Insulin receptor
ID: CHEMBL5486
Type: SINGLE PROTEIN
Preferred Name: Insulin receptor
Synonyms:
CD_antigen=CD220
Insr
Insulin receptor
Insulin receptor subunit alpha
Insulin receptor subunit beta
Synonyms: ---
organism: Rattus norvegicus
Species Group: No
Protein Target Classification:
1.
Description | Relationship | Accession |
---|---|---|
Insulin receptor | SINGLE PROTEIN | P15127 |
Associated Bioactivities
Total
1750
IC50
Ki
Inhibition
Activity
See all activities used in this plot (1)
Ligand Efficiencies for Target CHEMBL5486 (Insulin receptor)
Standard Value nM
<1
[1,100)
[100,1000)
>=1000
- GO:0005635 (nuclear envelope)
- GO:0005764 (lysosome)
- GO:0005768 (endosome)
- GO:0005770 (late endosome)
- GO:0005886 (plasma membrane)
- GO:0005899 (insulin receptor complex)
- GO:0005901 (caveola)
- GO:0009897 (external side of plasma membrane)
- GO:0016020 (membrane)
- GO:0030424 (axon)
- GO:0030425 (dendrite)
- GO:0031981 (nuclear lumen)
- GO:0032590 (dendrite membrane)
- GO:0032809 (neuronal cell body membrane)
- GO:0043025 (neuronal cell body)
- GO:0043235 (receptor complex)
- GO:0044297 (cell body)
- GO:0060417 (yolk)
- GO:0000166 (nucleotide binding)
- GO:0001540 (amyloid-beta binding)
- GO:0004672 (protein kinase activity)
- GO:0004713 (protein tyrosine kinase activity)
- GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
- GO:0005009 (insulin receptor activity)
- GO:0005159 (insulin-like growth factor receptor binding)
- GO:0005198 (structural molecule activity)
- GO:0005515 (protein binding)
- GO:0005524 (ATP binding)
- GO:0005525 (GTP binding)
- GO:0016301 (kinase activity)
- GO:0016740 (transferase activity)
- GO:0019901 (protein kinase binding)
- GO:0019903 (protein phosphatase binding)
- GO:0019904 (protein domain specific binding)
- GO:0031405 (lipoic acid binding)
- GO:0031994 (insulin-like growth factor I binding)
- GO:0031995 (insulin-like growth factor II binding)
- GO:0038024 (cargo receptor activity)
- GO:0043423 (3-phosphoinositide-dependent protein kinase binding)
- GO:0043548 (phosphatidylinositol 3-kinase binding)
- GO:0043559 (insulin binding)
- GO:0043560 (insulin receptor substrate binding)
- GO:0044877 (protein-containing complex binding)
- GO:0051425 (PTB domain binding)
- GO:0001666 (response to hypoxia)
- GO:0001889 (liver development)
- GO:0001933 (negative regulation of protein phosphorylation)
- GO:0001934 (positive regulation of protein phosphorylation)
- GO:0002092 (positive regulation of receptor internalization)
- GO:0003007 (heart morphogenesis)
- GO:0006111 (regulation of gluconeogenesis)
- GO:0006355 (regulation of DNA-templated transcription)
- GO:0006898 (receptor-mediated endocytosis)
- GO:0007169 (cell surface receptor protein tyrosine kinase signaling pathway)
- GO:0007186 (G protein-coupled receptor signaling pathway)
- GO:0008284 (positive regulation of cell population proliferation)
- GO:0008286 (insulin receptor signaling pathway)
- GO:0008544 (epidermis development)
- GO:0008584 (male gonad development)
- GO:0009725 (response to hormone)
- GO:0009749 (response to glucose)
- GO:0009887 (animal organ morphogenesis)
- GO:0010033 (response to organic substance)
- GO:0010042 (response to manganese ion)
- GO:0010310 (regulation of hydrogen peroxide metabolic process)
- GO:0010560 (positive regulation of glycoprotein biosynthetic process)
- GO:0010629 (negative regulation of gene expression)
- GO:0014823 (response to activity)
- GO:0016310 (phosphorylation)
- GO:0021549 (cerebellum development)
- GO:0021766 (hippocampus development)
- GO:0030238 (male sex determination)
- GO:0030325 (adrenal gland development)
- GO:0030335 (positive regulation of cell migration)
- GO:0031017 (exocrine pancreas development)
- GO:0031623 (receptor internalization)
- GO:0031667 (response to nutrient levels)
- GO:0032094 (response to food)
- GO:0032355 (response to estradiol)
- GO:0032868 (response to insulin)
- GO:0032869 (cellular response to insulin stimulus)
- GO:0033280 (response to vitamin D)
- GO:0033574 (response to testosterone)
- GO:0034224 (cellular response to zinc ion starvation)
- GO:0034612 (response to tumor necrosis factor)
- GO:0042327 (positive regulation of phosphorylation)
- GO:0042593 (glucose homeostasis)
- GO:0042594 (response to starvation)
- GO:0043243 (positive regulation of protein-containing complex disassembly)
- GO:0043410 (positive regulation of MAPK cascade)
- GO:0045429 (positive regulation of nitric oxide biosynthetic process)
- GO:0045444 (fat cell differentiation)
- GO:0045471 (response to ethanol)
- GO:0045719 (negative regulation of glycogen biosynthetic process)
- GO:0045725 (positive regulation of glycogen biosynthetic process)
- GO:0045821 (positive regulation of glycolytic process)
- GO:0045840 (positive regulation of mitotic nuclear division)
- GO:0045893 (positive regulation of DNA-templated transcription)
- GO:0045995 (regulation of embryonic development)
- GO:0046326 (positive regulation of glucose import)
- GO:0046718 (symbiont entry into host cell)
- GO:0048639 (positive regulation of developmental growth)
- GO:0051384 (response to glucocorticoid)
- GO:0051446 (positive regulation of meiotic cell cycle)
- GO:0051897 (positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction)
- GO:0060267 (positive regulation of respiratory burst)
- GO:0071363 (cellular response to growth factor stimulus)
- GO:0097062 (dendritic spine maintenance)
- GO:0097242 (amyloid-beta clearance)
- GO:0097421 (liver regeneration)
- GO:1902438 (response to vanadate(3-))
- GO:1904638 (response to resveratrol)
- GO:1990402 (embryonic liver development)
- GO:1990535 (neuron projection maintenance)
- GO:2000194 (regulation of female gonad development)
- GO:2000252 (negative regulation of feeding behavior)
- IPR000494 (Rcpt_L-dom.)
- IPR000719 (Prot_kinase_dom.)
- IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
- IPR002011 (Tyr_kinase_rcpt_2_CS.)
- IPR003961 (FN3_dom.)
- IPR006211 (Furin-like_Cys-rich_dom.)
- IPR006212 (Furin_repeat.)
- IPR008266 (Tyr_kinase_AS.)
- IPR009030 (Growth_fac_rcpt_cys_sf.)
- IPR011009 (Kinase-like_dom_sf.)
- IPR013783 (Ig-like_fold.)
- IPR016246 (Tyr_kinase_insulin-like_rcpt.)
- IPR017441 (Protein_kinase_ATP_BS.)
- IPR020635 (Tyr_kinase_cat_dom.)
- IPR036116 (FN3_sf.)
- IPR036941 (Rcpt_L-dom_sf.)
- IPR040969 (Insulin_TMD.)