Mitochondrial pyruvate carrier, fermentative isoform

ComplexAc: CPX-302

Saccharomyces cerevisiae; 559292

Curated by:

Saccharomyces Genome Database

Components

  • Collapse
  • Scale:
ComplexViewer 2.2.4by Rappsilber LaboratoryMPC1120406080100120130MPC2120406080100120129tooltip
Legend Description Stoichiometry
protein - MPC1 (unspecified role)
Mitochondrial pyruvate carrier 1
protein - MPC2 (unspecified role)
Mitochondrial pyruvate carrier 2

Function

The fermentative isoform of the mitochondrial pyruvate carrier resides in the mitochondrial inner membrane and mediates uptake of pyruvate into the mitochondrion during growth on fermentable carbon sources such as glucose.

Properties

The Mpc1 subunit has two transmembrane segments with a connecting loop that is in the mitochondrial intermembrane space (IMS); its N and C termini extend into the mitochondrial matrix. The Mpc2 subunit has three transmembrane segments; its N terminus and an internal loop are in the matrix, while its C terminus and an internal loop are in the IMS. The two subunits form a heterodimer. Mpc1 is expressed constitutively and is also a component of the respiratory isoform of the mitochondrial pyruvate carrier, while Mpc2 is expressed only during fermentative growth.

Assembly

Heterodimer

Expression and Cellular Location

Additional Information

Further Reading

Identifier Title Author(s)
22628554 Identification and functional expression of the mitochondrial pyruvate carrier. Herzig S, Raemy E, Montessuit S, Veuthey JL, Zamboni N, Westermann B, Kunji ER, Martinou JC.
22628558 A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N, Redin C, Boudina S, Gygi SP, Brivet M, Thummel CS, Rutter J.
25672363 Regulation of mitochondrial pyruvate uptake by alternative pyruvate carrier complexes. Bender T, Pena G, Martinou JC.

Systematic Name

MPC1:MPC2