EMD-23530

Single-particle
4.5 Å
EMD-23530
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Deposition: 24/02/2021
Map released: 05/05/2021
Last modified: 20/11/2024
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Overview 3D View Sample Experiment Validation Volume Browser Additional data Links

EMD-23530
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Marseillevirus heterotrimeric (hexameric) nucleosome

EMD-23530

Single-particle
4.5 Å
EMD-23530
3D View Gallery
Deposition: 24/02/2021
Map released: 05/05/2021
Last modified: 20/11/2024
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Sample Organism: Marseillevirus marseillevirus, synthetic construct
Sample: Marseillevirus heterotrimeric (hexameric) nucleosome
Fitted models: 7lv9 (Avg. Q-score: 0.217)

Deposition Authors: Valencia-Sanchez MI, Abini-Agbomson S
The structure of a virus-encoded nucleosome.
Valencia-Sanchez MI, Abini-Agbomson S , Wang M, Lee R , Vasilyev N, Zhang J, De Ioannes P , La Scola B , Talbert P , Henikoff S , Nudler E , Erives A , Armache KJ
(2021) Nat Struct Mol Biol , 28 , 413 - 417
PUBMED: 33927388
DOI: doi:10.1038/s41594-021-00585-7
ISSN: 1545-9985
Abstract:
Certain large DNA viruses, including those in the Marseilleviridae family, encode histones. Here we show that fused histone pairs Hβ-Hα and Hδ-Hγ from Marseillevirus are structurally analogous to the eukaryotic histone pairs H2B-H2A and H4-H3. These viral histones form 'forced' heterodimers, and a heterotetramer of four such heterodimers assembles DNA to form structures virtually identical to canonical eukaryotic nucleosomes.