Cryo-EM structure of ClassIII Lanthipeptide modification enzyme PneKC mutant H522A.
Li Y, Luo M, Shao K, Li J, Li Z
To Be Published
- Pnea (1 kDa, Protein from Streptococcus pneumoniae)
- Phosphate ion (94 Da, Ligand)
- Dimeric structure of class iii lanthipeptide modification enzyme pnekc h522a in complex with substrate pnea (210 kDa, Complex from Streptococcus pneumoniae)
- Pnea (1 kDa, Protein from Streptococcus pneumoniae)
- Protein kinase domain-containing protein (100 kDa, Protein from Streptococcus pneumoniae)
- Protein kinase domain-containing protein (99 kDa, Protein from Streptococcus pneumoniae)
Li Y, Shao K, Li Z, Zhu K, Gan BK, Shi J, Xiao Y, Luo M
Nat Commun (2024) 15 pp. 7090-7090 [ DOI: doi:10.1038/s41467-024-51600-6 Pubmed: 39154050 ]
- Phosphate ion (94 Da, Ligand)
- Protein kinase domain-containing protein (100 kDa, Protein from Streptococcus pneumoniae)
- Dimeric structure of class iii lanthipeptide modification enzyme pnekc with one protomer in complex with substrate pnea and gtp (210 kDa, Complex from Streptococcus pneumoniae)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Pnea lp (1 kDa, Protein from Streptococcus pneumoniae)
Li Y, Shao K, Li Z, Zhu K, Gan BK, Shi J, Xiao Y, Luo M
Nat Commun (2024) 15 pp. 7090-7090 [ DOI: doi:10.1038/s41467-024-51600-6 Pubmed: 39154050 ]
- Phosphate ion (94 Da, Ligand)
- Sapb/amfs family lantipeptide (4 kDa, Protein from Streptococcus pneumoniae)
- Dimeric structure of class iii lanthipeptide modification pnekc with gsp and pnea bound to one protomer. (210 kDa, Complex from Streptococcus pneumoniae)
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Protein kinase domain-containing protein (100 kDa, Protein from Streptococcus pneumoniae)
- 5'-guanosine-diphosphate-monothiophosphate (539 Da, Ligand)
Voltage-gated sodium channel Nav1.7 variant M9
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8xmm
Q-score: 0.544
Li Z, Wu Q, Huang G, Jin X, Li J, Pan X, Yan N
PNAS (2024) 121 pp. e2322899121-e2322899121 [ Pubmed: 38381792 DOI: doi:10.1073/pnas.2322899121 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Voltage-gated sodium channel nav1.7-m9 (Complex from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Sodium channel subunit beta-1 (26 kDa, Protein from Homo sapiens)
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
- (2s,3r,4e)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate (421 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Voltage-gated sodium channel Nav1.7 variant M2
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 8xmn
Q-score: 0.431
Li Z, Wu Q, Huang G, Jin X, Li J, Pan X, Yan N
PNAS (2024) 121 pp. e2322899121-e2322899121 [ Pubmed: 38381792 DOI: doi:10.1073/pnas.2322899121 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel subunit beta-2 (25 kDa, Protein from Homo sapiens)
- Voltage-gated sodium channel nav1.7-m2 (Complex from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Sodium channel subunit beta-1 (26 kDa, Protein from Homo sapiens)
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
Voltage-gated sodium channel Nav1.7 variant M4
Resolution: 3.39 Å
EM Method: Single-particle
Fitted PDBs: 8xmo
Q-score: 0.455
Li Z, Wu Q, Huang G, Jin X, Li J, Pan X, Yan N
PNAS (2024) 121 pp. e2322899121-e2322899121 [ Pubmed: 38381792 DOI: doi:10.1073/pnas.2322899121 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
- Voltage-gated sodium channel nav1.7-m4 (Complex from Homo sapiens)
- Sodium channel subunit beta-2 (25 kDa, Protein from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Sodium channel subunit beta-1 (26 kDa, Protein from Homo sapiens)
Cryo-EM structure of the erythromycin-bound motilin receptor-Gq protein complex
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8ibu
Q-score: 0.394
You C, Zhang Y, Xu Y, Xu P, Li Z, Li H, Huang S, Chen Z, Li J, Xu HE, Jiang Y
Sci Adv (2023) 9 pp. eade9020-eade9020 [ Pubmed: 36921049 DOI: doi:10.1126/sciadv.ade9020 ]
- Erythromycin a (733 Da, Ligand)
- Soluble cytochrome b562,motilin receptor,fusion tag (81 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Erythromycin-bound motilin receptor-gq protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Cryo-EM structure of the motilin-bound motilin receptor-Gq protein complex
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8ibv
Q-score: 0.412
You C, Zhang Y, Xu Y, Xu P, Li Z, Li H, Huang S, Chen Z, Li J, Xu HE, Jiang Y
Sci Adv (2023) 9 pp. eade9020-eade9020 [ Pubmed: 36921049 DOI: doi:10.1126/sciadv.ade9020 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Motilin-bound motilin receptor-gq protein complex (Complex from Homo sapiens)
- Soluble cytochrome b562,motilin receptor,soluble cytochrome b562, motilin receptor (81 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Motilin (2 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
SARS-CoV-2 Omicron BA.1 spike trimer (6P) in complex with 1 YB9-258 Fab (1 RBD up)
Resolution: 6.21 Å
EM Method: Single-particle
Fitted PDBs: 8hc2
Q-score: 0.154
Yu H, Liu B, Zhang Y, Gao X, Wang Q, Xiang H, Peng X, Xie C, Wang Y, Hu P, Shi J, Shi Q, Zheng P, Feng C, Tang G, Liu X, Guo L, Lin X, Li J, Liu C, Huang Y, Yang N, Chen Q, Li Z, Su M, Yan Q, Pei R, Chen X, Liu L, Hu F, Liang D, Ke B, Ke C, Li F, He J, Wang M, Chen L, Xiong X, Tang X
Nat Commun (2023) 14 pp. 1058-1058 [ DOI: doi:10.1038/s41467-023-36761-0 Pubmed: 36828833 ]
- Heavy chain of yb9-258 fab (23 kDa, Protein from Homo sapiens)
- Yb9-258 fab (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 omicron ba.1 spike trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of yb9-258 fab (23 kDa, Protein from Homo sapiens)
- Sars-cov-2 omicron ba.1 spike trimer with one rbd up in complex with one yb9-258 fab (Complex)
- Spike glycoprotein (138 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)