Laminin-332 complex variant A

ComplexAc: CPX-3012

Mus musculus; 10090

Curated by:

IntAct

Components

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ComplexViewer 2.2.4by Rappsilber LaboratoryLama312004006008001000120014001724Lamb3120040060080010001168Lamc2120040060080010001191tooltip
Legend Description Stoichiometry
protein - Lamb3 (unspecified role)
Laminin subunit beta-3
protein - Lamc2 (unspecified role)
Laminin subunit gamma-2
protein - Lama3 (unspecified role)
Laminin subunit alpha-3

Function

Major component of basment membranes which binds to cells via a high affinity, cell-surface receptor. Role in the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminin-5 is thought to be involved in cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, signal transduction via tyrosine phosphorylation of pp125-FAK and p80, differentiation of keratinocytes.

Properties

Complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Laminin-332 variant B (CPX-3164) only differs from this complex by the length of the alpha chain isoform.

Assembly

Heterotrimer.

Expression and Cellular Location

Gene Expression Map

Showing 2 genes:

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Expression level in TPM
0
17
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GO - Cellular Component (1)

laminin-5 complex

Additional Information

Further Reading

Identifier Title Author(s)
17453709 Physiological and pathological implications of laminins: from the gene to the protein. Páez MC, González MJ, Serrano NC, Shoenfeld Y, Anaya JM.

Synonyms (8)

ladsin
LM-5A
LM-3A32
LM-332
Laminin-5 complex
Show all

Systematic Name

Lama3:Lamb3:Lamc2