Serotonin 1d (5-HT1d) receptor


ID: CHEMBL1983
Type: SINGLE PROTEIN
Preferred Name: Serotonin 1d (5-HT1d) receptor
Synonyms:
5-HT1D 5-HT-1D 5-HT-1D-alpha 5-hydroxytryptamine receptor 1D HTR1D
Synonyms: ---
organism: Homo sapiens
Species Group: No
DescriptionRelationshipAccession
5-hydroxytryptamine receptor 1DSINGLE PROTEINP28221
ChEMBL IDRelationshipPref NameTarget Type
CHEMBL2095230 SUPERSET OFSerotonin 1 receptors; 5-HT1B & 5-HT1DSELECTIVITY GROUP
CHEMBL2096904 SUPERSET OFSerotonin (5-HT) receptorPROTEIN FAMILY
CHEMBL4523960 SUPERSET OF5-HT1D/5-HT1FSELECTIVITY GROUP
CHEMBL4524122 SUPERSET OFSerotonin 1 (5-HT1) receptorPROTEIN FAMILY
Showing 1-5 out of 13 records
#Parent Molecule ChEMBL IDParent Molecule NameParent Molecule TypeMechanism of ActionMax PhaseFirst ApprovalUSAN StemReferences
1.
SUMATRIPTAN
Small molecule
Serotonin 1d (5-HT1d) receptor agonist
4
1992
-triptan
2.
ERGOTAMINE
Small molecule
Serotonin 1d (5-HT1d) receptor agonist
4
1948
---
3.
NARATRIPTAN
Small molecule
Serotonin 1d (5-HT1d) receptor agonist
4
1998
-triptan
4.
RIZATRIPTAN
Small molecule
Serotonin 1d (5-HT1d) receptor agonist
4
1998
-triptan
5.
FENFLURAMINE
Small molecule
Serotonin 1d (5-HT1d) receptor agonist
4
2020
---
Showing 1-5 out of 13 records
Associated Bioactivities
Ki IC50 Inhibition Intrinsic activity EC50
Total
2897
Ki
IC50
Inhibition
Intrinsic activity
EC50
Efficacy
p[A50]
Activity
Relative efficacy
Selectivity
ED50
Response
Kb
Emax
Ratio
IA
NT
pKa
Log Ki
pKD
Other
Associated Assays
B - Binding F - Functional
Total
410
B - Binding
F - Functional
A - ADME
See all activities used in this plot (1439)
(Showing first 1000 data points out of 1439)


Ligand Efficiencies for Target CHEMBL1983 (Serotonin 1d (5-HT1d) receptor)
11.84 20.94 30.04 39.13 48.23 57.33 Binding Efficiency Index (BEI) 3.78 15.6 27.42 39.23 51.05 62.86 74.68 86.49 98.31 110.13 121.94 Surface Efficiency Index (SEI)
Standard Value nM
Showing 1000 data points.
Hover over a point to see the details.
The Ligand Efficiency chart plots Binding Efficiency Index (BEI) against Surface Efficiency Index (SEI), where:
  • SEI = (-log10(Standard Value*10^-9))*100/PSA
  • BEI = (-log10(Standard Value*10^-9))*1000/MWT
Histogram Settings


105 210 315 420 525 630 [107.75, 215.50) [215.50, 323.25) [323.25, 431.00) [431.00, 538.75) [538.75, 646.50) [646.50, 754.24) [754.24, 861.99) [861.99, 969.74) [969.74, 1077.49) [1077.49, 1165.32]
Total
1918
  • GO:0001588 (dopamine neurotransmitter receptor activity, coupled via Gs)
  • GO:0004930 (G protein-coupled receptor activity)
  • GO:0004993 (G protein-coupled serotonin receptor activity)
  • GO:0030594 (neurotransmitter receptor activity)
  • GO:0006939 (smooth muscle contraction)
  • GO:0007165 (signal transduction)
  • GO:0007186 (G protein-coupled receptor signaling pathway)
  • GO:0007187 (G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
  • GO:0007193 (adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)
  • GO:0007198 (adenylate cyclase-inhibiting serotonin receptor signaling pathway)
  • GO:0007268 (chemical synaptic transmission)
  • GO:0014827 (intestine smooth muscle contraction)
  • GO:0040012 (regulation of locomotion)
  • GO:0042310 (vasoconstriction)
  • GO:0050795 (regulation of behavior)
  • GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)
No cross references found.
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