Assays

1,527 items

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Per Property
922
F - Functional
220
B - Binding
208
T - Toxicity
126
A - ADME
51
P - Physicochemical
1,527
N/A
1,527
N/A
1,527
N/A
984
Viruses
333
N/A
210
Eukaryotes
983
retro-transcribing
333
N/A
198
Mammalia
6
Apicomplexa
6
Kinetoplastida
1
ssRNA
1,316
N/A
173
Primates
17
Rodentia
8
Carnivora
6
Plasmodium
5
Trypanosoma
1
Leishmania
1
ssRNA positive-strand viruses
941
Human immunodeficiency virus 1
333
N/A
171
Homo sapiens
23
Human immunodeficiency virus
16
Human immunodeficiency virus 2
8
Canis lupus familiaris
7
Cricetulus griseus
6
Mus musculus
6
Plasmodium falciparum
4
Rattus norvegicus
12
Other
792
organism-based format
442
cell-based format
113
single protein format
112
assay format
51
small-molecule physicochemical format
11
microsome format
5
cell-free format
1
tissue-based format
1,519
Scientific Literature
5
SARS-CoV-2 Screening Data
2
Fraunhofer Institute HDAC6 screening
1
EU-OPENSCREEN
957
1 - Target assigned is non-molecular
343
0 - Default value - Target unknown or has yet to be assigned
168
9 - Direct single protein target assigned
56
8 - Homologous single protein target assigned
2
6 - Homologous protein complex subunits assigned
1
2 - Target assigned is subcellular fraction
Showing 1-20 out of 1,527 records
#ChEMBL IDAssay TypeDescriptionOrganismCompoundsDocument ChEMBL IDBAO FormatSource
1.
CHEMBL1692704
F
Induction of ABCC2 mRNA expression in human LS180 cells at 0.1 to 1 umol/liter after 4 days by RT-PCR analysis
Homo sapiens
CHEMBL1687850
cell-based format
Scientific Literature
2.
CHEMBL4332378
P
Solubility of the compound
---
CHEMBL4330114
small-molecule physicochemical format
Scientific Literature
3.
CHEMBL1284941
A
Trough drug concentration at 12 hrs in healthy human plasma at 200 mg, po twice a day for 4 days coadministered with 400 mg of raltegravir, po twice a day for 4 days by reverse-phase HPLC-MS method
Homo sapiens
CHEMBL1275564
organism-based format
Scientific Literature
4.
CHEMBL1284943
A
AUC (0 to 12 hrs) in healthy human plasma at 200 mg, po twice a day for 4 days coadministered with 400 mg of raltegravir, po twice a day for 4 days by reverse-phase HPLC-MS method
Homo sapiens
CHEMBL1275564
organism-based format
Scientific Literature
5.
CHEMBL4362933
T
Sub-acute toxicity in Kunming mouse assessed as increase in alveolar hemorrhage administered for 14 days measured on day 14 by HE-staining based assay
Mus musculus
CHEMBL4359892
assay format
Scientific Literature
6.
CHEMBL1284946
A
Tmax in healthy human plasma at 200 mg, po twice a day for 8 days by reverse-phase HPLC-MS method
Homo sapiens
CHEMBL1275564
organism-based format
Scientific Literature
7.
CHEMBL3430486
F
Inhibition of slow delayed inward rectifying potassium current (Iks) in Chinese Hamster Ovary (CHO) cells expressing hKvLQT1/hminK measured using IonWorks Quattro automated patch clamp platform
Cricetulus griseus
CHEMBL3430320
cell-based format
Scientific Literature
8.
CHEMBL3430701
F
Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using IonWorks Quattro automated patch clamp platform
Cricetulus griseus
CHEMBL3430320
cell-based format
Scientific Literature
9.
CHEMBL1661353
F
Antiviral activity against HIV1 isolate R8 harboring reverse transcriptase Y181C and K103N mutant relative to drug-sensitive HIV1 CNDO
Human immunodeficiency virus 1
CHEMBL1649436
organism-based format
Scientific Literature
10.
CHEMBL3430366
F
Inhibition of long-lasting type calcium current (hICa) in Chinese Hamster Ovary (CHO) cells expressing hCav1.2 measured using IonWorks Quattro automated patch clamp platform
Cricetulus griseus
CHEMBL3430320
cell-based format
Scientific Literature
11.
CHEMBL1692701
A
fCmax in human plasma at 200 mg bid after 8 days
Homo sapiens
CHEMBL1687850
organism-based format
Scientific Literature
12.
CHEMBL4014643
P
Lipophilicity, log P of the compound
---
CHEMBL4014278
small-molecule physicochemical format
Scientific Literature
13.
CHEMBL4021690
B
Inhibition of wild-type HIV-1 3B reverse transcriptase infected in human MT4 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay
Human immunodeficiency virus 1
CHEMBL4020747
cell-based format
Scientific Literature
14.
CHEMBL1692696
B
Inhibition of BCRP expressed in MDCK2 cells assessed as cell growth inhibition by calcein and pheophorbide A efflux assays
---
CHEMBL1687850
cell-based format
Scientific Literature
15.
CHEMBL1284944
A
Cmax in healthy human plasma at 200 mg, po twice a day for 8 days by reverse-phase HPLC-MS method
Homo sapiens
CHEMBL1275564
organism-based format
Scientific Literature
16.
CHEMBL4370136
T
Sub-acute toxicity in Kunming mouse assessed as alveolar hemorrhage at 50 mg/kg/day, po administered for 2 weeks by hematoxylin and eosin staining-based assay
Mus musculus
CHEMBL4368909
organism-based format
Scientific Literature
17.
CHEMBL4359428
P
Aqueous solubility of the compound in pH 7 buffer
---
CHEMBL4354878
small-molecule physicochemical format
Scientific Literature
18.
CHEMBL5246978
A
Induction of CYP3A4 in human assessed as reduction in sildenafil AUC
Homo sapiens
CHEMBL5244274
single protein format
Scientific Literature
19.
CHEMBL1661354
F
Antiviral activity against HIV1 isolate R8 harboring reverse transcriptase Y181I mutant relative to drug-sensitive HIV1 CNDO
Human immunodeficiency virus 1
CHEMBL1649436
organism-based format
Scientific Literature
20.
CHEMBL1692697
B
Inhibition of MRP1 expressed in MDCK2 cells assessed as cell growth inhibition by calcein and pheophorbide A efflux assays
---
CHEMBL1687850
cell-based format
Scientific Literature
Showing 1-20 out of 1,527 records
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