Non-canonical polycomb repressive complex 1.1, RING2-PCGF1-YAF2 variant

ComplexAc: CPX-2272

Homo sapiens; 9606

Curated by:

IntAct

Components

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ComplexViewer 2.2.4by Rappsilber LaboratoryPCGF1YAF2KDM2BSKP1RNF2BCORtooltip
Legend Description Stoichiometry
protein - YAF2 (unspecified role)
YY1-associated factor 2
protein - SKP1 (unspecified role)
S-phase kinase-associated protein 1
protein - KDM2B (unspecified role)
Lysine-specific demethylase 2B
protein - RNF2 (unspecified role)
E3 ubiquitin-protein ligase RING2
protein - PCGF1 (unspecified role)
Polycomb group RING finger protein 1
Show all components

E3 ubiquitin-protein ligase that acts as a transcriptional repressor by mediating the monoubiquitination of Lys-119 of histone H2A, compacting chromatin, stalling RNA polymerase II and transcriptionally silencing genes critical for development. KDM2B contributes to generic genomic localization of this complex variant around promoters and other loci enriched for unmethylated CpG islands.

Catalytic Activity

EC Numbers (1)

2.3.2.27

Properties

The RNF2 and PCGF component associate through extensive contacts between partially hydrophilic surfaces of their RING fingers, forming a heterodimeric RING ubiquitin ligase. The RYBP/YAF2 subunit appears to play an important role in stimulating the E3 ubiquitin ligase activity of RNF2.

3D Structure

Curated structures (2):

Identifier Qualifier
5JH5 subset (MI:2179)
4HPM subset (MI:2179)

Expression and Cellular Location

Gene Expression Map

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GO - Cellular Component (2)

chromatin
PRC1 complex

Additional Information

Further Reading

Identifier Title Author(s)
22325352 PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. Gao Z, Zhang J, Bonasio R, Strino F, Sawai A, Parisi F, Kluger Y, Reinberg D.
27568929 KDM2B Recruitment of the Polycomb Group Complex, PRC1.1, Requires Cooperation between PCGF1 and BCORL1. Wong SJ, Gearhart MD, Taylor AB, Nanyes DR, Ha DJ, Robinson AK, Artigas JA, Lee OJ, Demeler B, Hart PJ, Bardwell VJ, Kim CA.
33202645 Mammalian PRC1 Complexes: Compositional Complexity and Diverse Molecular Mechanisms. Geng Z, Gao Z.
34680880 Polycomb Repressive Complex(es) and Their Role in Adult Stem Cells. Flora P, Dalal G, Cohen I, Ezhkova E.

Synonyms (2)

ncPRC1.1 complex
Non-canonical PRC1 complex

Systematic Name

BCOR:KDM2B:PCGF1:RNF2:YAF2:SKP1