Antitumor agents. 25. Synthesis and antitumor activity of uracil and thymine alpha-methylene-gamma-lactones and related derivatives.

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Basic Information

ID: CHEMBL3271954
Journal: J Med Chem
Title: Antitumor agents. 25. Synthesis and antitumor activity of uracil and thymine alpha-methylene-gamma-lactones and related derivatives.
Authors: Lee KH, Wu YS, Hall IH.
Abstract: Uracil and thymine alpha-methylene-gamma-lactones and related derivatives have been synthesized as novel potential alkylating antitumor agents. The synthesis of these compounds involved the convenient Reformatsky-type reaction between ethyl-alpha-(bromomethyl)acrylate and the proper pyrimidinyl ketones. Preliminary in vivo tumor assay indicated that these compounds were active against the Walker 256 carcinosarcoma in rats and the P-388 lymphocytic leukemia as well as the B-16 melanotic melanoma in mice at 2.5-25 mg/kg.
CiteXplore: 874966
Patent ID: ---

Compound Summaries

Associated Compounds for document CHEMBL3271954 (Antitumor agents. 25. Synthesis and antitumor acti...) (10)
Histogram Settings


0.5 1 1.5 2 2.5 3 [111.04, 148.05) [148.05, 185.06) [185.06, 222.07) [222.07, 259.09) [259.09, 296.10) [296.10, 333.11) [333.11, 370.12) [370.12, 407.13) [407.13, 444.15) [444.15, 460.44]
Total
10
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