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73 items

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12
Drug uptake
2
Stability
1
Retention_time
1
T1/2
16
TISSUE
16
Eukaryotes
16
Mammalia
16
Primates
16
Papio anubis
9
organism-based format
7
tissue-based format
16
N/A
1
Phase 3
2
Phase 2
13
Preclinical
0
N/A
14
0
2
1
0
N/A
4
[2,3)
8
[3,4)
2
[4,5)
2
[5,5.62]
0
N/A
2
[200,250)
2
[250,275)
4
[275,325)
1
[325,375)
2
[375,400)
3
[400,425)
1
[425,450)
1
[450,453.55]
16
Scientific Literature
Showing 1-20 out of 73 records
#Molecule ChEMBL IDCompound KeyStandard TypeStandard RelationStandard ValueStandard Text ValueStandard UnitspChEMBL ValueCommentAssay ChEMBL IDAssay DescriptionBAO LabelAssay OrganismTarget ChEMBL IDTarget NameTarget OrganismTarget TypeDocument ChEMBL IDSource DescriptionCell ChEMBL ID
1.
indomethacin
Fu
=
0.053
---
---
---
---
Fraction unbound in cynomolgus monkey brain homogenates at 1 uM after 6 hrs by equilibrium dialysis method
tissue-based format
Macaca fascicularis
Brain
Macaca fascicularis
TISSUE
Scientific Literature
2.
Ibutilide
Fu
=
0.078
---
---
---
---
Fraction unbound in cynomolgus monkey brain homogenates at 1 uM after 6 hrs by equilibrium dialysis method
tissue-based format
Macaca fascicularis
Brain
Macaca fascicularis
TISSUE
Scientific Literature
3.
Bupivacaine
Fu
=
0.195
---
---
---
---
Fraction unbound in cynomolgus monkey brain homogenates at 1 uM after 6 hrs by equilibrium dialysis method
tissue-based format
Macaca fascicularis
Brain
Macaca fascicularis
TISSUE
Scientific Literature
4.
Amfebutamone
Fu
=
0.167
---
---
---
---
Fraction unbound in cynomolgus monkey brain homogenates at 1 uM after 6 hrs by equilibrium dialysis method
tissue-based format
Macaca fascicularis
Brain
Macaca fascicularis
TISSUE
Scientific Literature
5.
Rimonabant
Fu
=
0.0006
---
---
---
---
Fraction unbound in cynomolgus monkey brain homogenates at 1 uM after 6 hrs by equilibrium dialysis method
tissue-based format
Macaca fascicularis
Brain
Macaca fascicularis
TISSUE
Scientific Literature
6.
Paliperidone
Fu
=
0.1
---
---
---
---
Fraction unbound in cynomolgus monkey brain homogenates at 1 uM after 6 hrs by equilibrium dialysis method
tissue-based format
Macaca fascicularis
Brain
Macaca fascicularis
TISSUE
Scientific Literature
7.
Warfarin
Fu
=
0.318
---
---
---
---
Fraction unbound in cynomolgus monkey brain homogenates at 1 uM after 6 hrs by equilibrium dialysis method
tissue-based format
Macaca fascicularis
Brain
Macaca fascicularis
TISSUE
Scientific Literature
8.
[18F]25
SUV
<=
1.0
---
---
---
---
Drug uptake in cynomolgus monkey brain assessed as whole-brain time-activity curve by MicroPET imaging analysis
tissue-based format
Macaca fascicularis
Brain
Macaca fascicularis
TISSUE
Scientific Literature
9.
[11C]-1
Drug uptake
---
---
---
---
---
Not Active
Drug uptake in cynomolgus monkey brain at 8.3 mCi, iv after 2 hrs by PET imaging analysis
organism-based format
Macaca fascicularis
Brain
Macaca fascicularis
TISSUE
Scientific Literature
10.
CE-157119
AUC
=
2250.0
---
ng.hr.mL-1
---
---
AUC(0 to 2 hrs) in cynomolgus monkey brain at 1 mg/kg, sc by LC-MS/MS analysis
organism-based format
Macaca fascicularis
Brain
Macaca fascicularis
TISSUE
Scientific Literature
11.
NIMODIPINE
Fu
=
0.009
---
---
---
---
Fraction unbound in cynomolgus monkey brain homogenates at 1 uM after 6 hrs by equilibrium dialysis method
tissue-based format
Macaca fascicularis
Brain
Macaca fascicularis
TISSUE
Scientific Literature
12.
Paroxetine
Fu
=
0.006
---
---
---
---
Fraction unbound in cynomolgus monkey brain homogenates at 1 uM after 6 hrs by equilibrium dialysis method
tissue-based format
Macaca fascicularis
Brain
Macaca fascicularis
TISSUE
Scientific Literature
13.
1m, AZD3759
Fu
=
0.0012
---
---
---
---
Fraction unbound in cynomolgus monkey brain at 150 MBq, iv by positron emission tomography
organism-based format
Macaca fascicularis
Brain
Macaca fascicularis
TISSUE
Scientific Literature
14.
[11C]5, [11C]6MemTyr
Drug uptake
---
---
---
---
---
Active
Drug uptake in cynomolgus monkey brain assessed as dopamine synthesis after 60 to 90 mins by PET imaging analysis in presence of carbidopa
tissue-based format
Macaca fascicularis
Brain
Macaca fascicularis
TISSUE
Scientific Literature
15.
Solifenacin
Fu
=
0.016
---
---
---
---
Fraction unbound in cynomolgus monkey brain homogenates at 1 uM after 6 hrs by equilibrium dialysis method
tissue-based format
Macaca fascicularis
Brain
Macaca fascicularis
TISSUE
Scientific Literature
16.
Tropisetron
Fu
=
0.064
---
---
---
---
Fraction unbound in cynomolgus monkey brain homogenates at 1 uM after 6 hrs by equilibrium dialysis method
tissue-based format
Macaca fascicularis
Brain
Macaca fascicularis
TISSUE
Scientific Literature
17.
Trazodone
Fu
=
0.082
---
---
---
---
Fraction unbound in cynomolgus monkey brain homogenates at 1 uM after 6 hrs by equilibrium dialysis method
tissue-based format
Macaca fascicularis
Brain
Macaca fascicularis
TISSUE
Scientific Literature
18.
Carbamazepine
Fu
=
0.185
---
---
---
---
Fraction unbound in cynomolgus monkey brain homogenates at 1 uM after 6 hrs by equilibrium dialysis method
tissue-based format
Macaca fascicularis
Brain
Macaca fascicularis
TISSUE
Scientific Literature
19.
4b
Drug uptake
---
---
---
---
---
Not Active
Drug uptake in cynomolgus monkey brain at 10 mg/kg, iv at 4 hrs post dose
organism-based format
Macaca fascicularis
Brain
Macaca fascicularis
TISSUE
Scientific Literature
20.
[11C]-1m
Fu
=
0.0014
---
---
---
---
Fraction unbound in cynomolgus monkey brain at 155 MBq, iv by positron emission tomography
organism-based format
Macaca fascicularis
Brain
Macaca fascicularis
TISSUE
Scientific Literature
Showing 1-20 out of 73 records
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