Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents.

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Basic Information

ID: CHEMBL1150213
Journal: J Nat Prod
Title: Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents.
Authors: Chang CJ, Geahlen RL.
Abstract: Protein-tyrosine kinases (PTKs) have been shown to induce the cascade of altered cell parameters characteristic of transformed cells. This proposition provides an important rationale for the discovery of potential antitumor agents from natural sources on the basis of inhibition of PTK activity. Numerous naturally occurring and synthetic analogues of PTK inhibitors were systematically evaluated in this review based on their structure-activity relationships and potential antitumor efficacy.
CiteXplore: 1479375
Patent ID: ---

Compound Summaries

Associated Compounds for document CHEMBL1150213 (Protein-tyrosine kinase inhibition: mechanism-base...) (214)
Histogram Settings


14.83 29.67 44.5 59.33 74.17 89 [0.00, 139.64) [139.64, 279.28) [279.28, 418.93) [418.93, 558.57) [558.57, 698.21) [698.21, 837.85) [837.85, 977.50) [977.50, 1117.14) [1117.14, 1256.78) [1256.78, 1396.42) [1396.42, 1452.40]
Total
214
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