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# | Molecule ChEMBL ID | Compound Key | Standard Type | Standard Relation | Standard Value | Standard Units | pChEMBL Value | Comment | Assay ChEMBL ID | Assay Description | BAO Label | Assay Organism | Target ChEMBL ID | Target Name | Target Organism | Target Type | Document ChEMBL ID | Source Description | Cell ChEMBL ID | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1. |
15
|
Ki
|
=
|
27.0
|
nM
|
7.57
|
---
|
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
|
tissue-based format
|
Mus musculus
|
AP2-associated protein kinase 1
|
Mus musculus
|
SINGLE PROTEIN
|
Scientific Literature
| ||||||
2. |
24
|
Ki
|
=
|
0.07
|
nM
|
10.15
|
---
|
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
|
tissue-based format
|
Mus musculus
|
AP2-associated protein kinase 1
|
Mus musculus
|
SINGLE PROTEIN
|
Scientific Literature
| ||||||
3. |
44
|
Ki
|
=
|
0.17
|
nM
|
9.77
|
---
|
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
|
tissue-based format
|
Mus musculus
|
AP2-associated protein kinase 1
|
Mus musculus
|
SINGLE PROTEIN
|
Scientific Literature
| ||||||
4. |
41
|
Ki
|
=
|
41.0
|
nM
|
7.39
|
---
|
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
|
tissue-based format
|
Mus musculus
|
AP2-associated protein kinase 1
|
Mus musculus
|
SINGLE PROTEIN
|
Scientific Literature
| ||||||
5. |
47
|
Ki
|
=
|
0.11
|
nM
|
9.96
|
---
|
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
|
tissue-based format
|
Mus musculus
|
AP2-associated protein kinase 1
|
Mus musculus
|
SINGLE PROTEIN
|
Scientific Literature
| ||||||
6. |
54
|
Ki
|
=
|
0.18
|
nM
|
9.74
|
---
|
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
|
tissue-based format
|
Mus musculus
|
AP2-associated protein kinase 1
|
Mus musculus
|
SINGLE PROTEIN
|
Scientific Literature
| ||||||
7. |
16
|
Ki
|
=
|
2.5
|
nM
|
8.60
|
---
|
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
|
tissue-based format
|
Mus musculus
|
AP2-associated protein kinase 1
|
Mus musculus
|
SINGLE PROTEIN
|
Scientific Literature
| ||||||
8. |
34
|
Ki
|
=
|
0.05
|
nM
|
10.30
|
---
|
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
|
tissue-based format
|
Mus musculus
|
AP2-associated protein kinase 1
|
Mus musculus
|
SINGLE PROTEIN
|
Scientific Literature
| ||||||
9. |
8
|
Ki
|
=
|
0.04
|
nM
|
10.40
|
---
|
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
|
tissue-based format
|
Mus musculus
|
AP2-associated protein kinase 1
|
Mus musculus
|
SINGLE PROTEIN
|
Scientific Literature
| ||||||
10. |
14
|
Ki
|
=
|
0.06
|
nM
|
10.22
|
---
|
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
|
tissue-based format
|
Mus musculus
|
AP2-associated protein kinase 1
|
Mus musculus
|
SINGLE PROTEIN
|
Scientific Literature
| ||||||
11. |
9
|
Ki
|
=
|
0.96
|
nM
|
9.02
|
---
|
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
|
tissue-based format
|
Mus musculus
|
AP2-associated protein kinase 1
|
Mus musculus
|
SINGLE PROTEIN
|
Scientific Literature
| ||||||
12. |
26
|
Ki
|
=
|
0.05
|
nM
|
10.30
|
---
|
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
|
tissue-based format
|
Mus musculus
|
AP2-associated protein kinase 1
|
Mus musculus
|
SINGLE PROTEIN
|
Scientific Literature
| ||||||
13. |
27
|
Ki
|
=
|
0.07
|
nM
|
10.15
|
---
|
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
|
tissue-based format
|
Mus musculus
|
AP2-associated protein kinase 1
|
Mus musculus
|
SINGLE PROTEIN
|
Scientific Literature
| ||||||
14. |
33
|
Ki
|
=
|
0.63
|
nM
|
9.20
|
---
|
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
|
tissue-based format
|
Mus musculus
|
AP2-associated protein kinase 1
|
Mus musculus
|
SINGLE PROTEIN
|
Scientific Literature
| ||||||
15. |
21
|
Ki
|
=
|
0.04
|
nM
|
10.40
|
---
|
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
|
tissue-based format
|
Mus musculus
|
AP2-associated protein kinase 1
|
Mus musculus
|
SINGLE PROTEIN
|
Scientific Literature
| ||||||
16. |
25
|
Ki
|
=
|
0.24
|
nM
|
9.62
|
---
|
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
|
tissue-based format
|
Mus musculus
|
AP2-associated protein kinase 1
|
Mus musculus
|
SINGLE PROTEIN
|
Scientific Literature
| ||||||
17. |
30
|
Ki
|
=
|
0.2
|
nM
|
9.70
|
---
|
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
|
tissue-based format
|
Mus musculus
|
AP2-associated protein kinase 1
|
Mus musculus
|
SINGLE PROTEIN
|
Scientific Literature
| ||||||
18. |
18
|
Ki
|
=
|
0.6
|
nM
|
9.22
|
---
|
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
|
tissue-based format
|
Mus musculus
|
AP2-associated protein kinase 1
|
Mus musculus
|
SINGLE PROTEIN
|
Scientific Literature
| ||||||
19. |
43
|
Ki
|
=
|
0.29
|
nM
|
9.54
|
---
|
Displacement of 3H-LP-927443 from AAK1 in C57BL6 mouse brain homogenate assessed as inhibition constant incubated for 1 hr by liquid scintillation counter analysis
|
tissue-based format
|
Mus musculus
|
AP2-associated protein kinase 1
|
Mus musculus
|
SINGLE PROTEIN
|
Scientific Literature
| ||||||
20. |
(R)-31
|
Activity
|
=
|
46.0
|
%
|
---
|
---
|
In vivo inhibition of AAK1 in C57BL6 mouse assessed as reduction in mu2 phosphorylation in brain lysate at 30 mg/kg, sc pretreated for 30 mins followed by focused beam microwave irradiation by Western blot analysis
|
organism-based format
|
Mus musculus
|
AP2-associated protein kinase 1
|
Mus musculus
|
SINGLE PROTEIN
|
Scientific Literature
|
Showing 1-20
out of 50 records