Laminin-332 complex variant B
Function
Major component of basment membranes which binds to cells via a high affinity, cell-surface receptor. Role in the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminin-5 is thought to be involved in cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, signal transduction via tyrosine phosphorylation of pp125-FAK and p80, differentiation of keratinocytes.
GO - Molecular Function (1)
extracellular matrix structural constituent |
GO - Biological Process (3)
regulation of embryonic development |
regulation of cell adhesion |
regulation of cell migration |
Properties
Complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.
Laminin-332 variant A (CPX-3012) only differs from this complex by the length of the alpha chain isoform.
Assembly
Heterotrimer. |
Expression and Cellular Location
Gene Expression Map
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GO - Cellular Component (1)
laminin-5 complex |
Additional Information
Further Reading
Identifier | Title | Author(s) |
---|---|---|
17453709 | Physiological and pathological implications of laminins: from the gene to the protein. | Páez MC, González MJ, Serrano NC, Shoenfeld Y, Anaya JM. |
Synonyms (3)
LM-5B |
LM-3B32 |
Laminin-5B complex |
Systematic Name
Lama3:Lamb3:Lamc2 |