Serotonin 1d (5-HT1d) receptor
ID: CHEMBL1983
Type: SINGLE PROTEIN
Preferred Name: Serotonin 1d (5-HT1d) receptor
Synonyms:
5-HT1D
5-HT-1D
5-HT-1D-alpha
5-hydroxytryptamine receptor 1D
HTR1D
Synonyms: ---
organism: Homo sapiens
Species Group: No
Protein Target Classification:
1.
Description | Relationship | Accession |
---|---|---|
5-hydroxytryptamine receptor 1D | SINGLE PROTEIN | P28221 |
ChEMBL ID | Relationship | Pref Name | Target Type |
---|---|---|---|
CHEMBL2095230 | SUPERSET OF | Serotonin 1 receptors; 5-HT1B & 5-HT1D | SELECTIVITY GROUP |
CHEMBL2096904 | SUPERSET OF | Serotonin (5-HT) receptor | PROTEIN FAMILY |
CHEMBL4523960 | SUPERSET OF | 5-HT1D/5-HT1F | SELECTIVITY GROUP |
CHEMBL4524122 | SUPERSET OF | Serotonin 1 (5-HT1) receptor | PROTEIN FAMILY |
5
Showing 1-5
out of 13 records
# | Parent Molecule ChEMBL ID | Parent Molecule Name | Parent Molecule Type | Mechanism of Action | Max Phase | First Approval | USAN Stem | References |
---|---|---|---|---|---|---|---|---|
1. |
SUMATRIPTAN
|
Small molecule
|
Serotonin 1d (5-HT1d) receptor agonist
| 4 |
1992
|
-triptan
| ||
2. |
ERGOTAMINE
|
Small molecule
|
Serotonin 1d (5-HT1d) receptor agonist
| 4 |
1948
|
---
| ||
3. |
NARATRIPTAN
|
Small molecule
|
Serotonin 1d (5-HT1d) receptor agonist
| 4 |
1998
|
-triptan
| ||
4. |
RIZATRIPTAN
|
Small molecule
|
Serotonin 1d (5-HT1d) receptor agonist
| 4 |
1998
|
-triptan
| ||
5. |
FENFLURAMINE
|
Small molecule
|
Serotonin 1d (5-HT1d) receptor agonist
| 4 |
2020
|
---
|
Showing 1-5
out of 13 records
Associated Bioactivities
Total
2897
Ki
IC50
Inhibition
Intrinsic activity
EC50
Efficacy
p[A50]
Activity
Relative efficacy
Selectivity
ED50
Response
Kb
Emax
Ratio
IA
NT
pKa
Log Ki
pKD
Other
Associated Assays
Total
410
B - Binding
F - Functional
A - ADME
See all activities used in this plot (1439)
(Showing first
1000 data points out of 1439)
Ligand Efficiencies for Target CHEMBL1983 (Serotonin 1d (5-HT1d) receptor)
Standard Value nM
<1
[1,100)
[100,1000)
>=1000
Histogram Settings
Total
1918
- GO:0005886 (plasma membrane)
- GO:0016020 (membrane)
- GO:0030425 (dendrite)
- GO:0045202 (synapse)
- GO:0001588 (dopamine neurotransmitter receptor activity, coupled via Gs)
- GO:0004930 (G protein-coupled receptor activity)
- GO:0004993 (G protein-coupled serotonin receptor activity)
- GO:0030594 (neurotransmitter receptor activity)
- GO:0006939 (smooth muscle contraction)
- GO:0007165 (signal transduction)
- GO:0007186 (G protein-coupled receptor signaling pathway)
- GO:0007187 (G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
- GO:0007193 (adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)
- GO:0007198 (adenylate cyclase-inhibiting serotonin receptor signaling pathway)
- GO:0007268 (chemical synaptic transmission)
- GO:0014827 (intestine smooth muscle contraction)
- GO:0040012 (regulation of locomotion)
- GO:0042310 (vasoconstriction)
- GO:0050795 (regulation of behavior)
- GO:0071880 (adenylate cyclase-activating adrenergic receptor signaling pathway)
No cross references found.