54S mitochondrial large ribosomal subunit

ComplexAc: CPX-1602

Saccharomyces cerevisiae; 559292

Curated by:

IntAct

Components

  • Collapse
  • Scale:
ComplexViewer 2.2.4by Rappsilber LaboratoryMNP121srrna_yeastMHR1MRPL36MRP20MRPL3MRPL23MRPL7MRPL37MRP7MRPL19MRPL32MRPL6MRPL15YML6IMG1MRPL4RML2MRPL20MRPL13MRPL40MRPL10MRPL8MRPL24MRPL27MRPL25MRPL17RTC6MRPL9MRPL33MRPL31MRPL39MRPL28MRPL16MRPL11MRPL49MRPL38MRP35MRPL35IMG2MRPL1MRPL22MRPL44MRPL51MRP49MRPL50rm34_yeasttooltip
Legend Description Stoichiometry
protein - MRPL6 (unspecified role)
Large ribosomal subunit protein uL6m
protein - MRPL7 (unspecified role)
Large ribosomal subunit protein uL5m
protein - MRPL9 (unspecified role)
Large ribosomal subunit protein uL3m
protein - MRPL10 (unspecified role)
Large ribosomal subunit protein uL15m
protein - MRPL11 (unspecified role)
Large ribosomal subunit protein uL10m
Show all components

Function

Component of the ribosome, the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). Responsible for the catalytic activity of the ribosome, the peptidyltransferase activity required to catalyze peptide bond formation. The mitochondrial ribosome (mitoribosome) is responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are tethered to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane. The inner membrane protein MBA1 (P38300) aligns the mitochondrial peptide exit tunnel with the membrane insertion machinery and supports the transfer of the mitochondrial nascent peptides towards the membrane

Properties

A distinct lateral protuberance called the stalk is located on the large ribosomal subuniit and plays a central role in the ribosome-mediated stimulation of translation factor-dependent GTP hydrolysis.

Assembly

Hetero 47-mer

3D Structure

Curated structures (1):

Identifier Qualifier
3j6b subset (MI:2179)

Additional Information

Further Reading

Identifier Title Author(s)
25609543 Organization of the mitochondrial translation machinery studied in situ by cryoelectron tomography. Pfeffer S, Woellhaf MW, Herrmann JM, Förster F.
28154081 The structure of the yeast mitochondrial ribosome. Desai N, Brown A, Amunts A, Ramakrishnan V.

Synonyms (1)

mt-LSU

Systematic Name

IMG1:MHR1:MNP1:MRP7:MRP20:MRPL3:MRPL4:MRPL6:MRPL7:MRPL8:MRPL:9MRPL10:MRPL13:MRPL15:MRPL16:MRPL17:MRPL19:MRPL20:MRPL23:MRPL24:MRPL25:MRPL27:MRPL28:MRPL30:MRPL32:MRPL33:MRPL36:MRPL37:MRPL39:MRPL40:RML2:RTC6:YML6