TP53 (ENSG00000141510)
human (Homo sapiens)
EMBL's European Bioinformatics Institute
EBI Search
Access all EMBL-EBI resources
Search results fortp53
Showing 58 results out of 110,802 in All results
(1 result • includes expression, structures, literature...)
(12,421 results)
Source: UniProtKB (ID: P53_HUMAN)
Cellular tumor antigen p53
Homo sapiens(Reviewed)
Secondary accession number(s): Q15086, Q15087, Q15088, Q16535, Q16807, Q16808, Q16809, Q16810, Q16811, Q16848, Q2XN98, Q3LRW1, Q3LRW2, Q3LRW3, Q3LRW4, Q3LRW5, Q86UG1, Q8J016, Q99659, Q9BTM4, Q9HAQ8, Q9NP68, Q9NPJ2, Q9NZD0, Q9UBI2, Q9UQ61
Cross references:
Cross references:
Source: UniProtKB (ID: T53G3_HUMAN)
TP53-target gene 3 protein
Homo sapiens(Reviewed)
Secondary accession number(s): B2R5K6, Q4KN31, Q9ULY9
Cross references:
(4,924 results)
Source: HGNC (ID: HGNC:11998)
Approved Symbol: TP53
Approved Name: tumor protein p53
Status: (Approved)
Aliases: p53 LFS1
Locus Type: gene with protein product
Chromosome: 17p13.1
Cross references:
Source: HGNC (ID: HGNC:16197)
Approved Symbol: TP53RK
Approved Name: TP53 regulating kinase
Status: (Approved)
Aliases: dJ101A2.2 prpk Nori-2p BUD32 TPRKB
Locus Type: gene with protein product
Chromosome: 20q13.12
Cross references:
Source: HGNC (ID: HGNC:17026)
Approved Symbol: TP53TG1
Approved Name: TP53 target 1
Status: (Approved)
Aliases: H_RG012D21.9 LINC00096 TP53LC12
Locus Type: RNA, long non-coding
Chromosome: 7q21.12
Cross references:
(4 results)
... products of the gene tp53 in different organisms. They have sent you a list of ...
https://www.ebi.ac.uk/training/online/courses/uniprot-exploring-protein-sequence-and-functional-info/exercise-mapping-other-database-identifiers-to-uniprot/
... -labelled probes complementary to one of REV-ERBα, CRY2, or TP53 transcripts ... -labelled probes complementary to one of REV-ERBα, CRY2, or TP53 transcripts ...
https://www.ebi.ac.uk/bioimage-archive/rembi-model-reference/
Modeling causal signal propagation in multi-omic factor space with COSMOS Dugourd A, Lafrenz P, Mañanes D, Paton V, Fallegger R, Kroger A, Turei D, Shtylla B, Saez-Rodriguez J. Preprint, 2024 doi:10.1 ...
https://www.ebi.ac.uk/research/saez/publications/
(1,732 results)
Source: GO (ID: GO:0030330)
Ontology: biological process
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
Cross references:
Source: Ontology Lookup Service (OLS) (ID: NCIT_C118396)
A change in the nucleotide sequence of the TP53 gene.
Source: Ontology Lookup Service (OLS) (ID: NCIT_C158957)
A procedure used to detect and identify mutations in the TP53 gene.
(12,204 results)
Source: PRIDE (ID: PXD051459)
Background: TP53, the most frequently mutated gene in human cancers, orchestrates a complex transcriptional program crucial for cancer prevention. While certain TP53-dependent genes have been ... , emphasizing its significance in the TP53 network. However, little is known about its targets and its role in ...
Cross references:
Source: PRIDE (ID: PXD028494)
... mutation of tumor suppressor genes, such as TP53 and PTEN. To generate functional signatures of TP53 or ... its congenic TP53- or PTEN-knockout derivatives, upon perturbation with the monofunctional DNA ... replicates. All data are publicly available and may be used to advance our understanding of the TP53
Cross references:
Source: PRIDE (ID: PXD034044)
Analysis of the immunopeptidome of Human Leukocyte Antigen(HLA)class I of SaOS-2 osteosarcoma cells transfected with pBR322 vector only, and 2 mutants of TP53 protein namely R175H and R273H.
Cross references:
(19,648 results)
Source: RNAcentral (ID: URS000075D314_9606)
Homo sapiens (human) TP53 target 1 (TP53TG1)
Cross references:
Cross references:
Cross references:
(6,354 results)
Source: GEO (ID: GSE76940)
... promotes leukemogenesis remains unclear. We found that combined loss of Lnk and tumor suppressors Tp53 ... profiling of bone marrow proB progenitors from WT, Tp53-/-, Lnk-/- and preleukemic healthy Tp53/Lnk ... . Results suggest that Tp53-/-Lnk-/- B-ALLs display similar gene expression profiles to human Ph ...
Cross references:
Source: GEO (ID: GSE157951)
... pathways. The goals of this study are to compare TP53-WT and TP53-KO HCT116 cells transcriptome ... profileing and chromatin accessibility under 5-FU treatment. Methods: HCT116 cell profiles of TP53-WT and TP53- KO were generated by deep sequencing, in duplicates, using Illumina GAIIx. The sequence ...
Cross references:
Source: GEO (ID: GSE8798)
... syndrome. Most cases are due to mutations in TP53. CHK2 is a minor predisposing locus; we recently mapped a third locus to 1q23. In both TP53 and non-TP53 LFS, there is evidence for risk heterogeneity ... constitutive samples of 10 LFS patients (6 with and 4 without TP53 mutations), to identify genome-wide ...
Cross references:
(36,455 results)
Source: Europe PMC (ID: 35030298)
Wang H, Wang X, Xu L, Zhang J
(2022 Jan 26), FEBS open bio 12 (3) 616-626
Cross references:
Source: Europe PMC (ID: 38010733)
Saba KH, Difilippo V, Kovac M, Cornmark L, Magnusson L, Nilsson J, van den Bos H, Spierings DC, Bidgoli M, Jonson T, Sumathi VP, Brosjö O, Staaf J, Foijer F, Styring E, Nathrath M, Baumhoer D, Nord KH
(2023 Nov 27), The Journal of pathology 262 (2) 147-160
Cross references:
Source: Europe PMC (ID: 27880943)
Cross references:
(1,508 results)
Source: IntAct Interactions (ID: EBI-714308-EBI-366083)
| Molecule A | Molecule B | Publications | Confidence value | Datasets |
|---|---|---|---|---|
| TP53TG1 EBI-714308 Homo sapiens | TP53 P04637 Homo sapiens | 16169070 | N.A. |
Cross references:
Source: IntAct Interactions (ID: EBI-366083-EBI-474016)
| Molecule A | Molecule B | Publications | Confidence value | Datasets |
|---|---|---|---|---|
| TP53 P04637 Homo sapiens | Tp53 P02340 Mus musculus | 15383276 | 0.36784992 | Chromatin - Epigenetic interactions resulting in chromatin modulation |
Cross references:
Source: IntAct Interactions (ID: EBI-474016-EBI-474016)
| Molecule A | Molecule B | Publications | Confidence value | Datasets |
|---|---|---|---|---|
| Tp53 P02340 Mus musculus | Tp53 P02340 Mus musculus | 25119037 | 0.40116468 | N.A. |
Cross references:
(214 results)
Source: Interpro family (ID: IPR029290)
The tumour suppressor TP53 gene (encoding cellular tumour antigen p53 or p53) is the most frequently altered gene in human tumours. TP53-target gene 5 protein (also known as cellular tumour antigen p53-inducible 5) suppresses cell growth and may play a significant role in p53/TP53-mediating ...
Cross references:
Source: Interpro domain (ID: IPR047250)
This entry represents the second BRCT domain of TP53-binding protein 1 (TP53BP1, also known as p53BP1 or 53BP1) and its homologue from C.elegans [[cite:PUB00102333], [cite:PUB00102314]]. TP53BP1 is a double-strand break (DSB) repair protein involved in response to DNA damage, telomere ...
Cross references:
Source: Interpro domain (ID: IPR047249)
This entry represents the BRCT domain of TP53BP1 and its orthologues. It corresponds to the first BRCT domain of TP53BP1 and hsr-9. This entry includes TP53-binding protein 1 (TP53BP1, also known as p53BP1 or 53BP1) and its orthologues, such as DNA repair protein RAD9 from S.cerevisiae ...
Cross references:
(5 results)
Source: Enzyme Portal (ID: 3.1.3.46)
3.1.3.46 Fructose-2,6-bisphosphate 2-phosphatase
Cross references:
Cross references:
Source: Enzyme Portal (ID: 1.17.4.1)
1.17.4.1 Ribonucleoside-diphosphate reductase
Cross references:
(773 results)
Source: OMIM (ID: 191170)
... , is located within the first intron. Bourdon et al. (2005) stated that the TP53 gene contains 11 exons ... TP53 gene to chromosome 17p13. By in situ hybridization with a mouse DNA probe, Le Beau et al. (1985 ... TP53 gene is on the short arm (Rowley, 1986). By Southern filter hybridization of DNAs from human ...
Cross references:
Source: OMIM (ID: 616403)
CLONING Using differential display to identify genes upregulated by TP53 (191170) expression ... anticancer drugs induced TP53TG1 in a TP53-dependent manner. The time lag between induction of TP53 and TP53TG1 suggested that TP53 may not directly induce TP53TG1 expression. GENE STRUCTURE Takei et ...
Cross references:
Source: OMIM (ID: 617482)
DESCRIPTION TP53 (191170) is a transcription factor involved in cell cycle arrest, apoptosis, DNA repair, chromosomal stability, and inhibition of angiogenesis. TP53TG3 is 1 of many TP53 target genes ... TP53 expression system, followed by screening a testis cDNA library and RT-PCR, Ng et al. (1999 ...
Cross references:
(1,607 results)
Cross references:
Cross references:
Cross references:
(3,333 results)
Source: Reactome (ID: 6804188)
Binding of PRDM1 (BLIMP1) to the promoter region of the TP53 (p53) gene inhibits TP53 transcription (Yan et al. 2007) probably by inducing repressive methylation of the TP53 promoter (Weige et al. 2014).
Stable Id: R-HSA-6804188
Type: Reaction
Species: Homo sapiens
Cross references:
Source: Reactome (ID: 2997706)
MDM2 in a complex with CDKN2A (p14-ARF) SUMOylates TP53 (p53) with SUMO2,3 at lysine-386 (Stindt et al. 2011, Hendriks et al. 2014, Tammsalu et al. 2014). SUMOylation decreases transcriptional activation by TP53 at some genes and decreases repression by TP53 at other genes (Stindt et al. 2011).
Stable Id: R-HSA-2997706
Type: Reaction
Species: Homo sapiens
Cross references:
Source: Reactome (ID: 6805479)
The atypical protein serine/threonine kinase TP53RK (TP53-regulating kinase), also known as PRPK (p53-related protein kinase), phosphorylates TP53 (p53) on serine residue S15 (Abe et al. 2001, Facchin et al. 2003).
Stable Id: R-HSA-6805479
Type: Reaction
Species: Homo sapiens
Cross references:
(213 results)
Source: BioStudies - Other data (ID: S-EPMC4495363)
... (TP53) to the role of a tumor suppressor gene. However, it is now an indisputable fact that many p53 ... signature of the TP53 gene in human cancer, the various gains-of-function (GOFs) of the different ... human TP53 mutations. In this review, we will shatter the classical and traditional image of tumor ...
Cross references:
Source: BioStudies - Other data (ID: S-EPMC3776635)
The tumor suppressor, microRNA-34 (miR-34), a transcriptional target of TP53, functions in a positive feedback loop to activate TP53. Although miR-34 can inhibit cancer cells carrying TP53 mutations, this feedback to TP53 may be a prerequisite for full miR-34 function and may restrict its ...
Cross references:
Source: BioStudies - Other data (ID: S-EPMC4680865)
... with early breast cancer. We evaluated whether incorporating TP53 mutation analysis can further enhance their prognostic accuracy. We examined TP53 mutation and the IHC4 score in tumors of 605 patients ... obtained information regarding TP53 mutation and PAM50 subtypes in 699 tumors from the Molecular ...
Cross references:
(161 results)
Source: ChEMBL Target Component (ID: 8214)
Accession: Q12888
Component Synonym: 53BP1, TP53-binding protein 1, TP53BP1, p53-binding protein 1, p53BP1
Cross references:
Source: ChEMBL Target Component (ID: 18210)
Accession: P70399
Component Synonym: 53BP1, Synonyms=Trp53bp1, TP53-binding protein 1, Tp53bp1, p53-binding protein 1, p53BP1
Cross references:
Cross references:
(3,037 results)
Source: Open Targets Genetics
Reported trait name: Sitting height
EFO mapped trait name: body weights and measures
Variant: 17_7668434_T_G
Prioritised gene: TP53
Locus2Gene score: 0.37308
Cross references:
Source: Open Targets Genetics
Reported trait name: Mean corpuscular volume
EFO mapped trait name: mean corpuscular volume
Variant: 17_7668434_T_G
Prioritised gene: TP53
Locus2Gene score: 0.37308
Cross references:
Source: Open Targets Genetics
Reported trait name: Forced vital capacity (fvc), best measure
EFO mapped trait name: vital capacity
Variant: 17_7668434_T_G
Prioritised gene: TP53
Locus2Gene score: 0.3669
Cross references:
(3 results)
Source: bio.tools (ID: LnCeVar)
A comprehensive database of genomic variations that disturb ceRNA network regulation. Genomic VA,T,C,G RIATION disturbing ceRNA regulations. LnCeVar is a comprehensive database that aims to infer genomic variations that disturb lncRNA-associated ceRNA regulation. e.g. NEAT1, TP53, hsa-let-7b-5p ...
Homepage: http://www.bio-bigdata.net/LnCeVar/
Cross references:
Formats: in bio.tools
Source: bio.tools (ID: lfspro)
... . TP53 germline mutation carrier estimation and cancer risk predictions.
Homepage: https://bioinformatics.mdanderson.org/public-software/lfspro/
Cross references:
Formats: in bio.tools
Source: ORCID data claims (ID: S-BIAD1114)
Multiplex imaging reveals spatially resolved DNA-damage response neighborhoods in TP53-mutated myelodysplastic neoplasms
ORCID(s): 
https://orcid.org/0000-0002-1970-5751
Cross references:
(6,205 results)
Source: CancerModels.org (ID: HCM-WCMC-0751-C54_WCMC)
External model ID: HCM-WCMC-0751-C54
Provider name: Weill Cornell Medical College
Model type: organoid
Histology: Endometrial Carcinoma
Cancer system: Reproductive System Cancer
Primary site: endometrium
Tumour type: Primary
Patient age: 50 - 59
Patient sex: female
Source: CancerModels.org (ID: TM00184_JAX)
External model ID: TM00184
Provider name: The Jackson laboratory
Model type: PDX
Histology: Colon Adenocarcinoma
Cancer system: Digestive System Cancer
Primary site: colon
Tumour type: Metastatic
Patient age: Not Provided
Patient sex: female
Source: CancerModels.org (ID: TM01144_JAX)
External model ID: TM01144
Provider name: The Jackson laboratory
Model type: PDX
Histology: Skin Squamous Cell Carcinoma
Cancer system: Skin Cancer
Primary site: skin
Tumour type: Primary
Patient age: Not Provided
Patient sex: male
(1 results)
Source: EVA Studies (ID: PRJEB73349)
CD20+ T cells in Monoclonal B Cell Lymphocytosis and Chronic Lymphocytic Leukemia
Cross references: