CHEMBL3623291
ID: CHEMBL3623291
Name: Undefined
Max Phase:
Preclinical
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Molecular Formula: C22H23ClFN5O3
Molecular Weight: 459.91
Molecule Type: Small molecule
Molfile:
Canonical SMILES:
Standard InChI:
Standard InChI Key:
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corresponding source.
Bioactivity Summary
Total
15
AUC
Fu
CL
F
IC50
K(p,uu,CSF)
K(p,uu,brain)
Papp
Ratio
T1/2
Vdss
Total
1
Journal:
J Med Chem
The table below displays ChEMBL targets which are predicted to interact with CHEMBL3623291. The target prediction returns four classes: ‘active’ or ‘inactive’ depending on whether or not CHEMBL3623291 is predicted to interact or not with the target. The value returned can also be 'empty' if the model was not able to predict the compound or 'both' if it could not conclude. The predictions are given at three different confidence levels. More information on the methodology is available at: https://jcheminf.biomedcentral.com/articles/10.1186/s13321-018-0325-4
Target | Target Pref. Name | Confidence 70% | Confidence 80% | Confidence 90% | Activity Threshold |
---|---|---|---|---|---|
CHEMBL2902 | Dihydrofolate reductase | inactive | inactive | inactive | 6 |
CHEMBL2725 | Beta-lactamase | active | active | active | 6 |
CHEMBL5062 | Coagulation factor X | empty | empty | empty | 6.5 |
CHEMBL1947 | Thyroid hormone receptor beta-1 | empty | empty | both | 7 |
CHEMBL2157850 | Ubiquitin carboxyl-terminal hydrolase 7 | inactive | inactive | inactive | 6 |
Molecular Weight:
459.91
Molecular Weight (Monoisotopic):
459.1473
AlogP:
4.31
#Rotatable Bonds:
4
Polar Surface Area:
79.82
Molecular Species:
NEUTRAL
HBA:
7
HBD:
1
#RO5 Violations:
0
HBA (Lipinski):
8
HBD (Lipinski):
1
#RO5 Violations (Lipinski):
0
CX Acidic pKa:
13.81
CX Basic pKa:
7.10
CX LogP:
4.03
CX LogD:
3.86
Aromatic Rings:
3
Heavy Atoms:
32
QED Weighted:
0.62
Np Likeness Score:
-1.19
UniChem Connectivity Layer Cross References for
CHEMBL3623291
Columns Legend:
- S: stereochemical difference.
- I: isotopic difference.
- P: protonation differences identified.
Match | Identical Component | S | I | P |
---|---|---|---|---|
CHEMBL3623291 | ||||
CHEMBL3623290 | ||||
DB14795 | ||||
10456 | ||||
ZINC000221149297 |