Assays

548 items

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Per Property
258
B - Binding
212
F - Functional
47
A - ADME
25
T - Toxicity
6
P - Physicochemical
495
N/A
41
MUSCULO-SKELETAL SYSTEM
11
NERVOUS SYSTEM
3
CARDIOVASCULAR SYSTEM
495
N/A
41
Anti-Inflammatory Activity
11
Analgesic Activity
10
Central Analgesic Activity
3
Influence on Lipid Metabolism
2
Inhibition of Cholesterol Absorption
1
Peripheral Analgesic Activity
495
N/A
41
General Anti-Inflammatory Models
25
Paw Edema Test
11
General Analgesic Nociceptic and Allodynic Activity
11
Pleurisy Test for Anti-Inflammatory Activity
7
Radiant Heat Method
3
Formalin Test for Chronic Pain
3
General Hyperlipidemia Models
3
General Lipid Metabolism
3
Triton Induced Hyperlipidemia
5
Other
283
Eukaryotes
168
N/A
83
Unclassified
12
Bacteria
1
Fungi
1
Viruses
273
Mammalia
251
N/A
10
Gram-Negative
6
Teleostei
2
Gram-Positive
1
Arthropoda
1
Ascomycota
1
Fornicata
1
Kinetoplastida
1
Viridiplantae
1
Other
252
N/A
159
Primates
97
Rodentia
14
Cetartiodactyla
10
Escherichia
6
Otomorpha
3
Lagomorpha
2
Bacillus
1
Diptera
1
Eudicotyledons
3
Other
251
N/A
156
Homo sapiens
77
Rattus norvegicus
13
Mus musculus
10
Escherichia coli
7
Ovis aries
6
Danio rerio
4
Cavia porcellus
3
Bos taurus
3
Capra hircus
18
Other
129
assay format
105
single protein format
104
cell-based format
83
cell membrane format
72
organism-based format
43
tissue-based format
5
small-molecule physicochemical format
3
microsome format
2
cell-free format
1
protein complex format
1
Other
343
Scientific Literature
133
DrugMatrix
61
PubChem BioAssays
5
SARS-CoV-2 Screening Data
2
Fraunhofer Institute HDAC6 screening
2
Open TG-GATEs
1
IMI-CARE SARS-CoV-2 Data
1
Karolinska Institute dNTPase SAMHD1 screening
233
8 - Homologous single protein target assigned
130
1 - Target assigned is non-molecular
112
9 - Direct single protein target assigned
62
0 - Default value - Target unknown or has yet to be assigned
4
5 - Multiple direct protein targets may be assigned
3
6 - Homologous protein complex subunits assigned
2
2 - Target assigned is subcellular fraction
1
3 - Target assigned is molecular non-protein target
1
4 - Multiple homologous protein targets may be assigned
Showing 1-20 out of 548 records
#ChEMBL IDAssay TypeDescriptionOrganismCompoundsDocument ChEMBL IDBAO FormatSource
1.
B
Inhibition of COX2-mediated decrease in gata1 expression in heat-stimulated heterozygous transgenic zebrafish embryo assessed as restoration of gata1 level at 40 uM by in-situ hybridization analysis
Danio rerio
assay format
Scientific Literature
2.
B
Inhibition of COX2-mediated decrease in gata1 expression in heterozygous transgenic zebrafish embryo assessed as restoration of gata1 level at 40 uM by in-situ hybridization analysis
Danio rerio
assay format
Scientific Literature
3.
F
Antiinflammatory activity in albino rat assessed as inhibition of carrageenan-induced paw oedema at 50 mg/kg, po measured after 180 mins of carrageenan challenge relative to control
Rattus norvegicus
organism-based format
Scientific Literature
4.
B
Inhibition of COX2 at 0.1 mM
---
single protein format
Scientific Literature
5.
B
Mixed type inhibition of Capra hircus (goat) brain DPP-3 using Arg-Arg-4mbetaNA as substrate assessed as liberation of 4mbetaNA from substrate preincubated for 10 min by Cornish-Bowden plot analysis
Capra hircus
assay format
Scientific Literature
6.
F
Antiinflammatory activity in Wistar albino rat assessed as inhibition of carrageenan-induced paw edema at 4 mg/kg, po administered 30 mins before carrageenan challenge measured after 90 mins relative to control
Rattus norvegicus
organism-based format
Scientific Literature
7.
F
Inhibition of heat-induced AML1-ETO protein expression in heterozygous transgenic zebrafish embryo at 40 uM by Western blot analysis
Danio rerio
organism-based format
Scientific Literature
8.
F
Inhibition of LPS/IFN-gamma-induced PGE2 production in PMA-treated human U937 cells at 5 uM after 17 to 20 hrs by enzyme immunoassay relative to control
Homo sapiens
cell-based format
Scientific Literature
9.
F
Antiinflammatory activity in albino rat assessed as inhibition of carrageenan-induced paw oedema at 50 mg/kg, po measured after 30 mins of carrageenan challenge relative to control
Rattus norvegicus
organism-based format
Scientific Literature
10.
B
Inhibition of COX1 in human platelet microsomes assessed as reduction in formation of oxidized TMPD at 500 uM using arachidonic acid as substrate preincubated for 3 to 5 mins followed by arachidonic acid addition measured for 25 secs by spectrophotometric assay
Homo sapiens
assay format
Scientific Literature
11.
F
Inhibition of LPS/IFN-gamma-induced PGE2 production in mouse RAW264.7 cells at 5 uM after 17 to 20 hrs by enzyme immunoassay relative to control
Mus musculus
cell-based format
Scientific Literature
12.
F
Analgesic activity in Swiss albino mouse assessed as protection against acetic acid-induced writhing at 50 mg/kg, po administered 1 hr prior to acetic acid challenge relative to control measured after 3 hrs
Mus musculus
organism-based format
Scientific Literature
13.
F
Antiinflammatory activity in rat assessed as inhibition of paw edema at 10 mg/kg
Rattus norvegicus
organism-based format
Scientific Literature
14.
F
Antiinflammatory activity in Wistar albino rat assessed as inhibition of carrageenan-induced paw edema at 4 mg/kg, po administered 30 mins before carrageenan challenge measured after 60 mins relative to control
Rattus norvegicus
organism-based format
Scientific Literature
15.
F
Inhibition of carrageenan-induced PGE2 production in Swiss mouse at 5 mg/kg, po dosed 45 mins before carrageenan dosing measured 3 hrs post carrageenan challenge by ELISA
Mus musculus
organism-based format
Scientific Literature
16.
F
Antiinflammatory activity in Wistar albino rat assessed as inhibition of carrageenan-induced paw edema at 4 mg/kg, po administered 30 mins before carrageenan challenge measured after 30 mins relative to control
Rattus norvegicus
organism-based format
Scientific Literature
17.
A
Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 5 uM by MTT assay relative to control
Mus musculus
cell-based format
Scientific Literature
18.
A
Drug activation in human Hep3B cells assessed as human CYP3A4-mediated drug metabolism-induced cytotoxicity measured as decrease in cell viability at 31.7 uM pre-incubated with BSO for 18 hrs followed by incubation with compound for 3 hrs in presence of NADPH measured after 24 hrs in absence of compound, CYP3A4 and NADPH by cell titer-glo luminescence assay relative to BSO alone
Homo sapiens
cell-based format
Scientific Literature
19.
P
Lipophilicity, LogD of the compound at pH 7.4 by HPLC C18 method
---
small-molecule physicochemical format
Scientific Literature
20.
F
Antiinflammatory activity in albino rat assessed as inhibition of carrageenan-induced paw oedema at 50 mg/kg, po measured after 60 mins of carrageenan challenge relative to control
Rattus norvegicus
organism-based format
Scientific Literature
Showing 1-20 out of 548 records
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