NAD-dependent deacetylase HST2

Target

Name and Classification

ID: CHEMBL5933

Type: SINGLE PROTEIN

Preferred Name: NAD-dependent deacetylase HST2

Synonyms:

Homologous to SIR2 protein 2 HST2 NAD-dependent protein deacetylase HST2 Regulatory protein SIR2 homolog 2

Synonyms: ---

organism: Saccharomyces cerevisiae S288c

Species Group: No

Protein Target Classification:

Enzyme

Target Components

Description	Relationship	Accession
NAD-dependent protein deacetylase HST2	SINGLE PROTEIN	P53686

Activity Charts

Associated Bioactivities

Activity Types for CHEMBL5933 (NAD-dependent deacetylase HST2)

Total

Activity

IC50

Inhibition

Kcat

Ratio

Vmax

Vmax/Km

Associated Assays

Assays for Target CHEMBL5933 (NAD-dependent deacetylase HST2)

Total

B - Binding

Ligand Efficiencies

See all activities used in this plot (28)

Ligand Efficiencies for Target CHEMBL5933 (NAD-dependent deacetylase HST2)

Standard Value nM

Showing 17 data points.

Hover over a point to see the details.

The Ligand Efficiency chart plots Binding Efficiency Index (BEI) against Surface Efficiency Index (SEI), where:

SEI = (-log10(Standard Value*10^-9))*100/PSA
BEI = (-log10(Standard Value*10^-9))*1000/MWT

Associated Compounds

Associated Compounds for Target CHEMBL5933 (NAD-dependent deacetylase HST2) (57)

Parent Molecular Weight

ALogP

Polar Surface Area

Histogram Settings

Interval Size (124.86)

Total

Gene Cross References

GoComponent (2)

GO:0005634 (nucleus)
GO:0005737 (cytoplasm)

GoFunction (12)

GO:0008270 (zinc ion binding)
GO:0016740 (transferase activity)
GO:0017136 (histone deacetylase activity, NAD-dependent)
GO:0032041 (histone H3K14 deacetylase activity, NAD-dependent)
GO:0034979 (NAD-dependent protein lysine deacetylase activity)
GO:0046872 (metal ion binding)
GO:0046969 (histone H3K9 deacetylase activity, NAD-dependent)
GO:0046970 (histone H4K16 deacetylase activity, NAD-dependent)
GO:0070403 (NAD+ binding)
GO:0097372 (histone H3K18 deacetylase activity, NAD-dependent)
GO:0140765 (histone H3K56 deacetylase activity, NAD-dependent)
GO:0141222 (histone H3K4 deacetylase activity, NAD-dependent)

GoProcess (3)

GO:0000183 (rDNA heterochromatin formation)
GO:0031507 (heterochromatin formation)
GO:0045950 (negative regulation of mitotic recombination)

PANTHER (2)

NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED, NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2

Protein Cross References

IntAct (1)

P53686

Reactome (1)

Transcriptional activation of mitochondrial biogenesis

UniProt (2)

NAD-dependent protein deacetylase HST2, NAD-dependent protein deacetylase HST2

Domain Cross References

InterPro (6)

IPR003000 (Sirtuin)
IPR017328 (Sirtuin_class_I)
IPR026590 (Ssirtuin_cat_dom)
IPR026591 (Sirtuin_cat_small_dom_sf)
IPR029035 (DHS-like_NAD/FAD-binding_dom)
IPR050134 (NAD-dep_sirtuin_deacylases)

Pfam (1)

PF02146 (SIR2)

Structure Cross References

AlphaFoldDB (1)

P53686

PDB (12)

1Q14, 1Q17, 1Q1A, 1SZC, 1SZD, 2OD2, 2OD7, 2OD9, 2QQF, 2QQG, 7F4E, 7F51

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