Assays
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# | ChEMBL ID | Assay Type | Description | Organism | Compounds | Document ChEMBL ID | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. |
B
|
Inhibition of COX2-mediated decrease in gata1 expression in heat-stimulated heterozygous transgenic zebrafish embryo assessed as restoration of gata1 level at 40 uM by in-situ hybridization analysis
|
Danio rerio
|
assay format
|
Scientific Literature
| ||||
2. |
B
|
Inhibition of COX2-mediated decrease in gata1 expression in heterozygous transgenic zebrafish embryo assessed as restoration of gata1 level at 40 uM by in-situ hybridization analysis
|
Danio rerio
|
assay format
|
Scientific Literature
| ||||
3. |
F
|
Antiinflammatory activity in albino rat assessed as inhibition of carrageenan-induced paw oedema at 50 mg/kg, po measured after 180 mins of carrageenan challenge relative to control
|
Rattus norvegicus
|
organism-based format
|
Scientific Literature
| ||||
4. |
B
|
Inhibition of COX2 at 0.1 mM
|
---
|
single protein format
|
Scientific Literature
| ||||
5. |
B
|
Mixed type inhibition of Capra hircus (goat) brain DPP-3 using Arg-Arg-4mbetaNA as substrate assessed as liberation of 4mbetaNA from substrate preincubated for 10 min by Cornish-Bowden plot analysis
|
Capra hircus
|
assay format
|
Scientific Literature
| ||||
6. |
F
|
Antiinflammatory activity in Wistar albino rat assessed as inhibition of carrageenan-induced paw edema at 4 mg/kg, po administered 30 mins before carrageenan challenge measured after 90 mins relative to control
|
Rattus norvegicus
|
organism-based format
|
Scientific Literature
| ||||
7. |
F
|
Inhibition of heat-induced AML1-ETO protein expression in heterozygous transgenic zebrafish embryo at 40 uM by Western blot analysis
|
Danio rerio
|
organism-based format
|
Scientific Literature
| ||||
8. |
F
|
Inhibition of LPS/IFN-gamma-induced PGE2 production in PMA-treated human U937 cells at 5 uM after 17 to 20 hrs by enzyme immunoassay relative to control
|
Homo sapiens
|
cell-based format
|
Scientific Literature
| ||||
9. |
F
|
Antiinflammatory activity in albino rat assessed as inhibition of carrageenan-induced paw oedema at 50 mg/kg, po measured after 30 mins of carrageenan challenge relative to control
|
Rattus norvegicus
|
organism-based format
|
Scientific Literature
| ||||
10. |
B
|
Inhibition of COX1 in human platelet microsomes assessed as reduction in formation of oxidized TMPD at 500 uM using arachidonic acid as substrate preincubated for 3 to 5 mins followed by arachidonic acid addition measured for 25 secs by spectrophotometric assay
|
Homo sapiens
|
assay format
|
Scientific Literature
| ||||
11. |
F
|
Inhibition of LPS/IFN-gamma-induced PGE2 production in mouse RAW264.7 cells at 5 uM after 17 to 20 hrs by enzyme immunoassay relative to control
|
Mus musculus
|
cell-based format
|
Scientific Literature
| ||||
12. |
F
|
Analgesic activity in Swiss albino mouse assessed as protection against acetic acid-induced writhing at 50 mg/kg, po administered 1 hr prior to acetic acid challenge relative to control measured after 3 hrs
|
Mus musculus
|
organism-based format
|
Scientific Literature
| ||||
13. |
F
|
Antiinflammatory activity in rat assessed as inhibition of paw edema at 10 mg/kg
|
Rattus norvegicus
|
organism-based format
|
Scientific Literature
| ||||
14. |
F
|
Antiinflammatory activity in Wistar albino rat assessed as inhibition of carrageenan-induced paw edema at 4 mg/kg, po administered 30 mins before carrageenan challenge measured after 60 mins relative to control
|
Rattus norvegicus
|
organism-based format
|
Scientific Literature
| ||||
15. |
F
|
Inhibition of carrageenan-induced PGE2 production in Swiss mouse at 5 mg/kg, po dosed 45 mins before carrageenan dosing measured 3 hrs post carrageenan challenge by ELISA
|
Mus musculus
|
organism-based format
|
Scientific Literature
| ||||
16. |
F
|
Antiinflammatory activity in Wistar albino rat assessed as inhibition of carrageenan-induced paw edema at 4 mg/kg, po administered 30 mins before carrageenan challenge measured after 30 mins relative to control
|
Rattus norvegicus
|
organism-based format
|
Scientific Literature
| ||||
17. |
A
|
Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 5 uM by MTT assay relative to control
|
Mus musculus
|
cell-based format
|
Scientific Literature
| ||||
18. |
A
|
Drug activation in human Hep3B cells assessed as human CYP3A4-mediated drug metabolism-induced cytotoxicity measured as decrease in cell viability at 31.7 uM pre-incubated with BSO for 18 hrs followed by incubation with compound for 3 hrs in presence of NADPH measured after 24 hrs in absence of compound, CYP3A4 and NADPH by cell titer-glo luminescence assay relative to BSO alone
|
Homo sapiens
|
cell-based format
|
Scientific Literature
| ||||
19. |
P
|
Lipophilicity, LogD of the compound at pH 7.4 by HPLC C18 method
|
---
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small-molecule physicochemical format
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Scientific Literature
| ||||
20. |
F
|
Antiinflammatory activity in albino rat assessed as inhibition of carrageenan-induced paw oedema at 50 mg/kg, po measured after 60 mins of carrageenan challenge relative to control
|
Rattus norvegicus
|
organism-based format
|
Scientific Literature
|
Showing 1-20
out of 548 records