Activities

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47
Ki
3
Activity
50
SINGLE PROTEIN
50
Eukaryotes
50
Mammalia
50
Rodentia
50
Mus musculus
47
tissue-based format
3
organism-based format
3
N/A
4
[7,8)
6
[8,9)
17
[9,10)
20
[10,10.4]
50
Preclinical
0
N/A
47
0
3
1
0
N/A
22
[3,4)
25
[4,5)
3
[5,5.16]
0
N/A
1
[272,304)
3
[304,320)
2
[320,336)
5
[336,352)
9
[352,368)
9
[368,384)
11
[384,400)
7
[400,416)
2
[416,432)
1
[432,441.45]
50
Scientific Literature
Showing 1-20 out of 50 records
#Molecule ChEMBL IDCompound KeyStandard TypeStandard RelationStandard ValueStandard UnitspChEMBL ValueCommentAssay ChEMBL IDAssay DescriptionBAO LabelAssay OrganismTarget ChEMBL IDTarget NameTarget OrganismTarget TypeDocument ChEMBL IDSource DescriptionCell ChEMBL ID
1.
15
Ki
=
27.0
nM
7.57
---
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
tissue-based format
Mus musculus
AP2-associated protein kinase 1
Mus musculus
SINGLE PROTEIN
Scientific Literature
2.
24
Ki
=
0.07
nM
10.15
---
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
tissue-based format
Mus musculus
AP2-associated protein kinase 1
Mus musculus
SINGLE PROTEIN
Scientific Literature
3.
44
Ki
=
0.17
nM
9.77
---
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
tissue-based format
Mus musculus
AP2-associated protein kinase 1
Mus musculus
SINGLE PROTEIN
Scientific Literature
4.
41
Ki
=
41.0
nM
7.39
---
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
tissue-based format
Mus musculus
AP2-associated protein kinase 1
Mus musculus
SINGLE PROTEIN
Scientific Literature
5.
47
Ki
=
0.11
nM
9.96
---
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
tissue-based format
Mus musculus
AP2-associated protein kinase 1
Mus musculus
SINGLE PROTEIN
Scientific Literature
6.
54
Ki
=
0.18
nM
9.74
---
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
tissue-based format
Mus musculus
AP2-associated protein kinase 1
Mus musculus
SINGLE PROTEIN
Scientific Literature
7.
16
Ki
=
2.5
nM
8.60
---
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
tissue-based format
Mus musculus
AP2-associated protein kinase 1
Mus musculus
SINGLE PROTEIN
Scientific Literature
8.
34
Ki
=
0.05
nM
10.30
---
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
tissue-based format
Mus musculus
AP2-associated protein kinase 1
Mus musculus
SINGLE PROTEIN
Scientific Literature
9.
8
Ki
=
0.04
nM
10.40
---
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
tissue-based format
Mus musculus
AP2-associated protein kinase 1
Mus musculus
SINGLE PROTEIN
Scientific Literature
10.
14
Ki
=
0.06
nM
10.22
---
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
tissue-based format
Mus musculus
AP2-associated protein kinase 1
Mus musculus
SINGLE PROTEIN
Scientific Literature
11.
9
Ki
=
0.96
nM
9.02
---
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
tissue-based format
Mus musculus
AP2-associated protein kinase 1
Mus musculus
SINGLE PROTEIN
Scientific Literature
12.
26
Ki
=
0.05
nM
10.30
---
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
tissue-based format
Mus musculus
AP2-associated protein kinase 1
Mus musculus
SINGLE PROTEIN
Scientific Literature
13.
27
Ki
=
0.07
nM
10.15
---
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
tissue-based format
Mus musculus
AP2-associated protein kinase 1
Mus musculus
SINGLE PROTEIN
Scientific Literature
14.
33
Ki
=
0.63
nM
9.20
---
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
tissue-based format
Mus musculus
AP2-associated protein kinase 1
Mus musculus
SINGLE PROTEIN
Scientific Literature
15.
21
Ki
=
0.04
nM
10.40
---
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
tissue-based format
Mus musculus
AP2-associated protein kinase 1
Mus musculus
SINGLE PROTEIN
Scientific Literature
16.
25
Ki
=
0.24
nM
9.62
---
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
tissue-based format
Mus musculus
AP2-associated protein kinase 1
Mus musculus
SINGLE PROTEIN
Scientific Literature
17.
30
Ki
=
0.2
nM
9.70
---
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
tissue-based format
Mus musculus
AP2-associated protein kinase 1
Mus musculus
SINGLE PROTEIN
Scientific Literature
18.
18
Ki
=
0.6
nM
9.22
---
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
tissue-based format
Mus musculus
AP2-associated protein kinase 1
Mus musculus
SINGLE PROTEIN
Scientific Literature
19.
43
Ki
=
0.29
nM
9.54
---
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
tissue-based format
Mus musculus
AP2-associated protein kinase 1
Mus musculus
SINGLE PROTEIN
Scientific Literature
20.
(R)-31
Activity
=
46.0
%
---
---
In vivo inhibition of AAK1 in C57BL6 mouse assessed as reduction in mu2 phosphorylation in brain lysate at 30 mg/kg, sc pretreated for 30 mins followed by focused beam microwave irradiation by Western blot analysis
organism-based format
Mus musculus
AP2-associated protein kinase 1
Mus musculus
SINGLE PROTEIN
Scientific Literature
Showing 1-20 out of 50 records
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