Induced myeloid leukemia cell differentiation protein Mcl-1
ID: CHEMBL4361
Type: SINGLE PROTEIN
Preferred Name: Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
Bcl2-L-3
BCL2L3
Bcl-2-like protein 3
Bcl-2-related protein EAT/mcl1
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms: ---
organism: Homo sapiens
Species Group: No
Protein Target Classification:
1.
| Description | Relationship | Accession |
|---|---|---|
| Induced myeloid leukemia cell differentiation protein Mcl-1 | SINGLE PROTEIN | Q07820 |
| ChEMBL ID | Relationship | Pref Name | Target Type |
|---|---|---|---|
| CHEMBL3430886 | SUPERSET OF | Induced myeloid leukemia cell differentiation protein Mcl-1/BH3-interacting domain death agonist | PROTEIN-PROTEIN INTERACTION |
| CHEMBL3430887 | SUPERSET OF | Induced myeloid leukemia cell differentiation protein Mcl-1/Bcl-2-like protein 11 | PROTEIN-PROTEIN INTERACTION |
| CHEMBL3885515 | SUPERSET OF | Apoptosis regulator BAX/Induced myeloid leukemia cell differentiation protein Mcl-1 | PROTEIN-PROTEIN INTERACTION |
| CHEMBL3885523 | SUPERSET OF | MCL1-BAK1 complex | PROTEIN COMPLEX |
| CHEMBL4523712 | SUPERSET OF | MCL1/Protein cereblon | PROTEIN-PROTEIN INTERACTION |
5
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out of 1 records
| # | Parent Molecule ChEMBL ID | Parent Molecule Name | Parent Molecule Type | Mechanism of Action | Max Phase | First Approval | USAN Stem | References |
|---|---|---|---|---|---|---|---|---|
| 1. |
OBATOCLAX
|
Small molecule
|
Induced myeloid leukemia cell differentiation protein Mcl-1 inhibitor
| 3 |
---
|
-toclax
|
Showing 1-1
out of 1 records
Associated Bioactivities
Total
3853
IC50
Ki
Activity
Kd
Inhibition
K
EC50
Delta Tm
T1/2
AC50
FC
Kinact
Ratio Ki(app)
IC5
INH
Ratio
Ratio Ki
Associated Assays
Total
370
B - Binding
F - Functional
See all activities used in this plot (1998)
(Showing first
1000 data points out of 1998)
Ligand Efficiencies for Target CHEMBL4361 (Induced myeloid leukemia cell differentiation protein Mcl-1)
Standard Value nM
<1
(63 items)
[1,100)
(218 items)
[100,1000)
(314 items)
>=1000
(397 items)
Showing 992 data points.
Hover over a point to see the details.
The Ligand Efficiency chart plots Binding Efficiency Index (BEI)
against Surface Efficiency Index (SEI), where:
- SEI = (-log10(Standard Value*10^-9))*100/PSA
- BEI = (-log10(Standard Value*10^-9))*1000/MWT
Histogram Settings
Total
2899
- GO:0005634 (nucleus)
- GO:0005654 (nucleoplasm)
- GO:0005737 (cytoplasm)
- GO:0005739 (mitochondrion)
- GO:0005741 (mitochondrial outer membrane)
- GO:0005829 (cytosol)
- GO:0016020 (membrane)
- GO:0097136 (Bcl-2 family protein complex)
- GO:0005515 (protein binding)
- GO:0008320 (protein transmembrane transporter activity)
- GO:0015267 (channel activity)
- GO:0046982 (protein heterodimerization activity)
- GO:0051434 (BH3 domain binding)
- GO:0001709 (cell fate determination)
- GO:0001836 (release of cytochrome c from mitochondria)
- GO:0006915 (apoptotic process)
- GO:0006974 (DNA damage response)
- GO:0008053 (mitochondrial fusion)
- GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
- GO:0010507 (negative regulation of autophagy)
- GO:0030154 (cell differentiation)
- GO:0042981 (regulation of apoptotic process)
- GO:0043065 (positive regulation of apoptotic process)
- GO:0043066 (negative regulation of apoptotic process)
- GO:0043525 (positive regulation of neuron apoptotic process)
- GO:0055085 (transmembrane transport)
- GO:0071806 (protein transmembrane transport)
- GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand)
- GO:1902531 (regulation of intracellular signal transduction)
- GO:1903378 (positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)
- GO:2000811 (negative regulation of anoikis)
- GO:2001233 (regulation of apoptotic signaling pathway)
- GO:2001240 (negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)
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