PI4-kinase beta subunit

Target

Name and Classification

ID: CHEMBL3268

Type: SINGLE PROTEIN

Preferred Name: PI4-kinase beta subunit

Synonyms:

NPIK Phosphatidylinositol 4-kinase beta PI4K92 PI4KB PI4K-beta

Synonyms: ---

organism: Homo sapiens

Species Group: No

Protein Target Classification:

Target Components

Description	Relationship	Accession
Phosphatidylinositol 4-kinase beta	SINGLE PROTEIN	Q9UBF8

Target Relations

ChEMBL ID	Relationship	Pref Name	Target Type
CHEMBL2096619	SUPERSET OF	Phosphatidylinositol 4-kinase, PI4K	PROTEIN FAMILY

Activity Charts

Associated Bioactivities

Activity Types for CHEMBL3268 (PI4-kinase beta subunit)

Total

1667

Inhibition

IC50

% Control

Activity

% of control

% of inhibition

% inhibition

% Ctrl

% of engagement

Time

% binding

Associated Assays

Assays for Target CHEMBL3268 (PI4-kinase beta subunit)

Total

194

B - Binding

A - ADME

Ligand Efficiencies

See all activities used in this plot (408)

Ligand Efficiencies for Target CHEMBL3268 (PI4-kinase beta subunit)

Standard Value nM

Showing 408 data points.

Hover over a point to see the details.

The Ligand Efficiency chart plots Binding Efficiency Index (BEI) against Surface Efficiency Index (SEI), where:

SEI = (-log10(Standard Value*10^-9))*100/PSA
BEI = (-log10(Standard Value*10^-9))*1000/MWT

Associated Compounds

Associated Compounds for Target CHEMBL3268 (PI4-kinase beta subunit) (1153)

Parent Molecular Weight

ALogP

Polar Surface Area

Histogram Settings

Interval Size (83.75)

Total

1153

Gene Cross References

ExpressionAtlas (1)

Q9UBF8

GoComponent (11)

GO:0000139 (Golgi membrane)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0005768 (endosome)
GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0030867 (rough endoplasmic reticulum membrane)
GO:0048471 (perinuclear region of cytoplasm)

GoFunction (5)

GO:0004430 (1-phosphatidylinositol 4-kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0071889 (14-3-3 protein binding)

GoProcess (7)

GO:0006629 (lipid metabolic process)
GO:0006661 (phosphatidylinositol biosynthetic process)
GO:0006898 (receptor-mediated endocytosis)
GO:0007165 (signal transduction)
GO:0046854 (phosphatidylinositol phosphate biosynthetic process)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0048839 (inner ear development)

HGNC (1)

PI4KB

PANTHER (2)

PHOSPHATIDYLINOSITOL KINASE, PHOSPHATIDYLINOSITOL 4-KINASE BETA

Protein Cross References

IntAct (1)

Q9UBF8

PharmGKB (1)

phosphatidylinositol 4-kinase beta

Pharos (1)

Q9UBF8

Reactome (1)

Synthesis of PIPs at the Golgi membrane

UniProt (8)

Phosphatidylinositol 4-kinase beta, Phosphatidylinositol 4-kinase beta, Phosphatidylinositol 4-kinase beta, Phosphatidylinositol 4-kinase beta, Phosphatidylinositol 4-kinase beta, Phosphatidylinositol 4-kinase beta, Phosphatidylinositol 4-kinase beta, Phosphatidylinositol 4-kinase beta

Domain Cross References

InterPro (7)

IPR000403 (PI3/4_kinase_cat_dom)
IPR001263 (PI3K_accessory_dom)
IPR011009 (Kinase-like_dom_sf)
IPR015433 (PI_Kinase)
IPR018936 (PI3/4_kinase_CS)
IPR036940 (PI3/4_kinase_cat_sf)
IPR049160 (PI4KB-PIK1_PIK)

Pfam (2)

PF00454 (PI3_PI4_kinase)
PF21245 (PI4KB-PIK1_PIK)

Structure Cross References

AlphaFoldDB (1)

Q9UBF8

PDB (18)

2N73, 4D0L, 4D0M, 4WAE, 4WAG, 5C46, 5C4G, 5EUQ, 5FBL, 5FBQ, 5FBR, 5FBV, 5FBW, 5LX2, 5NAS, 6GL3, 8Q6G, 8Q6H

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