Activities

345 items

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Per Property
218
Selectivity
58
Ratio
29
Relative efficacy
22
Selectivity ratio
5
Control
4
Ratio Ki
3
Degrees Centigrade
2
Body temperature drop
2
Ki
1
Body temp drop
1
Other
345
SELECTIVITY GROUP
345
Eukaryotes
345
Mammalia
345
Primates
345
Homo sapiens
260
protein format
68
cell-based format
12
assay format
5
organism-based format
344
N/A
1
[6,6.2]
14
Approved
331
Preclinical
0
N/A
300
0
26
1
19
2
0
N/A
2
[0,1)
35
[1,2)
53
[2,3)
135
[3,4)
78
[4,5)
39
[5,6)
2
[6,8)
1
[8,8.52]
0
N/A
7
[126,189)
24
[189,252)
49
[252,315)
9
[315,378)
151
[378,441)
86
[441,504)
18
[504,756)
1
[756,788.94]
345
Scientific Literature
Showing 1-20 out of 345 records
#Molecule ChEMBL IDCompound KeyStandard TypeStandard RelationStandard ValueStandard Text ValueStandard UnitspChEMBL ValueCommentAssay ChEMBL IDAssay DescriptionBAO LabelAssay OrganismTarget ChEMBL IDTarget NameTarget OrganismTarget TypeDocument ChEMBL IDSource DescriptionCell ChEMBL ID
1.
Sumatriptan (1)
Selectivity
=
2.0
---
---
---
---
Selectivity of compound towards human 5-HT1D receptor over human 5-HT1B receptor
protein format
---
Serotonin 1 receptors; 5-HT1B & 5-HT1D
Homo sapiens
SELECTIVITY GROUP
Scientific Literature
2.
L-747201 (4)
Selectivity
=
9.0
---
---
---
---
Selectivity of compound towards human 5-HT1D receptor over human 5-HT1B receptor
protein format
---
Serotonin 1 receptors; 5-HT1B & 5-HT1D
Homo sapiens
SELECTIVITY GROUP
Scientific Literature
3.
Sumatriptan
Ratio
=
3.2
---
---
---
---
Relative binding affinity for 5-HT1B and 5-HT1D receptor
protein format
---
Serotonin 1 receptors; 5-HT1B & 5-HT1D
Homo sapiens
SELECTIVITY GROUP
Scientific Literature
4.
Sumatriptan (1)
Selectivity
=
2.0
---
---
---
---
Selectivity of compound for human 5-HT1D receptor over human 5-HT1B receptor
protein format
---
Serotonin 1 receptors; 5-HT1B & 5-HT1D
Homo sapiens
SELECTIVITY GROUP
Scientific Literature
5.
2
Selectivity
=
62.0
---
---
---
---
Selectivity ratio for h-5-HT 1B receptor to that of h5-HT 1D receptors.
protein format
---
Serotonin 1 receptors; 5-HT1B & 5-HT1D
Homo sapiens
SELECTIVITY GROUP
Scientific Literature
6.
11d
Relative efficacy
=
68.0
---
%
---
---
Relative efficacy of compound in stimulation of [35S]GTP gamma-S binding in CHO cells compared to 5-HT
cell-based format
---
Serotonin 1 receptors; 5-HT1B & 5-HT1D
Homo sapiens
SELECTIVITY GROUP
Scientific Literature
7.
22c
Selectivity
=
82.0
---
---
---
---
Selectivity of compound for human 5-HT1D receptor over human 5-HT1B receptor
protein format
---
Serotonin 1 receptors; 5-HT1B & 5-HT1D
Homo sapiens
SELECTIVITY GROUP
Scientific Literature
8.
22c
Relative efficacy
=
87.0
---
%
---
---
Relative efficacy of compound in stimulation of [35S]GTP gamma-S binding in CHO cells compared to 5-HT
cell-based format
---
Serotonin 1 receptors; 5-HT1B & 5-HT1D
Homo sapiens
SELECTIVITY GROUP
Scientific Literature
9.
8
Selectivity
=
120.0
---
---
---
---
Relative binding to serotonin 5-HT 1B and 5-HT 1D receptors
protein format
---
Serotonin 1 receptors; 5-HT1B & 5-HT1D
Homo sapiens
SELECTIVITY GROUP
Scientific Literature
10.
15
Selectivity
=
1.0
---
---
---
---
Selectivity of compound towards human 5-HT1D receptor over human 5-HT1B receptor
protein format
---
Serotonin 1 receptors; 5-HT1B & 5-HT1D
Homo sapiens
SELECTIVITY GROUP
Scientific Literature
11.
3
Selectivity
=
40.0
---
---
---
---
Selectivity for human 5-hydroxytryptamine 1D receptor over 5-hydroxytryptamine 1B receptor
protein format
Homo sapiens
Serotonin 1 receptors; 5-HT1B & 5-HT1D
Homo sapiens
SELECTIVITY GROUP
Scientific Literature
12.
5
Selectivity
=
67.0
---
---
---
---
Selectivity towards 5-HT1D and to that of 5-HT1B in CHO cells
cell-based format
---
Serotonin 1 receptors; 5-HT1B & 5-HT1D
Homo sapiens
SELECTIVITY GROUP
Scientific Literature
13.
5
Selectivity
=
40.0
---
---
---
---
Relative binding to serotonin 5-HT1D and 5-HT1B receptors
protein format
---
Serotonin 1 receptors; 5-HT1B & 5-HT1D
Homo sapiens
SELECTIVITY GROUP
Scientific Literature
14.
3c
Selectivity
=
3.0
---
---
---
---
Selectivity of compound for human 5-HT1D receptor over human 5-HT1B receptor
protein format
---
Serotonin 1 receptors; 5-HT1B & 5-HT1D
Homo sapiens
SELECTIVITY GROUP
Scientific Literature
15.
11d
Selectivity
=
37.0
---
---
---
---
Selectivity of compound for human 5-HT1D receptor over human 5-HT1B receptor
protein format
---
Serotonin 1 receptors; 5-HT1B & 5-HT1D
Homo sapiens
SELECTIVITY GROUP
Scientific Literature
16.
15
Selectivity
=
125.0
---
---
---
---
Relative binding to serotonin 5-HT 1B and 5-HT 1D receptors
protein format
---
Serotonin 1 receptors; 5-HT1B & 5-HT1D
Homo sapiens
SELECTIVITY GROUP
Scientific Literature
17.
6b
Selectivity
=
30.0
---
---
---
---
Relative binding to serotonin 5-HT1D and 5-HT1B receptors
protein format
---
Serotonin 1 receptors; 5-HT1B & 5-HT1D
Homo sapiens
SELECTIVITY GROUP
Scientific Literature
18.
2s
Ratio
=
6.0
---
---
---
---
Binding affinity ratio was evaluated (5-HT1B / 5-HT1D receptor)
protein format
---
Serotonin 1 receptors; 5-HT1B & 5-HT1D
Homo sapiens
SELECTIVITY GROUP
Scientific Literature
19.
3
Selectivity
=
140.0
---
---
---
---
Selectivity towards 5-HT1D and to that of 5-HT1B in CHO cells
cell-based format
---
Serotonin 1 receptors; 5-HT1B & 5-HT1D
Homo sapiens
SELECTIVITY GROUP
Scientific Literature
20.
21k
Selectivity
=
19.0
---
---
---
---
Selectivity of compound for human 5-HT1D receptor over human 5-HT1B receptor
protein format
---
Serotonin 1 receptors; 5-HT1B & 5-HT1D
Homo sapiens
SELECTIVITY GROUP
Scientific Literature
Showing 1-20 out of 345 records
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