Ryanodine receptor 1
ID: CHEMBL2133
Type: SINGLE PROTEIN
Preferred Name: Ryanodine receptor 1
Synonyms:
Ryanodine receptor 1
Ryr1
RyR1
RYR-1
Skeletal muscle calcium release channel
Synonyms: ---
organism: Mus musculus
Species Group: No
Protein Target Classification:
1.
Description | Relationship | Accession |
---|---|---|
Ryanodine receptor 1 | SINGLE PROTEIN | E9PZQ0 |
Associated Bioactivities
Total
15
Activity
TIME
EC50
Inhibition
Associated Assays
Total
14
B - Binding
F - Functional
See all activities used in this plot (1)
Ligand Efficiencies for Target CHEMBL2133 (Ryanodine receptor 1)
Standard Value nM
<1
[1,100)
[100,1000)
>=1000
Histogram Settings
Total
4
- GO:0005737 (cytoplasm)
- GO:0005790 (smooth endoplasmic reticulum)
- GO:0009898 (cytoplasmic side of plasma membrane)
- GO:0014802 (terminal cisterna)
- GO:0016020 (membrane)
- GO:0016529 (sarcoplasmic reticulum)
- GO:0030017 (sarcomere)
- GO:0030018 (Z disc)
- GO:0030314 (junctional membrane complex)
- GO:0030315 (T-tubule)
- GO:0031090 (organelle membrane)
- GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
- GO:0031982 (vesicle)
- GO:0032991 (protein-containing complex)
- GO:0033017 (sarcoplasmic reticulum membrane)
- GO:0034704 (calcium channel complex)
- GO:0042383 (sarcolemma)
- GO:0048471 (perinuclear region of cytoplasm)
- GO:1990425 (ryanodine receptor complex)
- GO:0000166 (nucleotide binding)
- GO:0002020 (protease binding)
- GO:0005216 (monoatomic ion channel activity)
- GO:0005219 (ryanodine-sensitive calcium-release channel activity)
- GO:0005245 (voltage-gated calcium channel activity)
- GO:0005262 (calcium channel activity)
- GO:0005509 (calcium ion binding)
- GO:0005515 (protein binding)
- GO:0005516 (calmodulin binding)
- GO:0005524 (ATP binding)
- GO:0019899 (enzyme binding)
- GO:0046872 (metal ion binding)
- GO:0003151 (outflow tract morphogenesis)
- GO:0006811 (monoatomic ion transport)
- GO:0006816 (calcium ion transport)
- GO:0006874 (intracellular calcium ion homeostasis)
- GO:0006936 (muscle contraction)
- GO:0006937 (regulation of muscle contraction)
- GO:0006941 (striated muscle contraction)
- GO:0014808 (release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)
- GO:0019722 (calcium-mediated signaling)
- GO:0030512 (negative regulation of transforming growth factor beta receptor signaling pathway)
- GO:0031000 (response to caffeine)
- GO:0034220 (monoatomic ion transmembrane transport)
- GO:0043588 (skin development)
- GO:0043931 (ossification involved in bone maturation)
- GO:0047484 (regulation of response to osmotic stress)
- GO:0048741 (skeletal muscle fiber development)
- GO:0051209 (release of sequestered calcium ion into cytosol)
- GO:0051289 (protein homotetramerization)
- GO:0051480 (regulation of cytosolic calcium ion concentration)
- GO:0055085 (transmembrane transport)
- GO:0070296 (sarcoplasmic reticulum calcium ion transport)
- GO:0070588 (calcium ion transmembrane transport)
- GO:0071277 (cellular response to calcium ion)
- GO:0071313 (cellular response to caffeine)
- GO:0071318 (cellular response to ATP)
- IPR000699 (RIH_dom.)
- IPR001870 (B30.2/SPRY.)
- IPR003032 (Ryanodine_rcpt.)
- IPR003877 (SPRY_dom.)
- IPR005821 (Ion_trans_dom.)
- IPR009460 (Ryanrecept_TM4-6.)
- IPR011992 (EF-hand-dom_pair.)
- IPR013320 (ConA-like_dom_sf.)
- IPR013333 (Ryan_recept.)
- IPR013662 (RIH_assoc-dom.)
- IPR014821 (Ins145_P3_rcpt.)
- IPR015925 (Ryanodine_IP3_receptor.)
- IPR016093 (MIR_motif.)
- IPR035761 (SPRY1_RyR.)
- IPR035762 (SPRY3_RyR.)
- IPR035764 (SPRY2_RyR.)
- IPR035910 (RyR/IP3R_RIH_dom_sf.)
- IPR036300 (MIR_dom_sf.)
- IPR043136 (B30.2/SPRY_sf.)
- IPR048581 (RYDR_Jsol.)
No cross references found.