Tyrosine-protein kinase HCK
ID: CHEMBL3234
Type: SINGLE PROTEIN
Preferred Name: Tyrosine-protein kinase HCK
Synonyms:
HCK
Hematopoietic cell kinase
Hemopoietic cell kinase
p59Hck
p59-HCK/p60-HCK
Synonyms: ---
organism: Homo sapiens
Species Group: No
Protein Target Classification:
1.
| Description | Relationship | Accession |
|---|---|---|
| Tyrosine-protein kinase HCK | SINGLE PROTEIN | P08631 |
| ChEMBL ID | Relationship | Pref Name | Target Type |
|---|---|---|---|
| CHEMBL2363074 | SUPERSET OF | SRC | PROTEIN FAMILY |
5
Showing 1-1
out of 1 records
| # | Parent Molecule ChEMBL ID | Parent Molecule Name | Parent Molecule Type | Mechanism of Action | Max Phase | First Approval | USAN Stem | References |
|---|---|---|---|---|---|---|---|---|
| 1. |
BOSUTINIB
|
Small molecule
|
Tyrosine-protein kinase HCK inhibitor
| 4 |
2012
|
-tinib
|
Showing 1-1
out of 1 records
Associated Bioactivities
Total
2809
Inhibition
Residual Activity
IC50
Kd
% Control
Activity
Ki
% of control
% of inhibition
Residual activity
GI50
% residual kinase activity
FC
log2FC
% Ctrl
% Residual activity with Skepinone-L
% binding
Delta Tm
EC50
Fold selectivity
Associated Assays
Total
340
B - Binding
A - ADME
F - Functional
See all activities used in this plot (537)
Ligand Efficiencies for Target CHEMBL3234 (Tyrosine-protein kinase HCK)
Standard Value nM
<1
(9 items)
[1,100)
(211 items)
[100,1000)
(158 items)
>=1000
(157 items)
Showing 535 data points.
Hover over a point to see the details.
The Ligand Efficiency chart plots Binding Efficiency Index (BEI)
against Surface Efficiency Index (SEI), where:
- SEI = (-log10(Standard Value*10^-9))*100/PSA
- BEI = (-log10(Standard Value*10^-9))*1000/MWT
- GO:0005634 (nucleus)
- GO:0005737 (cytoplasm)
- GO:0005764 (lysosome)
- GO:0005794 (Golgi apparatus)
- GO:0005829 (cytosol)
- GO:0005856 (cytoskeleton)
- GO:0005884 (actin filament)
- GO:0005886 (plasma membrane)
- GO:0005901 (caveola)
- GO:0005925 (focal adhesion)
- GO:0009898 (cytoplasmic side of plasma membrane)
- GO:0042995 (cell projection)
- GO:0070161 (anchoring junction)
- GO:0001784 (phosphotyrosine residue binding)
- GO:0005102 (signaling receptor binding)
- GO:0005515 (protein binding)
- GO:0005524 (ATP binding)
- GO:0008289 (lipid binding)
- GO:0002522 (leukocyte migration involved in immune response)
- GO:0002758 (innate immune response-activating signaling pathway)
- GO:0002862 (negative regulation of inflammatory response to antigenic stimulus)
- GO:0006468 (protein phosphorylation)
- GO:0006887 (exocytosis)
- GO:0006909 (phagocytosis)
- GO:0007155 (cell adhesion)
- GO:0007169 (cell surface receptor protein tyrosine kinase signaling pathway)
- GO:0007229 (integrin-mediated signaling pathway)
- GO:0007498 (mesoderm development)
- GO:0008284 (positive regulation of cell population proliferation)
- GO:0008360 (regulation of cell shape)
- GO:0018108 (peptidyl-tyrosine phosphorylation)
- GO:0019221 (cytokine-mediated signaling pathway)
- GO:0030154 (cell differentiation)
- GO:0030838 (positive regulation of actin filament polymerization)
- GO:0031663 (lipopolysaccharide-mediated signaling pathway)
- GO:0032956 (regulation of actin cytoskeleton organization)
- GO:0035556 (intracellular signal transduction)
- GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
- GO:0043066 (negative regulation of apoptotic process)
- GO:0043299 (leukocyte degranulation)
- GO:0045087 (innate immune response)
- GO:0045728 (respiratory burst after phagocytosis)
- GO:0046777 (protein autophosphorylation)
- GO:0050727 (regulation of inflammatory response)
- GO:0050764 (regulation of phagocytosis)
- GO:0060333 (type II interferon-mediated signaling pathway)
- GO:0071801 (regulation of podosome assembly)
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- IPR000719 (Prot_kinase_dom)
- IPR000980 (SH2)
- IPR001245 (Ser-Thr/Tyr_kinase_cat_dom)
- IPR001452 (SH3_domain)
- IPR008266 (Tyr_kinase_AS)
- IPR011009 (Kinase-like_dom_sf)
- IPR017441 (Protein_kinase_ATP_BS)
- IPR020635 (Tyr_kinase_cat_dom)
- IPR035851 (HCK_SH2)
- IPR036028 (SH3-like_dom_sf)
- IPR036860 (SH2_dom_sf)
- IPR050198 (Non-receptor_tyrosine_kinases)
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