CaM-kinase kinase beta
ID: CHEMBL5284
Type: SINGLE PROTEIN
Preferred Name: CaM-kinase kinase beta
Synonyms:
Calcium/calmodulin-dependent protein kinase kinase 2
Calcium/calmodulin-dependent protein kinase kinase beta
CaM-kinase kinase 2
CaM-kinase kinase beta
CaM-KK 2
Synonyms: ---
organism: Homo sapiens
Species Group: No
Protein Target Classification:
1.
| Description | Relationship | Accession |
|---|---|---|
| Calcium/calmodulin-dependent protein kinase kinase 2 | SINGLE PROTEIN | Q96RR4 |
Associated Bioactivities
Total
1378
Kd
Activity
Thermal melting change
IC50
% Control
Inhibition
Ki
Delta TM
% of control
% of inhibition
EC50
Residual activity
% inhibition
Delta Tm
Occ
Residual_activity
% Activity remaining
% Ctrl
% residual kinase activity
Emax
Other
Associated Assays
Total
248
B - Binding
F - Functional
See all activities used in this plot (220)
Ligand Efficiencies for Target CHEMBL5284 (CaM-kinase kinase beta)
Standard Value nM
<1
(3 items)
[1,100)
(77 items)
[100,1000)
(69 items)
>=1000
(69 items)
Showing 218 data points.
Hover over a point to see the details.
The Ligand Efficiency chart plots Binding Efficiency Index (BEI)
against Surface Efficiency Index (SEI), where:
- SEI = (-log10(Standard Value*10^-9))*100/PSA
- BEI = (-log10(Standard Value*10^-9))*1000/MWT
- GO:0005634 (nucleus)
- GO:0005654 (nucleoplasm)
- GO:0005737 (cytoplasm)
- GO:0005829 (cytosol)
- GO:0042995 (cell projection)
- GO:0043005 (neuron projection)
- GO:0005509 (calcium ion binding)
- GO:0005516 (calmodulin binding)
- GO:0005524 (ATP binding)
- GO:0000165 (MAPK cascade)
- GO:0001934 (positive regulation of protein phosphorylation)
- GO:0006468 (protein phosphorylation)
- GO:0019722 (calcium-mediated signaling)
- GO:0034614 (cellular response to reactive oxygen species)
- GO:0045859 (regulation of protein kinase activity)
- GO:0045893 (positive regulation of DNA-templated transcription)
- GO:0046777 (protein autophosphorylation)
- GO:0061762 (CAMKK-AMPK signaling cascade)
- GO:1903599 (positive regulation of autophagy of mitochondrion)
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