Hepatocyte growth factor receptor
ID: CHEMBL3717
Type: SINGLE PROTEIN
Preferred Name: Hepatocyte growth factor receptor
Synonyms:
Hepatocyte growth factor receptor
HGF receptor
HGF/SF receptor
MET
Proto-oncogene c-Met
Synonyms: ---
organism: Homo sapiens
Species Group: No
Protein Target Classification:
1.
| Description | Relationship | Accession |
|---|---|---|
| Hepatocyte growth factor receptor | SINGLE PROTEIN | P08581 |
5
Showing 1-5
out of 37 records
| # | Parent Molecule ChEMBL ID | Parent Molecule Name | Parent Molecule Type | Mechanism of Action | Max Phase | First Approval | USAN Stem | References |
|---|---|---|---|---|---|---|---|---|
| 1. |
CAPMATINIB
|
Small molecule
|
Hepatocyte growth factor receptor inhibitor
| 4 |
2020
|
-tinib
| ||
| 2. |
TEPOTINIB
|
Small molecule
|
Hepatocyte growth factor receptor inhibitor
| 4 |
2020
|
-tinib
| ||
| 3. |
CABOZANTINIB
|
Small molecule
|
Hepatocyte growth factor receptor inhibitor
| 4 |
2012
|
-tinib
| ||
| 4. |
CRIZOTINIB
|
Small molecule
|
Hepatocyte growth factor receptor inhibitor
| 4 |
2011
|
-tinib
| ||
| 5. |
Antibody
|
AMIVANTAMAB
|
Antibody
|
Hepatocyte growth factor receptor inhibitor
| 4 |
2021
|
-mab
|
Showing 1-5
out of 37 records
Associated Bioactivities
Total
11007
IC50
Inhibition
Ki
Kd
Activity
% Control
Residual Activity
EC50
% of control
% of inhibition
% Residual activity with Skepinone-L
Residual activity
Efficacy
INH
% Ctrl
Ratio IC50
% binding
% residual kinase activity
K
GI50
Other
Associated Assays
Total
1624
B - Binding
A - ADME
F - Functional
See all activities used in this plot (5151)
(Showing first
1000 data points out of 5151)
Ligand Efficiencies for Target CHEMBL3717 (Hepatocyte growth factor receptor)
Standard Value nM
<1
(36 items)
[1,100)
(536 items)
[100,1000)
(234 items)
>=1000
(192 items)
Showing 998 data points.
Hover over a point to see the details.
The Ligand Efficiency chart plots Binding Efficiency Index (BEI)
against Surface Efficiency Index (SEI), where:
- SEI = (-log10(Standard Value*10^-9))*100/PSA
- BEI = (-log10(Standard Value*10^-9))*1000/MWT
- GO:0005576 (extracellular region)
- GO:0005886 (plasma membrane)
- GO:0009925 (basal plasma membrane)
- GO:0009986 (cell surface)
- GO:0016020 (membrane)
- GO:0043235 (receptor complex)
- GO:0098794 (postsynapse)
- GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
- GO:0005004 (GPI-linked ephrin receptor activity)
- GO:0005005 (transmembrane-ephrin receptor activity)
- GO:0005006 (epidermal growth factor receptor activity)
- GO:0005007 (fibroblast growth factor receptor activity)
- GO:0005008 (hepatocyte growth factor receptor activity)
- GO:0005009 (insulin receptor activity)
- GO:0005010 (insulin-like growth factor receptor activity)
- GO:0005011 (macrophage colony-stimulating factor receptor activity)
- GO:0005018 (platelet-derived growth factor alpha-receptor activity)
- GO:0005019 (platelet-derived growth factor beta-receptor activity)
- GO:0005020 (stem cell factor receptor activity)
- GO:0005021 (vascular endothelial growth factor receptor activity)
- GO:0005515 (protein binding)
- GO:0005524 (ATP binding)
- GO:0008288 (boss receptor activity)
- GO:0017154 (semaphorin receptor activity)
- GO:0019903 (protein phosphatase binding)
- GO:0036332 (placental growth factor receptor activity)
- GO:0038062 (protein tyrosine kinase collagen receptor activity)
- GO:0042802 (identical protein binding)
- GO:0060175 (brain-derived neurotrophic factor receptor activity)
- GO:0001886 (endothelial cell morphogenesis)
- GO:0001889 (liver development)
- GO:0006909 (phagocytosis)
- GO:0007165 (signal transduction)
- GO:0007166 (cell surface receptor signaling pathway)
- GO:0007169 (cell surface receptor protein tyrosine kinase signaling pathway)
- GO:0007173 (epidermal growth factor receptor signaling pathway)
- GO:0007399 (nervous system development)
- GO:0008286 (insulin receptor signaling pathway)
- GO:0008543 (fibroblast growth factor receptor signaling pathway)
- GO:0010507 (negative regulation of autophagy)
- GO:0016477 (cell migration)
- GO:0030182 (neuron differentiation)
- GO:0031016 (pancreas development)
- GO:0031116 (positive regulation of microtubule polymerization)
- GO:0031547 (brain-derived neurotrophic factor receptor signaling pathway)
- GO:0035024 (negative regulation of Rho protein signal transduction)
- GO:0035790 (platelet-derived growth factor receptor-alpha signaling pathway)
- GO:0035791 (platelet-derived growth factor receptor-beta signaling pathway)
- GO:0036323 (vascular endothelial growth factor receptor-1 signaling pathway)
- GO:0038063 (collagen-activated tyrosine kinase receptor signaling pathway)
- GO:0038084 (vascular endothelial growth factor signaling pathway)
- GO:0038109 (Kit signaling pathway)
- GO:0038145 (macrophage colony-stimulating factor signaling pathway)
- GO:0045944 (positive regulation of transcription by RNA polymerase II)
- GO:0048009 (insulin-like growth factor receptor signaling pathway)
- GO:0048012 (hepatocyte growth factor receptor signaling pathway)
- GO:0048013 (ephrin receptor signaling pathway)
- GO:0048754 (branching morphogenesis of an epithelial tube)
- GO:0050918 (positive chemotaxis)
- GO:0051497 (negative regulation of stress fiber assembly)
- GO:0060079 (excitatory postsynaptic potential)
- GO:0061436 (establishment of skin barrier)
- GO:0070495 (negative regulation of thrombin-activated receptor signaling pathway)
- GO:0071526 (semaphorin-plexin signaling pathway)
- GO:1901299 (negative regulation of hydrogen peroxide-mediated programmed cell death)
- GO:1905098 (negative regulation of guanyl-nucleotide exchange factor activity)
- GO:2001028 (positive regulation of endothelial cell chemotaxis)
PIP3 activates AKT signaling, Constitutive Signaling by Aberrant PI3K in Cancer, Sema4D mediated inhibition of cell attachment and migration, RAF/MAP kinase cascade, MET Receptor Activation, Negative regulation of MET activity, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling, MET activates RAS signaling, MET activates PI3K/AKT signaling, MET activates PTPN11, MET activates PTK2 signaling, InlB-mediated entry of Listeria monocytogenes into host cell, MET interacts with TNS proteins, MET activates RAP1 and RAC1, MET receptor recycling, MET activates STAT3, MECP2 regulates neuronal receptors and channels, Drug-mediated inhibition of MET activation, Regulation of MITF-M-dependent genes involved in cell cycle and proliferation
- IPR000719 (Prot_kinase_dom)
- IPR001245 (Ser-Thr/Tyr_kinase_cat_dom)
- IPR001627 (Semap_dom)
- IPR002165 (Plexin_repeat)
- IPR002909 (IPT_dom)
- IPR008266 (Tyr_kinase_AS)
- IPR011009 (Kinase-like_dom_sf)
- IPR013783 (Ig-like_fold)
- IPR014756 (Ig_E-set)
- IPR015943 (WD40/YVTN_repeat-like_dom_sf)
- IPR016201 (PSI)
- IPR016244 (Tyr_kinase_HGF/MSP_rcpt)
- IPR017441 (Protein_kinase_ATP_BS)
- IPR020635 (Tyr_kinase_cat_dom)
- IPR031148 (Plexin)
- IPR036352 (Semap_dom_sf)
1FYR, 1R0P, 1R1W, 1SHY, 1SSL, 2G15, 2RFN, 2RFS, 2UZX, 2UZY, 2WD1, 2WGJ, 2WKM, 3A4P, 3BUX, 3C1X, 3CCN, 3CD8, 3CE3, 3CTH, 3CTJ, 3DKC, 3DKF, 3DKG, 3EFJ, 3EFK, 3F66, 3F82, 3I5N, 3L8V, 3LQ8, 3Q6U, 3Q6W, 3QTI, 3R7O, 3RHK, 3U6H, 3U6I, 3VW8, 3ZBX, 3ZC5, 3ZCL, 3ZXZ, 3ZZE, 4AOI, 4AP7, 4DEG, 4DEH, 4DEI, 4EEV, 4GG5, 4GG7, 4IWD, 4K3J, 4KNB, 4MXC, 4O3T, 4O3U, 4R1V, 4R1Y, 4XMO, 4XYF, 5DG5, 5EOB, 5EYC, 5EYD, 5HLW, 5HNI, 5HO6, 5HOA, 5HOR, 5HTI, 5LSP, 5T3Q, 5UAB, 5UAD, 5YA5, 6GCU, 6I04, 6SD9, 6SDC, 6SDD, 6SDE, 6UBW, 6WVZ, 7B3Q, 7B3T, 7B3V, 7B3W, 7B3Z, 7B40, 7B41, 7B42, 7B43, 7B44, 7MO7, 7MO8, 7MO9, 7MOA, 7MOB, 7V3R, 7V3S, 7Y4T, 7Y4U, 8AN8, 8ANS, 8AU3, 8AU5, 8AW1, 8GVJ, 8OUU, 8OUV, 8OV7, 8OVZ, 8OW3, 8OWG
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