Solute carrier family 22 member 8
ID: CHEMBL1641348
Type: SINGLE PROTEIN
Preferred Name: Solute carrier family 22 member 8
Synonyms:
hOAT3
OAT3
Organic anion/dicarboxylate exchanger
Organic anion transporter 3
SLC22A8
Synonyms: ---
organism: Homo sapiens
Species Group: No
Protein Target Classification:
1.
| Description | Relationship | Accession |
|---|---|---|
| Organic anion transporter 3 | SINGLE PROTEIN | Q8TCC7 |
5
Showing 1-2
out of 2 records
| # | Parent Molecule ChEMBL ID | Parent Molecule Name | Parent Molecule Type | Mechanism of Action | Max Phase | First Approval | USAN Stem | References |
|---|---|---|---|---|---|---|---|---|
| 1. |
PROBENECID
|
Small molecule
|
Solute carrier family 22 member 8 inhibitor
| 4 |
1951
|
---
| ||
| 2. |
PRATOSARTAN
|
Small molecule
|
Solute carrier family 22 member 8 inhibitor
| 2 |
---
|
-sartan
|
Showing 1-2
out of 2 records
Associated Bioactivities
Total
243
Activity
Inhibition
Ki
IC50
Km
Ratio
Vmax
Drug uptake
Drug transport
FC
Jmax
INH
Associated Assays
Total
102
F - Functional
A - ADME
B - Binding
See all activities used in this plot (20)
Ligand Efficiencies for Target CHEMBL1641348 (Solute carrier family 22 member 8)
Standard Value nM
<1
(0 items)
[1,100)
(0 items)
[100,1000)
(2 items)
>=1000
(18 items)
Showing 20 data points.
Hover over a point to see the details.
The Ligand Efficiency chart plots Binding Efficiency Index (BEI)
against Surface Efficiency Index (SEI), where:
- SEI = (-log10(Standard Value*10^-9))*100/PSA
- BEI = (-log10(Standard Value*10^-9))*1000/MWT
Histogram Settings
Total
142
- GO:0005886 (plasma membrane)
- GO:0009925 (basal plasma membrane)
- GO:0016020 (membrane)
- GO:0016323 (basolateral plasma membrane)
- GO:0016324 (apical plasma membrane)
- GO:0070062 (extracellular exosome)
- GO:0005452 (solute:inorganic anion antiporter activity)
- GO:0008514 (organic anion transmembrane transporter activity)
- GO:0015132 (prostaglandin transmembrane transporter activity)
- GO:0022857 (transmembrane transporter activity)
- GO:0042910 (xenobiotic transmembrane transporter activity)
- GO:0006811 (monoatomic ion transport)
- GO:0006869 (lipid transport)
- GO:0009636 (response to toxic substance)
- GO:0015698 (inorganic anion transport)
- GO:0015732 (prostaglandin transport)
- GO:0042908 (xenobiotic transport)
- GO:0055085 (transmembrane transport)
- GO:0150104 (transport across blood-brain barrier)
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