Serine/threonine-protein kinase VRK1
ID: CHEMBL1293199
Type: SINGLE PROTEIN
Preferred Name: Serine/threonine-protein kinase VRK1
Synonyms:
Serine/threonine-protein kinase VRK1
Vaccinia-related kinase 1
VRK1
Synonyms: ---
organism: Homo sapiens
Species Group: No
Protein Target Classification:
1.
| Description | Relationship | Accession |
|---|---|---|
| Serine/threonine-protein kinase VRK1 | SINGLE PROTEIN | Q99986 |
Associated Bioactivities
Total
264
Thermal melting change
Delta TM
Activity
Inhibition
IC50
Residual activity
Delta Tm
delta Tm
delta Tm Staurosporine positive control
% of control
dTM
% Residual activity with Skepinone-L
% residual kinase activity
Kd
Tm
Associated Assays
Total
53
B - Binding
See all activities used in this plot (9)
Ligand Efficiencies for Target CHEMBL1293199 (Serine/threonine-protein kinase VRK1)
Standard Value nM
<1
(0 items)
[1,100)
(1 items)
[100,1000)
(5 items)
>=1000
(3 items)
Showing 9 data points.
Hover over a point to see the details.
The Ligand Efficiency chart plots Binding Efficiency Index (BEI)
against Surface Efficiency Index (SEI), where:
- SEI = (-log10(Standard Value*10^-9))*100/PSA
- BEI = (-log10(Standard Value*10^-9))*1000/MWT
- GO:0000785 (chromatin)
- GO:0005634 (nucleus)
- GO:0005654 (nucleoplasm)
- GO:0005730 (nucleolus)
- GO:0005737 (cytoplasm)
- GO:0005795 (Golgi stack)
- GO:0005829 (cytosol)
- GO:0015030 (Cajal body)
- GO:0005515 (protein binding)
- GO:0005524 (ATP binding)
- GO:0016301 (kinase activity)
- GO:0019901 (protein kinase binding)
- GO:0031492 (nucleosomal DNA binding)
- GO:0042393 (histone binding)
- GO:0006468 (protein phosphorylation)
- GO:0006974 (DNA damage response)
- GO:0007077 (mitotic nuclear membrane disassembly)
- GO:0007165 (signal transduction)
- GO:0046777 (protein autophosphorylation)
- GO:0051301 (cell division)
- GO:0120187 (positive regulation of protein localization to chromatin)
- GO:2001222 (regulation of neuron migration)
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