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Bioactivity data for target CHEMBL613414 (Brain)
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Showing 1-20
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# | Molecule ChEMBL ID | Compound Key | Standard Type | Standard Relation | Standard Value | Standard Text Value | Standard Units | pChEMBL Value | Comment | Assay ChEMBL ID | Assay Description | BAO Label | Assay Organism | Target ChEMBL ID | Target Name | Target Organism | Target Type | Document ChEMBL ID | Source Description | Cell ChEMBL ID | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1. |
indomethacin
|
Fu
|
=
|
0.053
|
---
|
---
|
---
|
---
|
Fraction unbound in cynomolgus monkey brain homogenates at 1 uM after 6 hrs by equilibrium dialysis method
|
tissue-based format
|
Macaca fascicularis
|
Brain
|
Macaca fascicularis
|
TISSUE
|
Scientific Literature
| ||||||
2. |
Ibutilide
|
Fu
|
=
|
0.078
|
---
|
---
|
---
|
---
|
Fraction unbound in cynomolgus monkey brain homogenates at 1 uM after 6 hrs by equilibrium dialysis method
|
tissue-based format
|
Macaca fascicularis
|
Brain
|
Macaca fascicularis
|
TISSUE
|
Scientific Literature
| ||||||
3. |
Bupivacaine
|
Fu
|
=
|
0.195
|
---
|
---
|
---
|
---
|
Fraction unbound in cynomolgus monkey brain homogenates at 1 uM after 6 hrs by equilibrium dialysis method
|
tissue-based format
|
Macaca fascicularis
|
Brain
|
Macaca fascicularis
|
TISSUE
|
Scientific Literature
| ||||||
4. |
Amfebutamone
|
Fu
|
=
|
0.167
|
---
|
---
|
---
|
---
|
Fraction unbound in cynomolgus monkey brain homogenates at 1 uM after 6 hrs by equilibrium dialysis method
|
tissue-based format
|
Macaca fascicularis
|
Brain
|
Macaca fascicularis
|
TISSUE
|
Scientific Literature
| ||||||
5. |
Rimonabant
|
Fu
|
=
|
0.0006
|
---
|
---
|
---
|
---
|
Fraction unbound in cynomolgus monkey brain homogenates at 1 uM after 6 hrs by equilibrium dialysis method
|
tissue-based format
|
Macaca fascicularis
|
Brain
|
Macaca fascicularis
|
TISSUE
|
Scientific Literature
| ||||||
6. |
Paliperidone
|
Fu
|
=
|
0.1
|
---
|
---
|
---
|
---
|
Fraction unbound in cynomolgus monkey brain homogenates at 1 uM after 6 hrs by equilibrium dialysis method
|
tissue-based format
|
Macaca fascicularis
|
Brain
|
Macaca fascicularis
|
TISSUE
|
Scientific Literature
| ||||||
7. |
Warfarin
|
Fu
|
=
|
0.318
|
---
|
---
|
---
|
---
|
Fraction unbound in cynomolgus monkey brain homogenates at 1 uM after 6 hrs by equilibrium dialysis method
|
tissue-based format
|
Macaca fascicularis
|
Brain
|
Macaca fascicularis
|
TISSUE
|
Scientific Literature
| ||||||
8. |
[18F]25
|
SUV
|
<=
|
1.0
|
---
|
---
|
---
|
---
|
Drug uptake in cynomolgus monkey brain assessed as whole-brain time-activity curve by MicroPET imaging analysis
|
tissue-based format
|
Macaca fascicularis
|
Brain
|
Macaca fascicularis
|
TISSUE
|
Scientific Literature
| ||||||
9. |
[11C]-1
|
Drug uptake
|
---
|
---
|
---
|
---
|
---
|
Not Active
|
Drug uptake in cynomolgus monkey brain at 8.3 mCi, iv after 2 hrs by PET imaging analysis
|
organism-based format
|
Macaca fascicularis
|
Brain
|
Macaca fascicularis
|
TISSUE
|
Scientific Literature
| ||||||
10. |
CE-157119
|
AUC
|
=
|
2250.0
|
---
|
ng.hr.mL-1
|
---
|
---
|
AUC(0 to 2 hrs) in cynomolgus monkey brain at 1 mg/kg, sc by LC-MS/MS analysis
|
organism-based format
|
Macaca fascicularis
|
Brain
|
Macaca fascicularis
|
TISSUE
|
Scientific Literature
| ||||||
11. |
NIMODIPINE
|
Fu
|
=
|
0.009
|
---
|
---
|
---
|
---
|
Fraction unbound in cynomolgus monkey brain homogenates at 1 uM after 6 hrs by equilibrium dialysis method
|
tissue-based format
|
Macaca fascicularis
|
Brain
|
Macaca fascicularis
|
TISSUE
|
Scientific Literature
| ||||||
12. |
Paroxetine
|
Fu
|
=
|
0.006
|
---
|
---
|
---
|
---
|
Fraction unbound in cynomolgus monkey brain homogenates at 1 uM after 6 hrs by equilibrium dialysis method
|
tissue-based format
|
Macaca fascicularis
|
Brain
|
Macaca fascicularis
|
TISSUE
|
Scientific Literature
| ||||||
13. |
1m, AZD3759
|
Fu
|
=
|
0.0012
|
---
|
---
|
---
|
---
|
Fraction unbound in cynomolgus monkey brain at 150 MBq, iv by positron emission tomography
|
organism-based format
|
Macaca fascicularis
|
Brain
|
Macaca fascicularis
|
TISSUE
|
Scientific Literature
| ||||||
14. |
[11C]5, [11C]6MemTyr
|
Drug uptake
|
---
|
---
|
---
|
---
|
---
|
Active
|
Drug uptake in cynomolgus monkey brain assessed as dopamine synthesis after 60 to 90 mins by PET imaging analysis in presence of carbidopa
|
tissue-based format
|
Macaca fascicularis
|
Brain
|
Macaca fascicularis
|
TISSUE
|
Scientific Literature
| ||||||
15. |
Solifenacin
|
Fu
|
=
|
0.016
|
---
|
---
|
---
|
---
|
Fraction unbound in cynomolgus monkey brain homogenates at 1 uM after 6 hrs by equilibrium dialysis method
|
tissue-based format
|
Macaca fascicularis
|
Brain
|
Macaca fascicularis
|
TISSUE
|
Scientific Literature
| ||||||
16. |
Tropisetron
|
Fu
|
=
|
0.064
|
---
|
---
|
---
|
---
|
Fraction unbound in cynomolgus monkey brain homogenates at 1 uM after 6 hrs by equilibrium dialysis method
|
tissue-based format
|
Macaca fascicularis
|
Brain
|
Macaca fascicularis
|
TISSUE
|
Scientific Literature
| ||||||
17. |
Trazodone
|
Fu
|
=
|
0.082
|
---
|
---
|
---
|
---
|
Fraction unbound in cynomolgus monkey brain homogenates at 1 uM after 6 hrs by equilibrium dialysis method
|
tissue-based format
|
Macaca fascicularis
|
Brain
|
Macaca fascicularis
|
TISSUE
|
Scientific Literature
| ||||||
18. |
Carbamazepine
|
Fu
|
=
|
0.185
|
---
|
---
|
---
|
---
|
Fraction unbound in cynomolgus monkey brain homogenates at 1 uM after 6 hrs by equilibrium dialysis method
|
tissue-based format
|
Macaca fascicularis
|
Brain
|
Macaca fascicularis
|
TISSUE
|
Scientific Literature
| ||||||
19. |
4b
|
Drug uptake
|
---
|
---
|
---
|
---
|
---
|
Not Active
|
Drug uptake in cynomolgus monkey brain at 10 mg/kg, iv at 4 hrs post dose
|
organism-based format
|
Macaca fascicularis
|
Brain
|
Macaca fascicularis
|
TISSUE
|
Scientific Literature
| ||||||
20. |
[11C]-1m
|
Fu
|
=
|
0.0014
|
---
|
---
|
---
|
---
|
Fraction unbound in cynomolgus monkey brain at 155 MBq, iv by positron emission tomography
|
organism-based format
|
Macaca fascicularis
|
Brain
|
Macaca fascicularis
|
TISSUE
|
Scientific Literature
|
Showing 1-20
out of 73 records