Cyclin-dependent kinase 13/Cyclin-K

Target

Name and Classification

ID: CHEMBL4296067

Type: PROTEIN COMPLEX

Preferred Name: Cyclin-dependent kinase 13/Cyclin-K

Synonyms:

CDC2L CDC2L5 CDC2-related protein kinase 5 CDK13 Cell division cycle 2-like protein kinase 5

Synonyms: ---

organism: Homo sapiens

Species Group: No

Protein Target Classification:

Enzyme

Target Components

Description	Relationship	Accession
Cyclin-dependent kinase 13	PROTEIN SUBUNIT	Q14004
Cyclin-K	PROTEIN SUBUNIT	O75909

Target Relations

ChEMBL ID	Relationship	Pref Name	Target Type
CHEMBL1795192	SUBSET OF	Cyclin-dependent kinase 13	SINGLE PROTEIN
CHEMBL2346490	SUBSET OF	Cyclin-K	SINGLE PROTEIN
CHEMBL3038475	OVERLAPS WITH	CDK9/Cyclin K	PROTEIN COMPLEX
CHEMBL3559691	OVERLAPS WITH	Cyclin-dependent kinase	PROTEIN FAMILY
CHEMBL4106169	OVERLAPS WITH	CDK12/Cyclin K	PROTEIN COMPLEX

Activity Charts

Associated Bioactivities

Activity Types for CHEMBL4296067 (Cyclin-dependent kinase 13/Cyclin-K)

Total

IC50

Inhibition

% of inhibition

Activity

% Ctrl

% residual kinase activity

Associated Assays

Assays for Target CHEMBL4296067 (Cyclin-dependent kinase 13/Cyclin-K)

Total

B - Binding

Ligand Efficiencies

See all activities used in this plot (43)

Ligand Efficiencies for Target CHEMBL4296067 (Cyclin-dependent kinase 13/Cyclin-K)

Standard Value nM

Showing 43 data points.

Hover over a point to see the details.

The Ligand Efficiency chart plots Binding Efficiency Index (BEI) against Surface Efficiency Index (SEI), where:

SEI = (-log10(Standard Value*10^-9))*100/PSA
BEI = (-log10(Standard Value*10^-9))*1000/MWT

Associated Compounds

Associated Compounds for Target CHEMBL4296067 (Cyclin-dependent kinase 13/Cyclin-K) (66)

Parent Molecular Weight

ALogP

Polar Surface Area

Histogram Settings

Interval Size (48.45)

Total

Gene Cross References

ExpressionAtlas (2)

Q14004, O75909

GoComponent (9)

GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0008024 (cyclin/CDK positive transcription elongation factor complex)
GO:0016607 (nuclear speck)
GO:1904813 (ficolin-1-rich granule lumen)

GoFunction (5)

GO:0003723 (RNA binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0019901 (protein kinase binding)
GO:0030332 (cyclin binding)

GoProcess (14)

GO:0000380 (alternative mRNA splicing, via spliceosome)
GO:0006397 (mRNA processing)
GO:0008380 (RNA splicing)
GO:0009966 (regulation of signal transduction)
GO:0030097 (hemopoiesis)
GO:0032968 (positive regulation of transcription elongation by RNA polymerase II)
GO:0045944 (positive regulation of transcription by RNA polymerase II)
GO:0051726 (regulation of cell cycle)
GO:2000737 (negative regulation of stem cell differentiation)
GO:0000079 (regulation of cyclin-dependent protein serine/threonine kinase activity)
GO:0006974 (DNA damage response)
GO:0032786 (positive regulation of DNA-templated transcription, elongation)
GO:0044828 (negative regulation by host of viral genome replication)
GO:0051301 (cell division)