In-vivo analgesic and anti-inflammatory activities of newly synthesized benzimidazole derivatives.


ID: CHEMBL1157854
Journal: Eur J Med Chem
Title: In-vivo analgesic and anti-inflammatory activities of newly synthesized benzimidazole derivatives.
Authors: Achar KC, Hosamani KM, Seetharamareddy HR.
Abstract: A series of 2-methylaminobenzimidazole derivatives (1-11) were synthesized by the reaction of 2-(chloromethyl)-1H-benzimidazole derivatives with primary aromatic amines. All these compounds were characterized by IR, 1H NMR, 13C NMR, GC-MS and elemental analysis. The newly synthesized compounds were screened for analgesic and anti-inflammatory activities on acetic acid induced writhing in mice and carrageenan induced paw oedema in rats. Compounds (7) and (2) showed a potent analgesic (89% at 100 mg/kg b.w) and anti-inflammatory (100% at 100 mg/kg b.w) activities compared with standard drug Nimesulide (100% at 50 mg/kg b.w) respectively. The other compounds showed good analgesic and anti-inflammatory activities.
CiteXplore: 20133024
Patent ID: ---
ChEMBL IDTarget SimilarityCompound SimilarityReferenceTitlePubMed IDDOI
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Histogram Settings


0.67 1.33 2 2.67 3.33 4 [217.95, 234.71) [234.71, 251.48) [251.48, 268.24) [268.24, 285.01) [285.01, 301.77) [301.77, 318.54) [318.54, 335.30) [335.30, 352.07) [352.07, 368.83) [368.83, 381.07]
Total
12
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