EMD-41153
Integrin alpha-v beta-8 in complex with minibinder B8_BP_dsulf
EMD-41153
Single-particle2.9 Å
![EMD-41153](https://www.ebi.ac.uk/emdb/images/entry/EMD-41153/400_41153.gif)
Map released: 27/09/2023
Last modified: 27/09/2023
Sample Organism:
Homo sapiens,
synthetic construct
Sample: Ternary complex of integrin heterodimer (alpha-v beta-8) and the de novo minibinder protein B8_BP_dslf
Fitted models: 8tcf
Deposition Authors: Campbell MG
,
Fernandez A
,
Roy A,
Kraft J,
Baker D
Sample: Ternary complex of integrin heterodimer (alpha-v beta-8) and the de novo minibinder protein B8_BP_dslf
Fitted models: 8tcf
Deposition Authors: Campbell MG
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De novo design of highly selective miniprotein inhibitors of integrins alpha v beta 6 and alpha v beta 8.
Roy A,
Shi L,
Chang A,
Dong X,
Fernandez A
,
Kraft JC
,
Li J,
Le VQ
,
Winegar RV,
Cherf GM,
Slocum D
,
Poulson PD
,
Casper GE,
Vallecillo-Zuniga ML
,
Valdoz JC
,
Miranda MC
,
Bai H,
Kipnis Y
,
Olshefsky A
,
Priya T,
Carter L,
Ravichandran R,
Chow CM,
Johnson MR,
Cheng S,
Smith M,
Overed-Sayer C,
Finch DK,
Lowe D,
Bera AK
,
Matute-Bello G,
Birkland TP,
DiMaio F,
Raghu G,
Cochran JR
,
Stewart LJ,
Campbell MG
,
Van Ry PM,
Springer T
,
Baker D
(2023) Nat Commun , 14 , 5660 - 5660
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(2023) Nat Commun , 14 , 5660 - 5660