Assays

42 items

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21
B - Binding
10
F - Functional
4
A - ADME
4
P - Physicochemical
3
T - Toxicity
42
N/A
42
N/A
42
N/A
36
Eukaryotes
6
N/A
36
Mammalia
6
N/A
35
Primates
6
N/A
1
Rodentia
35
Homo sapiens
6
N/A
1
Mus musculus
18
cell-based format
16
single protein format
4
small-molecule physicochemical format
3
assay format
1
protein format
24
Scientific Literature
14
EUbOPEN Chemogenomic Library
4
PubChem BioAssays
21
9 - Direct single protein target assigned
14
1 - Target assigned is non-molecular
5
0 - Default value - Target unknown or has yet to be assigned
1
5 - Multiple direct protein targets may be assigned
1
8 - Homologous single protein target assigned
Showing 1-20 out of 42 records
#ChEMBL IDAssay TypeDescriptionOrganismCompoundsDocument ChEMBL IDBAO FormatSource
1.
CHEMBL4681034
B
Agonist activity at human PXR
Homo sapiens
CHEMBL4680080
single protein format
Scientific Literature
2.
CHEMBL3998015
P
Thermodynamic aqueous solubility of the compound in phosphate buffered saline at pH 7.4 after overnight incubation
---
CHEMBL3997764
small-molecule physicochemical format
Scientific Literature
3.
CHEMBL4726291
A
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability at 10 uM incubated for 4 hrs by CytoRed viability assay
Homo sapiens
CHEMBL4725260
cell-based format
Scientific Literature
4.
CHEMBL3385882
B
Agonist activity at human pregnane X receptor expressed in HEK293 cells by luciferase reporter gene assay
Homo sapiens
CHEMBL3352412
cell-based format
Scientific Literature
5.
CHEMBL975047
F
Induction of CYP3A4 mRNA expression in human hepatocyte FT271 at 1 uM after 24 hrs by RT-PCR relative to control
Homo sapiens
CHEMBL1157161
cell-based format
Scientific Literature
6.
CHEMBL3998016
P
Thermodynamic aqueous solubility of the compound in simulated gastric fluid at pH 1.2 after overnight incubation
---
CHEMBL3997764
small-molecule physicochemical format
Scientific Literature
7.
CHEMBL3998014
P
Thermodynamic aqueous solubility of the compound in water after overnight incubation
---
CHEMBL3997764
small-molecule physicochemical format
Scientific Literature
8.
CHEMBL3998017
P
Thermodynamic aqueous solubility of the compound in simulated intestinal fluid at pH 6.8 after overnight incubation
---
CHEMBL3997764
small-molecule physicochemical format
Scientific Literature
9.
CHEMBL975044
F
Induction of CYP3B6 mRNA expression in human hepatocyte FT268 at 1 uM after 24 hrs by RT-PCR relative to control
Homo sapiens
CHEMBL1157161
cell-based format
Scientific Literature
10.
CHEMBL975043
F
Induction of CYP3A4 mRNA expression in human hepatocyte FT268 at 1 uM after 24 hrs by RT-PCR relative to control
Homo sapiens
CHEMBL1157161
cell-based format
Scientific Literature
11.
CHEMBL975049
F
Induction of CYP3A4 mRNA expression in human hepatocyte FT272 at 1 uM after 24 hrs by RT-PCR relative to control
Homo sapiens
CHEMBL1157161
cell-based format
Scientific Literature
12.
CHEMBL975045
F
Induction of CYP3A4 mRNA expression in human hepatocyte FT269 at 1 uM after 24 hrs by RT-PCR relative to control
Homo sapiens
CHEMBL1157161
cell-based format
Scientific Literature
13.
CHEMBL975048
F
Induction of CYP3B6 mRNA expression in human hepatocyte FT271 at 1 uM after 24 hrs by RT-PCR relative to control
Homo sapiens
CHEMBL1157161
cell-based format
Scientific Literature
14.
CHEMBL975046
F
Induction of CYP3B6 mRNA expression in human hepatocyte FT269 at 1 uM after 24 hrs by RT-PCR relative to control
Homo sapiens
CHEMBL1157161
cell-based format
Scientific Literature
15.
CHEMBL975050
F
Induction of CYP3B6 mRNA expression in human hepatocyte FT272 at 1 uM after 24 hrs by RT-PCR relative to control
Homo sapiens
CHEMBL1157161
cell-based format
Scientific Literature
16.
CHEMBL3998013
B
Activation of PXR in human LS180 cells assessed as P-gp induction by measuring intracellular accumulation of rhodamine 123 preincubated for 48 hrs followed by rhodamine 123 addition after 40 mins and measured after 90 mins by fluorescence assay
Homo sapiens
CHEMBL3997764
cell-based format
Scientific Literature
17.
CHEMBL5246986
B
Activation of human PXR
Homo sapiens
CHEMBL5244274
single protein format
Scientific Literature
18.
CHEMBL5156500
B
Binding affinity to human PXR-LBD assessed as change in melting temperature at 100 uM incubated for 30 mins by thermal shift assay
Homo sapiens
CHEMBL5154673
single protein format
Scientific Literature
19.
CHEMBL5246994
B
Activation of PXR (unknown origin) relative to control
Homo sapiens
CHEMBL5244274
single protein format
Scientific Literature
20.
CHEMBL4726289
B
Induction of degradation of Flag-tagged human HMGCR-dCat-ELuc membrane domain (1 to 499 residues) expressed in HEK293 cells assessed as reduction in HMGCR-dCat-Eluc protein level after 4 hrs by luciferase reporter assay
Homo sapiens
CHEMBL4725260
cell-based format
Scientific Literature
Showing 1-20 out of 42 records
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