54S mitochondrial large ribosomal subunit
Components
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protein -
MRPL6 (unspecified role)
Large ribosomal subunit protein uL6m
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protein -
MRPL7 (unspecified role)
Large ribosomal subunit protein uL5m
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protein -
MRPL9 (unspecified role)
Large ribosomal subunit protein uL3m
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protein -
MRPL10 (unspecified role)
Large ribosomal subunit protein uL15m
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protein -
MRPL11 (unspecified role)
Large ribosomal subunit protein uL10m
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Show all components |
Function
Component of the ribosome, the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). Responsible for the catalytic activity of the ribosome, the peptidyltransferase activity required to catalyze peptide bond formation. The mitochondrial ribosome (mitoribosome) is responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are tethered to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. The inner membrane protein MBA1 (P38300) aligns the mitochondrial peptide exit tunnel with the membrane insertion machinery and supports the transfer of the mitochondrial nascent peptides towards the membrane
GO - Molecular Function (2)
peptidyltransferase activity |
translation regulator activity |
GO - Biological Process (1)
mitochondrial translation |
Properties
Assembly
Hetero 47-mer |
Expression and Cellular Location
Gene Expression Map
GO - Cellular Component (2)
mitochondrial large ribosomal subunit |
mitochondrial inner membrane |
Additional Information
Further Reading
Identifier | Title | Author(s) |
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25609543 | Organization of the mitochondrial translation machinery studied in situ by cryoelectron tomography. | Pfeffer S, Woellhaf MW, Herrmann JM, Förster F. |
28154081 | The structure of the yeast mitochondrial ribosome. | Desai N, Brown A, Amunts A, Ramakrishnan V. |
Synonyms (1)
mt-LSU |
Systematic Name
IMG1:MHR1:MNP1:MRP7:MRP20:MRPL3:MRPL4:MRPL6:MRPL7:MRPL8:MRPL:9MRPL10:MRPL13:MRPL15:MRPL16:MRPL17:MRPL19:MRPL20:MRPL23:MRPL24:MRPL25:MRPL27:MRPL28:MRPL30:MRPL32:MRPL33:MRPL36:MRPL37:MRPL39:MRPL40:RML2:RTC6:YML6 |