PAR cell polarity complex, PARD6G-PRKCZ variant
Function
Conserved serine/threonine kinase complex that localises at tight junctions where it is required for the establishment of a cell polarity axis during the cell division cycle of epithelial cells.
GO - Molecular Function (1)
protein serine/threonine kinase activity |
GO - Biological Process (1)
establishment or maintenance of epithelial cell apical/basal polarity |
Properties
Two PAR3 genes (PARD3A-B), three PAR6 (PARD6A,B,G) and two aPKC/PRKC (PRKCI and PRKCZ) genes have been identified in humans.
Every PAR6 and PRKC can function as part of the PAR polarity complex, while PARD3B does not seem to interact with aPKC/PRKCs.
Expression and Cellular Location
Gene Expression Map
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GO - Cellular Component (2)
tight junction |
PAR polarity complex |
Additional Information
Further Reading
Identifier | Title | Author(s) |
---|---|---|
18005931 | Polarity complex proteins. | Assémat E, Bazellières E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D. |
Synonyms (2)
PAR6-PAR3-aPKC complex |
apical polarity complex |
Systematic Name
PARD3:PARD6G:PRKCZ |