Proliferating cell nuclear antigen
ID: CHEMBL2346488
Type: SINGLE PROTEIN
Preferred Name: Proliferating cell nuclear antigen
Synonyms:
Cyclin
PCNA
Proliferating cell nuclear antigen
Synonyms: ---
organism: Homo sapiens
Species Group: No
Protein Target Classification:
1.
| Description | Relationship | Accession |
|---|---|---|
| Proliferating cell nuclear antigen | SINGLE PROTEIN | P12004 |
Associated Bioactivities
Total
81
Inhibition
IC50
Associated Assays
Total
11
B - Binding
See all activities used in this plot (27)
Ligand Efficiencies for Target CHEMBL2346488 (Proliferating cell nuclear antigen)
Standard Value nM
<1
(0 items)
[1,100)
(0 items)
[100,1000)
(0 items)
>=1000
(27 items)
Showing 27 data points.
Hover over a point to see the details.
The Ligand Efficiency chart plots Binding Efficiency Index (BEI)
against Surface Efficiency Index (SEI), where:
- SEI = (-log10(Standard Value*10^-9))*100/PSA
- BEI = (-log10(Standard Value*10^-9))*1000/MWT
Histogram Settings
Total
32
- GO:0000781 (chromosome, telomeric region)
- GO:0000785 (chromatin)
- GO:0001673 (male germ cell nucleus)
- GO:0005634 (nucleus)
- GO:0005652 (nuclear lamina)
- GO:0005654 (nucleoplasm)
- GO:0005657 (replication fork)
- GO:0005813 (centrosome)
- GO:0016604 (nuclear body)
- GO:0030894 (replisome)
- GO:0043596 (nuclear replication fork)
- GO:0043626 (PCNA complex)
- GO:0070062 (extracellular exosome)
- GO:0070557 (PCNA-p21 complex)
- GO:0000701 (purine-specific mismatch base pair DNA N-glycosylase activity)
- GO:0003677 (DNA binding)
- GO:0003682 (chromatin binding)
- GO:0003684 (damaged DNA binding)
- GO:0005515 (protein binding)
- GO:0019899 (enzyme binding)
- GO:0030331 (nuclear estrogen receptor binding)
- GO:0030337 (DNA polymerase processivity factor activity)
- GO:0030971 (receptor tyrosine kinase binding)
- GO:0032139 (dinucleotide insertion or deletion binding)
- GO:0035035 (histone acetyltransferase binding)
- GO:0042802 (identical protein binding)
- GO:0070182 (DNA polymerase binding)
- GO:0000122 (negative regulation of transcription by RNA polymerase II)
- GO:0006272 (leading strand elongation)
- GO:0006281 (DNA repair)
- GO:0006287 (base-excision repair, gap-filling)
- GO:0006298 (mismatch repair)
- GO:0006979 (response to oxidative stress)
- GO:0007507 (heart development)
- GO:0019985 (translesion synthesis)
- GO:0030855 (epithelial cell differentiation)
- GO:0031297 (replication fork processing)
- GO:0032077 (positive regulation of deoxyribonuclease activity)
- GO:0034644 (cellular response to UV)
- GO:0044849 (estrous cycle)
- GO:0045739 (positive regulation of DNA repair)
- GO:0045740 (positive regulation of DNA replication)
- GO:0070301 (cellular response to hydrogen peroxide)
- GO:0071466 (cellular response to xenobiotic stimulus)
- GO:0097421 (liver regeneration)
- GO:1900264 (positive regulation of DNA-directed DNA polymerase activity)
- GO:1902990 (mitotic telomere maintenance via semi-conservative replication)
Translesion synthesis by REV1, Recognition of DNA damage by PCNA-containing replication complex, Translesion Synthesis by POLH, Transcription of E2F targets under negative control by DREAM complex, Polymerase switching on the C-strand of the telomere, Processive synthesis on the C-strand of the telomere, Telomere C-strand (Lagging Strand) Synthesis, Removal of the Flap Intermediate from the C-strand, SUMOylation of DNA replication proteins, Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha), Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta), PCNA-Dependent Long Patch Base Excision Repair, Translesion synthesis by POLK, Translesion synthesis by POLI, Termination of translesion DNA synthesis, HDR through Homologous Recombination (HRR), Gap-filling DNA repair synthesis and ligation in GG-NER, Dual Incision in GG-NER, Dual incision in TC-NER, Gap-filling DNA repair synthesis and ligation in TC-NER, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest, Polymerase switching, Removal of the Flap Intermediate, Processive synthesis on the lagging strand, G1/S-Specific Transcription, E3 ubiquitin ligases ubiquitinate target proteins
1AXC, 1U76, 1U7B, 1UL1, 1VYJ, 1VYM, 1W60, 2ZVK, 2ZVL, 2ZVM, 3JA9, 3P87, 3TBL, 3VKX, 3WGW, 4D2G, 4RJF, 4ZTD, 5E0T, 5E0U, 5E0V, 5IY4, 5MAV, 5MLO, 5MLW, 5MOM, 5YCO, 5YD8, 6CBI, 6EHT, 6FCM, 6FCN, 6GIS, 6GWS, 6HVO, 6K3A, 6QC0, 6QCG, 6S1M, 6S1N, 6S1O, 6TNY, 6TNZ, 6VVO, 7EFA, 7KQ0, 7KQ1, 7M5L, 7M5M, 7M5N, 7NV0, 7NV1, 7QNZ, 7QO1, 8B8T, 8COB, 8E84, 8F5Q, 8GCJ, 8GL9, 8GLA, 8UI7, 8UI8, 8UI9, 8UII, 8UMT, 8UMU, 8UMV, 8UMW, 8UMY, 8UN0
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