Flap endonuclease 1

Target

Name and Classification

ID: CHEMBL5027

Type: SINGLE PROTEIN

Preferred Name: Flap endonuclease 1

Synonyms:

DNase IV FEN-1 FEN1 Flap endonuclease 1 Flap structure-specific endonuclease 1

Synonyms: ---

organism: Homo sapiens

Species Group: No

Protein Target Classification:

Target Components

Description	Relationship	Accession
Flap endonuclease 1	SINGLE PROTEIN	P39748

Activity Charts

Associated Bioactivities

Activity Types for CHEMBL5027 (Flap endonuclease 1)

Total

12055

Potency

IC50

Inhibition

Associated Assays

Assays for Target CHEMBL5027 (Flap endonuclease 1)

Total

B - Binding

F - Functional

Ligand Efficiencies

See all activities used in this plot (91)

Ligand Efficiencies for Target CHEMBL5027 (Flap endonuclease 1)

Standard Value nM

Showing 91 data points.

Hover over a point to see the details.

The Ligand Efficiency chart plots Binding Efficiency Index (BEI) against Surface Efficiency Index (SEI), where:

SEI = (-log10(Standard Value*10^-9))*100/PSA
BEI = (-log10(Standard Value*10^-9))*1000/MWT

Associated Compounds

Associated Compounds for Target CHEMBL5027 (Flap endonuclease 1) (11110)

Parent Molecular Weight

ALogP

Polar Surface Area

Histogram Settings

Interval Size (153.39)

Total

11080

Items with no undefined (30)

Gene Cross References

ExpressionAtlas (1)

P39748

GoComponent (7)

GO:0000781 (chromosome, telomeric region)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005739 (mitochondrion)
GO:0016020 (membrane)
GO:0032991 (protein-containing complex)

GoFunction (16)

GO:0000287 (magnesium ion binding)
GO:0003677 (DNA binding)
GO:0003684 (damaged DNA binding)
GO:0003690 (double-stranded DNA binding)
GO:0004518 (nuclease activity)
GO:0004519 (endonuclease activity)
GO:0004520 (DNA endonuclease activity)
GO:0004523 (RNA-DNA hybrid ribonuclease activity)
GO:0004527 (exonuclease activity)
GO:0005515 (protein binding)
GO:0008309 (double-stranded DNA exodeoxyribonuclease activity)
GO:0008409 (5'-3' exonuclease activity)
GO:0017108 (5'-flap endonuclease activity)
GO:0030145 (manganese ion binding)
GO:0046872 (metal ion binding)
GO:0048256 (flap endonuclease activity)

GoProcess (10)

GO:0000724 (double-strand break repair via homologous recombination)
GO:0006281 (DNA repair)
GO:0006284 (base-excision repair)
GO:0006287 (base-excision repair, gap-filling)
GO:0006302 (double-strand break repair)
GO:0006310 (DNA recombination)
GO:0007613 (memory)
GO:0032201 (telomere maintenance via semi-conservative replication)
GO:0043137 (DNA replication, removal of RNA primer)
GO:0045876 (positive regulation of sister chromatid cohesion)

HGNC (1)

FEN1

PANTHER (2)

FLAP ENDONUCLEASE FAMILY MEMBER, FLAP ENDONUCLEASE 1

Protein Cross References

IntAct (1)

P39748

PharmGKB (1)

flap structure-specific endonuclease 1

Pharos (1)

P39748

Reactome (6)

POLB-Dependent Long Patch Base Excision Repair, Early Phase of HIV Life Cycle, Removal of the Flap Intermediate from the C-strand, PCNA-Dependent Long Patch Base Excision Repair, HDR through MMEJ (alt-NHEJ), Removal of the Flap Intermediate

UniProt (1)

Flap endonuclease 1

Domain Cross References

InterPro (8)

IPR006084 (XPG/Rad2)
IPR006085 (XPG_DNA_repair_N)
IPR006086 (XPG-I_dom)
IPR008918 (HhH2)
IPR019974 (XPG_CS)
IPR023426 (Flap_endonuc)
IPR029060 (PIN-like_dom_sf)
IPR036279 (5-3_exonuclease_C_sf)

Pfam (2)

PF00752 (XPG_N)
PF00867 (XPG_I)

Structure Cross References

AlphaFoldDB (1)

P39748

PDB (17)

1U7B, 1UL1, 3Q8K, 3Q8L, 3Q8M, 3UVU, 5E0V, 5FV7, 5K97, 5KSE, 5UM9, 5ZOD, 5ZOE, 5ZOF, 5ZOG, 6TNZ, 7QO1

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