EMD-41871
BG505.664 Env SOSIP in complex with polyclonal antibodies from NHP 8147 (C3/V5, V1/V2/V3 apex, gp41 glycan hole/fusion peptide and trimer base epitopes)
EMD-41871
Composite mapSingle-particle
25.0 Å
![EMD-41871](https://www.ebi.ac.uk/emdb/images/entry/EMD-41871/400_41871.gif)
Map released: 11/09/2024
Last modified: 11/09/2024
Sample Organism:
Human immunodeficiency virus 1,
Macaca
Sample: BG505.664 Env SOSIP in complex with polyclonal antibodies from NHP 8147 (C3/V5, V1/V2/V3 apex, gp41 glycan hole/fusion peptide and trimer base epitopes)
Deposition Authors: Zhang S
,
Ward AB
Sample: BG505.664 Env SOSIP in complex with polyclonal antibodies from NHP 8147 (C3/V5, V1/V2/V3 apex, gp41 glycan hole/fusion peptide and trimer base epitopes)
Deposition Authors: Zhang S
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Immunization with germ line-targeting SOSIP trimers elicits broadly neutralizing antibody precursors in infant macaques.
Nelson AN
,
Shen X
,
Vekatayogi S
,
Zhang S
,
Ozorowski G
,
Dennis M
,
Sewall LM
,
Milligan E
,
Davis D
,
Cross KA
,
Chen Y
,
van Schooten J
,
Eudailey J
,
Isaac J
,
Memon S
,
Weinbaum C
,
Gao H
,
Stanfield-Oakley S
,
Byrd A,
Chutkan S,
Berendam S
,
Cronin K
,
Yasmeen A
,
Alam S
,
LaBranche CC
,
Rogers K
,
Shirreff L
,
Cupo A
,
Derking R,
Villinger F
,
Klasse PJ
,
Ferrari G
,
Williams WB
,
Hudgens MG
,
Ward AB
,
Montefiori DC
,
Van Rompay KKA
,
Wiehe K
,
Moore JP
,
Sanders RW
,
De Paris K
,
Permar SR
(2024) Sci Immunol , 9 , eadm7097 - eadm7097
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(2024) Sci Immunol , 9 , eadm7097 - eadm7097
Abstract:
Adolescents are a growing population of people living with HIV. The period between weaning and sexual debut presents a low-risk window for HIV acquisition, making early childhood an ideal time for implementing an immunization regimen. Because the elicitation of broadly neutralizing antibodies (bnAbs) is critical for an effective HIV vaccine, our goal was to assess the ability of a bnAb B cell lineage-designed HIV envelope SOSIP (protein stabilized by a disulfide bond between gp120-gp41-named "SOS"-and an isoleucine-to-proline point mutation-named "IP"-at residue 559) to induce precursor CD4 binding site (CD4bs)-targeting bnAbs in early life. Infant rhesus macaques received either a BG505 SOSIP, based on the infant BG505 transmitted/founder virus, or the CD4bs germ line-targeting BG505 SOSIP GT1.1 (n = 5 per group). Although both strategies induced durable, high-magnitude plasma autologous virus neutralization responses, only GT1.1-immunized infants (n = 3 of 5) exhibited VRC01-like CD4bs bnAb precursor development. Thus, a multidose immunization regimen with bnAb lineage-designed SOSIPs shows promise for inducing early B cell responses with the potential to mature into protective HIV bnAbs before sexual debut.
Adolescents are a growing population of people living with HIV. The period between weaning and sexual debut presents a low-risk window for HIV acquisition, making early childhood an ideal time for implementing an immunization regimen. Because the elicitation of broadly neutralizing antibodies (bnAbs) is critical for an effective HIV vaccine, our goal was to assess the ability of a bnAb B cell lineage-designed HIV envelope SOSIP (protein stabilized by a disulfide bond between gp120-gp41-named "SOS"-and an isoleucine-to-proline point mutation-named "IP"-at residue 559) to induce precursor CD4 binding site (CD4bs)-targeting bnAbs in early life. Infant rhesus macaques received either a BG505 SOSIP, based on the infant BG505 transmitted/founder virus, or the CD4bs germ line-targeting BG505 SOSIP GT1.1 (n = 5 per group). Although both strategies induced durable, high-magnitude plasma autologous virus neutralization responses, only GT1.1-immunized infants (n = 3 of 5) exhibited VRC01-like CD4bs bnAb precursor development. Thus, a multidose immunization regimen with bnAb lineage-designed SOSIPs shows promise for inducing early B cell responses with the potential to mature into protective HIV bnAbs before sexual debut.