficacy of compound in stimulation of [35S]GTP gamma-S binding in CHO cells compared to 5-HT
|
cell-based format
|
---
|
Serotonin 1 receptors; 5-HT1B & 5-HT1D
|
Homo sapiens
|
SELECTIVITY GROUP
|
Scientific Literature
| ||||||
7. |
22c
|
Selectivity
|
=
|
82.0
|
---
|
---
|
---
|
---
|
Selectivity of compound for human 5-HT1D receptor over human 5-HT1B receptor
|
protein format
|
---
|
Serotonin 1 receptors; 5-HT1B & 5-HT1D
|
Homo sapiens
|
SELECTIVITY GROUP
|
Scientific Literature
| ||||||
8. |
22c
|
Relative efficacy
|
=
|
87.0
|
---
|
%
|
---
|
---
|
Relative efficacy of compound in stimulation of [35S]GTP gamma-S binding in CHO cells compared to 5-HT
|
cell-based format
|
---
|
Serotonin 1 receptors; 5-HT1B & 5-HT1D
|
Homo sapiens
|
SELECTIVITY GROUP
|
Scientific Literature
| ||||||
9. |
8
|
Selectivity
|
=
|
120.0
|
---
|
---
|
---
|
---
|
Relative binding to serotonin 5-HT 1B and 5-HT 1D receptors
|
protein format
|
---
|
Serotonin 1 receptors; 5-HT1B & 5-HT1D
|
Homo sapiens
|
SELECTIVITY GROUP
|
Scientific Literature
| ||||||
10. |
15
|
Selectivity
|
=
|
1.0
|
---
|
---
|
---
|
---
|
Selectivity of compound towards human 5-HT1D receptor over human 5-HT1B receptor
|
protein format
|
---
|
Serotonin 1 receptors; 5-HT1B & 5-HT1D
|
Homo sapiens
|
SELECTIVITY GROUP
|
Scientific Literature
| ||||||
11. |
3
|
Selectivity
|
=
|
40.0
|
---
|
---
|
---
|
---
|
Selectivity for human 5-hydroxytryptamine 1D receptor over 5-hydroxytryptamine 1B receptor
|
protein format
|
Homo sapiens
|
Serotonin 1 receptors; 5-HT1B & 5-HT1D
|
Homo sapiens
|
SELECTIVITY GROUP
|
Scientific Literature
| ||||||
12. |
5
|
Selectivity
|
=
|
67.0
|
---
|
---
|
---
|
---
|
Selectivity towards 5-HT1D and to that of 5-HT1B in CHO cells
|
cell-based format
|
---
|
Serotonin 1 receptors; 5-HT1B & 5-HT1D
|
Homo sapiens
|
SELECTIVITY GROUP
|
Scientific Literature
| ||||||
13. |
5
|
Selectivity
|
=
|
40.0
|
---
|
---
|
---
|
---
|
Relative binding to serotonin 5-HT1D and 5-HT1B receptors
|
protein format
|
---
|
Serotonin 1 receptors; 5-HT1B & 5-HT1D
|
Homo sapiens
|
SELECTIVITY GROUP
|
Scientific Literature
| ||||||
14. |
3c
|
Selectivity
|
=
|
3.0
|
---
|
---
|
---
|
---
|
Selectivity of compound for human 5-HT1D receptor over human 5-HT1B receptor
|
protein format
|
---
|
Serotonin 1 receptors; 5-HT1B & 5-HT1D
|
Homo sapiens
|
SELECTIVITY GROUP
|
Scientific Literature
| ||||||
15. |
11d
|
Selectivity
|
=
|
37.0
|
---
|
---
|
---
|
---
|
Selectivity of compound for human 5-HT1D receptor over human 5-HT1B receptor
|
protein format
|
---
|
Serotonin 1 receptors; 5-HT1B & 5-HT1D
|
Homo sapiens
|
SELECTIVITY GROUP
|
Scientific Literature
| ||||||
16. |
15
|
Selectivity
|
=
|
125.0
|
---
|
---
|
---
|
---
|
Relative binding to serotonin 5-HT 1B and 5-HT 1D receptors
|
protein format
|
---
|
Serotonin 1 receptors; 5-HT1B & 5-HT1D
|
Homo sapiens
|
SELECTIVITY GROUP
|
Scientific Literature
| ||||||
17. |
6b
|
Selectivity
|
=
|
30.0
|
---
|
---
|
---
|
---
|
Relative binding to serotonin 5-HT1D and 5-HT1B receptors
|
protein format
|
---
|
Serotonin 1 receptors; 5-HT1B & 5-HT1D
|
Homo sapiens
|
SELECTIVITY GROUP
|
Scientific Literature
| ||||||
18. |
2s
|
Ratio
|
=
|
6.0
|
---
|
---
|
---
|
---
|
Binding affinity ratio was evaluated (5-HT1B / 5-HT1D receptor)
|
protein format
|
---
|
Serotonin 1 receptors; 5-HT1B & 5-HT1D
|
Homo sapiens
|
SELECTIVITY GROUP
|
Scientific Literature
| ||||||
19. |
3
|
Selectivity
|
=
|
140.0
|
---
|
---
|
---
|
---
|
Selectivity towards 5-HT1D and to that of 5-HT1B in CHO cells
|
cell-based format
|
---
|
Serotonin 1 receptors; 5-HT1B & 5-HT1D
|
Homo sapiens
|
SELECTIVITY GROUP
|
Scientific Literature
| ||||||
20. |
21k
|
Selectivity
|
=
|
19.0
|
---
|
---
|
---
|
---
|
Selectivity of compound for human 5-HT1D receptor over human 5-HT1B receptor
|
protein format
|
---
|
Serotonin 1 receptors; 5-HT1B & 5-HT1D
|
Homo sapiens
|
SELECTIVITY GROUP
|
Scientific Literature
|
Showing 1-20
out of 345 records