Non-canonical polycomb repressive complex 1.1, RING2-PCGF1-YAF2 variant
Components
Legend | Description | Stoichiometry | |||
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protein -
YAF2 (unspecified role)
YY1-associated factor 2
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protein -
SKP1 (unspecified role)
S-phase kinase-associated protein 1
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protein -
KDM2B (unspecified role)
Lysine-specific demethylase 2B
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protein -
RNF2 (unspecified role)
E3 ubiquitin-protein ligase RING2
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protein -
PCGF1 (unspecified role)
Polycomb group RING finger protein 1
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Show all components |
Function
E3 ubiquitin-protein ligase that acts as a transcriptional repressor by mediating the monoubiquitination of Lys-119 of histone H2A, compacting chromatin, stalling RNA polymerase II and transcriptionally silencing genes critical for development. KDM2B contributes to generic genomic localization of this complex variant around promoters and other loci enriched for unmethylated CpG islands.
Catalytic Activity
EC Numbers (1)
2.3.2.27 |
GO - Molecular Function (1)
histone ubiquitin ligase activity (H2A-K119 specific) |
GO - Biological Process (2)
heterochromatin formation |
negative regulation of DNA-templated transcription |
Properties
The RNF2 and PCGF component associate through extensive contacts between partially hydrophilic surfaces of their RING fingers, forming a heterodimeric RING ubiquitin ligase. The RYBP/YAF2 subunit appears to play an important role in stimulating the E3 ubiquitin ligase activity of RNF2.
3D Structure
Curated structures (2):
Identifier | Qualifier | |
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5JH5 |
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4HPM |
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Expression and Cellular Location
Gene Expression Map
GO - Cellular Component (2)
chromatin |
PRC1 complex |
Additional Information
Further Reading
Identifier | Title | Author(s) |
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22325352 | PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. | Gao Z, Zhang J, Bonasio R, Strino F, Sawai A, Parisi F, Kluger Y, Reinberg D. |
27568929 | KDM2B Recruitment of the Polycomb Group Complex, PRC1.1, Requires Cooperation between PCGF1 and BCORL1. | Wong SJ, Gearhart MD, Taylor AB, Nanyes DR, Ha DJ, Robinson AK, Artigas JA, Lee OJ, Demeler B, Hart PJ, Bardwell VJ, Kim CA. |
33202645 | Mammalian PRC1 Complexes: Compositional Complexity and Diverse Molecular Mechanisms. | Geng Z, Gao Z. |
34680880 | Polycomb Repressive Complex(es) and Their Role in Adult Stem Cells. | Flora P, Dalal G, Cohen I, Ezhkova E. |
Synonyms (2)
ncPRC1.1 complex |
Non-canonical PRC1 complex |
Systematic Name
BCOR:KDM2B:PCGF1:RNF2:YAF2:SKP1 |