Purine nucleoside phosphorylase
ID: CHEMBL4338
Type: SINGLE PROTEIN
Preferred Name: Purine nucleoside phosphorylase
Synonyms:
Inosine-guanosine phosphorylase
Inosine phosphorylase
NP
PNP
Purine nucleoside phosphorylase
Synonyms: ---
organism: Homo sapiens
Species Group: No
Protein Target Classification:
1.
| Description | Relationship | Accession |
|---|---|---|
| Purine nucleoside phosphorylase | SINGLE PROTEIN | P00491 |
5
Showing 1-2
out of 2 records
| # | Parent Molecule ChEMBL ID | Parent Molecule Name | Parent Molecule Type | Mechanism of Action | Max Phase | First Approval | USAN Stem | References |
|---|---|---|---|---|---|---|---|---|
| 1. |
FORODESINE
|
Small molecule
|
Purine nucleoside phosphorylase inhibitor
| 2 |
---
|
---
| ||
| 2. |
ULODESINE
|
Small molecule
|
Purine nucleoside phosphorylase inhibitor
| 2 |
---
|
---
|
Showing 1-2
out of 2 records
Associated Bioactivities
Total
826
Ki
IC50
Inhibition
Activity
Ratio
Kd
Km
k
Drug metabolism
K6
Kcat
NS
Associated Assays
Total
147
B - Binding
F - Functional
A - ADME
See all activities used in this plot (476)
Ligand Efficiencies for Target CHEMBL4338 (Purine nucleoside phosphorylase)
Standard Value nM
<1
(73 items)
[1,100)
(221 items)
[100,1000)
(101 items)
>=1000
(81 items)
Showing 476 data points.
Hover over a point to see the details.
The Ligand Efficiency chart plots Binding Efficiency Index (BEI)
against Surface Efficiency Index (SEI), where:
- SEI = (-log10(Standard Value*10^-9))*100/PSA
- BEI = (-log10(Standard Value*10^-9))*1000/MWT
Histogram Settings
Total
421
- GO:0005576 (extracellular region)
- GO:0005737 (cytoplasm)
- GO:0005829 (cytosol)
- GO:0034774 (secretory granule lumen)
- GO:0070062 (extracellular exosome)
- GO:1904813 (ficolin-1-rich granule lumen)
- GO:0004731 (purine-nucleoside phosphorylase activity)
- GO:0005515 (protein binding)
- GO:0016757 (glycosyltransferase activity)
- GO:0042301 (phosphate ion binding)
- GO:0042802 (identical protein binding)
- GO:0047975 (guanosine phosphorylase activity)
- GO:0000255 (allantoin metabolic process)
- GO:0006148 (inosine catabolic process)
- GO:0006149 (deoxyinosine catabolic process)
- GO:0006157 (deoxyadenosine catabolic process)
- GO:0006166 (purine ribonucleoside salvage)
- GO:0006204 (IMP catabolic process)
- GO:0006738 (nicotinamide riboside catabolic process)
- GO:0006955 (immune response)
- GO:0009165 (nucleotide biosynthetic process)
- GO:0032743 (positive regulation of interleukin-2 production)
- GO:0034418 (urate biosynthetic process)
- GO:0042102 (positive regulation of T cell proliferation)
- GO:0043101 (purine-containing compound salvage)
- GO:0046059 (dAMP catabolic process)
- GO:0046638 (positive regulation of alpha-beta T cell differentiation)
ChEMBL is part of the ELIXIR infrastructure
ChEMBL is and Elixir Core Data Resource
Learn More
ChEMBL is a Global Core Biodata Resource