Matrix metalloproteinase-1
ID: CHEMBL332
Type: SINGLE PROTEIN
Preferred Name: Matrix metalloproteinase-1
Synonyms:
22 kDa interstitial collagenase
27 kDa interstitial collagenase
CLG
Fibroblast collagenase
Interstitial collagenase
Synonyms: ---
organism: Homo sapiens
Species Group: No
Protein Target Classification:
1.
| Description | Relationship | Accession |
|---|---|---|
| Interstitial collagenase | SINGLE PROTEIN | P03956 |
| ChEMBL ID | Relationship | Pref Name | Target Type |
|---|---|---|---|
| CHEMBL2095216 | SUPERSET OF | Collagenase | PROTEIN FAMILY |
| CHEMBL2111422 | SUPERSET OF | Matrix metalloproteinase (1 and 13) | SELECTIVITY GROUP |
| CHEMBL4523984 | SUPERSET OF | MMP-1/MMP-2 | SELECTIVITY GROUP |
5
Showing 1-3
out of 3 records
| # | Parent Molecule ChEMBL ID | Parent Molecule Name | Parent Molecule Type | Mechanism of Action | Max Phase | First Approval | USAN Stem | References |
|---|---|---|---|---|---|---|---|---|
| 1. |
DOXYCYCLINE ANHYDROUS
|
Small molecule
|
Matrix metalloproteinase-1 inhibitor
| 4 |
1967
|
-cycline
| ||
| 2. |
MARIMASTAT
|
Small molecule
|
Matrix metalloproteinase-1 inhibitor
| 3 |
---
|
-stat
| ||
| 3. |
REBIMASTAT
|
Small molecule
|
Matrix metalloproteinase-1 inhibitor
| 2 |
---
|
-stat
|
Showing 1-3
out of 3 records
Associated Bioactivities
Total
7065
IC50
Ki
Inhibition
Activity
log(10^6/IC50)
EC50
% Ctrl
INH
Ratio IC50
Kd
Selectivity
% Enzyme Activity (relative to DMSO controls, average n=2)
% Inhibition of Control Values
A0.5
Control compound IC50
Associated Assays
Total
544
B - Binding
A - ADME
See all activities used in this plot (3020)
(Showing first
1000 data points out of 3020)
Ligand Efficiencies for Target CHEMBL332 (Matrix metalloproteinase-1)
Standard Value nM
<1
(14 items)
[1,100)
(361 items)
[100,1000)
(229 items)
>=1000
(394 items)
Showing 998 data points.
Hover over a point to see the details.
The Ligand Efficiency chart plots Binding Efficiency Index (BEI)
against Surface Efficiency Index (SEI), where:
- SEI = (-log10(Standard Value*10^-9))*100/PSA
- BEI = (-log10(Standard Value*10^-9))*1000/MWT
- GO:0005576 (extracellular region)
- GO:0005615 (extracellular space)
- GO:0004175 (endopeptidase activity)
- GO:0004222 (metalloendopeptidase activity)
- GO:0004252 (serine-type endopeptidase activity)
- GO:0008233 (peptidase activity)
- GO:0008237 (metallopeptidase activity)
- GO:0008270 (zinc ion binding)
- GO:0046872 (metal ion binding)
- GO:0006508 (proteolysis)
- GO:0022617 (extracellular matrix disassembly)
- GO:0030198 (extracellular matrix organization)
- GO:0030574 (collagen catabolic process)
- GO:0031334 (positive regulation of protein-containing complex assembly)
- GO:0071492 (cellular response to UV-A)
- IPR000585 (Hemopexin-like_dom)
- IPR001818 (Pept_M10_metallopeptidase)
- IPR002477 (Peptidoglycan-bd-like)
- IPR006026 (Peptidase_Metallo)
- IPR018486 (Hemopexin_CS)
- IPR018487 (Hemopexin-like_repeat)
- IPR021158 (Pept_M10A_Zn_BS)
- IPR021190 (Pept_M10A)
- IPR024079 (MetalloPept_cat_dom_sf)
- IPR033739 (M10A_MMP)
- IPR036365 (PGBD-like_sf)
- IPR036375 (Hemopexin-like_dom_sf)
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