Assays
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| # | ChEMBL ID | Assay Type | Description | Organism | Compounds | Document ChEMBL ID | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. |
B
|
Inhibition of human mitochondrial NADP-ME E59L mutant expressed in Escherichia coli XL-1 assessed as residual enzyme activity by spectrophotometry in presence of fumarate
|
Homo sapiens
|
assay format
|
Scientific Literature
| ||||
| 2. |
B
|
Inhibition of wild type human recombinant mitochondrial NADP-ME expressed in Escherichia coli BL21 assessed as residual enzyme activity by spectrophotometry in presence of fumarate
|
Homo sapiens
|
assay format
|
Scientific Literature
| ||||
| 3. |
B
|
Inhibition of wild type human recombinant mitochondrial NADP-ME expressed in Escherichia coli BL21 assessed as residual enzyme activity by spectrophotometry in absence of fumarate
|
Homo sapiens
|
assay format
|
Scientific Literature
| ||||
| 4. |
B
|
Inhibition of human mitochondrial NADP-ME E59L mutant expressed in Escherichia coli XL-1 assessed as residual enzyme activity by spectrophotometry in absence of fumarate
|
Homo sapiens
|
assay format
|
Scientific Literature
| ||||
| 5. |
B
|
Inhibition of Sporosarcina pasteurii CCM 2056 urease assessed as reduction in ammonia production using urea as substrate measured for 120 mins by phenol-hypochlorite method
|
Sporosarcina pasteurii
|
assay format
|
Scientific Literature
| ||||
| 6. |
B
|
Competitive inhibition of Sporosarcina pasteurii CCM 2056 urease assessed as reduction in ammonia production preincubated with enzyme followed by addition of varying levels of urea as substrate measured for 120 mins by Lineweaver-Burk plot analysis
|
Sporosarcina pasteurii
|
assay format
|
Scientific Literature
| ||||
| 7. |
B
|
Inhibition of Sporosarcina pasteurii CCM 2056 urease assessed as reduction in ammonia production by measuring initial state enzyme-inhibitor complex using urea as substrate measured for 120 mins by phenol-hypochlorite method
|
Sporosarcina pasteurii
|
assay format
|
Scientific Literature
| ||||
| 8. |
B
|
Inhibition of Sporosarcina pasteurii CCM 2056 urease assessed as reduction in ammonia production by measuring steady state enzyme-inhibitor complex using urea as substrate measured for 120 mins by phenol-hypochlorite method
|
Sporosarcina pasteurii
|
assay format
|
Scientific Literature
| ||||
| 9. |
B
|
Reversible inhibition of Sporosarcina pasteurii CCM 2056 urease assessed as reduction in ammonia production by measuring recovery of enzyme activity at 10 times IC50 preincubated for 60 mins followed by 100-fold dilution in to PBS containing urea as substrate by Berthelot colorimetric assay relative to control
|
Sporosarcina pasteurii
|
assay format
|
Scientific Literature
| ||||
| 10. |
B
|
Time-dependent Sporosarcina pasteurii CCM 2056 urease assessed as reduction in ammonia production using urea as substrate by phenol-hypochlorite method
|
Sporosarcina pasteurii
|
assay format
|
Scientific Literature
| ||||
| 11. |
A
|
Human drug-induced liver injury (DILI) modelling dataset from Ekins et al
|
Homo sapiens
|
tissue-based format
|
Scientific Literature
| ||||
| 12. |
A
|
Literature-mined public compounds from Greene et al multi-species hepatotoxicity modelling dataset
|
---
|
assay format
|
Scientific Literature
| ||||
| 13. |
F
|
PubChem BioAssay. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory)
|
Homo sapiens
|
assay format
|
PubChem BioAssays
| ||||
| 14. |
F
|
PubChem BioAssay. qHTS Assay for Identifying Compounds that block Entry of Ebola Virus: Screen 2, green channel. (Class of assay: confirmatory)
|
---
|
assay format
|
PubChem BioAssays
| ||||
| 15. |
F
|
PubChem BioAssay. qHTS Assay for Identifying Compounds that block Entry of Ebola Virus, Screen 2 green channel. (Class of assay: confirmatory)
|
---
|
assay format
|
PubChem BioAssays
| ||||
| 16. |
F
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
organism-based format
|
IMI-CARE SARS-CoV-2 Data
| ||||
| 17. |
F
|
PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory)
|
Homo sapiens
|
assay format
|
PubChem BioAssays
| ||||
| 18. |
F
|
PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ]
|
Homo sapiens
|
assay format
|
PubChem BioAssays
| ||||
| 19. |
F
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
organism-based format
|
SARS-CoV-2 Screening Data
| ||||
| 20. |
F
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
assay format
|
SARS-CoV-2 Screening Data
|
Showing 1-20
out of 25 records
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