EMD-9601

Single-particle
4.0 Å
EMD-9601 Deposition: 27/07/2018
Map released: 21/11/2018
Last modified: 29/05/2024
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links

EMD-9601

The structure of CVA10 virus procapsid particle

EMD-9601

Single-particle
4.0 Å
EMD-9601 Deposition: 27/07/2018
Map released: 21/11/2018
Last modified: 29/05/2024
Overview 3D View Sample Experiment Validation Volume Browser Additional data Links
Sample Organism: Coxsackievirus A10
Sample: CVA10 virus procapsid particle
Fitted models: 6acw (Avg. Q-score: 0.476)

Deposition Authors: Zhu R , Xu LF
Discovery and structural characterization of a therapeutic antibody against coxsackievirus A10.
Zhu R , Xu L , Zheng Q , Cui Y , Li S , He M, Yin Z , Liu D, Li S , Li Z, Chen Z, Yu H , Que Y, Liu C, Kong Z, Zhang J, Baker TS , Yan X , Hong Zhou Z , Cheng T , Xia N
(2018) Sci Adv , 4 , eaat7459 - eaat7459
PUBMED: 30255146
DOI: doi:10.1126/sciadv.aat7459
ISSN: 2375-2548
Abstract:
Coxsackievirus A10 (CVA10) recently emerged as a major pathogen of hand, foot, and mouth disease and herpangina in children worldwide, and lack of a vaccine or a cure against CVA10 infections has made therapeutic antibody identification a public health priority. By targeting a local isolate, CVA10-FJ-01, we obtained a potent antibody, 2G8, against all three capsid forms of CVA10. We show that 2G8 exhibited both 100% preventive and 100% therapeutic efficacy against CVA10 infection in mice. Comparisons of the near-atomic cryo-electron microscopy structures of the three forms of CVA10 capsid and their complexes with 2G8 Fab reveal that a single Fab binds a border region across the three capsid proteins (VP1 to VP3) and explain 2G8's remarkable cross-reactivities against all three capsid forms. The atomic structures of this first neutralizing antibody of CVA10 should inform strategies for designing vaccines and therapeutics against CVA10 infections.